Ngf (nerve growth factor) - Rat Genome Database
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Gene: Ngf (nerve growth factor) Chinchilla lanigera
Analyze
Symbol: Ngf
Name: nerve growth factor
RGD ID: 8930299
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); death receptor agonist activity (ortholog); metalloendopeptidase inhibitor activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adult locomotory behavior (ortholog); aging (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); amnestic disorder (ortholog); FOUND IN extracellular space (ortholog); neuron projection terminus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: beta-nerve growth factor; nerve growth factor (beta polypeptide)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
bacterial meningitis  (ISO)
bladder disease  (ISO)
bladder neck obstruction  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
Charcot-Marie-Tooth disease  (ISO)
chronic kidney disease  (ISO)
Chronic Pancreatitis  (ISO)
chronic ulcer of skin  (ISO)
Cocaine-Related Disorders  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
cystitis  (ISO)
degenerative disc disease  (ISO)
diabetic encephalopathy  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
hereditary sensory and autonomic neuropathy type 5  (ISO)
hereditary sensory neuropathy  (ISO)
heroin dependence  (ISO)
Hyperalgesia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
interstitial nephritis  (ISO)
Lewy body dementia  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myofascial pain syndrome  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurobehavioral Manifestations  (ISO)
neurodegenerative disease  (ISO)
neurogenic bladder  (ISO)
Neurogenic Inflammation  (ISO)
obstructive sleep apnea  (ISO)
Overactive Urinary Bladder  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
Parkinsonian Disorders  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinitis pigmentosa  (ISO)
rhinitis  (ISO)
Rib Fractures  (ISO)
sciatic neuropathy  (ISO)
sensorineural hearing loss  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adult locomotory behavior  (ISO)
aging  (ISO)
circadian rhythm  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
inflammatory response  (ISO)
memory  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
nerve growth factor signaling pathway  (ISO)
neuron apoptotic process  (ISO)
neuron development  (ISO)
neuron projection development  (ISO)
neuron projection morphogenesis  (ISO)
peripheral nervous system development  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collateral sprouting  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotrophin TRK receptor signaling pathway  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of stem cell proliferation  (ISO)
regulation of neuron differentiation  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to drug  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to ozone  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
sensory perception of pain  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Ngf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBIChiLan1.0ChiLan1.0
NGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1115,285,917 - 115,338,249 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1115,285,917 - 115,338,256 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1115,285,918 - 115,338,236 (-)EnsemblGRCh38hg38GRCh38
GRCh381115,285,915 - 115,338,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371115,828,537 - 115,880,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,630,060 - 115,682,380 (-)NCBINCBI36hg18NCBI36
Build 341115,540,580 - 115,592,899NCBI
Celera1114,057,456 - 114,109,776 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1113,686,915 - 113,739,240 (-)NCBIHuRef
CHM1_11115,943,440 - 115,995,752 (-)NCBICHM1_1
Ngf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,377,235 - 102,428,329 (+)NCBIGRCm39mm39
GRCm383102,469,919 - 102,521,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,469,919 - 102,521,013 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,273,851 - 102,324,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv363102,598,989 - 102,650,066 (+)NCBImm8
Celera3104,674,123 - 104,724,621 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Ngf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21294.4RGD
NGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,272,750 - 122,325,909 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0187,223,597 - 87,276,759 (+)NCBIMhudiblu_PPA_v0panPan3
NGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1752,900,647 - 52,901,607 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11752,900,647 - 52,901,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ngf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,256,417 - 105,307,842 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,256,691 - 105,307,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,436,784 - 115,446,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2018,413,108 - 18,413,833 (+)Ensembl
ChlSab1.12018,361,795 - 18,413,987 (+)NCBI
Ngf
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477211,009,765 - 11,070,050 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006948   ⟹   ENSCLAP00000006836
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006949   ⟹   ENSCLAP00000006837
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543518,582,048 - 18,594,852 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006950   ⟹   ENSCLAP00000006838
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543518,582,048 - 18,594,556 (-)Ensembl
RefSeq Acc Id: XM_005389020   ⟹   XP_005389077
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543518,581,889 - 18,601,886 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005389022   ⟹   XP_005389079
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543518,581,889 - 18,633,290 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005389026   ⟹   XP_005389083
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543518,581,889 - 18,632,465 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005389027   ⟹   XP_005389084
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543518,581,889 - 18,632,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005389028   ⟹   XP_005389085
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516567   ⟹   XP_013372021
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543518,581,889 - 18,601,886 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005389085   ⟸   XM_005389028
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005389079   ⟸   XM_005389022
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005389084   ⟸   XM_005389027
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005389083   ⟸   XM_005389026
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005389077   ⟸   XM_005389020
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013372021   ⟸   XM_013516567
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000006838   ⟸   ENSCLAT00000006950
RefSeq Acc Id: ENSCLAP00000006837   ⟸   ENSCLAT00000006949
RefSeq Acc Id: ENSCLAP00000006836   ⟸   ENSCLAT00000006948


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004815 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000006836 ENTREZGENE
Ensembl Transcript ENSCLAT00000006948 ENTREZGENE
NCBI Gene Ngf ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ngf  nerve growth factor    nerve growth factor (beta polypeptide)  Symbol and/or name change 5135510 APPROVED