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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736649
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP8B1
Name: cytochrome P450 family 8 subfamily B member 1
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP8B1increases expressionEXP 6480464CTDobeticholic acid results in increased expression of CYP8B1 mRNAPMID:27939613
CYP8B1decreases expressionISOCyp8b1 (Rattus norvegicus)6480464CTDobeticholic acid results in decreased expression of CYP8B1 mRNAPMID:15644430
CYP8B1multiple interactionsISOCyp8b1 (Mus musculus)6480464CTDobeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]PMID:29660435
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