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Gene: PC (pyruvate carboxylase) Homo sapiens
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Symbol: PC
Name: pyruvate carboxylase
RGD ID: 733418
Description: Exhibits identical protein binding activity. Involved in negative regulation of gene expression; positive regulation by host of viral release from host cell; and viral RNA genome packaging. Localizes to mitochondrion. Implicated in pyruvate carboxylase deficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PCB; pyruvate carboxylase, mitochondrial; pyruvic carboxylase
Orthologs:
Mus musculus (house mouse) : Pcx (pyruvate carboxylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pc (pyruvate carboxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pc (pyruvate carboxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : PC (pyruvate carboxylase)
Canis lupus familiaris (dog) : PC (pyruvate carboxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pc (pyruvate carboxylase)
Sus scrofa (pig) : PC (pyruvate carboxylase)
Chlorocebus sabaeus (African green monkey) : PC (pyruvate carboxylase)
Heterocephalus glaber (naked mole-rat) : Pc (pyruvate carboxylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,848,417 - 66,958,386 (-)EnsemblGRCh38hg38GRCh38
GRCh381166,848,420 - 66,958,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,615,993 - 66,725,847 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,372,573 - 66,482,423 (-)NCBINCBI36hg18NCBI36
Build 341166,372,572 - 66,431,998NCBI
Celera1163,944,403 - 64,054,124 (-)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1162,944,043 - 63,053,644 (-)NCBIHuRef
CHM1_11166,499,596 - 66,607,614 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733418
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.