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Gene: VKORC1 (vitamin K epoxide reductase complex subunit 1) Chlorocebus sabaeus

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Symbol:

VKORC1

Name:

vitamin K epoxide reductase complex subunit 1

RGD ID:

18768697

Description:

ENCODES a protein that exhibits vitamin-K-epoxide reductase (warfarin-insensitive) activity (ortholog); vitamin-K-epoxide reductase (warfarin-sensitive) activity (ortholog); INVOLVED IN peptidyl-glutamic acid carboxylation (ortholog); positive regulation of coagulation (ortholog); regulation of blood coagulation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH Aortic Calcification (ortholog); Aortic Rupture (ortholog); blood coagulation disease (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,778,553 - 27,782,639 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,776,416 - 27,782,640 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,685,255 - 1,689,345 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aortic Calcification (ISO)

Aortic Rupture (ISO)

blood coagulation disease (ISO)

branched-chain keto acid dehydrogenase kinase deficiency (ISO)

combined deficiency of vitamin K-dependent clotting factors 2 (ISO)

Coronary Disease (ISO)

Coumarin Sensitivity (ISO)

dilated cardiomyopathy (ISO)

Hemorrhage (ISO)

Stroke (ISO)

thrombosis (ISO)

vascular disease (ISO)

Venous Thromboembolism (ISO)

warfarin resistance (ISO)

warfarin sensitivity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

bone development (IEA)

peptidyl-glutamic acid carboxylation (ISO)

positive regulation of coagulation (IEA,ISO)

regulation of blood coagulation (ISO)

vitamin K metabolic process (IEA,ISO)

xenobiotic metabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum lumen (IEA,ISO)

endoplasmic reticulum membrane (IEA,ISO)

membrane (IEA)

Molecular Function

oxidoreductase activity (IEA)

oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor (IEA)

protein binding (ISO)

quinone binding (IEA)

vitamin-K-epoxide reductase (warfarin-insensitive) activity (IEA,ISO)

vitamin-K-epoxide reductase (warfarin-sensitive) activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (ISO)

alteplase pharmacodynamics pathway (ISO)

aminocaproic acid pharmacodynamics pathway (ISO)

anistreplase pharmacodynamics pathway (ISO)

aprotinin pharmacodynamics pathway (ISO)

argatroban pharmacodynamics pathway (ISO)

bivalirudin pharmacodynamics pathway (ISO)

dicoumarol pharmacodynamics pathway (ISO)

enoxaparin pharmacodynamics pathway (ISO)

fondaparinux pharmacodynamics pathway (ISO)

heparin pharmacodynamics pathway (ISO)

phenindione pharmacodynamics pathway (ISO)

reteplase pharmacodynamics pathway (ISO)

tranexamic acid pharmacodynamics pathway (ISO)

vitamin K cycle pathway (ISO)

vitamin K metabolic pathway (ISO)

warfarin pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

VKORC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,778,553 - 27,782,639 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,776,416 - 27,782,640 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,685,255 - 1,689,345 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

VKORC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	31,090,854 - 31,094,797 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	31,090,842 - 31,095,980 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	31,102,175 - 31,106,118 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	31,009,676 - 31,013,777 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	29,191,224 - 29,195,328 (+)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	28,663,874 - 28,667,978 (-)	NCBI		HuRef
CHM1_1	16	32,419,476 - 32,423,596 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	31,478,282 - 31,482,234 (-)	NCBI		T2T-CHM13v2.0

Vkorc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	127,492,235 - 127,494,833 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	127,485,399 - 127,494,626 (-)	Ensembl		GRCm39 Ensembl
GRCm39 Ensembl	7	127,492,235 - 127,494,789 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,893,063 - 127,895,658 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,886,227 - 127,895,454 (-)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	7	127,893,063 - 127,895,617 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	135,036,577 - 135,039,131 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,684,211 - 127,686,765 (-)	NCBI		MGSCv36	mm8
Celera	7	127,728,262 - 127,730,816 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.81	NCBI

Vkorc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,932,969 - 191,935,490 (-)	NCBI		GRCr8
mRatBN7.2	1	182,502,491 - 182,505,012 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,500,844 - 182,505,008 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,853,032 - 190,855,553 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	198,039,126 - 198,041,647 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	190,709,541 - 190,712,063 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	199,338,785 - 199,341,306 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,337,138 - 199,341,302 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,361,380 - 206,363,901 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,176,745 - 187,179,266 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,326,627 - 187,329,147 (-)	NCBI
Celera	1	180,153,292 - 180,155,813 (-)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

Vkorc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955493	7,928,516 - 7,931,265 (-)	NCBI	ChiLan1.0	ChiLan1.0

VKORC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	34,298,329 - 34,303,550 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	39,099,732 - 39,104,570 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	23,871,756 - 23,876,599 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	31,459,556 - 31,464,617 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	31,459,560 - 31,464,897 (-)	Ensembl	panpan1.1		panPan2

VKORC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,140,565 - 17,142,621 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	17,140,633 - 17,142,547 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	18,715,931 - 18,717,978 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,271,459 - 17,273,505 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	17,271,517 - 17,273,431 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	17,071,856 - 17,073,902 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	16,990,716 - 16,992,762 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,303,101 - 17,305,147 (+)	NCBI		UU_Cfam_GSD_1.0

Vkorc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	125,361,540 - 125,363,993 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	13,459,022 - 13,462,174 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	13,459,400 - 13,461,864 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VKORC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	17,386,245 - 17,389,905 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	17,386,230 - 17,389,162 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	17,483,272 - 17,485,908 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Vkorc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	14,141,545 - 14,144,177 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	14,141,545 - 14,144,181 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in VKORC1
126 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007990494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007990495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000003773 ⟹ ENSCSAP00000002047

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	5	27,776,416 - 27,782,640 (-)	Ensembl

RefSeq Acc Id:

XM_007990494 ⟹ XP_007988685

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	27,778,553 - 27,782,639 (-)	NCBI
Vero_WHO_p1.0	NW_023666068	1,685,261 - 1,689,345 (+)	NCBI

Sequence:

show sequence

CGATTCCCCACGTCTCTTACCCGCCTCACCAGTCTGGGCATTCTTAGCTGTTTTCCTAACTCTC
TCGCCTGACTAGCCCCCGGGAACAGCCGTTTGGGTCGCGGAGTGCGAACCCGGCCGGCCAATCG
CCAAGTCAGAGGGGCAGGAGGGGCGTGGCCATTCCCCGCCCCGCCCCTGCCCCGTGGCTGGTTT
TCACTGCTGGCGCCTCAGACGGAACCTGGAGATAATGGACAGCACCTGGGGGAGCCCTGGCTGG
GTGCGGCTCGCTCTTTGCTTGGCCGGCCTAGTGCTTTCGCTCTACGCGCTGCACGTGAAGGCAG
CGCGCGCCCGGGACAGGGATTACCGCGCGCTCTGCGACGTAGGCACCGCCATCAGCTGTTCCCG
TGTCTTCTCCTCCAGGTGGGGCAGGGGCTTCGGGCTGGTGGAGCATGTGCTGGGACCGGACAGC
ATCCTCAATCAATCCAACAGCATATTCGGTTGCATCTTCTACACACTACAGCTATTGTTAGGTT
GCCTGCGGACGCGCTGGGCCTCTGTCGTGCTGCTGCTGAGCTCCCTGGTGTCTCTTGCTGGTTC
TGTCTACCTGGCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATCGTTTGCATCACCACC
TATGCCATCAATGTGGGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAACCCCAGGGCAAGG
CTAAGAGGCACTGAGCCCTCACCCCAAGCCAGGCTGGCCTCGTCTGCTTTGCTTTGGCATGTGA
GCCTTGCCCAAGGGGGCATATCTGGGTCCCTAGAAGGCCCTAGATGCGGGGCCTTCTAGAGTCC
CCCCTCCTCCTGCCATACCTGCACATGACAATGGACCAAGTGCCACACACTTGCTCTTTTTTCC
ACCCAGTGCCTCTGACTCTGTCCCCAAGGGCTGGTCTCCAAAGCTCTTGCCATTGCCCAGGGAG
GGAAGGTTCTGAGCAATAAAGTTTCTTAGATCAATCA

hide sequence

RefSeq Acc Id:

XM_007990495 ⟹ XP_007988686

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	27,778,553 - 27,782,639 (-)	NCBI
Vero_WHO_p1.0	NW_023666068	1,685,255 - 1,689,345 (+)	NCBI

Sequence:

show sequence

CGATTCCCCACGTCTCTTACCCGCCTCACCAGTCTGGGCATTCTTAGCTGTTTTCCTAACTCTC
TCGCCTGACTAGCCCCCGGGAACAGCCGTTTGGGTCGCGGAGTGCGAACCCGGCCGGCCAATCG
CCAAGTCAGAGGGGCAGGAGGGGCGTGGCCATTCCCCGCCCCGCCCCTGCCCCGTGGCTGGTTT
TCACTGCTGGCGCCTCAGACGGAACCTGGAGATAATGGACAGCACCTGGGGGAGCCCTGGCTGG
GTGCGGCTCGCTCTTTGCTTGGCCGGCCTAGTGCTTTCGCTCTACGCGCTGCACGTGAAGGCAG
CGCGCGCCCGGGACAGGGATTACCGCGCGCTCTGCGACGTAGGCACCGCCATCAGCTGTTCCCG
TGTCTTCTCCTCCAGGTTGCCTGCGGACGCGCTGGGCCTCTGTCGTGCTGCTGCTGAGCTCCCT
GGTGTCTCTTGCTGGTTCTGTCTACCTGGCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGC
ATCGTTTGCATCACCACCTATGCCATCAATGTGGGCCTGATGTGGCTCAGTTTCCGGAAGGTCC
AAGAACCCCAGGGCAAGGCTAAGAGGCACTGAGCCCTCACCCCAAGCCAGGCTGGCCTCGTCTG
CTTTGCTTTGGCATGTGAGCCTTGCCCAAGGGGGCATATCTGGGTCCCTAGAAGGCCCTAGATG
CGGGGCCTTCTAGAGTCCCCCCTCCTCCTGCCATACCTGCACATGACAATGGACCAAGTGCCAC
ACACTTGCTCTTTTTTCCACCCAGTGCCTCTGACTCTGTCCCCAAGGGCTGGTCTCCAAAGCTC
TTGCCATTGCCCAGGGAGGGAAGGTTCTGAGCAATAAAGTTTCTTAGATCAATCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007988685	(Get FASTA)	NCBI Sequence Viewer
	XP_007988686	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000002047
	ENSCSAP00000002047.1

RefSeq Acc Id:	XP_007988686 ⟸ XM_007990495
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_007988685 ⟸ XM_007990494
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9R0A8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000002047 ⟸ ENSCSAT00000003773

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005735	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003773.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1440.130	UniProtKB/TrEMBL
InterPro	VKOR	UniProtKB/TrEMBL
	VKOR_sf	UniProtKB/TrEMBL
	VKORC1/VKORC1L1	UniProtKB/TrEMBL
KEGG Report	csab:103231221	UniProtKB/TrEMBL
NCBI Gene	VKORC1	ENTREZGENE
PANTHER	PTHR14519	UniProtKB/TrEMBL
	VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1	UniProtKB/TrEMBL
Pfam	VKOR	UniProtKB/TrEMBL
SMART	VKc	UniProtKB/TrEMBL
UniProt	A0A0D9R0A8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB