Tgfb3 (transforming growth factor beta 3) - Rat Genome Database

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Gene: Tgfb3 (transforming growth factor beta 3) Ictidomys tridecemlineatus
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Symbol: Tgfb3
Name: transforming growth factor beta 3
RGD ID: 12488958
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); cell-cell junction organization (ortholog); PARTICIPATES IN glypican signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); Brugada syndrome (ortholog); FOUND IN cell surface (ortholog); collagen-containing extracellular matrix (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: transforming growth factor beta-3; transforming growth factor beta-3 proprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,060,257 - 27,083,429 (+)NCBI
SpeTri2.0NW_0049364884,986,712 - 5,008,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (ISO)
cell-cell junction organization  (ISO)
cellular response to growth factor stimulus  (ISO)
detection of hypoxia  (ISO)
digestive tract development  (ISO)
embryonic neurocranium morphogenesis  (ISO)
face morphogenesis  (ISO)
female pregnancy  (ISO)
frontal suture morphogenesis  (ISO)
gene expression  (ISO)
in utero embryonic development  (ISO)
inner ear development  (ISO)
lung alveolus development  (ISO)
mammary gland development  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
ossification involved in bone remodeling  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of tight junction disassembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to progesterone  (ISO)
roof of mouth development  (ISO)
salivary gland morphogenesis  (ISO)
secondary palate development  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Tgfb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,060,257 - 27,083,429 (+)NCBI
SpeTri2.0NW_0049364884,986,712 - 5,008,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1475,958,099 - 75,982,991 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1475,958,097 - 75,983,011 (-)EnsemblGRCh38hg38GRCh38
GRCh381475,958,097 - 75,983,011 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371476,424,440 - 76,449,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361475,494,195 - 75,517,242 (-)NCBINCBI36hg18NCBI36
Build 341475,494,194 - 75,517,242NCBI
Celera1456,462,579 - 56,486,236 (-)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1456,593,103 - 56,616,766 (-)NCBIHuRef
CHM1_11476,362,233 - 76,386,169 (-)NCBICHM1_1
Tgfb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391286,103,517 - 86,125,815 (-)NCBIGRCm39mm39
GRCm39 Ensembl1286,103,519 - 86,125,815 (-)Ensembl
GRCm381286,056,743 - 86,079,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1286,056,745 - 86,079,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv371287,397,693 - 87,419,991 (-)NCBIGRCm37mm9NCBIm37
MGSCv361286,945,847 - 86,967,637 (-)NCBImm8
Celera1287,516,891 - 87,539,154 (-)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1240.09NCBI
Tgfb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26105,704,058 - 105,726,661 (-)NCBI
Rnor_6.0 Ensembl6109,913,757 - 109,935,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06109,913,757 - 109,936,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06119,222,052 - 119,244,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46110,173,443 - 110,195,215 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16110,176,974 - 110,198,746 (-)NCBI
Celera6103,530,785 - 103,552,563 (-)NCBICelera
RH 3.4 Map6742.1RGD
Cytogenetic Map6q31NCBI
Tgfb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543829,415 - 55,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543833,129 - 55,180 (-)NCBIChiLan1.0ChiLan1.0
TGFB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11475,359,505 - 75,382,412 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1475,359,505 - 75,382,412 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01456,516,697 - 56,542,097 (-)NCBIMhudiblu_PPA_v0panPan3
TGFB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,920,874 - 48,946,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,923,423 - 48,945,816 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,603,511 - 48,629,028 (-)NCBI
ROS_Cfam_1.0849,145,129 - 49,170,643 (-)NCBI
UMICH_Zoey_3.1848,817,670 - 48,843,148 (-)NCBI
UNSW_CanFamBas_1.0848,839,598 - 48,865,116 (-)NCBI
UU_Cfam_GSD_1.0849,235,714 - 49,261,227 (-)NCBI
TGFB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl799,133,511 - 99,162,232 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1799,133,873 - 99,162,239 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27105,178,639 - 105,208,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFB3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12453,203,593 - 53,227,483 (-)NCBI
ChlSab1.1 Ensembl2453,203,301 - 53,227,325 (-)Ensembl
Tgfb3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473425,717,011 - 25,739,942 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005321257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005321257   ⟹   XP_005321314
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864027,060,257 - 27,083,429 (+)NCBI
SpeTri2.0NW_0049364884,986,712 - 5,008,728 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321314 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321314   ⟸   XM_005321257
- UniProtKB: I3ND79 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028492 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000022326 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027912 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFB3 UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene Tgfb3 ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PIRSF TGF-beta UniProtKB/TrEMBL
PRINTS TGFBETA UniProtKB/TrEMBL
  TGFBETA3 UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt I3ND79 ENTREZGENE, UniProtKB/TrEMBL