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Gene: Pcsk9 (proprotein convertase subtilisin/kexin type 9) Chinchilla lanigera

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Symbol:

Pcsk9

Name:

proprotein convertase subtilisin/kexin type 9

RGD ID:

8887471

Description:

ENCODES a protein that exhibits apolipoprotein binding (ortholog); apolipoprotein receptor binding (ortholog); low-density lipoprotein particle binding (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); cellular response to starvation (ortholog); cholesterol homeostasis (ortholog); ASSOCIATED WITH autosomal recessive hypercholesterolemia (ortholog); classic citrullinemia (ortholog); coronary artery disease (ortholog); FOUND IN cell surface (ortholog); COPII-coated ER to Golgi transport vesicle (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	4,425,435 - 4,439,842 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	4,424,583 - 4,439,805 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive hypercholesterolemia (ISO)

classic citrullinemia (ISO)

coronary artery disease (ISO)

Coronary Disease (ISO)

familial hypercholesterolemia (ISO)

High Myopia (ISO)

Hypercholesterolemia (ISO)

Hypercholesterolemia, Autosomal Dominant, 3 (ISO)

Hyperlipoproteinemia Type II (ISO)

hypobetalipoproteinemia (ISO)

Hypocholesterolemia (ISO)

Metabolic Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (ISO)

cellular response to starvation (ISO)

cholesterol homeostasis (ISO)

cholesterol metabolic process (ISO)

kidney development (ISO)

lipoprotein metabolic process (ISO)

liver development (ISO)

low-density lipoprotein particle receptor catabolic process (ISO)

low-density lipoprotein receptor particle metabolic process (ISO)

lysosomal transport (ISO)

negative regulation of low-density lipoprotein particle clearance (ISO)

negative regulation of low-density lipoprotein receptor activity (ISO)

negative regulation of receptor internalization (ISO)

negative regulation of receptor recycling (ISO)

negative regulation of receptor-mediated endocytosis involved in cholesterol transport (ISO)

negative regulation of sodium ion transmembrane transporter activity (ISO)

neurogenesis (ISO)

neuron differentiation (ISO)

phospholipid metabolic process (ISO)

positive regulation of low-density lipoprotein particle receptor catabolic process (ISO)

positive regulation of neuron apoptotic process (ISO)

positive regulation of receptor internalization (ISO)

protein autoprocessing (ISO)

protein processing (ISO)

regulation of low-density lipoprotein particle receptor catabolic process (ISO)

regulation of neuron apoptotic process (ISO)

regulation of signaling receptor activity (ISO)

triglyceride metabolic process (ISO)

Cellular Component

cell surface (ISO)

COPII-coated ER to Golgi transport vesicle (ISO)

cytoplasm (ISO)

early endosome (ISO)

endoplasmic reticulum (ISO)

extracellular region (ISO)

extracellular space (ISO)

Golgi apparatus (ISO)

late endosome (ISO)

lysosome (ISO)

PCSK9-AnxA2 complex (ISO)

PCSK9-LDLR complex (ISO)

perinuclear region of cytoplasm (ISO)

plasma membrane (ISO)

Molecular Function

apolipoprotein binding (ISO)

apolipoprotein receptor binding (ISO)

low-density lipoprotein particle binding (ISO)

low-density lipoprotein particle receptor binding (ISO)

protein binding (ISO)

serine-type endopeptidase activity (ISO)

signaling receptor inhibitor activity (ISO)

sodium channel inhibitor activity (ISO)

very-low-density lipoprotein particle binding (ISO)

very-low-density lipoprotein particle receptor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pcsk9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	4,425,435 - 4,439,842 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	4,424,583 - 4,439,805 (-)	NCBI	ChiLan1.0	ChiLan1.0

PCSK9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	55,039,548 - 55,064,852 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	55,039,445 - 55,064,852 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	55,505,221 - 55,530,525 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	55,277,808 - 55,303,111 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	55,217,240 - 55,242,544	NCBI
Celera	1	53,792,769 - 53,818,130 (+)	NCBI		Celera
Cytogenetic Map	1	p32.3	NCBI
HuRef	1	53,618,200 - 53,643,557 (+)	NCBI		HuRef
CHM1_1	1	55,621,314 - 55,646,685 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	54,913,987 - 54,945,736 (+)	NCBI		T2T-CHM13v2.0

Pcsk9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	106,299,531 - 106,321,522 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	106,299,526 - 106,321,526 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	106,442,334 - 106,464,325 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	106,442,329 - 106,464,329 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	106,114,939 - 106,136,930 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	105,940,274 - 105,974,961 (-)	NCBI		MGSCv36	mm8
Celera	4	104,803,009 - 104,824,874 (-)	NCBI		Celera
Cytogenetic Map	4	C7	NCBI
cM Map	4	49.67	NCBI

Pcsk9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	126,440,102 - 126,462,507 (-)	NCBI		GRCr8
mRatBN7.2	5	121,211,278 - 121,233,688 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	121,211,278 - 121,233,688 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	123,824,322 - 123,846,721 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	125,547,373 - 125,569,772 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	125,598,631 - 125,621,028 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	126,031,368 - 126,053,726 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	126,031,368 - 126,053,726 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	129,878,797 - 129,900,625 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	127,501,476 - 127,524,289 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	127,507,768 - 127,529,490 (-)	NCBI
Celera	5	119,960,965 - 119,983,199 (-)	NCBI		Celera
Cytogenetic Map	5	q34	NCBI

PCSK9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	171,754,941 - 171,787,297 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	170,895,635 - 170,927,961 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	54,323,036 - 54,355,397 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	55,911,016 - 55,943,404 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	55,911,016 - 55,936,456 (+)	Ensembl	panpan1.1		panPan2

PCSK9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	54,197,211 - 54,210,724 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	54,264,679 - 54,280,339 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	54,383,361 - 54,399,016 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	54,380,525 - 54,396,181 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	54,270,491 - 54,282,704 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	54,658,929 - 54,672,888 (-)	NCBI		UU_Cfam_GSD_1.0

Pcsk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	69,116,048 - 69,144,955 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936522	6,272,507 - 6,299,917 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936522	6,271,339 - 6,300,202 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PCSK9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	157,388,372 - 157,409,551 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	157,388,370 - 157,409,620 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	145,451,983 - 145,473,336 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PCSK9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	77,893,574 - 77,921,076 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	77,893,590 - 77,918,613 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	39,376,139 - 39,401,572 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pcsk9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624862	4,879,561 - 4,895,776 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624862	4,873,457 - 4,895,836 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005398505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01049990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01049991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01046754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023689 ⟹ ENSCLAP00000023467

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955464	4,425,435 - 4,439,842 (-)	Ensembl

RefSeq Acc Id:

XM_005398505 ⟹ XP_005398562

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955464	4,424,583 - 4,439,805 (-)	NCBI

Sequence:

show sequence

TCCTCCCGTCCCGGGGCTCCGTTAATGTTTAATCAGATAGGATCGTCCGATGGGGCTCCGGTGG
CGTGATCTCCCGGCCCCCGGGCGTCGAGCGCCCACACCCTAGAAGGCTCGGCGGGCGTCGAGGC
CCGGACTCTCCCGCCGGACAGAGGCCCAGCTTCCAGCCGGGCGCGCCTGGTCCTCCGCCCGGGC
CGGTCCCGCGCCGCCGCCGTGATGCGCACCCGCGGGCCCGCGCCGCCCTGGTGCTCGCTGCTGC
TGCTCCTGCTGCTGCTCCTGCTGCTGGGCCCCGCGAGGGCCGGCGCCCCGGAGGACGAGGACGG
CGACTACGCGGAGCTGGCGCTCGCCTTCCAGTCGGAGGAGGATGGCCTGCCCGACGCGGCCCCG
CACGTGCCCGGCGCCACCTTCCACCGCTGCGCCAAGGCCGCATGGAGGCTGCCGGGCACCTACA
TGGTGGTGCTGAAGGAGGGGACCCACCACGAGCAGACCAAGCACACGGCCCGCCGCCTGCAGGC
CAGGGCTGCCCGCCGGGGCTATCTCACCACAGTCCTGCACCTTTTCCACCACCTGATCCCTGGC
TTCCTGGTGAAGATGAGCGCAGACCTGCTGGAGCTGGCCCTGCGGCTGCCACACGTCGAGTACA
TCGAGGAAGACTCCTCCGTCTTCGCGCAGAAGGTCCCGTGGAACCTGGAGCGGATCCTCCCTGT
GCGGTACCAGGCGGAGGAGTACAGCGCCCCCAGTGGAGGCGGCCCGGTGGAGGTGTACCTCTTA
GATACCAGCGTCCAGAGCGGCCACCGGGAAATCCAGGGCAGGATCACAGTCACCGACTTTGAGA
GTGTGCCTGAGGAGGACGGGACACGCTTCCACAGACAGGCAAGCAAGTGTGACAGTCACGGCAC
CCACCTGGCCGGCGTGGTCGGCGGTCGGGATGCGGGTGTGGCCAAGGGCGCCAGCCTGCGCAGC
CTGCGTGTGCTCAACTGCCAAGGGAAGGGCACAGTCAGCAGCACCCTCATAGGCCTGGAGTTCA
TTCAGAAAAGCCAGCTGGCCCAGCCCGTGGGGCCACTGGTGGTGCTGCTGCCCCTGGCCGGTGG
GTACAGCCGCACCCTCAATGCTGCCTGCCACCACCTGGTGAGGGTGGGGGTGGTGCTGGTTGCC
GCAGCCGGCAACTTCCGGGACGACGCCTGCCTCTACTCGCCAGCCTCGGCTCCTGAGGTCATCA
CAGTTGGGGCCACCAATGCCCAGGACCAGCCCGTGACCCTAGGGACTTTGGGGACCAACTTTGG
CCGCTGTGTGGACCTCTTTGCCCCGGGGGAGGATATTATTGGTGCCTCCAGTGATTGCAGCACC
TGCTTTGTGTCACAGAGTGGGACGTCGCAGGCCGCTGCCCATGTGGCAGGCATTGTGGCCATGA
TGCTGACGGCCGAGCCGGACCTCACGCTGGCTGAGCTGCGGCAGAGACTGATCCACTTCTCTGC
CAAAGATGTCATCAATGAGTCCTGGTTCCCTGAGGACCAGCGAGTGCTGACACCCAACCTGGTA
GCCAGGCTGCCCCCCAGCACCCACGGAGCAGGGAGACGGCTGCTCTGCAGGACAGTGTGGTCAG
CACATTCGGGGCCCACACGCACGGCCACTGCCCTGGCCCACTGCGCCCCCGGTGAGGAGCTGCT
GAGCTGCTCCAGTTTCTCCCGGAGCGGGAAGCGGCGGGGCGAACGCATCGAGGCCCTCAGGGGC
AGGCGAGTGTGCTTGGCCCACAACGCGTTTGGGGGTGAGGGCGTCTATGCTGTCGCCAGGTGCT
GCCTGCTGCCCCAGGCCAACTGCAGCATTCATACCGCTCCAGCCGGGGCTGGAATGGAGCCCCG
CGTTCACTGCCACCAGCAGGACGAGGTCCTCACAGGCTGCAGCACCCACTGGGAGGCTGAGGAT
TTTGGCGCCCACAGGTGGCCTGTGCCAAGGCCAGGTGGGCCTGGCCAATGTGTGGGCCACAAGG
AGGCCAGCATACATGCGTCCTGCTGCCAGGCCCCGGGCCTGGAGTGCAGAGTCAGGGAGCACGG
GGTCCCGTGGCCTGTGGAGCAGGTCACGGTGGCCTGTGAAGATGGCTGGACCCTGACGGGCTGC
AGCGCCCTCCCTGGGACCGCCTTGGTCCTTGGGGCCTACGCCGTGGACAACACGTGTGTGGTGA
GGAGCCGTGACGTCAAGGTGGCAGGCAGGACCAGCGAGGAGGCCGTGGCAGCTGCTGCCATCTG
CTGCCGGAGCTGGGCCTCGGAGCAGGCCTTCTGGGAGCACCAGTGACAGCCCGGTTGGGATGGG
GGCCTGTGTAGGGCCAGGGTCTGGGCCTGCAGGGACAGACTCCTTGCCTGGGAGGACTTCGGTC
TCACACCGTGACGGGCTGCAGCTTGGTGCTACCCTCACACCCCCACCTCCACCTCCACAGCACA
GCAAGGAAGCTGGGCTCTGCCTGCCAGCAGCCGAGGTGCCGCCCACGGCAGATGACGTGCCTGT
GTCTGAGCTCTTGCCCTGTGCCAGGCACTGGGTCAGTCTCCCCAGAGGAGGGAGGATGTGGGGT
ACGGAAGGAGCTGAGTGTCAGGCTGGGGATGGGAGGGTGAGGGAGCTGGTGGCCTTCCACTGGC
CTGCCCACTTTGGAGAAGCCCCTTTGGGATCCTTGGTTAATGGGGGATCTGTTTTCCATACCCC
TGGGGTAAGGGCAGGGATGAGATCCTTGCCTGTTTCTCCCAGCTGCCCTCACTCTGCTCCCCGT
CAGTAGCACTGGCACCCTGCTTTATGGAGGAAGATACAGGGGCTAGAGAGGGGCAGTGCCCCCC
GCACATGCCATGGAAAGGGGGACAGGCTGGGACGAGACCCGGAGTGGCCTGGTGAGAAGCCAAG
CCTCCACTGTGCCAGGCTGGGCACTGGCCCGCAGGTCGCATGGGACCCAGCTTGCTCTTGATGG
CCCGGTGGGCCGCAGAAGGGGGTGACTGTCTCCCCAACACAAGTATGTGTCTCCCCTAGGTCTC
CTCTCTGCTGCCTTTTTATACCAAGAAGCTTTTCCCAGACCTGTTTGGCTTTTGTAACTTGGTA
TTTATTCTGGGTTTTGTAGTGTTTTTATGATGTGACTTTTTAAAATAAAAGTAACTTTGTCATG
AC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005398562	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023467
	ENSCLAP00000023467.1

RefSeq Acc Id:

XP_005398562 ⟸ XM_005398505

- UniProtKB:

A0A8C2YU50 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRTRGPAPPWCSLLLLLLLLLLLGPARAGAPEDEDGDYAELALAFQSEEDGLPDAAPHVPGATF
HRCAKAAWRLPGTYMVVLKEGTHHEQTKHTARRLQARAARRGYLTTVLHLFHHLIPGFLVKMSA
DLLELALRLPHVEYIEEDSSVFAQKVPWNLERILPVRYQAEEYSAPSGGGPVEVYLLDTSVQSG
HREIQGRITVTDFESVPEEDGTRFHRQASKCDSHGTHLAGVVGGRDAGVAKGASLRSLRVLNCQ
GKGTVSSTLIGLEFIQKSQLAQPVGPLVVLLPLAGGYSRTLNAACHHLVRVGVVLVAAAGNFRD
DACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSG
TSQAAAHVAGIVAMMLTAEPDLTLAELRQRLIHFSAKDVINESWFPEDQRVLTPNLVARLPPST
HGAGRRLLCRTVWSAHSGPTRTATALAHCAPGEELLSCSSFSRSGKRRGERIEALRGRRVCLAH
NAFGGEGVYAVARCCLLPQANCSIHTAPAGAGMEPRVHCHQQDEVLTGCSTHWEAEDFGAHRWP
VPRPGGPGQCVGHKEASIHASCCQAPGLECRVREHGVPWPVEQVTVACEDGWTLTGCSALPGTA
LVLGAYAVDNTCVVRSRDVKVAGRTSEEAVAAAAICCRSWASEQAFWEHQ

hide sequence

Ensembl Acc Id:

ENSCLAP00000023467 ⟸ ENSCLAT00000023689

Protein Domains

Inhibitor I9 Peptidase S8/S53 Proprotein convertase subtilisin/kexin type 9 C-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016094	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023689	ENTREZGENE
	ENSCLAT00000023689.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.80	UniProtKB/TrEMBL
	3.40.50.200	UniProtKB/TrEMBL
	Proprotein convertase subtilisin/kexin type 9	UniProtKB/TrEMBL
InterPro	PCSK9_C	UniProtKB/TrEMBL
	PCSK9_C2	UniProtKB/TrEMBL
	PCSK9_C3	UniProtKB/TrEMBL
	PCSK9_ProteinaseK-like	UniProtKB/TrEMBL
	Peptidase_S8/S53_dom	UniProtKB/TrEMBL
	Peptidase_S8/S53_dom_sf	UniProtKB/TrEMBL
	Peptidase_S8_subtilisin-like	UniProtKB/TrEMBL
	Peptidase_S8_subtilisin-rel	UniProtKB/TrEMBL
	S8pro/Inhibitor_I9	UniProtKB/TrEMBL
	S8pro/Inhibitor_I9_sf	UniProtKB/TrEMBL
NCBI Gene	Pcsk9	ENTREZGENE
PANTHER	PEPTIDASE S8	UniProtKB/TrEMBL
	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9	UniProtKB/TrEMBL
Pfam	Inhibitor_I9	UniProtKB/TrEMBL
	PCSK9_C1	UniProtKB/TrEMBL
	PCSK9_C2	UniProtKB/TrEMBL
	PCSK9_C3	UniProtKB/TrEMBL
	Peptidase_S8	UniProtKB/TrEMBL
PRINTS	SUBTILISIN	UniProtKB/TrEMBL
PROSITE	SUBTILASE	UniProtKB/TrEMBL
Superfamily-SCOP	Protease propeptides/inhibitors	UniProtKB/TrEMBL
	SSF52743	UniProtKB/TrEMBL
UniProt	A0A8C2YU50	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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