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Gene: APOA1 (apolipoprotein A1) Homo sapiens
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Symbol: APOA1
Name: apolipoprotein A1
Description: Exhibits several functions, including amyloid-beta binding activity; cholesterol binding activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of Rho protein signal transduction. Localizes to the endocytic vesicle; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in Alzheimer's disease; artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia; and systemic lupus erythematosus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal failure; idiopathic pulmonary fibrosis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo(a); apo-AI; apoA-I; apolipoprotein A-I; HPALP2; MGC117399
Orthologs:
Mus musculus (house mouse) : Apoa1 (apolipoprotein A-I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apoa1 (apolipoprotein A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoa1 (apolipoprotein A1)
Pan paniscus (bonobo/pygmy chimpanzee) : APOA1 (apolipoprotein A1)
Canis lupus familiaris (dog) : APOA1 (apolipoprotein A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoa1 (apolipoprotein A1)
Sus scrofa (pig) : APOA1 (apolipoprotein A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,835,751 - 116,837,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,706,467 - 116,708,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,211,679 - 116,213,548 (-)NCBINCBI36hg18NCBI36
Celera11113,864,272 - 113,866,141 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,638,728 - 112,640,597 (-)NCBIHuRef
CHM1_111116,591,219 - 116,593,418 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on APOA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735962
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.