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Gene: CASP10 (caspase 10) Homo sapiens
Symbol: CASP10
Name: caspase 10
Description: Exhibits cysteine-type endopeptidase activity involved in apoptotic signaling pathway; death effector domain binding activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to the CD95 death-inducing signaling complex and ripoptosome. Implicated in autoimmune lymphoproliferative syndrome type 2A and non-Hodgkin lymphoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALPS2; apoptotic protease MCH-4; CASP-10; caspase 10 apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine protease; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; MCH4
Pan paniscus (bonobo/pygmy chimpanzee) : CASP10 (caspase 10)
Canis lupus familiaris (dog) : CASP10 (caspase 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp10 (caspase 10)
Sus scrofa (pig) : CASP10 (caspase 10)
Chlorocebus sabaeus (green monkey) : CASP10 (caspase 10)
Heterocephalus glaber (naked mole-rat) : Casp10 (caspase 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2201,182,898 - 201,229,406 (+)Ensembl
GRCh38 Ensembl2201,182,881 - 201,229,406 (+)Ensembl
GRCh382201,182,885 - 201,229,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,047,621 - 202,094,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,755,866 - 201,802,355 (+)NCBINCBI36hg18NCBI36
Build 342201,873,360 - 201,910,373NCBI
Celera2195,802,231 - 195,848,720 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,898,993 - 193,945,498 (+)NCBIHuRef
CHM1_12202,053,583 - 202,100,108 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CASP10
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347736
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.