Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TGFB3 (transforming growth factor beta 3) Homo sapiens
Analyze
Symbol: TGFB3
Name: transforming growth factor beta 3
RGD ID: 735686
Description: Exhibits identical protein binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including face morphogenesis; positive regulation of biosynthetic process; and positive regulation of cellular component organization. Localizes to collagen-containing extracellular matrix and intracellular membrane-bounded organelle. Implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Biomarker of colon cancer and colorectal cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: arrhythmogenic right ventricular dysplasia 1; ARVD; ARVD1; FLJ16571; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF-beta-3; TGF-beta3; transforming growth factor beta-3; transforming growth factor beta-3 proprotein; transforming growth factor, beta 3
Orthologs:
Mus musculus (house mouse) : Tgfb3 (transforming growth factor, beta 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgfb3 (transforming growth factor, beta 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfb3 (transforming growth factor beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFB3 (transforming growth factor beta 3)
Canis lupus familiaris (dog) : TGFB3 (transforming growth factor beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfb3 (transforming growth factor beta 3)
Sus scrofa (pig) : TGFB3 (transforming growth factor beta 3)
Chlorocebus sabaeus (African green monkey) : TGFB3 (transforming growth factor beta 3)
Heterocephalus glaber (naked mole-rat) : Tgfb3 (transforming growth factor beta 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1475,958,099 - 75,982,991 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1475,958,097 - 75,983,011 (-)EnsemblGRCh38hg38GRCh38
GRCh381475,958,097 - 75,983,011 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371476,424,440 - 76,449,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361475,494,195 - 75,517,242 (-)NCBINCBI36hg18NCBI36
Build 341475,494,194 - 75,517,242NCBI
Celera1456,462,579 - 56,486,236 (-)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1456,593,103 - 56,616,766 (-)NCBIHuRef
CHM1_11476,362,233 - 76,386,169 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TGFB3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735686
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.