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Gene: LSS (lanosterol synthase) Homo sapiens
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Symbol: LSS
Name: lanosterol synthase
Description: Exhibits lanosterol synthase activity. Involved in cholesterol biosynthetic process and regulation of protein stability. Localizes to the lipid droplet. Implicated in cataract 44 and hypotrichosis 14.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2,3-epoxysqualene--lanosterol cyclase; 2,3-epoxysqualene-lanosterol cyclase; 2,3-oxidosqualene: lanosterol cyclase; CTRCT44; FLJ25486; FLJ35015; FLJ39450; FLJ46393; hOSC; HYPT14; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); OSC; oxidosqualene--lanosterol cyclase
Orthologs:
Mus musculus (house mouse) : Lss (lanosterol synthase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lss (lanosterol synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lss (lanosterol synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : LSS (lanosterol synthase)
Canis lupus familiaris (dog) : LSS (lanosterol synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lss (lanosterol synthase)
Sus scrofa (pig) : LSS (lanosterol synthase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382146,188,446 - 46,228,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372147,608,360 - 47,648,738 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,432,788 - 46,473,119 (-)NCBINCBI36hg18NCBI36
Build 342146,433,466 - 46,473,119NCBI
Celera2132,720,748 - 32,761,140 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2132,990,213 - 33,031,026 (-)NCBIHuRef
CHM1_12147,167,889 - 47,208,226 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
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Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LSS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736635
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.