ACSL5 (acyl-CoA synthetase long chain family member 5) - Rat Genome Database
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Gene: ACSL5 (acyl-CoA synthetase long chain family member 5) Homo sapiens
Analyze
Symbol: ACSL5
Name: acyl-CoA synthetase long chain family member 5
RGD ID: 1604361
HGNC Page HGNC
Description: Exhibits long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process and regulation of extrinsic apoptotic signaling pathway. Localizes to several cellular components, including endoplasmic reticulum; mitochondrion; and nuclear lumen.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACS2; ACS5; acyl-CoA synthetase long-chain family member 5; arachidonate--CoA ligase; FACL5; FACL5 for fatty acid coenzyme A ligase 5; fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5; LACS 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; long-chain-fatty-acid--CoA ligase 5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10112,374,018 - 112,428,380 (+)EnsemblGRCh38hg38GRCh38
GRCh3810112,374,116 - 112,428,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710114,133,916 - 114,188,138 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3710114,133,874 - 114,188,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,123,906 - 114,178,128 (+)NCBINCBI36hg18NCBI36
Celera10107,861,444 - 107,915,662 (+)NCBI
Cytogenetic Map10q25.2NCBI
HuRef10107,761,898 - 107,815,784 (+)NCBIHuRef
CHM1_110114,415,634 - 114,469,870 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
azathioprine  (EXP)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diethylstilbestrol  (ISO)
dioscin  (ISO)
doxorubicin  (EXP)
ethanol  (ISO)
farnesol  (EXP)
fenofibrate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
GW 4064  (EXP)
GW 7647  (EXP,ISO)
isotretinoin  (EXP)
levofloxacin  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel sulfate  (EXP)
nimesulide  (ISO)
O-methyleugenol  (EXP)
obeticholic acid  (EXP)
oleic acid  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picrotoxin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tolcapone  (EXP)
topotecan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8125298   PMID:8944226   PMID:11127823   PMID:11319232   PMID:11707336   PMID:12147264   PMID:12477932   PMID:12975309   PMID:14608540   PMID:15164054   PMID:15292367   PMID:15489334  
PMID:15736044   PMID:15809837   PMID:16198472   PMID:16385451   PMID:17495181   PMID:17681178   PMID:17761945   PMID:18228202   PMID:18806831   PMID:19218499   PMID:19946888   PMID:20379614  
PMID:20470896   PMID:20877624   PMID:21516116   PMID:21873635   PMID:22163040   PMID:22171129   PMID:22633490   PMID:23348389   PMID:24222123   PMID:24269233   PMID:24663101   PMID:24770931  
PMID:25356045   PMID:26496610   PMID:27189022   PMID:27499296   PMID:27503909   PMID:28153554   PMID:28498416   PMID:28808653   PMID:29180619   PMID:29360040   PMID:29605434   PMID:30463708  
PMID:30712446   PMID:31010829   PMID:31053784   PMID:31980649   PMID:32296183  


Genomics

Comparative Map Data
ACSL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10112,374,018 - 112,428,380 (+)EnsemblGRCh38hg38GRCh38
GRCh3810112,374,116 - 112,428,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710114,133,916 - 114,188,138 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3710114,133,874 - 114,188,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,123,906 - 114,178,128 (+)NCBINCBI36hg18NCBI36
Celera10107,861,444 - 107,915,662 (+)NCBI
Cytogenetic Map10q25.2NCBI
HuRef10107,761,898 - 107,815,784 (+)NCBIHuRef
CHM1_110114,415,634 - 114,469,870 (+)NCBICHM1_1
Acsl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,240,298 - 55,285,060 (+)NCBIGRCm39mm39
GRCm381955,251,861 - 55,296,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,251,938 - 55,297,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371955,327,859 - 55,371,118 (+)NCBIGRCm37mm9NCBIm37
MGSCv361955,306,619 - 55,349,878 (+)NCBImm8
Celera1957,444,332 - 57,487,767 (+)NCBICelera
Cytogenetic Map19D2NCBI
Acsl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,289,513 - 254,336,608 (+)NCBI
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01276,240,703 - 276,290,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01283,637,899 - 283,685,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41261,554,383 - 261,599,373 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11261,765,427 - 261,810,418 (+)NCBI
Celera1249,999,118 - 250,043,312 (+)NCBICelera
Cytogenetic Map1q55NCBI
Acsl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543117,477,086 - 17,524,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543117,477,113 - 17,524,539 (+)NCBIChiLan1.0ChiLan1.0
ACSL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110112,405,069 - 112,457,892 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,407,161 - 112,457,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010108,965,559 - 109,019,240 (+)NCBIMhudiblu_PPA_v0panPan3
ACSL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2823,440,387 - 23,478,762 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12823,437,838 - 23,478,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Acsl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364862,952,379 - 2,992,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14122,777,130 - 122,828,051 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114122,777,135 - 122,828,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214133,689,844 - 133,751,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,259,546 - 105,311,500 (+)NCBI
ChlSab1.1 Ensembl9105,257,429 - 105,311,690 (+)Ensembl
Acsl5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473734,038,610 - 34,091,579 (-)NCBI

Position Markers
G20863  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,187,909 - 114,188,096UniSTSGRCh37
Build 3610114,177,899 - 114,178,086RGDNCBI36
Celera10107,915,433 - 107,915,620RGD
Cytogenetic Map10q25.1-q25.2UniSTS
HuRef10107,815,555 - 107,815,742UniSTS
A006J06  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,187,909 - 114,188,096UniSTSGRCh37
Build 3610114,177,899 - 114,178,086RGDNCBI36
Celera10107,915,433 - 107,915,620RGD
Cytogenetic Map10q25.1-q25.2UniSTS
HuRef10107,815,555 - 107,815,742UniSTS
GeneMap99-GB4 RH Map10516.88UniSTS
NCBI RH Map101234.5UniSTS
RH47726  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,187,034 - 114,187,159UniSTSGRCh37
Build 3610114,177,024 - 114,177,149RGDNCBI36
Celera10107,914,558 - 107,914,683RGD
Cytogenetic Map10q25.1-q25.2UniSTS
HuRef10107,814,680 - 107,814,805UniSTS
GeneMap99-GB4 RH Map10545.19UniSTS
NCBI RH Map101205.7UniSTS
D10S1429  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,150,342 - 114,150,596UniSTSGRCh37
Build 3610114,140,332 - 114,140,586RGDNCBI36
Celera10107,877,871 - 107,878,125RGD
Cytogenetic Map10q25.1-q25.2UniSTS
HuRef10107,778,326 - 107,778,580UniSTS
Marshfield Genetic Map10130.9UniSTS
deCODE Assembly Map10129.4UniSTS
Stanford-G3 RH Map105193.0UniSTS
Whitehead-RH Map10617.3UniSTS
Whitehead-YAC Contig Map10 UniSTS
NCBI RH Map101234.5UniSTS
WI-12237  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,187,993 - 114,188,094UniSTSGRCh37
Build 3610114,177,983 - 114,178,084RGDNCBI36
Celera10107,915,517 - 107,915,618RGD
Cytogenetic Map10q25.1-q25.2UniSTS
HuRef10107,815,639 - 107,815,740UniSTS
GeneMap99-GB4 RH Map10516.56UniSTS
Whitehead-RH Map10617.2UniSTS
NCBI RH Map101237.0UniSTS
ACSL5_3592  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710114,187,272 - 114,188,146UniSTSGRCh37
Build 3610114,177,262 - 114,178,136RGDNCBI36
Celera10107,914,796 - 107,915,670RGD
HuRef10107,814,918 - 107,815,792UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2580
Count of miRNA genes:676
Interacting mature miRNAs:769
Transcripts:ENST00000354273, ENST00000354655, ENST00000356116, ENST00000369410, ENST00000393081, ENST00000433418, ENST00000467340, ENST00000479936, ENST00000495539, ENST00000496328
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1159 623 949 442 1497 430 1202 174 786 185 1082 1211 22 1202 469 1
Low 1266 2361 768 178 437 32 2935 1988 2886 226 341 306 148 2 2319 1
Below cutoff 7 5 2 9 2 185 12 19 7 22 64 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001387037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_203379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_203380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB033920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ347687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ496489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL157786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL708480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM262166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD689921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF595490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS248458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000354273   ⟹   ENSP00000346223
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,376,199 - 112,428,380 (+)Ensembl
RefSeq Acc Id: ENST00000354655   ⟹   ENSP00000346680
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,374,018 - 112,428,376 (+)Ensembl
RefSeq Acc Id: ENST00000356116   ⟹   ENSP00000348429
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,376,198 - 112,428,379 (+)Ensembl
RefSeq Acc Id: ENST00000393081   ⟹   ENSP00000376796
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,375,265 - 112,428,379 (+)Ensembl
RefSeq Acc Id: ENST00000433418   ⟹   ENSP00000403647
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,376,198 - 112,428,379 (+)Ensembl
RefSeq Acc Id: ENST00000467340
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,411,383 - 112,417,938 (+)Ensembl
RefSeq Acc Id: ENST00000479936
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,375,235 - 112,408,521 (+)Ensembl
RefSeq Acc Id: ENST00000495539
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,409,533 - 112,421,626 (+)Ensembl
RefSeq Acc Id: ENST00000496328
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10112,421,981 - 112,426,608 (+)Ensembl
RefSeq Acc Id: NM_001387037   ⟹   NP_001373966
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,376,205 - 112,428,376 (+)NCBI
RefSeq Acc Id: NM_016234   ⟹   NP_057318
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,376,205 - 112,428,376 (+)NCBI
GRCh3710114,133,916 - 114,188,138 (+)ENTREZGENE
Build 3610114,125,946 - 114,178,128 (+)NCBI Archive
HuRef10107,761,898 - 107,815,784 (+)ENTREZGENE
CHM1_110114,417,674 - 114,469,870 (+)NCBI
Sequence:
RefSeq Acc Id: NM_203379   ⟹   NP_976313
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,374,116 - 112,428,376 (+)NCBI
GRCh3710114,133,916 - 114,188,138 (+)ENTREZGENE
Build 3610114,123,906 - 114,178,128 (+)NCBI Archive
HuRef10107,761,898 - 107,815,784 (+)ENTREZGENE
CHM1_110114,415,634 - 114,469,870 (+)NCBI
Sequence:
RefSeq Acc Id: NM_203380   ⟹   NP_976314
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,375,268 - 112,428,376 (+)NCBI
GRCh3710114,133,916 - 114,188,138 (+)ENTREZGENE
Build 3610114,125,013 - 114,178,128 (+)NCBI Archive
HuRef10107,761,898 - 107,815,784 (+)ENTREZGENE
CHM1_110114,416,741 - 114,469,870 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_976313   ⟸   NM_203379
- Peptide Label: isoform b
- UniProtKB: Q9ULC5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_976314   ⟸   NM_203380
- Peptide Label: isoform b
- UniProtKB: Q9ULC5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_057318   ⟸   NM_016234
- Peptide Label: isoform a
- UniProtKB: Q9ULC5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000346223   ⟸   ENST00000354273
RefSeq Acc Id: ENSP00000346680   ⟸   ENST00000354655
RefSeq Acc Id: ENSP00000376796   ⟸   ENST00000393081
RefSeq Acc Id: ENSP00000403647   ⟸   ENST00000433418
RefSeq Acc Id: ENSP00000348429   ⟸   ENST00000356116
RefSeq Acc Id: NP_001373966   ⟸   NM_001387037
- Peptide Label: isoform c

Promoters
RGD ID:7218687
Promoter ID:EPDNEW_H15089
Type:multiple initiation site
Name:ACSL5_2
Description:acyl-CoA synthetase long-chain family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15090  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,372,397 - 112,372,457EPDNEW
RGD ID:7218689
Promoter ID:EPDNEW_H15090
Type:initiation region
Name:ACSL5_1
Description:acyl-CoA synthetase long-chain family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15089  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810112,376,205 - 112,376,265EPDNEW
RGD ID:6787306
Promoter ID:HG_KWN:11188
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:NM_203380,   OTTHUMT00000050388
Position:
Human AssemblyChrPosition (strand)Source
Build 3610114,124,789 - 114,125,289 (+)MPROMDB
RGD ID:6787639
Promoter ID:HG_KWN:11189
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000369410,   NM_016234
Position:
Human AssemblyChrPosition (strand)Source
Build 3610114,124,981 - 114,126,097 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3
pathogenic
GRCh38/hg38 10q25.1-26.11(chr10:107191100-118761489)x1 copy number loss See cases [RCV000052570] Chr10:107191100..118761489 [GRCh38]
Chr10:108950858..120521001 [GRCh37]
Chr10:108940848..120510991 [NCBI36]
Chr10:10q25.1-26.11
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
NM_016234.3(ACSL5):c.378C>T (p.Cys126=) single nucleotide variant Malignant melanoma [RCV000068801] Chr10:112398954 [GRCh38]
Chr10:114158712 [GRCh37]
Chr10:114148702 [NCBI36]
Chr10:10q25.2
not provided
NM_016234.3(ACSL5):c.756G>A (p.Gly252=) single nucleotide variant Malignant melanoma [RCV000061999] Chr10:112409562 [GRCh38]
Chr10:114169320 [GRCh37]
Chr10:114159310 [NCBI36]
Chr10:10q25.2
not provided
GRCh38/hg38 10q25.1-26.3(chr10:108102587-133620674)x3 copy number gain See cases [RCV000133688] Chr10:108102587..133620674 [GRCh38]
Chr10:109862345..135434178 [GRCh37]
Chr10:109852335..135284168 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:112074094-115537174)x1 copy number loss See cases [RCV000135960] Chr10:112074094..115537174 [GRCh38]
Chr10:113833852..117032437 [GRCh37]
Chr10:113823842..117286674 [NCBI36]
Chr10:10q25.2-25.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.2-25.3(chr10:110804735-114884010)x1 copy number loss See cases [RCV000139783] Chr10:110804735..114884010 [GRCh38]
Chr10:112564493..116643769 [GRCh37]
Chr10:112554483..116633759 [NCBI36]
Chr10:10q25.2-25.3
likely pathogenic
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:104633712-135427143)x3 copy number gain See cases [RCV000449386] Chr10:104633712..135427143 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q25.2(chr10:113700361-114355981)x3 copy number gain See cases [RCV000449159] Chr10:113700361..114355981 [GRCh37]
Chr10:10q25.2
uncertain significance
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q24.32-25.3(chr10:104030479-115410590)x1 copy number loss See cases [RCV000448581] Chr10:104030479..115410590 [GRCh37]
Chr10:10q24.32-25.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:106003533-135427143)x3 copy number gain See cases [RCV000510813] Chr10:106003533..135427143 [GRCh37]
Chr10:10q25.1-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q24.33-26.3(chr10:105613040-135427143)x3 copy number gain not provided [RCV000683290] Chr10:105613040..135427143 [GRCh37]
Chr10:10q24.33-26.3
pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10q25.2(chr10:113698114-114352961)x3 copy number gain not provided [RCV000749823] Chr10:113698114..114352961 [GRCh37]
Chr10:10q25.2
benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_016234.3(ACSL5):c.287C>A (p.Pro96His) single nucleotide variant not provided [RCV000879037] Chr10:112395065 [GRCh38]
Chr10:114154823 [GRCh37]
Chr10:10q25.2
benign
NM_016234.3(ACSL5):c.1299G>A (p.Leu433=) single nucleotide variant not provided [RCV000965863] Chr10:112416935 [GRCh38]
Chr10:114176693 [GRCh37]
Chr10:10q25.2
benign
GRCh37/hg19 10q25.1-26.3(chr10:110022170-135439095) copy number gain not provided [RCV000767665] Chr10:110022170..135439095 [GRCh37]
Chr10:10q25.1-26.3
pathogenic
NM_016234.3(ACSL5):c.1624A>G (p.Thr542Ala) single nucleotide variant not provided [RCV000962053] Chr10:112422015 [GRCh38]
Chr10:114181773 [GRCh37]
Chr10:10q25.2
benign
NM_016234.3(ACSL5):c.601-10C>T single nucleotide variant not provided [RCV000965817] Chr10:112408412 [GRCh38]
Chr10:114168170 [GRCh37]
Chr10:10q25.2
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16526 AgrOrtholog
COSMIC ACSL5 COSMIC
Ensembl Genes ENSG00000197142 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000346223 UniProtKB/Swiss-Prot
  ENSP00000346680 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000348429 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376796 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000403647 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000354273 UniProtKB/Swiss-Prot
  ENST00000354655 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000356116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393081 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000433418 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot
GTEx ENSG00000197142 GTEx
HGNC ID HGNC:16526 ENTREZGENE
Human Proteome Map ACSL5 Human Proteome Map
InterPro AMP-binding_CS UniProtKB/Swiss-Prot
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:51703 UniProtKB/Swiss-Prot
NCBI Gene 51703 ENTREZGENE
OMIM 605677 OMIM
Pfam AMP-binding UniProtKB/Swiss-Prot
PharmGKB PA27969 PharmGKB
PROSITE AMP_BINDING UniProtKB/Swiss-Prot
UniProt ACSL5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6GV77 UniProtKB/Swiss-Prot
  D3DRB3 UniProtKB/Swiss-Prot
  Q6UX44 UniProtKB/Swiss-Prot
  Q9UIU4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 ACSL5  acyl-CoA synthetase long chain family member 5  ACSL5  acyl-CoA synthetase long-chain family member 5  Symbol and/or name change 5135510 APPROVED