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Gene: SREBF2 (sterol regulatory element binding transcription factor 2) Homo sapiens
Symbol: SREBF2
Name: sterol regulatory element binding transcription factor 2
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and protein C-terminus binding activity. Involved in several processes, including negative regulation of cholesterol efflux; positive regulation of cholesterol biosynthetic process; and regulation of transcription by RNA polymerase II. Localizes to SREBP-SCAP-Insig complex and nucleoplasm. Implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHd2; class D basic helix-loop-helix protein 2; SREBP-2; SREBP2; sterol regulatory element-binding protein 2; sterol regulatory element-binding transcription factor 2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2241,833,079 - 41,907,307 (+)EnsemblGRCh38hg38GRCh38
GRCh382241,833,105 - 41,907,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372242,229,083 - 42,303,312 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,559,052 - 40,632,321 (+)NCBINCBI36hg18NCBI36
Build 342240,553,605 - 40,626,873NCBI
Celera2226,035,175 - 26,108,609 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2225,194,635 - 25,269,011 (+)NCBIHuRef
CHM1_12242,189,135 - 42,263,520 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SREBF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730972
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.