Pten (phosphatase and tensin homolog) - Rat Genome Database

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Gene: Pten (phosphatase and tensin homolog) Chinchilla lanigera
Analyze
Symbol: Pten
Name: phosphatase and tensin homolog
RGD ID: 8706988
Description: ENCODES a protein that exhibits anaphase-promoting complex binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN adult behavior (ortholog); aging (ortholog); angiogenesis (ortholog); PARTICIPATES IN altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; endometrial cancer pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute myocardial infarction (ortholog); adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); cell projection (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,014,147 - 5,091,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554255,007,811 - 5,091,829 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute megakaryocytic leukemia  (ISO)
acute myocardial infarction  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
angiomyolipoma  (ISO)
anisometropia  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
biliary atresia  (ISO)
bladder squamous cell carcinoma  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Cardiovascular Abnormalities  (ISO)
cataract  (ISO)
cerebral cavernous malformation  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydiaceae Infections  (ISO)
cholangiocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Hypomyelinating Neuropathy  (ISO)
Cowden syndrome  (ISO)
Cowden syndrome 4  (ISO)
Cowden-Like Syndrome  (ISO)
Craniofacial Abnormalities  (ISO)
developmental coordination disorder  (ISO)
Developmental Disabilities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
Epstein-Barr Virus Infections  (ISO)
esophageal cancer  (ISO)
Experimental Melanoma  (ISO)
familial meningioma  (ISO)
fatty liver disease  (ISO)
fetal alcohol spectrum disorder  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hemangioma  (ISO)
Hemimegalencephaly  (ISO)
hepatitis B  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertrophy  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
Intimal Hyperplasia  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
Language Development Disorders  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
lipoma  (ISO)
lipomatosis  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
Macrocephaly  (ISO)
macrocephaly-autism syndrome  (ISO)
major depressive disorder  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
meningioma  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Sheath Neoplasms  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
papillomavirus infectious disease  (ISO)
peripheral nervous system neoplasm  (ISO)
Pneumococcal Pneumonia  (ISO)
polydactyly  (ISO)
portal hypertension  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO)
Pseudomonas Infections  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Reperfusion Injury  (ISO)
retinitis pigmentosa  (ISO)
rhabdomyosarcoma  (ISO)
Septic Peritonitis  (ISO)
Sezary's disease  (ISO)
silicosis  (ISO)
skin disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
skin squamous cell carcinoma  (ISO)
sporadic breast cancer  (ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
substance-related disorder  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
visual epilepsy  (ISO)
X-linked VACTERL association  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
aging  (ISO)
angiogenesis  (ISO)
B cell proliferation  (ISO)
brain morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac muscle tissue development  (ISO)
cell migration  (ISO)
cell population proliferation  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to leptin stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
central nervous system development  (ISO)
central nervous system myelin maintenance  (ISO)
central nervous system neuron axonogenesis  (ISO)
dendritic spine morphogenesis  (ISO)
dentate gyrus development  (ISO)
endothelial cell migration  (ISO)
forebrain morphogenesis  (ISO)
heart development  (ISO)
inositol phosphate dephosphorylation  (ISO)
learning or memory  (ISO)
localization  (ISO)
locomotor rhythm  (ISO)
locomotory behavior  (ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (ISO)
male mating behavior  (ISO)
maternal behavior  (ISO)
memory  (ISO)
multicellular organismal response to stress  (ISO)
myelination  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of axon regeneration  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of defense response to bacterium  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine morphogenesis  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of excitatory postsynaptic potential  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of keratinocyte migration  (ISO)
negative regulation of myelination  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of organ growth  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of phagocytosis, engulfment  (ISO)
negative regulation of potassium ion transmembrane transporter activity  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of ribosome biogenesis  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of synaptic vesicle clustering  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of wound healing, spreading of epidermal cells  (ISO)
neuron projection development  (ISO)
neuron-neuron synaptic transmission  (ISO)
phosphatidylinositol dephosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
positive regulation of ubiquitin protein ligase activity  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
postsynaptic density assembly  (ISO)
prepulse inhibition  (ISO)
presynaptic membrane assembly  (ISO)
prostate gland growth  (ISO)
protein dephosphorylation  (ISO)
protein kinase B signaling  (ISO)
protein stabilization  (ISO)
regulation of axon regeneration  (ISO)
regulation of B cell apoptotic process  (ISO)
regulation of cell cycle  (ISO)
regulation of cellular component size  (ISO)
regulation of cellular localization  (ISO)
regulation of macrophage apoptotic process  (ISO)
regulation of neuron projection development  (ISO)
regulation of protein stability  (ISO)
regulation of synaptic transmission, GABAergic  (ISO)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to ATP  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to inorganic substance  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
rhythmic synaptic transmission  (ISO)
social behavior  (ISO)
synapse assembly  (ISO)
synapse maturation  (ISO)
T cell proliferation  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Pten
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,014,147 - 5,091,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554255,007,811 - 5,091,829 (-)NCBIChiLan1.0ChiLan1.0
PTEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,863,625 - 87,971,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1087,862,638 - 87,971,930 (+)EnsemblGRCh38hg38GRCh38
GRCh371089,623,382 - 89,731,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361089,613,175 - 89,718,512 (+)NCBINCBI36hg18NCBI36
Build 341089,613,174 - 89,716,382NCBI
Celera1083,369,676 - 83,474,975 (+)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1083,258,013 - 83,363,313 (+)NCBIHuRef
CHM1_11089,905,493 - 90,010,826 (+)NCBICHM1_1
T2T-CHM13v2.01088,747,528 - 88,855,830 (+)NCBI
Pten
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBImm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
Pten
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21230,631,303 - 230,696,754 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)Ensembl
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Celera1227,746,622 - 227,812,108 (+)NCBICelera
Cytogenetic Map1q52NCBI
PTEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11088,093,539 - 88,197,902 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,093,539 - 88,194,605 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01084,587,841 - 84,689,043 (+)NCBIMhudiblu_PPA_v0panPan3
PTEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,853,148 - 37,913,176 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,835,661 - 37,913,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,711,222 - 37,730,964 (+)NCBI
ROS_Cfam_1.02639,359,420 - 39,447,205 (+)NCBI
ROS_Cfam_1.0 Ensembl2639,359,407 - 39,447,189 (+)Ensembl
UMICH_Zoey_3.12637,265,630 - 37,349,813 (+)NCBI
UNSW_CanFamBas_1.02636,847,668 - 36,931,645 (+)NCBI
UU_Cfam_GSD_1.02638,118,261 - 38,202,372 (+)NCBI
Pten
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721377,454,602 - 77,542,975 (+)NCBI
SpeTri2.0NW_0049367351,252,414 - 1,338,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11499,929,590 - 100,021,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214108,911,519 - 109,003,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1981,308,058 - 81,412,386 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl981,309,099 - 81,409,146 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604841,972,612 - 42,077,014 (+)NCBIVero_WHO_p1.0
Pten
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479113,975,235 - 14,056,900 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021850   ⟹   ENSCLAP00000021647
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554255,014,147 - 5,091,829 (-)Ensembl
RefSeq Acc Id: XM_013514767   ⟹   XP_013370221
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554255,007,811 - 5,091,829 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370221 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013370221   ⟸   XM_013514767
- Sequence:
RefSeq Acc Id: ENSCLAP00000021647   ⟸   ENSCLAT00000021850

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014815 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000021647.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021850.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Bifunc_PIno_P3_Pase/Pase_PTEN UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_PTEN UniProtKB/TrEMBL
  Tensin_C2-dom UniProtKB/TrEMBL
  Tensin_phosphatase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
NCBI Gene Pten ENTREZGENE
Pfam PTEN_C2 UniProtKB/TrEMBL
PIRSF PTEN UniProtKB/TrEMBL
PROSITE C2_TENSIN UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
SMART PTEN_C2 UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A8C2W3G4_CHILA UniProtKB/TrEMBL