Opa1 (OPA1 mitochondrial dynamin like GTPase) - Rat Genome Database

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Gene: Opa1 (OPA1 mitochondrial dynamin like GTPase) Chinchilla lanigera
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Symbol: Opa1
Name: OPA1 mitochondrial dynamin like GTPase
RGD ID: 8905668
Description: ENCODES a protein that exhibits cardiolipin binding (ortholog); GTPase activity (ortholog); kinase binding (ortholog); INVOLVED IN calcium import into the mitochondrion (ortholog); cellular response to glucose stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN mitochondria fusion pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); Auditory Neuropathy (ortholog); FOUND IN cytosol (ortholog); dendrite (ortholog); mitochondrial crista (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dynamin-like 120 kDa protein, mitochondrial; OPA1, mitochondrial dynamin like GTPase; optic atrophy 1 (autosomal dominant)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,927,490 - 15,007,082 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Opa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,927,490 - 15,007,082 (-)NCBIChiLan1.0ChiLan1.0
OPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383193,593,208 - 193,697,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3193,593,144 - 193,697,811 (+)EnsemblGRCh38hg38GRCh38
GRCh373193,310,997 - 193,415,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363194,793,806 - 194,898,009 (+)NCBINCBI36Build 36hg18NCBI36
Build 343194,793,813 - 194,898,017NCBI
Celera3191,726,124 - 191,830,778 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3190,698,074 - 190,803,338 (+)NCBIHuRef
CHM1_13193,273,732 - 193,378,486 (+)NCBICHM1_1
T2T-CHM13v2.03196,288,807 - 196,394,453 (+)NCBIT2T-CHM13v2.0
Opa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,398,099 - 29,481,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,398,152 - 29,473,702 (+)EnsemblGRCm39 Ensembl
GRCm381629,579,281 - 29,663,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1629,579,334 - 29,654,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv371629,579,428 - 29,652,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361629,499,089 - 29,572,237 (+)NCBIMGSCv36mm8
Celera1630,084,446 - 30,156,121 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1620.65NCBI
Opa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,612,943 - 84,690,025 (-)NCBIGRCr8
mRatBN7.21171,108,100 - 71,185,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,954,641 - 80,028,866 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,589,604 - 72,663,829 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,643,710 - 71,718,085 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Celera1170,077,956 - 70,151,932 (-)NCBICelera
Cytogenetic Map11q22NCBI
OPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22191,515,499 - 191,620,475 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13191,520,223 - 191,625,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03190,890,242 - 190,995,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13201,207,609 - 201,312,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,207,607 - 201,312,358 (+)Ensemblpanpan1.1panPan2
OPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12352,068,123 - 52,154,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2352,068,118 - 52,151,593 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2351,880,860 - 51,967,154 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02352,711,633 - 52,798,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2352,711,607 - 52,797,401 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,292,969 - 52,379,474 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,346,071 - 52,432,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02352,630,584 - 52,717,188 (+)NCBIUU_Cfam_GSD_1.0
Opa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,136,008 - 123,222,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367111,032,935 - 1,106,847 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367111,027,531 - 1,113,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13130,624,796 - 130,719,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113130,624,771 - 130,718,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,148,025 - 140,230,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11587,679,656 - 87,778,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1587,679,077 - 87,779,102 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604161,348,078 - 61,447,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,911,066 - 63,995,596 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473063,911,066 - 63,994,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000018743   ⟹   ENSCLAP00000018561
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018744   ⟹   ENSCLAP00000018562
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018745   ⟹   ENSCLAP00000018563
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,006,869 (-)Ensembl
RefSeq Acc Id: XM_005383200   ⟹   XP_005383257
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542014,927,490 - 15,007,082 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383201   ⟹   XP_005383258
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542014,927,490 - 15,007,081 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383203   ⟹   XP_005383260
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542014,927,490 - 15,007,081 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383205   ⟹   XP_005383262
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542014,927,490 - 15,007,081 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005383262   ⟸   XM_005383205
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VTC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383258   ⟸   XM_005383201
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005383260   ⟸   XM_005383203
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VRF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383257   ⟸   XM_005383200
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VW94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018562   ⟸   ENSCLAT00000018744
RefSeq Acc Id: ENSCLAP00000018563   ⟸   ENSCLAT00000018745
RefSeq Acc Id: ENSCLAP00000018561   ⟸   ENSCLAT00000018743
Protein Domains
Dynamin-type G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012734 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018743 ENTREZGENE
  ENSCLAT00000018743.1 UniProtKB/TrEMBL
  ENSCLAT00000018744 ENTREZGENE
  ENSCLAT00000018744.1 UniProtKB/TrEMBL
  ENSCLAT00000018745 ENTREZGENE
  ENSCLAT00000018745.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Dynamin UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  OPA1_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Opa1 ENTREZGENE
PANTHER PTHR11566 UniProtKB/TrEMBL
  PTHR11566:SF67 UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/TrEMBL
  OPA1_C UniProtKB/TrEMBL
PRINTS DYNAMIN UniProtKB/TrEMBL
PROSITE G_DYNAMIN_2 UniProtKB/TrEMBL
SMART DYNc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2VRF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VTC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VW94 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Opa1  OPA1 mitochondrial dynamin like GTPase    OPA1, mitochondrial dynamin like GTPase  Symbol and/or name change 5135510 APPROVED
2016-08-03 Opa1  OPA1, mitochondrial dynamin like GTPase    optic atrophy 1 (autosomal dominant)  Symbol and/or name change 5135510 APPROVED