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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:obeticholic acid
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Accession:CHEBI:43602 term browser browse the term
Definition:A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Synonyms:exact_synonym: 6alpha-ethyl-3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
 related_synonym: (3alpha,5beta,6alpha,7alpha)-6-ethyl-3,7-dihydroxycholan-24-oic acid;   6-ECDCA;   6-Ethyl-CDCA;   6-Ethylchenodeoxycholic acid;   6alpha-Ethyl-chenodeoxycholic acid;   6alpha-ethylchenodeoxycholic acid;   Formula=C26H44O4;   INT 747;   INT747;   InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1;   InChIKey=ZXERDUOLZKYMJM-ZWECCWDJSA-N;   Ocaliva;   SMILES=C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@@H]([C@@H]([C@@]2(C[C@@H](C1)O)[H])CC)O)[H])(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)[H])C
 alt_id: CHEBI:132971;   CHEBI:41467;   CHEBI:43599;   MESH:C464660
 xref: CAS:459789-99-2;   Drug_Central:5155;   KEGG:C15636;   KEGG:D09360
 xref_mesh: MESH:C464660
 xref: PDBeChem:CHC;   PMID:22406511;   PMID:23593273;   PMID:24382005;   PMID:24623154;   PMID:25329562;   PMID:25421586;   PMID:25468160;   PMID:25500425;   PMID:25592258;   PMID:25726736;   PMID:25753820;   PMID:25864227;   PMID:26136168;   PMID:26169860;   PMID:26169861;   PMID:26169862;   PMID:26549695;   PMID:26723896;   PMID:26811456;   PMID:26812075;   PMID:27109453;   PMID:27406083;   PMID:27425465;   PMID:27468093;   PMID:27475255;   Reaxys:9238543;   Wikipedia:Obeticholic_acid


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obeticholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin decreases expression EXP obeticholic acid results in decreased expression of A2M mRNA CTD PMID:27939613 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 decreases expression EXP obeticholic acid results in decreased expression of ABCA1 mRNA CTD PMID:27939613 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression		 EXP
ISO		 obeticholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Abcb11 protein in liver]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]
obeticholic acid results in increased expression of ABCB11 mRNA
obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB11 mRNA]		 CTD
RGD		 PMID:15644430 PMID:15911693 PMID:27255380 PMID:27939613 PMID:29660435 More... RGD:15036816 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions
increases expression		 ISO
EXP		 obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB4 mRNA]
obeticholic acid results in increased expression of ABCB4 mRNA		 CTD PMID:15644430 PMID:27255380 PMID:27939613 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 ISO obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCC2 mRNA]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC2 protein; [triptolide co-treated with Lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mRNA; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein]
obeticholic acid results in increased expression of ABCC2 mRNA		 CTD PMID:15644430 PMID:27255380 PMID:29660435 PMID:36328986 PMID:36787806 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions ISO obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA]
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 protein		 CTD PMID:32673658 PMID:36787806 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) multiple interactions ISO [obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 protein CTD PMID:36787806 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 decreases expression EXP obeticholic acid results in decreased expression of ABCG1 mRNA CTD PMID:27939613 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G ACAA1 acetyl-CoA acyltransferase 1 increases expression EXP obeticholic acid results in increased expression of ACAA1 mRNA CTD PMID:27939613 NCBI chr 3:38,122,715...38,137,127
Ensembl chr 3:38,103,129...38,137,242 		JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 increases expression EXP obeticholic acid results in increased expression of ACAA2 mRNA CTD PMID:27939613 NCBI chr18:49,782,164...49,813,533
Ensembl chr18:49,782,164...49,813,953 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha decreases expression EXP obeticholic acid results in decreased expression of ACACA mRNA CTD PMID:27939613 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACOT9 acyl-CoA thioesterase 9 increases expression EXP obeticholic acid results in increased expression of ACOT9 mRNA CTD PMID:27939613 NCBI chr  X:23,701,055...23,743,276
Ensembl chr  X:23,701,055...23,766,475 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression ISO
EXP		 obeticholic acid results in increased expression of ACOX1 mRNA CTD PMID:26655953 PMID:27939613 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ACOX2 acyl-CoA oxidase 2 increases expression EXP obeticholic acid results in increased expression of ACOX2 mRNA CTD PMID:27939613 NCBI chr 3:58,505,136...58,537,190
Ensembl chr 3:58,505,136...58,537,283 		JBrowse link
G ACOX3 acyl-CoA oxidase 3, pristanoyl increases expression EXP obeticholic acid results in increased expression of ACOX3 mRNA CTD PMID:27939613 NCBI chr 4:8,355,305...8,440,723
Ensembl chr 4:8,366,282...8,440,723 		JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 decreases expression EXP obeticholic acid results in decreased expression of ACSL1 mRNA CTD PMID:27939613 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818 		JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 increases expression EXP obeticholic acid results in increased expression of ACSL4 mRNA CTD PMID:27939613 NCBI chr  X:109,641,335...109,733,257
Ensembl chr  X:109,624,244...109,733,403 		JBrowse link
G ACSL5 acyl-CoA synthetase long chain family member 5 increases expression EXP obeticholic acid results in increased expression of ACSL5 mRNA CTD PMID:27939613 NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 increases expression EXP obeticholic acid results in increased expression of ACSL6 mRNA CTD PMID:27939613 NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243 		JBrowse link
G ADAMTSL2 ADAMTS like 2 decreases expression EXP obeticholic acid results in decreased expression of ADAMTSL2 mRNA CTD PMID:27939613 NCBI chr 9:133,532,164...133,575,519
Ensembl chr 9:133,532,164...133,575,519 		JBrowse link
G ADCY1 adenylate cyclase 1 increases expression EXP obeticholic acid results in increased expression of ADCY1 mRNA CTD PMID:27939613 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116 		JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP obeticholic acid results in decreased expression of ADH1C mRNA CTD PMID:27939613 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746 		JBrowse link
G AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression EXP obeticholic acid results in decreased expression of AGPAT2 mRNA CTD PMID:27939613 NCBI chr 9:136,673,143...136,687,457
Ensembl chr 9:136,673,143...136,687,457 		JBrowse link
G AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 decreases expression EXP obeticholic acid results in decreased expression of AGPAT5 mRNA CTD PMID:27939613 NCBI chr 8:6,708,642...6,761,503
Ensembl chr 8:6,708,642...6,761,503 		JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 decreases expression EXP obeticholic acid results in decreased expression of AKR1D1 mRNA CTD PMID:27939613 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases expression
decreases phosphorylation
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of AKT1 mRNA
obeticholic acid results in decreased phosphorylation of AKT1 protein
obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; obeticholic acid promotes the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]		 CTD PMID:27865854 PMID:27939613 PMID:35267068 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 decreases expression EXP obeticholic acid results in decreased expression of AKT2 mRNA CTD PMID:27939613 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536 		JBrowse link
G ALB albumin decreases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of ALB mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of ALB mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of ALB protein		 CTD PMID:27939613 PMID:35267068 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALDOA aldolase, fructose-bisphosphate A decreases expression EXP obeticholic acid results in decreased expression of ALDOA mRNA CTD PMID:27939613 NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457 		JBrowse link
G ALDOB aldolase, fructose-bisphosphate B decreases expression EXP obeticholic acid results in decreased expression of ALDOB mRNA CTD PMID:27939613 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664 		JBrowse link
G ALDOC aldolase, fructose-bisphosphate C increases expression EXP obeticholic acid results in increased expression of ALDOC mRNA CTD PMID:27939613 NCBI chr17:28,573,120...28,576,895
Ensembl chr17:28,573,115...28,576,948 		JBrowse link
G AMN amnion associated transmembrane protein decreases expression EXP obeticholic acid results in decreased expression of AMN mRNA CTD PMID:27939613 NCBI chr14:102,922,663...102,930,842
Ensembl chr14:102,922,663...102,933,596 		JBrowse link
G AOC4P amine oxidase copper containing 4, pseudogene increases expression EXP obeticholic acid results in increased expression of AOC4P mRNA CTD PMID:27939613 NCBI chr17:42,867,145...42,869,217
Ensembl chr17:42,865,922...42,874,246
Ensembl chr17:42,865,922...42,874,246 		JBrowse link
G APOA1 apolipoprotein A1 decreases expression EXP obeticholic acid results in decreased expression of APOA1 mRNA CTD PMID:27939613 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622 		JBrowse link
G APOA2 apolipoprotein A2 increases expression EXP obeticholic acid results in increased expression of APOA2 mRNA CTD PMID:27939613 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631 		JBrowse link
G APOB apolipoprotein B increases expression EXP obeticholic acid results in increased expression of APOB mRNA CTD PMID:27939613 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073 		JBrowse link
G APOC2 apolipoprotein C2 increases expression EXP obeticholic acid results in increased expression of APOC2 mRNA CTD PMID:27939613 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,946,035...44,949,565 		JBrowse link
G APOC3 apolipoprotein C3 decreases expression EXP obeticholic acid results in decreased expression of APOC3 mRNA CTD PMID:27939613 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072 		JBrowse link
G APOE apolipoprotein E decreases expression EXP obeticholic acid results in decreased expression of APOE mRNA CTD PMID:27939613 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G ASPG asparaginase decreases expression EXP obeticholic acid results in decreased expression of ASPG mRNA CTD PMID:27939613 NCBI chr14:104,085,700...104,115,582
Ensembl chr14:104,085,686...104,115,582 		JBrowse link
G ATG5 autophagy related 5 multiple interactions ISO obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in decreased expression of ATG5 mRNA] CTD PMID:35439472 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BAD BCL2 associated agonist of cell death decreases expression EXP obeticholic acid results in decreased expression of BAD mRNA CTD PMID:27939613 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in increased expression of BCL2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of BCL2 protein		 CTD PMID:27939613 PMID:35267068 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP obeticholic acid results in decreased expression of BID mRNA CTD PMID:27939613 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression EXP obeticholic acid results in decreased expression of BIRC3 mRNA CTD PMID:27939613 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G C5AR2 complement C5a receptor 2 decreases expression EXP obeticholic acid results in decreased expression of C5AR2 mRNA CTD PMID:27939613 NCBI chr19:47,332,175...47,347,329
Ensembl chr19:47,332,175...47,347,329 		JBrowse link
G CA14 carbonic anhydrase 14 increases expression EXP obeticholic acid results in increased expression of CA14 mRNA CTD PMID:27939613 NCBI chr 1:150,257,774...150,265,078
Ensembl chr 1:150,257,251...150,265,078 		JBrowse link
G CASP10 caspase 10 increases expression EXP obeticholic acid results in increased expression of CASP10 mRNA CTD PMID:27939613 NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO obeticholic acid promotes the reaction [Cycloheximide results in increased activity of CASP3 protein]
obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of CASP3 protein]		 CTD PMID:15860571 PMID:26655953 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP4 caspase 4 multiple interactions ISO obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein] CTD PMID:36328986 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP8 caspase 8 increases expression EXP obeticholic acid results in increased expression of CASP8 mRNA CTD PMID:27939613 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA] CTD PMID:27865854 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCNB1 cyclin B1 multiple interactions ISO obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein] CTD PMID:29660435 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 multiple interactions ISO obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in decreased expression of CCND1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein] CTD PMID:29660435 PMID:35439472 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCS copper chaperone for superoxide dismutase decreases expression EXP obeticholic acid results in decreased expression of CCS mRNA CTD PMID:27939613 NCBI chr11:66,593,185...66,606,019
Ensembl chr11:66,593,153...66,606,019 		JBrowse link
G CD14 CD14 molecule decreases expression EXP obeticholic acid results in decreased expression of CD14 mRNA CTD PMID:27939613 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CLDN5 claudin 5 multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein] CTD PMID:36720452 NCBI chr22:19,523,024...19,525,337
Ensembl chr22:19,523,024...19,527,545 		JBrowse link
G CLIC4 chloride intracellular channel 4 increases expression EXP obeticholic acid results in increased expression of CLIC4 mRNA CTD PMID:27939613 NCBI chr 1:24,745,447...24,844,321
Ensembl chr 1:24,745,382...24,844,321 		JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in decreased expression of COL1A1 mRNA; obeticholic acid results in decreased expression of COL1A1 protein
obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]
obeticholic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]		 CTD PMID:15860571 PMID:15980055 PMID:27939613 PMID:30745416 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions
increases expression		 ISO
EXP		 obeticholic acid promotes the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
obeticholic acid results in increased expression of CPT1A protein
Obeticholic acid inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver]
obeticholic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]
obeticholic acid results in increased expression of CPT1A mRNA		 CTD
RGD		 PMID:26655953 PMID:27939613 PMID:27939985 PMID:32738331 PMID:27939985 RGD:15036816 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 increases expression EXP obeticholic acid results in increased expression of CPT2 mRNA CTD PMID:27939613 NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197 		JBrowse link
G CRCT1 cysteine rich C-terminal 1 decreases expression EXP obeticholic acid results in decreased expression of CRCT1 mRNA CTD PMID:27939613 NCBI chr 1:152,514,482...152,516,008
Ensembl chr 1:152,514,482...152,516,008 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 decreases expression EXP obeticholic acid results in decreased expression of CREB3L1 mRNA CTD PMID:27939613 NCBI chr11:46,277,662...46,321,409
Ensembl chr11:46,277,662...46,321,409 		JBrowse link
G CREB3L3 cAMP responsive element binding protein 3 like 3 increases expression EXP obeticholic acid results in increased expression of CREB3L3 mRNA CTD PMID:27939613 NCBI chr19:4,153,631...4,173,054
Ensembl chr19:4,153,631...4,173,054 		JBrowse link
G CRP C-reactive protein decreases expression EXP obeticholic acid results in decreased expression of CRP mRNA CTD PMID:27939613 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CTAGE15 CTAGE family member 15 increases expression EXP obeticholic acid results in increased expression of CTAGE15 mRNA CTD PMID:27939613 NCBI chr 7:143,571,801...143,574,387
Ensembl chr 7:143,571,801...143,574,387 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL1 mRNA] CTD PMID:27865854 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2 mRNA] CTD PMID:27865854 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP19A1 mRNA CTD PMID:27939613 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP1A1 mRNA CTD PMID:27939613 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression
multiple interactions
decreases activity		 EXP
ISO		 obeticholic acid results in decreased expression of CYP1A2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of CYP1A2 protein
obeticholic acid results in decreased activity of CYP1A2 protein
obeticholic acid inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of Acetaminophen]; obeticholic acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]		 CTD PMID:27939613 PMID:35267068 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP21A2 cytochrome P450 family 21 subfamily A member 2 decreases expression EXP obeticholic acid results in decreased expression of CYP21A2 mRNA CTD PMID:27939613 NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644 		JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP27A1 mRNA CTD PMID:27939613 NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression EXP obeticholic acid results in increased expression of CYP2A6 mRNA CTD PMID:27939613 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases expression EXP obeticholic acid results in decreased expression of CYP2C8 mRNA CTD PMID:27939613 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases expression EXP obeticholic acid results in decreased expression of CYP2C9 mRNA CTD PMID:27939613 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases expression EXP obeticholic acid results in increased expression of CYP2D6 mRNA CTD PMID:27939613 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP2E1 mRNA CTD PMID:27939613 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 increases expression EXP obeticholic acid results in increased expression of CYP2R1 mRNA CTD PMID:27939613 NCBI chr11:14,877,440...14,892,443
Ensembl chr11:14,877,440...14,892,231 		JBrowse link
G CYP2S1 cytochrome P450 family 2 subfamily S member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP2S1 mRNA CTD PMID:27939613 NCBI chr19:41,193,219...41,207,539
Ensembl chr19:41,193,210...41,207,539 		JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 increases expression EXP obeticholic acid results in increased expression of CYP2U1 mRNA CTD PMID:27939613 NCBI chr 4:107,931,549...107,953,461
Ensembl chr 4:107,931,549...107,953,461 		JBrowse link
G CYP39A1 cytochrome P450 family 39 subfamily A member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP39A1 mRNA CTD PMID:27939613 NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
decreases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased activity of CYP3A4 protein
obeticholic acid results in decreased expression of CYP3A2 mRNA
obeticholic acid results in decreased expression of CYP3A4 mRNA
obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; obeticholic acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]		 CTD PMID:27939613 PMID:35267068 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A43 cytochrome P450 family 3 subfamily A member 43 decreases expression EXP obeticholic acid results in decreased expression of CYP3A43 mRNA CTD PMID:27939613 NCBI chr 7:99,828,013...99,866,093
Ensembl chr 7:99,828,013...99,866,093 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 decreases expression EXP obeticholic acid results in decreased expression of CYP3A5 mRNA CTD PMID:27939613 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 decreases expression EXP obeticholic acid results in decreased expression of CYP3A7 mRNA CTD PMID:27939613 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 increases expression EXP obeticholic acid results in increased expression of CYP4A11 mRNA CTD PMID:27939613 NCBI chr 1:46,929,188...46,941,476
Ensembl chr 1:46,929,177...46,941,484 		JBrowse link
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 decreases expression EXP obeticholic acid results in decreased expression of CYP4F11 mRNA CTD PMID:27939613 NCBI chr19:15,912,377...15,934,867
Ensembl chr19:15,912,367...15,934,867 		JBrowse link
G CYP4F12 cytochrome P450 family 4 subfamily F member 12 decreases expression EXP obeticholic acid results in decreased expression of CYP4F12 mRNA CTD PMID:27939613 NCBI chr19:15,673,087...15,697,174
Ensembl chr19:15,673,018...15,697,174 		JBrowse link
G CYP4F22 cytochrome P450 family 4 subfamily F member 22 decreases expression EXP obeticholic acid results in decreased expression of CYP4F22 mRNA CTD PMID:27939613 NCBI chr19:15,508,525...15,552,317
Ensembl chr19:15,508,525...15,552,317 		JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 decreases expression EXP obeticholic acid results in decreased expression of CYP4F3 mRNA CTD PMID:27939613 NCBI chr19:15,640,897...15,662,825
Ensembl chr19:15,640,897...15,662,825 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 decreases expression EXP obeticholic acid results in decreased expression of CYP51A1 mRNA CTD PMID:27939613 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of CYP7A1 mRNA
obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]
Obeticholic acid inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver]
obeticholic acid decreases expression of CYP7a1 mRNA in liver in porcine serum induced model of cirrhosis in rat
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP7A1 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]		 CTD
RGD		 PMID:15644430 PMID:15911693 PMID:27939613 PMID:29660435 PMID:32673658 More... RGD:15036816, RGD:15045602 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 decreases expression
multiple interactions
increases expression		 ISO
EXP		 obeticholic acid results in decreased expression of CYP8B1 mRNA
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]
obeticholic acid results in increased expression of CYP8B1 mRNA		 CTD PMID:15644430 PMID:27939613 PMID:29660435 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of DDIT3 protein] CTD PMID:26655953 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 decreases expression EXP obeticholic acid results in decreased expression of DGAT2 mRNA CTD PMID:27939613 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535 		JBrowse link
G DHCR7 7-dehydrocholesterol reductase increases expression EXP obeticholic acid results in increased expression of DHCR7 mRNA CTD PMID:27939613 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 increases expression EXP obeticholic acid results in increased expression of DNAJB11 mRNA CTD PMID:27939613 NCBI chr 3:186,570,720...186,585,793
Ensembl chr 3:186,567,403...186,585,800 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase decreases expression EXP obeticholic acid results in decreased expression of DPYD mRNA CTD PMID:27939613 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000 		JBrowse link
G DUSP6 dual specificity phosphatase 6 increases expression EXP obeticholic acid results in increased expression of DUSP6 mRNA CTD PMID:27939613 NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501 		JBrowse link
G ECSIT ECSIT signaling integrator decreases expression EXP obeticholic acid results in decreased expression of ECSIT mRNA CTD PMID:27939613 NCBI chr19:11,505,929...11,529,134
Ensembl chr19:11,505,929...11,529,172 		JBrowse link
G ELOVL1 ELOVL fatty acid elongase 1 increases expression EXP obeticholic acid results in increased expression of ELOVL1 mRNA CTD PMID:27939613 NCBI chr 1:43,363,401...43,368,011
Ensembl chr 1:43,363,398...43,368,074 		JBrowse link
G ELOVL2 ELOVL fatty acid elongase 2 increases expression EXP obeticholic acid results in increased expression of ELOVL2 mRNA CTD PMID:27939613 NCBI chr 6:10,980,759...11,044,305
Ensembl chr 6:10,980,759...11,044,305 		JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 decreases expression EXP obeticholic acid results in decreased expression of ELOVL6 mRNA CTD PMID:27939613 NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199 		JBrowse link
G ELOVL7 ELOVL fatty acid elongase 7 increases expression EXP obeticholic acid results in increased expression of ELOVL7 mRNA CTD PMID:27939613 NCBI chr 5:60,751,791...60,844,269
Ensembl chr 5:60,751,791...60,844,274 		JBrowse link
G ENC1 ectodermal-neural cortex 1 increases expression EXP obeticholic acid results in increased expression of ENC1 mRNA CTD PMID:27939613 NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424 		JBrowse link
G ENO1 enolase 1 decreases expression EXP obeticholic acid results in decreased expression of ENO1 mRNA CTD PMID:27939613 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190 		JBrowse link
G ENO3 enolase 3 increases expression EXP obeticholic acid results in increased expression of ENO3 mRNA CTD PMID:27939613 NCBI chr17:4,948,710...4,957,129
Ensembl chr17:4,948,092...4,957,131 		JBrowse link
G FABP6 fatty acid binding protein 6 multiple interactions
increases expression		 ISO NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA] CTD PMID:22918042 NCBI chr 5:160,187,381...160,238,722
Ensembl chr 5:160,187,367...160,238,735 		JBrowse link
G FADD Fas associated via death domain increases expression EXP obeticholic acid results in increased expression of FADD mRNA CTD PMID:27939613 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions ISO Obeticholic acid inhibits the reaction [ethanol increases expression of Fas mRNA and protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASN fatty acid synthase multiple interactions
decreases expression		 ISO
EXP		 obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA]
obeticholic acid inhibits the reaction [Ethanol results in increased expression of FASN protein]
obeticholic acid results in decreased expression of FASN mRNA		 CTD PMID:26655953 PMID:27939613 PMID:27939985 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FBP1 fructose-bisphosphatase 1 decreases expression EXP obeticholic acid results in decreased expression of FBP1 mRNA CTD PMID:27939613 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249 		JBrowse link
G FDPS farnesyl diphosphate synthase decreases expression EXP obeticholic acid results in decreased expression of FDPS mRNA CTD PMID:27939613 NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666 		JBrowse link
G FETUB fetuin B increases expression EXP obeticholic acid results in increased expression of FETUB mRNA CTD PMID:27939613 NCBI chr 3:186,635,969...186,653,141
Ensembl chr 3:186,635,969...186,653,141 		JBrowse link
G FGF19 fibroblast growth factor 19 increases expression
multiple interactions
increases secretion		 ISO
EXP		 obeticholic acid results in increased expression of FGF15 mRNA
Obeticholic acid inhibits the reaction [ethanol decreases expression of FGF19 protein in liver and intestine]
obeticholic acid results in increased expression of FGF19 mRNA
obeticholic acid results in increased secretion of FGF19 protein
NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]		 CTD
RGD		 PMID:22918042 PMID:27939613 PMID:27939985 RGD:15036816 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 decreases expression EXP obeticholic acid results in decreased expression of FGFR4 mRNA CTD PMID:27939613 NCBI chr 5:177,086,915...177,098,144
Ensembl chr 5:177,086,905...177,098,144 		JBrowse link
G FN1 fibronectin 1 decreases expression ISO obeticholic acid decreases expression of fibronectin mRNA in liver in porcine serum induced model of cirrhosis in rat RGD PMID:15980055 RGD:1625201 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP obeticholic acid results in decreased expression of FOS mRNA CTD PMID:27939613 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXM1 forkhead box M1 multiple interactions
increases expression		 ISO NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein] CTD PMID:22135065 PMID:29660435 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,680...2,877,174 		JBrowse link
G FOXP3 forkhead box P3 increases expression EXP obeticholic acid results in increased expression of FOXP3 mRNA CTD PMID:27939613 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP obeticholic acid results in decreased expression of GAPDH mRNA CTD PMID:27939613 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression ISO obeticholic acid results in increased expression of GCLM mRNA CTD PMID:26655953 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GFER growth factor, augmenter of liver regeneration multiple interactions ISO [Dietary Fats co-treated with obeticholic acid] results in decreased expression of GFER mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of GFER protein CTD PMID:35267068 NCBI chr16:1,984,193...1,987,749
Ensembl chr16:1,984,193...1,987,749 		JBrowse link
G GK glycerol kinase decreases expression EXP obeticholic acid results in decreased expression of GK mRNA CTD PMID:27939613 NCBI chr  X:30,653,423...30,731,462
Ensembl chr  X:30,653,359...30,731,462 		JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP obeticholic acid results in decreased expression of GPAM mRNA CTD PMID:27939613 NCBI chr10:112,149,865...112,227,677
Ensembl chr10:112,149,865...112,215,377 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases expression EXP obeticholic acid results in decreased expression of GPD1 mRNA CTD PMID:27939613 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; obeticholic acid promotes the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:35267068 PMID:36328986 PMID:36581201 PMID:36787806 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPX1 glutathione peroxidase 1 increases expression ISO obeticholic acid results in increased expression of GPX1 mRNA CTD PMID:26655953 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX2 glutathione peroxidase 2 decreases expression EXP obeticholic acid results in decreased expression of GPX2 mRNA CTD PMID:27939613 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746 		JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP obeticholic acid results in increased expression of GPX3 mRNA CTD PMID:27939613 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988 		JBrowse link
G GSDMD gasdermin D multiple interactions ISO obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein] CTD PMID:36328986 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062 		JBrowse link
G GSR glutathione-disulfide reductase increases expression ISO
EXP		 obeticholic acid results in increased expression of GSR mRNA CTD PMID:26655953 PMID:27939613 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases expression EXP obeticholic acid results in decreased expression of GSTP1 mRNA CTD PMID:27939613 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 increases expression EXP obeticholic acid results in increased expression of GSTT1 mRNA CTD PMID:27939613
G GYS2 glycogen synthase 2 increases expression EXP obeticholic acid results in increased expression of GYS2 mRNA CTD PMID:27939613 NCBI chr12:21,532,577...21,604,847
Ensembl chr12:21,536,107...21,604,847 		JBrowse link
G H2BC11 H2B clustered histone 11 decreases expression EXP obeticholic acid results in decreased expression of H2BC11 mRNA CTD PMID:27939613 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,125,897...27,132,795 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP obeticholic acid results in decreased expression of HMGCR mRNA CTD PMID:27939613 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP obeticholic acid results in decreased expression of HMGCS1 mRNA CTD PMID:27939613 NCBI chr 5:43,287,470...43,313,412
Ensembl chr 5:43,287,470...43,313,512 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha multiple interactions
decreases expression		 ISO [Dietary Fats co-treated with obeticholic acid] results in decreased expression of HNF4A mRNA; [Dietary Fats co-treated with obeticholic acid] results in decreased expression of HNF4A protein
obeticholic acid results in decreased expression of HNF4A mRNA		 CTD PMID:35267068 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845 		JBrowse link
G HRAS HRas proto-oncogene, GTPase decreases expression EXP obeticholic acid results in decreased expression of HRAS mRNA CTD PMID:27939613 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 decreases expression EXP obeticholic acid results in decreased expression of HSD17B7 mRNA CTD PMID:27939613 NCBI chr 1:162,790,702...162,812,823
Ensembl chr 1:162,790,702...162,812,823 		JBrowse link
G HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 decreases expression EXP obeticholic acid results in decreased expression of HSD3B7 mRNA CTD PMID:27939613 NCBI chr16:30,985,207...30,989,147
Ensembl chr16:30,985,207...30,989,147 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]; obeticholic acid inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein] CTD PMID:26655953 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HSPG2 heparan sulfate proteoglycan 2 decreases expression EXP obeticholic acid results in decreased expression of HSPG2 mRNA CTD PMID:27939613 NCBI chr 1:21,822,244...21,937,310
Ensembl chr 1:21,822,244...21,937,310 		JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression EXP obeticholic acid results in decreased expression of ID2 mRNA CTD PMID:27939613 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP obeticholic acid results in decreased expression of IDI1 mRNA CTD PMID:27939613 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119 		JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit decreases expression EXP obeticholic acid results in decreased expression of IGFALS mRNA CTD PMID:27939613 NCBI chr16:1,790,413...1,794,908
Ensembl chr16:1,790,413...1,794,971 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL10 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL10 protein] CTD PMID:30745416 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL18 mRNA] CTD PMID:35688268 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA] CTD PMID:27865854 PMID:29660435 PMID:35688268 PMID:38103844 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL4 interleukin 4 multiple interactions ISO obeticholic acid promotes the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:27865854 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA] CTD PMID:29660435 PMID:30745416 PMID:35688268 PMID:36720452 PMID:38103844 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor decreases expression EXP obeticholic acid results in decreased expression of IL6R mRNA CTD PMID:27939613 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer decreases expression EXP obeticholic acid results in decreased expression of IL6ST mRNA CTD PMID:27939613 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G INHBB inhibin subunit beta B increases expression EXP obeticholic acid results in increased expression of INHBB mRNA CTD PMID:27939613 NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 decreases expression EXP obeticholic acid results in decreased expression of IRAK1 mRNA CTD PMID:27939613 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 decreases expression EXP obeticholic acid results in decreased expression of IRAK2 mRNA CTD PMID:27939613 NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP obeticholic acid results in increased expression of JUN mRNA CTD PMID:27939613 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP obeticholic acid results in decreased expression of JUNB mRNA CTD PMID:27939613 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]] CTD PMID:15860571 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KRT16P2 keratin 16 pseudogene 2 decreases expression EXP obeticholic acid results in decreased expression of KRT16P2 mRNA CTD PMID:27939613 NCBI chr17:16,830,483...16,832,833
Ensembl chr17:16,829,999...16,832,753 		JBrowse link
G KRT16P3 keratin 16 pseudogene 3 decreases expression EXP obeticholic acid results in decreased expression of KRT16P3 mRNA CTD PMID:27939613 NCBI chr17:20,501,513...20,504,498
Ensembl chr17:20,501,513...20,512,357
Ensembl chr17:20,501,513...20,512,357 		JBrowse link
G KRT18 keratin 18 multiple interactions ISO [Dietary Fats co-treated with obeticholic acid] results in decreased expression of KRT18 mRNA CTD PMID:35267068 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906 		JBrowse link
G LBR lamin B receptor decreases expression EXP obeticholic acid results in decreased expression of LBR mRNA CTD PMID:27939613 NCBI chr 1:225,401,502...225,428,821
Ensembl chr 1:225,401,502...225,428,925 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase decreases expression EXP obeticholic acid results in decreased expression of LCAT mRNA CTD PMID:27939613 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131 		JBrowse link
G LDLR low density lipoprotein receptor decreases expression EXP obeticholic acid results in decreased expression of LDLR mRNA CTD PMID:27939613 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LENG8 leukocyte receptor cluster member 8 increases expression EXP obeticholic acid results in increased expression of LENG8 mRNA CTD PMID:27939613 NCBI chr19:54,449,199...54,462,016
Ensembl chr19:54,449,190...54,462,016 		JBrowse link
G LGI4 leucine rich repeat LGI family member 4 increases expression EXP obeticholic acid results in increased expression of LGI4 mRNA CTD PMID:27939613 NCBI chr19:35,124,513...35,135,059
Ensembl chr19:35,124,513...35,142,451 		JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 decreases expression EXP obeticholic acid results in decreased expression of LIME1 mRNA CTD PMID:27939613 NCBI chr20:63,735,701...63,739,103
Ensembl chr20:63,736,283...63,739,103 		JBrowse link
G LINC00870 long intergenic non-protein coding RNA 870 increases expression EXP obeticholic acid results in increased expression of LINC00870 mRNA CTD PMID:27939613 NCBI chr 3:72,151,257...72,174,339
Ensembl chr 3:72,151,236...72,207,776 		JBrowse link
G LIPC lipase C, hepatic type decreases expression EXP obeticholic acid results in decreased expression of LIPC mRNA CTD PMID:27939613 NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844 		JBrowse link
G LPA lipoprotein(a) decreases expression EXP obeticholic acid results in decreased expression of LPA mRNA CTD PMID:27939613 NCBI chr 6:160,531,482...160,664,275
Ensembl chr 6:160,531,482...160,664,275 		JBrowse link
G LPIN1 lipin 1 decreases expression EXP obeticholic acid results in decreased expression of LPIN1 mRNA CTD PMID:27939613 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409 		JBrowse link
G LPIN2 lipin 2 decreases expression EXP obeticholic acid results in decreased expression of LPIN2 mRNA CTD PMID:27939613 NCBI chr18:2,916,994...3,013,144
Ensembl chr18:2,885,296...3,013,144 		JBrowse link
G LSS lanosterol synthase decreases expression EXP obeticholic acid results in decreased expression of LSS mRNA CTD PMID:27939613 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824 		JBrowse link
G MAF MAF bZIP transcription factor increases expression EXP obeticholic acid results in increased expression of MAF mRNA CTD PMID:27939613 NCBI chr16:79,202,622...79,600,737
Ensembl chr16:79,585,843...79,600,737 		JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP obeticholic acid results in increased expression of MAFF mRNA CTD PMID:27939613 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of MAP1LC3B protein] CTD PMID:26655953 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 decreases expression EXP obeticholic acid results in decreased expression of MAP2K3 mRNA CTD PMID:27939613 NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 decreases expression EXP obeticholic acid results in decreased expression of MAP2K6 mRNA CTD PMID:27939613 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 decreases expression EXP obeticholic acid results in decreased expression of MAP2K7 mRNA CTD PMID:27939613 NCBI chr19:7,903,877...7,914,478
Ensembl chr19:7,903,843...7,914,478 		JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 decreases expression EXP obeticholic acid results in decreased expression of MAP3K14 mRNA CTD PMID:27939613 NCBI chr17:45,263,119...45,317,020
Ensembl chr17:45,263,119...45,317,029 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 decreases expression EXP obeticholic acid results in decreased expression of MAP3K5 mRNA CTD PMID:27939613 NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097 		JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 increases expression EXP obeticholic acid results in increased expression of MAP3K8 mRNA CTD PMID:27939613 NCBI chr10:30,434,021...30,461,833
Ensembl chr10:30,434,021...30,461,833 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein] CTD PMID:27865854 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 decreases expression EXP obeticholic acid results in decreased expression of MAPK11 mRNA CTD PMID:27939613 NCBI chr22:50,263,713...50,270,380
Ensembl chr22:50,263,713...50,270,767 		JBrowse link
G MAPK12 mitogen-activated protein kinase 12 decreases expression EXP obeticholic acid results in decreased expression of MAPK12 mRNA CTD PMID:27939613 NCBI chr22:50,252,901...50,261,683
Ensembl chr22:50,245,450...50,261,716 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein] CTD PMID:27865854 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MDH1 malate dehydrogenase 1 increases expression EXP obeticholic acid results in increased expression of MDH1 mRNA CTD PMID:27939613 NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197 		JBrowse link
G METRNL meteorin like, glial cell differentiation regulator decreases expression EXP obeticholic acid results in decreased expression of METRNL mRNA CTD PMID:27939613 NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122 		JBrowse link
G MFSD2A MFSD2 lysolipid transporter A, lysophospholipid increases expression EXP obeticholic acid results in increased expression of MFSD2A mRNA CTD PMID:27939613 NCBI chr 1:39,955,145...39,969,956
Ensembl chr 1:39,955,112...39,969,968 		JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase decreases expression EXP obeticholic acid results in decreased expression of MLKL mRNA CTD PMID:27939613 NCBI chr16:74,671,855...74,700,862
Ensembl chr16:74,671,855...74,700,960 		JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor increases expression EXP obeticholic acid results in increased expression of MLLT11 mRNA CTD PMID:27939613 NCBI chr 1:151,060,397...151,069,544
Ensembl chr 1:151,060,397...151,069,544 		JBrowse link
G MMP2 matrix metallopeptidase 2 increases activity ISO obeticholic acid results in increased activity of MMP2 protein CTD PMID:15860571 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein] CTD PMID:36328986 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MRTFB myocardin related transcription factor B decreases expression EXP obeticholic acid results in decreased expression of MRTFB mRNA CTD PMID:27939613 NCBI chr16:13,994,774...14,266,779
Ensembl chr16:14,071,319...14,266,773 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 decreases expression EXP obeticholic acid results in decreased expression of MSMO1 mRNA CTD PMID:27939613 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164 		JBrowse link
G MT1H metallothionein 1H decreases expression EXP obeticholic acid results in decreased expression of MT1H mRNA CTD PMID:27939613 NCBI chr16:56,669,814...56,671,129
Ensembl chr16:56,669,814...56,671,129 		JBrowse link
G MVD mevalonate diphosphate decarboxylase decreases expression EXP obeticholic acid results in decreased expression of MVD mRNA CTD PMID:27939613 NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161 		JBrowse link
G MVK mevalonate kinase decreases expression EXP obeticholic acid results in decreased expression of MVK mRNA CTD PMID:27939613 NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP obeticholic acid results in decreased expression of MYC mRNA CTD PMID:27939613 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein] CTD PMID:35688268 PMID:36720452 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in increased expression of NFE2L2 mRNA
[Dietary Fats co-treated with obeticholic acid] results in decreased expression of NFE2L2 protein		 CTD PMID:27939613 PMID:35267068 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in increased expression of NFKB1 mRNA
Obeticholic acid inhibits the reaction [ethanol increases expression of NF-kB protein in liver]		 CTD
RGD		 PMID:27939613 PMID:27939985 RGD:15036816 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 decreases expression EXP obeticholic acid results in decreased expression of NFKB2 mRNA CTD PMID:27939613 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Obeticholic acid inhibits the reaction [ethanol decreases expression of Nfkbia protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO Obeticholic acid inhibits the reaction [ethanol increases expression of Nrlp3 protein in liver] RGD PMID:27939985 RGD:15036816 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NPW neuropeptide W decreases expression EXP obeticholic acid results in decreased expression of NPW mRNA CTD PMID:27939613 NCBI chr16:2,019,785...2,020,755
Ensembl chr16:2,009,926...2,020,755 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions
increases expression		 EXP
ISO		 obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter]
obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR0B2 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR0B2 protein]; obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of NR0B2 mRNA]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr0b2 protein in liver and intestine]
NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]; NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA]
obeticholic acid results in increased expression of NR0B2 mRNA; obeticholic acid results in increased expression of NR0B2 protein		 CTD
RGD		 PMID:15644430 PMID:15860571 PMID:15911693 PMID:15980055 PMID:26655953 More... RGD:15036816 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 increases activity
multiple interactions
increases expression
increases response to substance		 EXP
ISO		 obeticholic acid results in increased activity of NR1H4 protein
Obeticholic acid inhibits the reaction [ethanol decreases expression of Nr1h4 mRNA and protein in liver and liver cell nuclei and intestine]
obeticholic acid increases expression of Nr1H4 mRNA in rat hepatic stellate cells; obeticholic acid increases expression of Nr1h4 mRNA in bile duct ligation and porcine serum induced models of cirrhosis in rat
obeticholic acid results in increased expression of NR1H4 protein
obeticholic acid results in increased expression of NR1H4 mRNA
obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]
NR1H4 protein results in increased susceptibility to obeticholic acid
[obeticholic acid co-treated with 1-Naphthylisothiocyanate] results in increased expression of NR1H4 protein; NR1H4 affects the reaction [obeticholic acid results in increased expression of FOXM1 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [obeticholic acid results in increased expression of FGF15 mRNA]; NR1H4 promotes the reaction [obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]]; obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR1H4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 protein]
obeticholic acid binds to and results in increased activity of NR1H4 protein; obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]		 CTD
RGD		 PMID:15860571 PMID:15911693 PMID:15980055 PMID:17567710 PMID:21242261 More... RGD:15036816, RGD:1625201 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 decreases expression EXP obeticholic acid results in decreased expression of NR5A2 mRNA CTD PMID:27939613 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420 		JBrowse link
G OCLN occludin multiple interactions ISO obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of OCLN protein]; obeticholic acid promotes the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of OCLN protein] CTD PMID:35439472 PMID:36720452 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G P4HB prolyl 4-hydroxylase subunit beta increases expression EXP obeticholic acid results in increased expression of P4HB mRNA CTD PMID:27939613 NCBI chr17:81,843,166...81,860,535
Ensembl chr17:81,843,159...81,860,856 		JBrowse link
G PC pyruvate carboxylase decreases expression EXP obeticholic acid results in decreased expression of PC mRNA CTD PMID:27939613 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP obeticholic acid results in decreased expression of PCK1 mRNA CTD PMID:27939613 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP obeticholic acid results in increased expression of PFKFB1 mRNA CTD PMID:27939613 NCBI chr  X:54,932,961...54,998,789
Ensembl chr  X:54,932,961...54,998,534 		JBrowse link
G PGM1 phosphoglucomutase 1 decreases expression EXP obeticholic acid results in decreased expression of PGM1 mRNA CTD PMID:27939613 NCBI chr 1:63,593,411...63,660,245
Ensembl chr 1:63,593,411...63,660,245 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta decreases expression EXP obeticholic acid results in decreased expression of PIK3CD mRNA CTD PMID:27939613 NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression EXP obeticholic acid results in decreased expression of PIK3R1 mRNA CTD PMID:27939613 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PKD1P1 polycystin 1, transient receptor potential channel interacting pseudogene 1 decreases expression EXP obeticholic acid results in decreased expression of PKD1P1 mRNA CTD PMID:27939613 NCBI chr16:16,310,134...16,332,477
Ensembl chr16:16,310,341...16,334,190 		JBrowse link
G PLTP phospholipid transfer protein decreases expression EXP obeticholic acid results in decreased expression of PLTP mRNA CTD PMID:27939613 NCBI chr20:45,898,620...45,912,155
Ensembl chr20:45,898,621...45,912,155 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases expression		 ISO
EXP		 Palmitic Acid inhibits the reaction [obeticholic acid results in increased expression of PPARA mRNA]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Ppara mRNA and protein in liver]
obeticholic acid inhibits the reaction [Ethanol results in decreased expression of PPARA protein]
obeticholic acid results in increased expression of PPARA mRNA; obeticholic acid results in increased expression of PPARA protein		 CTD
RGD		 PMID:15980055 PMID:26655953 PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression ISO obeticholic acid results in increased expression of PPARG mRNA; obeticholic acid results in increased expression of PPARG protein CTD PMID:15980055 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPP1R3C protein phosphatase 1 regulatory subunit 3C decreases expression EXP obeticholic acid results in decreased expression of PPP1R3C mRNA CTD PMID:27939613 NCBI chr10:91,628,442...91,633,071
Ensembl chr10:91,628,442...91,633,071 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta increases expression EXP obeticholic acid results in increased expression of PPP2CB mRNA CTD PMID:27939613 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PPP2R1B protein phosphatase 2 scaffold subunit Abeta increases expression EXP obeticholic acid results in increased expression of PPP2R1B mRNA CTD PMID:27939613 NCBI chr11:111,688,000...111,766,389
Ensembl chr11:111,726,908...111,766,389 		JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP obeticholic acid results in decreased expression of PRDX1 mRNA CTD PMID:27939613 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732 		JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP obeticholic acid results in decreased expression of PRDX6 mRNA CTD PMID:27939613 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815 		JBrowse link
G PRKCA protein kinase C alpha increases expression EXP obeticholic acid results in increased expression of PRKCA mRNA CTD PMID:27939613 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PRKCE protein kinase C epsilon increases expression EXP obeticholic acid results in increased expression of PRKCE mRNA CTD PMID:27939613 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 multiple interactions
increases activity		 EXP obeticholic acid promotes the reaction [NR1H4 protein binds to PRMT1 protein]; obeticholic acid promotes the reaction [PRMT1 protein binds to ABCB11 promoter]
obeticholic acid results in increased activity of PRMT1 protein		 CTD PMID:15911693 NCBI chr19:49,676,153...49,688,447
Ensembl chr19:49,675,786...49,689,029 		JBrowse link
G PRMT2 protein arginine methyltransferase 2 multiple interactions EXP obeticholic acid promotes the reaction [PRMT2 protein binds to NR0B2 promoter] CTD PMID:15911693 NCBI chr21:46,635,674...46,665,124
Ensembl chr21:46,635,595...46,665,124 		JBrowse link
G PTBP2 polypyrimidine tract binding protein 2 decreases expression EXP obeticholic acid results in decreased expression of PTBP2 mRNA CTD PMID:27939613 NCBI chr 1:96,721,784...96,823,739
Ensembl chr 1:96,721,665...96,823,738 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of RELA protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of RELA protein] CTD PMID:29660435 PMID:35688268 PMID:36720452 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G ROS1 ROS proto-oncogene 1, receptor tyrosine kinase increases expression EXP obeticholic acid results in increased expression of ROS1 mRNA CTD PMID:27939613 NCBI chr 6:117,287,353...117,425,942
Ensembl chr 6:117,287,353...117,425,942 		JBrowse link
G RPS6KA2 ribosomal protein S6 kinase A2 increases expression EXP obeticholic acid results in increased expression of RPS6KA2 mRNA CTD PMID:27939613 NCBI chr 6:166,409,364...166,862,773
Ensembl chr 6:166,409,364...166,906,451 		JBrowse link
G RPS6KA4 ribosomal protein S6 kinase A4 decreases expression EXP obeticholic acid results in decreased expression of RPS6KA4 mRNA CTD PMID:27939613 NCBI chr11:64,359,162...64,372,215
Ensembl chr11:64,359,148...64,372,215 		JBrowse link
G RPS6KA5 ribosomal protein S6 kinase A5 decreases expression EXP obeticholic acid results in decreased expression of RPS6KA5 mRNA CTD PMID:27939613 NCBI chr14:90,847,861...91,060,641
Ensembl chr14:90,847,861...91,060,641 		JBrowse link
G RRAS2 RAS related 2 increases expression EXP obeticholic acid results in increased expression of RRAS2 mRNA CTD PMID:27939613 NCBI chr11:14,277,920...14,364,506
Ensembl chr11:14,277,922...14,364,506 		JBrowse link
G RTP3 receptor transporter protein 3 increases expression EXP obeticholic acid results in increased expression of RTP3 mRNA CTD PMID:27939613 NCBI chr 3:46,497,976...46,500,950
Ensembl chr 3:46,494,611...46,500,950 		JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP obeticholic acid results in decreased expression of RXRA mRNA CTD PMID:27939613 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G S100A3 S100 calcium binding protein A3 decreases expression EXP obeticholic acid results in decreased expression of S100A3 mRNA CTD PMID:27939613 NCBI chr 1:153,547,329...153,549,258
Ensembl chr 1:153,547,329...153,549,258 		JBrowse link
G SAA1 serum amyloid A1 increases expression EXP obeticholic acid results in increased expression of SAA1 mRNA CTD PMID:27939613 NCBI chr11:18,266,264...18,269,967
Ensembl chr11:18,266,260...18,269,977 		JBrowse link
G SC5D sterol-C5-desaturase decreases expression EXP obeticholic acid results in decreased expression of SC5D mRNA CTD PMID:27939613 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410 		JBrowse link
G SCARB1 scavenger receptor class B member 1 increases expression EXP obeticholic acid results in increased expression of SCARB1 mRNA CTD PMID:27939613 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G SDC1 syndecan 1 increases expression EXP obeticholic acid results in increased expression of SDC1 mRNA CTD PMID:27939613 NCBI chr 2:20,200,797...20,225,475
Ensembl chr 2:20,200,797...20,225,433 		JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SDHA protein] CTD PMID:26655953 NCBI chr 5:218,320...268,746
Ensembl chr 5:218,303...257,082 		JBrowse link
G SELP selectin P multiple interactions ISO NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA] CTD PMID:22135065 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SERPINA1 serpin family A member 1 decreases expression EXP obeticholic acid results in decreased expression of SERPINA1 mRNA CTD PMID:27939613 NCBI chr14:94,376,747...94,390,635
Ensembl chr14:94,376,747...94,390,693 		JBrowse link
G SERPINE1 serpin family E member 1 decreases expression EXP obeticholic acid results in decreased expression of SERPINE1 mRNA CTD PMID:27939613 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SFN stratifin decreases expression EXP obeticholic acid results in decreased expression of SFN mRNA CTD PMID:27939613 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456 		JBrowse link
G SIGIRR single Ig and TIR domain containing decreases expression EXP obeticholic acid results in decreased expression of SIGIRR mRNA CTD PMID:27939613 NCBI chr11:405,716...417,397
Ensembl chr11:405,715...417,455 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in decreased expression of SLC10A1 mRNA
obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA]
Obeticholic acid inhibits the reaction [ethanol decreases expression of Slc10a1 protein in liver]
[1-Naphthylisothiocyanate co-treated with obeticholic acid] results in decreased expression of SLC10A1 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of SLC10A1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein]		 CTD
RGD		 PMID:15644430 PMID:15911693 PMID:29660435 PMID:32673658 PMID:36328986 More... RGD:15036816 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SLC13A5 solute carrier family 13 member 5 decreases expression EXP obeticholic acid results in decreased expression of SLC13A5 mRNA CTD PMID:27939613 NCBI chr17:6,684,719...6,713,369
Ensembl chr17:6,684,719...6,713,377 		JBrowse link
G SLC25A1 solute carrier family 25 member 1 decreases expression EXP obeticholic acid results in decreased expression of SLC25A1 mRNA CTD PMID:27939613 NCBI chr22:19,175,581...19,178,736
Ensembl chr22:19,175,581...19,178,739 		JBrowse link
G SLC25A10 solute carrier family 25 member 10 decreases expression EXP obeticholic acid results in decreased expression of SLC25A10 mRNA CTD PMID:27939613 NCBI chr17:81,712,284...81,721,012
Ensembl chr17:81,712,236...81,721,016 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 decreases expression EXP obeticholic acid results in decreased expression of SLC25A12 mRNA CTD PMID:27939613 NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859 		JBrowse link
G SLC27A5 solute carrier family 27 member 5 decreases expression EXP obeticholic acid results in decreased expression of SLC27A5 mRNA CTD PMID:27939613 NCBI chr19:58,498,333...58,511,992
Ensembl chr19:58,479,512...58,512,413 		JBrowse link
G SLC51A solute carrier family 51 member A increases expression ISO
EXP		 obeticholic acid results in increased expression of SLC51A mRNA; obeticholic acid results in increased expression of SLC51A protein CTD PMID:26655953 PMID:27939613 NCBI chr 3:196,216,534...196,233,427
Ensembl chr 3:196,211,487...196,243,178 		JBrowse link
G SLC51B SLC51 subunit beta increases expression
multiple interactions		 ISO
EXP		 obeticholic acid results in increased expression of SLC51B mRNA
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLC51B mRNA]		 CTD PMID:26655953 PMID:27255380 PMID:27939613 NCBI chr15:65,045,387...65,053,397
Ensembl chr15:65,045,387...65,053,397 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 decreases expression EXP obeticholic acid results in decreased expression of SLCO1B1 mRNA CTD PMID:27939613 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases expression
multiple interactions		 EXP
ISO		 obeticholic acid results in increased expression of SLCO1B3 mRNA
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLCO1B2 mRNA]
obeticholic acid results in increased expression of SLCO1B2 mRNA		 CTD PMID:27255380 PMID:27939613 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 decreases expression EXP obeticholic acid results in decreased expression of SOCS2 mRNA CTD PMID:27939613 NCBI chr12:93,569,969...93,626,236
Ensembl chr12:93,569,814...93,583,487 		JBrowse link
G SOD2 superoxide dismutase 2 decreases expression EXP obeticholic acid results in decreased expression of SOD2 mRNA CTD PMID:27939613 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO obeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SQSTM1 protein] CTD PMID:26655953 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 EXP
ISO		 obeticholic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]
Obeticholic acid inhibits the reaction [ethanol increases expression of Srebf1 mRNA and protein in liver]
obeticholic acid results in decreased expression of SREBF1 mRNA		 CTD
RGD		 PMID:27939613 PMID:27939985 PMID:27939985 RGD:15036816 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions
decreases expression		 ISO
EXP		 obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]
obeticholic acid results in decreased expression of SREBF2 mRNA		 CTD PMID:26655953 PMID:27939613 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 multiple interactions ISO obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA] CTD PMID:29660435 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G SZRD1 SUZ RNA binding domain containing 1 increases expression EXP obeticholic acid results in increased expression of SZRD1 mRNA CTD PMID:27939613 NCBI chr 1:16,367,242...16,398,145
Ensembl chr 1:16,352,575...16,398,145 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 decreases expression EXP obeticholic acid results in decreased expression of TAB1 mRNA CTD PMID:27939613 NCBI chr22:39,399,780...39,437,132
Ensembl chr22:39,399,778...39,437,060 		JBrowse link
G TAPBP TAP binding protein decreases expression EXP obeticholic acid results in decreased expression of TAPBP mRNA CTD PMID:27939613 NCBI chr 6:33,299,694...33,314,078
Ensembl chr 6:33,299,694...33,314,284 		JBrowse link
G TCEA2 transcription elongation factor A2 increases expression EXP obeticholic acid results in increased expression of TCEA2 mRNA CTD PMID:27939613 NCBI chr20:64,055,596...64,072,347
Ensembl chr20:64,049,836...64,072,347 		JBrowse link
G TECR trans-2,3-enoyl-CoA reductase decreases expression EXP obeticholic acid results in decreased expression of TECR mRNA CTD PMID:27939613 NCBI chr19:14,527,726...14,565,980
Ensembl chr19:14,517,085...14,565,980 		JBrowse link
G TEDC1 tubulin epsilon and delta complex 1 decreases expression EXP obeticholic acid results in decreased expression of TEDC1 mRNA CTD PMID:27939613 NCBI chr14:105,489,855...105,499,248
Ensembl chr14:105,489,855...105,499,575 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases expression		 ISO
EXP		 obeticholic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein]
obeticholic acid results in decreased expression of TGFB1 mRNA		 CTD PMID:15980055 PMID:27939613 PMID:35439472 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 decreases expression EXP obeticholic acid results in decreased expression of TGFB2 mRNA CTD PMID:27939613 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFB3 transforming growth factor beta 3 increases expression EXP obeticholic acid results in increased expression of TGFB3 mRNA CTD PMID:27939613 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 decreases expression EXP obeticholic acid results in decreased expression of TGFBR1 mRNA CTD PMID:27939613 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 ISO
EXP		 NR0B2 protein affects the reaction [obeticholic acid inhibits the reaction [JUND protein binds to TIMP1 promoter]]; NR0B2 protein affects the reaction [obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; obeticholic acid results in decreased expression of and results in decreased secretion of TIMP1 protein
obeticholic acid results in decreased expression of TIMP1 mRNA		 CTD PMID:15860571 PMID:27939613 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA] CTD PMID:15860571 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions ISO obeticholic acid promotes the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TJP1 protein] CTD PMID:35439472 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TK1 thymidine kinase 1 decreases expression EXP obeticholic acid results in decreased expression of TK1 mRNA CTD PMID:27939613 NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO obeticholic acid inhibits the reaction [[Dietary Fats co-treated with Dextran Sulfate] results in increased expression of TLR4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] CTD PMID:35439472 PMID:35688268 PMID:36720452 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases secretion		 ISO
EXP		 NR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]
Obeticholic acid inhibits the reaction [ethanol increases expression of Tnf protein in liver]
obeticholic acid results in decreased secretion of TNF protein
obeticholic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD
RGD		 PMID:21242261 PMID:22135065 PMID:27865854 PMID:29660435 PMID:30745416 More... RGD:15036816 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B increases expression EXP obeticholic acid results in increased expression of TNFRSF1B mRNA CTD PMID:27939613 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
G TRAF2 TNF receptor associated factor 2 decreases expression EXP obeticholic acid results in decreased expression of TRAF2 mRNA CTD PMID:27939613 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607 		JBrowse link
G TXN thioredoxin decreases expression EXP obeticholic acid results in decreased expression of TXN mRNA CTD PMID:27939613 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
G TXNRD2 thioredoxin reductase 2 decreases expression EXP obeticholic acid results in decreased expression of TXNRD2 mRNA CTD PMID:27939613 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820 		JBrowse link
G TYK2 tyrosine kinase 2 decreases expression EXP obeticholic acid results in decreased expression of TYK2 mRNA CTD PMID:27939613 NCBI chr19:10,350,533...10,380,572
Ensembl chr19:10,350,533...10,380,608 		JBrowse link
G TYMP thymidine phosphorylase decreases expression EXP obeticholic acid results in decreased expression of TYMP mRNA CTD PMID:27939613 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
G UBE2E3 ubiquitin conjugating enzyme E2 E3 increases expression EXP obeticholic acid results in increased expression of UBE2E3 mRNA CTD PMID:27939613 NCBI chr 2:180,980,360...181,063,425
Ensembl chr 2:180,967,248...181,076,585 		JBrowse link
G UBXN10 UBX domain protein 10 increases expression EXP obeticholic acid results in increased expression of UBXN10 mRNA CTD PMID:27939613 NCBI chr 1:20,183,331...20,196,050
Ensembl chr 1:20,186,096...20,196,050 		JBrowse link
G UCKL1 uridine-cytidine kinase 1 like 1 decreases expression EXP obeticholic acid results in decreased expression of UCKL1 mRNA CTD PMID:27939613 NCBI chr20:63,939,829...63,956,416
Ensembl chr20:63,939,829...63,956,416 		JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 increases expression EXP obeticholic acid results in increased expression of UGP2 mRNA CTD PMID:27939613 NCBI chr 2:63,840,969...63,891,560
Ensembl chr 2:63,840,952...63,891,562 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases glucuronidation		 EXP obeticholic acid results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of obeticholic acid		 CTD PMID:27939613 PMID:31299240 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 multiple interactions
increases glucuronidation		 EXP [Lapatinib results in decreased activity of UGT1A3 protein] which results in decreased glucuronidation of obeticholic acid
UGT1A3 protein results in increased glucuronidation of obeticholic acid		 CTD PMID:31299240 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 decreases expression
increases glucuronidation		 EXP obeticholic acid results in decreased expression of UGT1A4 mRNA
UGT1A4 protein results in increased glucuronidation of obeticholic acid		 CTD PMID:27939613 PMID:31299240 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP obeticholic acid results in decreased expression of UGT1A6 mRNA CTD PMID:27939613 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 decreases expression EXP obeticholic acid results in decreased expression of UGT1A7 mRNA CTD PMID:27939613 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 decreases expression EXP obeticholic acid results in decreased expression of UGT1A9 mRNA CTD PMID:27939613 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B10 UDP glucuronosyltransferase family 2 member B10 increases expression EXP obeticholic acid results in increased expression of UGT2B10 mRNA CTD PMID:27939613 NCBI chr 4:68,815,994...68,832,023
Ensembl chr 4:68,815,994...68,832,023 		JBrowse link
G UGT2B11 UDP glucuronosyltransferase family 2 member B11 increases expression EXP obeticholic acid results in increased expression of UGT2B11 mRNA CTD PMID:27939613 NCBI chr 4:69,199,951...69,224,984
Ensembl chr 4:69,199,951...69,214,748 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases expression EXP obeticholic acid results in increased expression of UGT2B15 mRNA CTD PMID:27939613 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 decreases expression EXP obeticholic acid results in decreased expression of UGT2B7 mRNA CTD PMID:27939613 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
G UPB1 beta-ureidopropionase 1 decreases expression EXP obeticholic acid results in decreased expression of UPB1 mRNA CTD PMID:27939613 NCBI chr22:24,495,332...24,528,390
Ensembl chr22:24,494,107...24,528,390 		JBrowse link
G UPP1 uridine phosphorylase 1 increases expression EXP obeticholic acid results in increased expression of UPP1 mRNA CTD PMID:27939613 NCBI chr 7:48,088,704...48,108,736
Ensembl chr 7:48,088,628...48,108,736 		JBrowse link
G UPP2 uridine phosphorylase 2 increases expression EXP obeticholic acid results in increased expression of UPP2 mRNA CTD PMID:27939613 NCBI chr 2:157,995,179...158,136,154
Ensembl chr 2:157,876,679...158,136,154 		JBrowse link
G UROC1 urocanate hydratase 1 increases expression EXP obeticholic acid results in increased expression of UROC1 mRNA CTD PMID:27939613 NCBI chr 3:126,481,166...126,517,773
Ensembl chr 3:126,481,166...126,517,773 		JBrowse link
G XDH xanthine dehydrogenase increases expression EXP obeticholic acid results in increased expression of XDH mRNA CTD PMID:27939613 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        pharmacological role 22059
          agonist 20327
            farnesoid X receptor agonist 310
              obeticholic acid 310
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic polycyclic compound 18790
                                  steroid 15858
                                    steroid fundamental parent 15620
                                      cholane 1043
                                        cholanoid 1043
                                          cholanic acids 1026
                                            cholanic acid 1026
                                              5beta-cholanic acid 1026
                                                hydroxy-5beta-cholanic acid 1026
                                                  dihydroxy-5beta-cholanic acid 873
                                                    chenodeoxycholic acid 567
                                                      obeticholic acid 310
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