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Gene: DPYD (dihydropyrimidine dehydrogenase) Homo sapiens
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Symbol: DPYD
Name: dihydropyrimidine dehydrogenase
Description: Exhibits dihydropyrimidine dehydrogenase (NADP+) activity and protein homodimerization activity. Involved in nucleobase catabolic process and thymidine catabolic process. Localizes to the cytosol. Implicated in dihydropyrimidine dehydrogenase deficiency; pancreatic cancer; and precursor lymphoblastic lymphoma/leukemia. Biomarker of gallbladder cancer and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DHP; DHPDHASE; dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP+]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DPD; MGC132008; MGC70799
Orthologs:
Mus musculus (house mouse) : Dpyd (dihydropyrimidine dehydrogenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dpyd (dihydropyrimidine dehydrogenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dpyd (dihydropyrimidine dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : DPYD (dihydropyrimidine dehydrogenase)
Canis lupus familiaris (dog) : DPYD (dihydropyrimidine dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dpyd (dihydropyrimidine dehydrogenase)
Sus scrofa (pig) : DPYD (dihydropyrimidine dehydrogenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DPYD
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731730
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.