TXN (thioredoxin) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TXN (thioredoxin) Homo sapiens
Analyze
Symbol: TXN
Name: thioredoxin
RGD ID: 732441
Description: Exhibits protein disulfide oxidoreductase activity; protein homodimerization activity; and protein-disulfide reductase activity. Involved in several processes, including cell redox homeostasis; negative regulation of hydrogen peroxide-induced cell death; and positive regulation of protein modification process. Localizes to cytosol; extracellular region; and nucleoplasm. Biomarker of dilated cardiomyopathy; intermediate coronary syndrome; myocardial infarction; and myocarditis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADF; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; surface-associated sulphydryl protein; testicular tissue protein Li 199; thioredoxin delta 3; TRDX; TRX; TRX1; TXN delta 3
Orthologs:
Mus musculus (house mouse) : Txn1 (thioredoxin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Txn1 (thioredoxin 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : TXN (thioredoxin)
Canis lupus familiaris (dog) : LOC100687127 (thioredoxin-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txn (thioredoxin)
Sus scrofa (pig) : TXN (thioredoxin)
Chlorocebus sabaeus (African green monkey) : TXN (thioredoxin)
Heterocephalus glaber (naked mole-rat) : Txn (thioredoxin)
more info ...
Related Pseudogenes: LOC171417   TXNP1   TXNP2   TXNP3   TXNP4   TXNP5   TXNP6   TXNP7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9110,243,810 - 110,256,507 (-)EnsemblGRCh38hg38GRCh38
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379113,006,092 - 113,018,920 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBI
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-quinic acid  (EXP)
(-)-selegiline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-methylumbelliferyl acetate  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
atenolol  (EXP)
ATP  (EXP)
atrazine  (ISO)
auranofin  (EXP)
benfotiamine  (ISO)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[d]isothiazol-3-one  (EXP)
benzoic acid  (EXP)
benzyl cinnamate  (EXP)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (ISO)
bromobenzene  (ISO)
bucladesine  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
cerium trichloride  (EXP)
chenodeoxycholic acid  (EXP)
chloroacetaldehyde  (EXP)
chloroform  (ISO)
chlorogenic acid  (EXP)
chlorpromazine  (ISO)
chromium(6+)  (EXP,ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP)
clodronic acid  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
cytochalasin D  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
diethyl maleate  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diphenylcyclopropenone  (EXP)
dipyridamole  (ISO)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (ISO)
fipronil  (ISO)
fluorescein 5-isothiocyanate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fumaraldehyde  (EXP)
fumonisin B1  (ISO)
furan  (ISO)
gamma-linolenic acid  (EXP)
genistein  (EXP)
glucose  (EXP,ISO)
herbicide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxycitronellal  (EXP)
ifosfamide  (EXP)
indometacin  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (EXP)
isoprenaline  (ISO)
KT 5823  (ISO)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (ISO)
linalool  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP,ISO)
LY294002  (EXP,ISO)
maneb  (EXP)
Manumycin A  (EXP)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
methamphetamine  (EXP,ISO)
methyl non-2-ynoate  (EXP)
methylarsonic acid  (EXP)
methylene blue  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin RR  (EXP)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrogen dioxide  (ISO)
Nonidet P-40  (EXP)
obeticholic acid  (EXP)
okadaic acid  (EXP,ISO)
omeprazole  (ISO)
Osajin  (EXP)
ouabain  (EXP)
ozone  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
perillyl aldehyde  (EXP)
phenethyl isothiocyanate  (EXP,ISO)
phenylmercury acetate  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (EXP)
phosphatidylethanolamine  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
Pomiferin  (EXP)
potassium dichromate  (ISO)
propiconazole  (ISO)
puerarin  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
Rosavin  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (EXP)
SB 431542  (EXP)
selenium atom  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sodium dodecyl sulfate  (EXP)
sodium selenide  (EXP)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulforaphane  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
TCEP  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:1332947   PMID:1874447   PMID:1998498   PMID:2001356   PMID:2176490   PMID:2684271   PMID:2785919   PMID:3170595   PMID:7601465   PMID:7788295   PMID:7821789   PMID:7922028  
PMID:8049254   PMID:8736558   PMID:8805557   PMID:9108029   PMID:9369469   PMID:9433926   PMID:9464857   PMID:9564042   PMID:9915858   PMID:10397171   PMID:10419473   PMID:10585464  
PMID:10814541   PMID:10843682   PMID:10947064   PMID:10982790   PMID:11012661   PMID:11118054   PMID:11298454   PMID:11323689   PMID:11517226   PMID:11689443   PMID:11751890   PMID:11778846  
PMID:11841832   PMID:11972307   PMID:12008049   PMID:12029072   PMID:12089063   PMID:12099690   PMID:12119401   PMID:12189205   PMID:12244106   PMID:12244325   PMID:12477932   PMID:12529245  
PMID:12660821   PMID:12804587   PMID:12816947   PMID:12878985   PMID:12882768   PMID:14503974   PMID:14644168   PMID:14688353   PMID:14695120   PMID:14703116   PMID:14730345   PMID:15096327  
PMID:15128745   PMID:15234975   PMID:15246877   PMID:15480426   PMID:15489334   PMID:15494431   PMID:15507528   PMID:15657067   PMID:15696199   PMID:15723974   PMID:15824742   PMID:15894171  
PMID:16097034   PMID:16115022   PMID:16207716   PMID:16263712   PMID:16269462   PMID:16311508   PMID:16408020   PMID:16424062   PMID:16458196   PMID:16492688   PMID:16507315   PMID:16712525  
PMID:16750198   PMID:16766796   PMID:16868544   PMID:16916647   PMID:16966583   PMID:17007870   PMID:17045827   PMID:17113580   PMID:17115890   PMID:17182577   PMID:17220299   PMID:17260951  
PMID:17316609   PMID:17331951   PMID:17353931   PMID:17360766   PMID:17369362   PMID:17557078   PMID:17574940   PMID:17601350   PMID:17603038   PMID:17606900   PMID:17634480   PMID:17651689  
PMID:17652454   PMID:17724081   PMID:17823364   PMID:17896802   PMID:17917077   PMID:17949784   PMID:17972886   PMID:17982132   PMID:18209488   PMID:18384140   PMID:18420212   PMID:18457020  
PMID:18497292   PMID:18544525   PMID:18579387   PMID:18835792   PMID:18848838   PMID:18976655   PMID:18977241   PMID:18983687   PMID:19018770   PMID:19032234   PMID:19056867   PMID:19120277  
PMID:19124506   PMID:19135121   PMID:19208085   PMID:19328186   PMID:19337991   PMID:19385090   PMID:19540723   PMID:19558833   PMID:19561639   PMID:19566940   PMID:19570036   PMID:19592618  
PMID:19601712   PMID:19605364   PMID:19620238   PMID:19671194   PMID:19681600   PMID:19690162   PMID:19723146   PMID:19773351   PMID:19799607   PMID:19805025   PMID:19913121   PMID:20029029  
PMID:20074557   PMID:20103619   PMID:20172870   PMID:20218863   PMID:20298786   PMID:20347035   PMID:20379614   PMID:20385180   PMID:20423474   PMID:20430109   PMID:20458337   PMID:20485444  
PMID:20536427   PMID:20619274   PMID:20628086   PMID:20661909   PMID:20662007   PMID:20847814   PMID:20877624   PMID:20929309   PMID:20943653   PMID:20955789   PMID:20974843   PMID:21030559  
PMID:21145461   PMID:21150319   PMID:21158569   PMID:21212402   PMID:21250889   PMID:21319273   PMID:21324905   PMID:21353370   PMID:21526215   PMID:21557999   PMID:21620911   PMID:21636804  
PMID:21642987   PMID:21704743   PMID:21705327   PMID:21771788   PMID:21800051   PMID:21908620   PMID:21963718   PMID:21988832   PMID:22134635   PMID:22248473   PMID:22384152   PMID:22430737  
PMID:22447839   PMID:22492997   PMID:22505815   PMID:22516068   PMID:22658674   PMID:22681889   PMID:22760822   PMID:22810585   PMID:22863883   PMID:22867430   PMID:22882193   PMID:22933306  
PMID:22939629   PMID:22977247   PMID:23068965   PMID:23105116   PMID:23112551   PMID:23133653   PMID:23206338   PMID:23212077   PMID:23223577   PMID:23238053   PMID:23246001   PMID:23291592  
PMID:23319048   PMID:23335265   PMID:23356570   PMID:23376485   PMID:23398456   PMID:23402259   PMID:23485938   PMID:23519408   PMID:23533145   PMID:23571504   PMID:23606123   PMID:23671274  
PMID:23743503   PMID:23747528   PMID:23850970   PMID:23880345   PMID:24008424   PMID:24062305   PMID:24086714   PMID:24130091   PMID:24130874   PMID:24147004   PMID:24198286   PMID:24244333  
PMID:24270206   PMID:24295294   PMID:24338024   PMID:24376827   PMID:24389582   PMID:24459704   PMID:24632182   PMID:24658140   PMID:24689038   PMID:24720336   PMID:24925443   PMID:24962940  
PMID:24976139   PMID:24999758   PMID:25098452   PMID:25106706   PMID:25113059   PMID:25174623   PMID:25184225   PMID:25197784   PMID:25218830   PMID:25231459   PMID:25297388   PMID:25350977  
PMID:25402766   PMID:25483711   PMID:25483731   PMID:25520003   PMID:25547896   PMID:25555670   PMID:25561728   PMID:25576832   PMID:25622749   PMID:25656992   PMID:25735211   PMID:25737280  
PMID:25756610   PMID:25839660   PMID:25921289   PMID:25945832   PMID:25959826   PMID:25963833   PMID:25979194   PMID:26021764   PMID:26028649   PMID:26119781   PMID:26167880   PMID:26210445  
PMID:26276860   PMID:26325518   PMID:26329592   PMID:26334622   PMID:26344197   PMID:26453009   PMID:26460805   PMID:26496610   PMID:26536897   PMID:26561776   PMID:26656445   PMID:26687479  
PMID:26752685   PMID:26760912   PMID:26777405   PMID:26816344   PMID:26933812   PMID:26972000   PMID:26990986   PMID:27000227   PMID:27132507   PMID:27158980   PMID:27432908   PMID:27512140  
PMID:27545878   PMID:27588831   PMID:27665998   PMID:27684187   PMID:27751915   PMID:27779244   PMID:27835927   PMID:27869172   PMID:27923281   PMID:27993729   PMID:28003361   PMID:28027390  
PMID:28087409   PMID:28093200   PMID:28111273   PMID:28162284   PMID:28270496   PMID:28319085   PMID:28347674   PMID:28411237   PMID:28442424   PMID:28483515   PMID:28514442   PMID:28515276  
PMID:28581483   PMID:28667779   PMID:28685749   PMID:28688762   PMID:28774816   PMID:28844667   PMID:28878015   PMID:28977666   PMID:29053012   PMID:29089489   PMID:29128334   PMID:29186683  
PMID:29227477   PMID:29229926   PMID:29327078   PMID:29328386   PMID:29334756   PMID:29348167   PMID:29383839   PMID:29449217   PMID:29467282   PMID:29482577   PMID:29507755   PMID:29509009  
PMID:29509190   PMID:29568061   PMID:29845934   PMID:29999276   PMID:30104382   PMID:30209976   PMID:30367780   PMID:30442662   PMID:30442762   PMID:30455355   PMID:30575818   PMID:30890647  
PMID:30911354   PMID:30948266   PMID:31028843   PMID:31045571   PMID:31059266   PMID:31091453   PMID:31180492   PMID:31300519   PMID:31371767   PMID:31470801   PMID:31501420   PMID:31527615  
PMID:31536960   PMID:31540324   PMID:31586073   PMID:31727737   PMID:31980649   PMID:32296183   PMID:32814053  


Genomics

Comparative Map Data
TXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9110,243,810 - 110,256,507 (-)EnsemblGRCh38hg38GRCh38
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379113,006,092 - 113,018,920 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBI
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
Txn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,943,373 - 57,956,411 (-)NCBI
GRCm38457,943,373 - 57,956,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,956,245 - 57,969,283 (-)NCBIGRCm37mm9NCBIm37
MGSCv36458,037,427 - 58,050,345 (-)NCBImm8
Celera457,856,035 - 57,868,968 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
Txn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
Cytogenetic Map5q24NCBI
RH 3.4 Map5494.0RGD
TXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19109,565,557 - 109,578,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,565,557 - 109,578,311 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0981,399,056 - 81,411,607 (-)NCBIMhudiblu_PPA_v0panPan3
LOC100687127
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,986,288 - 82,986,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Txn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365592,811,786 - 2,822,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,263,175 - 251,277,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,264,180 - 251,278,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,027,082 - 282,035,642 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
TXN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11229,296,166 - 29,308,979 (+)NCBI
Txn
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247581,318,108 - 1,329,011 (+)NCBI

Position Markers
D9S1707  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379113,006,253 - 113,006,429UniSTSGRCh37
Build 369112,046,074 - 112,046,250RGDNCBI36
Celera983,507,879 - 83,508,055RGD
Cytogenetic Map9q31UniSTS
HuRef982,607,972 - 82,608,148UniSTS
GeneMap99-GB4 RH Map9350.7UniSTS
Whitehead-RH Map9413.0UniSTS
Whitehead-YAC Contig Map9 UniSTS
GeneMap99-G3 RH Map93608.0UniSTS
RH70008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37477,879,896 - 77,880,141UniSTSGRCh37
GRCh372149,924,993 - 149,925,240UniSTSGRCh37
Build 362149,633,239 - 149,633,486RGDNCBI36
Celera475,181,270 - 75,181,515UniSTS
Celera2143,538,892 - 143,539,139RGD
Cytogenetic Map2q23.2UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map9q31UniSTS
HuRef473,631,724 - 73,631,969UniSTS
HuRef2141,823,208 - 141,823,455UniSTS
GDB:593240  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37477,879,893 - 77,880,367UniSTSGRCh37
Build 36478,098,917 - 78,099,391RGDNCBI36
Celera475,181,267 - 75,181,741RGD
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map9q31UniSTS
HuRef473,631,721 - 73,632,195UniSTS
SHGC-145294  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379113,013,366 - 113,013,666UniSTSGRCh37
Build 369112,053,187 - 112,053,487RGDNCBI36
Celera983,514,986 - 83,515,286RGD
Cytogenetic Map9q31UniSTS
HuRef982,615,149 - 82,615,449UniSTS
RH70912  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q31UniSTS
G54088  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q31UniSTS
SHGC-35694  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q31UniSTS
GeneMap99-GB4 RH Map1746.33UniSTS
Whitehead-RH Map1755.2UniSTS
NCBI RH Map1767.1UniSTS
GeneMap99-G3 RH Map44293.0UniSTS
GDB:512873  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q31UniSTS
RH71341  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q31UniSTS
GeneMap99-GB4 RH Map9352.62UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:117
Interacting mature miRNAs:120
Transcripts:ENST00000374515, ENST00000374517, ENST00000487892
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 64 18 36 175 19 3 3 6 14 80 79 25
Medium 2368 2954 1704 585 1769 444 4352 2164 3702 403 1368 1529 146 1204 2788 4
Low 30 1 1 4 1 26 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001244938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF065241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF085844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF276919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF313911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF548001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL158158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW160756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY004872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ774337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ313905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X70288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X77584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000374515   ⟹   ENSP00000363639
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9110,243,811 - 110,256,466 (-)Ensembl
RefSeq Acc Id: ENST00000374517   ⟹   ENSP00000363641
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9110,243,810 - 110,256,507 (-)Ensembl
RefSeq Acc Id: ENST00000487892
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9110,244,019 - 110,245,116 (-)Ensembl
RefSeq Acc Id: NM_001244938   ⟹   NP_001231867
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389110,243,810 - 110,256,507 (-)NCBI
HuRef982,607,811 - 82,620,710 (-)NCBI
CHM1_19113,152,543 - 113,165,343 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003329   ⟹   NP_003320
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389110,243,810 - 110,256,507 (-)NCBI
GRCh379113,006,092 - 113,018,920 (-)NCBI
Build 369112,046,131 - 112,058,599 (-)NCBI Archive
HuRef982,607,811 - 82,620,710 (-)NCBI
CHM1_19113,152,543 - 113,165,343 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003320   ⟸   NM_003329
- Peptide Label: isoform 1
- UniProtKB: P10599 (UniProtKB/Swiss-Prot),   H9ZYJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231867   ⟸   NM_001244938
- Peptide Label: isoform 2
- UniProtKB: P10599 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000363639   ⟸   ENST00000374515
RefSeq Acc Id: ENSP00000363641   ⟸   ENST00000374517
Protein Domains
Thioredoxin

Promoters
RGD ID:7215825
Promoter ID:EPDNEW_H13659
Type:initiation region
Name:TXN_1
Description:thioredoxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389110,256,507 - 110,256,567EPDNEW
RGD ID:6808341
Promoter ID:HG_KWN:64496
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000053614,   OTTHUMT00000053615,   UC004BER.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369112,058,496 - 112,059,662 (-)MPROMDB
RGD ID:6851672
Promoter ID:EP73638
Type:multiple initiation site
Name:HS_TXN
Description:Thioredoxin.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 369112,058,608 - 112,058,668EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000050315] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99349916-115767475)x1 copy number loss See cases [RCV000052921] Chr9:99349916..115767475 [GRCh38]
Chr9:102112198..118529754 [GRCh37]
Chr9:101152019..117569575 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.1-32(chr9:88522292-113687796)x3 copy number gain See cases [RCV000053752] Chr9:88522292..113687796 [GRCh38]
Chr9:91137207..116450076 [GRCh37]
Chr9:90327027..115489897 [NCBI36]
Chr9:9q22.1-32
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q31.1-32(chr9:103767420-112984794)x1 copy number loss See cases [RCV000134976] Chr9:103767420..112984794 [GRCh38]
Chr9:106529701..115747074 [GRCh37]
Chr9:105569522..114786895 [NCBI36]
Chr9:9q31.1-32
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3
pathogenic
GRCh38/hg38 9q31.2-33.1(chr9:107530314-117965944)x1 copy number loss See cases [RCV000140794] Chr9:107530314..117965944 [GRCh38]
Chr9:110292595..120728222 [GRCh37]
Chr9:109332416..119768043 [NCBI36]
Chr9:9q31.2-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000148264] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.3(chr9:111529810-113539990)x3 copy number gain See cases [RCV000449057] Chr9:111529810..113539990 [GRCh37]
Chr9:9q31.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.3-33.1(chr9:111348809-118687200)x1 copy number loss See cases [RCV000449308] Chr9:111348809..118687200 [GRCh37]
Chr9:9q31.3-33.1
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain See cases [RCV000447207] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089)x1 copy number loss See cases [RCV000447763] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3
pathogenic
GRCh37/hg19 9q31.1-31.3(chr9:103271401-113948226)x1 copy number loss See cases [RCV000447957] Chr9:103271401..113948226 [GRCh37]
Chr9:9q31.1-31.3
pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3
likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.2-32(chr9:108664157-115356416)x3 copy number gain not provided [RCV000683161] Chr9:108664157..115356416 [GRCh37]
Chr9:9q31.2-32
likely pathogenic
GRCh37/hg19 9q31.1-31.3(chr9:106487247-114541579)x1 copy number loss not provided [RCV000683163] Chr9:106487247..114541579 [GRCh37]
Chr9:9q31.1-31.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic
GRCh37/hg19 9q31.3(chr9:112794010-113113206)x3 copy number gain not provided [RCV001006253] Chr9:112794010..113113206 [GRCh37]
Chr9:9q31.3
likely benign
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3
pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12435 AgrOrtholog
COSMIC TXN COSMIC
Ensembl Genes ENSG00000136810 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000363639 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000363641 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000374515 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000374517 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000136810 GTEx
HGNC ID HGNC:12435 ENTREZGENE
Human Proteome Map TXN Human Proteome Map
InterPro Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7295 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7295 ENTREZGENE
OMIM 187700 OMIM
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37091 PharmGKB
PIRSF Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs thioredoxin UniProtKB/TrEMBL
UniGene Hs.435136 ENTREZGENE
UniProt A0A1S5UZH5_HUMAN UniProtKB/TrEMBL
  H9ZYJ2 ENTREZGENE, UniProtKB/TrEMBL
  P10599 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1ALW1 UniProtKB/Swiss-Prot
  O60744 UniProtKB/Swiss-Prot
  Q53X69 UniProtKB/Swiss-Prot
  Q96KI3 UniProtKB/Swiss-Prot
  Q9UDG5 UniProtKB/Swiss-Prot