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Gene: A2M (alpha-2-macroglobulin) Homo sapiens
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Symbol: A2M
Name: alpha-2-macroglobulin
Description: Exhibits several functions, including calcium-dependent protein binding activity; cytokine binding activity; and serine-type endopeptidase inhibitor activity. Involved in negative regulation of complement activation, lectin pathway. Localizes to blood microparticle; collagen-containing extracellular matrix; and extracellular exosome. Implicated in background diabetic retinopathy; neurodegenerative disease (multiple); and obstructive lung disease. Biomarker of cerebral infarction and heart disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A2MD; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863-7
Orthologs:
Mus musculus (house mouse) : A2m (alpha-2-macroglobulin)  MGI  Alliance
Rattus norvegicus (Norway rat) : A2m (alpha-2-macroglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102021956 (alpha-2-macroglobulin)
Canis lupus familiaris (dog) : LOC477699 (alpha-2-macroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : A2m (alpha-2-macroglobulin)
Sus scrofa (pig) : A2M (alpha-2-macroglobulin)
more info ...
Related Pseudogenes: A2MP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl129,067,664 - 9,116,229 (-)EnsemblGRCh38hg38GRCh38
GRCh38129,067,708 - 9,116,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37129,220,304 - 9,268,558 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,111,571 - 9,159,825 (-)NCBINCBI36hg18NCBI36
Build 34129,111,576 - 9,159,754NCBI
Celera1210,757,430 - 10,805,676 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef129,000,837 - 9,049,088 (-)NCBIHuRef
CHM1_1129,189,284 - 9,237,532 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on A2M
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735738
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.