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Gene: Tgfb3 (transforming growth factor beta 3) Chinchilla lanigera

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Symbol:

Tgfb3

Name:

transforming growth factor beta 3

RGD ID:

8708144

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); protein-containing complex binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); cell population proliferation (ortholog); cell-cell junction organization (ortholog); PARTICIPATES IN glypican signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); Brugada syndrome (ortholog); FOUND IN cell surface (ortholog); collagen-containing extracellular matrix (ortholog); extracellular matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transforming growth factor beta-3; transforming growth factor, beta 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	29,415 - 55,180 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	33,129 - 55,180 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	Carotid Artery Injuries		ISO	Tgfb3 (Rattus norvegicus)	9068941	mRNA:increased expression:carotic artery (rat)	RGD	PMID:9622270 and REF_RGD_ID:329845558
Tgfb3	Chinchilla	cleft palate		ISO	Tgfb3 (Mus musculus)	9068941		RGD	PMID:17097601 and REF_RGD_ID:12801424
Tgfb3	Chinchilla	colon cancer	disease_progression	ISO	TGFB3 (Homo sapiens)	9068941		RGD	PMID:18360718 and REF_RGD_ID:13432091
Tgfb3	Chinchilla	colorectal cancer	treatment	ISO	TGFB3 (Homo sapiens)	9068941		RGD	PMID:12778073 and REF_RGD_ID:13432088
Tgfb3	Chinchilla	diabetic neuropathy		ISO	Tgfb3 (Rattus norvegicus)	9068941	associated with Diabetes Mellitus more ...	RGD	PMID:18406405 and REF_RGD_ID:2302086
Tgfb3	Chinchilla	hypertension	no_association	ISO	TGFB3 (Homo sapiens)	9068941	DNA:polymorphism and SNPs	RGD	PMID:15924806 and REF_RGD_ID:1625704
Tgfb3	Chinchilla	pancreatic ductal adenocarcinoma	ameliorates	ISO	TGFB3 (Homo sapiens)	9068941	protein:decreased expression:pancreas (human)	RGD	PMID:8253361 and REF_RGD_ID:155630628
Tgfb3	Chinchilla	Wounds and Injuries		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:18205704 and REF_RGD_ID:2292158

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	arrhythmogenic right ventricular cardiomyopathy		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:23861362 more ...
Tgfb3	Chinchilla	arrhythmogenic right ventricular dysplasia 1		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:12529708 more ...
Tgfb3	Chinchilla	Brugada syndrome		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Brugada syndrome	ClinVar	PMID:25741868 and PMID:28492532
Tgfb3	Chinchilla	cardiomyopathy		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Cardiomyopathies	ClinVar	PMID:25741868 more ...
Tgfb3	Chinchilla	Contracture		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Contractures	ClinVar
Tgfb3	Chinchilla	cranioectodermal dysplasia		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Cranioectodermal dysplasia	ClinVar	PMID:25741868
Tgfb3	Chinchilla	Developmental Disease		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Developmental disorder	ClinVar	PMID:25741868 more ...
Tgfb3	Chinchilla	dilated cardiomyopathy		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Primary dilated cardiomyopathy	ClinVar	PMID:25741868 and PMID:28492532
Tgfb3	Chinchilla	hypertrophic cardiomyopathy		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hypertrophic cardiomyopathy	ClinVar	PMID:23861362 more ...
Tgfb3	Chinchilla	intellectual disability		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability and mild	ClinVar
Tgfb3	Chinchilla	left ventricular noncompaction		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Left ventricular noncompaction	ClinVar	PMID:23861362 more ...
Tgfb3	Chinchilla	Loeys-Dietz syndrome		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Loeys-Dietz syndrome	ClinVar	PMID:25741868
Tgfb3	Chinchilla	Loeys-Dietz syndrome		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:28492532
Tgfb3	Chinchilla	Loeys-Dietz syndrome 4		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Loeys-Dietz syndrome 4	ClinVar	PMID:24798638 more ...
Tgfb3	Chinchilla	Loeys-Dietz syndrome 5		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:12529708 more ...
Tgfb3	Chinchilla	long QT syndrome		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Long QT syndrome	ClinVar	PMID:23861362 more ...
Tgfb3	Chinchilla	thoracic aortic aneurysm		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17576681 more ...
Tgfb3	Chinchilla	thoracic aortic aneurysm		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17576681 more ...
Tgfb3	Chinchilla	thoracic aortic aneurysm		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17576681 more ...
Tgfb3	Chinchilla	thoracic aortic aneurysm		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17576681 more ...
Tgfb3	Chinchilla	thoracic aortic aneurysm		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17576681 more ...
Tgfb3	Chinchilla	Ventricular Premature Complexes		ISO	TGFB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Premature ventricular contraction	ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	cleft palate		ISO	TGFB3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26971374 and PMID:7493022
Tgfb3	Chinchilla	Experimental Liver Cirrhosis		ISO	TGFB3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25380136
Tgfb3	Chinchilla	nonsyndromic deafness		ISO	TGFB3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27356075
Tgfb3	Chinchilla	Respiratory System Abnormalities		ISO	TGFB3 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:7493022

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	arrhythmogenic right ventricular dysplasia 1		ISO	TGFB3 (Homo sapiens)	7240710		OMIM
Tgfb3	Chinchilla	Loeys-Dietz syndrome 5		ISO	TGFB3 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	animal organ morphogenesis	acts_upstream_of_or_within	ISO	MGI:1857259	9068941	PMID:14697364	MGI	PMID:14697364
Tgfb3	Chinchilla	cell population proliferation	acts_upstream_of	ISO	Tgfb3 (Mus musculus)	9068941	PMID:12815624	MGI	PMID:12815624
Tgfb3	Chinchilla	cell-cell junction organization	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18505915	BHF-UCL	PMID:18505915
Tgfb3	Chinchilla	cellular response to growth factor stimulus	acts_upstream_of_or_within	ISO	Tgfb3 (Mus musculus)	9068941	PMID:7848824	MGI	PMID:7848824
Tgfb3	Chinchilla	detection of hypoxia	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18156205	BHF-UCL	PMID:18156205
Tgfb3	Chinchilla	digestive tract development		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:12815632 and REF_RGD_ID:2302031
Tgfb3	Chinchilla	embryonic neurocranium morphogenesis		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:11002343 and REF_RGD_ID:1579866
Tgfb3	Chinchilla	epithelial cell proliferation	acts_upstream_of	ISO	Tgfb3 (Mus musculus)	9068941	PMID:12815624	MGI	PMID:12815624
Tgfb3	Chinchilla	face morphogenesis	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:18498113	UniProt	PMID:18498113
Tgfb3	Chinchilla	face morphogenesis	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:12651933	BHF-UCL	PMID:12651933
Tgfb3	Chinchilla	female pregnancy		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:15927076 and REF_RGD_ID:2302099
Tgfb3	Chinchilla	filopodium assembly	acts_upstream_of	ISO	MGI:2158731	9068941	PMID:16806156	MGI	PMID:16806156
Tgfb3	Chinchilla	frontal suture morphogenesis		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:12416537 and REF_RGD_ID:2302805
Tgfb3	Chinchilla	gene expression	acts_upstream_of_or_within_positive_effect	ISO	Tgfb3 (Mus musculus)	9068941	PMID:16245336	MGI	PMID:16245336
Tgfb3	Chinchilla	in utero embryonic development	acts_upstream_of_or_within	ISO	MGI:2158731	9068941	PMID:14729481	MGI	PMID:14729481
Tgfb3	Chinchilla	inner ear development		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:16479080 and REF_RGD_ID:2302094
Tgfb3	Chinchilla	lung alveolus development	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:7493022	BHF-UCL	PMID:7493022
Tgfb3	Chinchilla	mammary gland development	acts_upstream_of_or_within	ISO	Tgfb3 (Mus musculus)	9068941	PMID:1821856	MGI	PMID:1821856
Tgfb3	Chinchilla	negative regulation of cell population proliferation		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:11002343 and REF_RGD_ID:1579866
Tgfb3	Chinchilla	negative regulation of cell population proliferation	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:11158066	BHF-UCL	PMID:11158066
Tgfb3	Chinchilla	negative regulation of epithelial cell proliferation	acts_upstream_of_or_within	ISO	Tgfb3 (Mus musculus)	9068941	PMID:12815624	MGI	PMID:12815624
Tgfb3	Chinchilla	negative regulation of macrophage cytokine production	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:20875417	DFLAT	PMID:20875417
Tgfb3	Chinchilla	negative regulation of neuron apoptotic process	acts_upstream_of_or_within	ISO	MGI:1857259	9068941	PMID:17159989	MGI	PMID:17159989
Tgfb3	Chinchilla	negative regulation of transforming growth factor beta receptor signaling pathway		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:12071374 and REF_RGD_ID:730235
Tgfb3	Chinchilla	negative regulation of vascular associated smooth muscle cell proliferation	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:26315405	BHF-UCL	PMID:26315405
Tgfb3	Chinchilla	neuron apoptotic process	acts_upstream_of	ISO	MGI:1857259	9068941	PMID:17159989	MGI	PMID:17159989
Tgfb3	Chinchilla	positive regulation of apoptotic process	acts_upstream_of_or_within	ISO	MGI:2158731	9068941	PMID:16806156	MGI	PMID:16806156
Tgfb3	Chinchilla	positive regulation of apoptotic process		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:11002343 more ...
Tgfb3	Chinchilla	positive regulation of cell population proliferation	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:11158066	BHF-UCL	PMID:11158066
Tgfb3	Chinchilla	positive regulation of collagen biosynthetic process	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:11158066	BHF-UCL	PMID:11158066
Tgfb3	Chinchilla	positive regulation of DNA-templated transcription	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18156205	BHF-UCL	PMID:18156205
Tgfb3	Chinchilla	positive regulation of DNA-templated transcription	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:14691138	BHF-UCL	PMID:14691138
Tgfb3	Chinchilla	positive regulation of epithelial to mesenchymal transition	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18505915 and PMID:18718461	BHF-UCL	PMID:18505915 and PMID:18718461
Tgfb3	Chinchilla	positive regulation of epithelial to mesenchymal transition	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:14691138	BHF-UCL	PMID:14691138
Tgfb3	Chinchilla	positive regulation of filopodium assembly	acts_upstream_of_or_within	ISO	MGI:2158731	9068941	PMID:16806156	MGI	PMID:16806156
Tgfb3	Chinchilla	positive regulation of gene expression	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:21984612	UniProt	PMID:21984612
Tgfb3	Chinchilla	positive regulation of MAPK cascade		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:14605008 and REF_RGD_ID:1579859
Tgfb3	Chinchilla	positive regulation of protein secretion	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18505915	BHF-UCL	PMID:18505915
Tgfb3	Chinchilla	positive regulation of SMAD protein signal transduction	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:14691138	BHF-UCL	PMID:14691138
Tgfb3	Chinchilla	positive regulation of stress fiber assembly	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18718461	BHF-UCL	PMID:18718461
Tgfb3	Chinchilla	positive regulation of tight junction disassembly	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18718461	BHF-UCL	PMID:18718461
Tgfb3	Chinchilla	positive regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	ISO	MGI:108051 more ...	9068941	PMID:17159989	MGI	PMID:17159989
Tgfb3	Chinchilla	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	NOT\|involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:19161227	BHF-UCL	PMID:19161227
Tgfb3	Chinchilla	response to estrogen		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:14605008 and REF_RGD_ID:1579859
Tgfb3	Chinchilla	response to hypoxia		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:14697406 and REF_RGD_ID:1625703
Tgfb3	Chinchilla	response to hypoxia	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18156205	BHF-UCL	PMID:18156205
Tgfb3	Chinchilla	response to laminar fluid shear stress		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:16217485 and REF_RGD_ID:2302098
Tgfb3	Chinchilla	response to progesterone	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18039789	BHF-UCL	PMID:18039789
Tgfb3	Chinchilla	roof of mouth development	acts_upstream_of_or_within	ISO	Tgfb3 (Mus musculus)	9068941	PMID:16245336	MGI	PMID:16245336
Tgfb3	Chinchilla	salivary gland morphogenesis	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18080134	BHF-UCL	PMID:18080134
Tgfb3	Chinchilla	secondary palate development	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:10433915 more ...	UniProt	PMID:10433915 more ...
Tgfb3	Chinchilla	transforming growth factor beta receptor signaling pathway	involved_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:14691138	BHF-UCL	PMID:14691138
Tgfb3	Chinchilla	transforming growth factor beta receptor signaling pathway	involved_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:11157754 and PMID:18718461	BHF-UCL	PMID:11157754 and PMID:18718461

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	cell surface		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:16479080 and REF_RGD_ID:2302094
Tgfb3	Chinchilla	collagen-containing extracellular matrix	located_in	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18049952	BHF-UCL	PMID:18049952
Tgfb3	Chinchilla	extracellular matrix	located_in	ISO	Tgfb3 (Mus musculus)	9068941	PMID:10521784	MGI	PMID:10521784
Tgfb3	Chinchilla	extracellular space		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:16891311 and REF_RGD_ID:1625706
Tgfb3	Chinchilla	intracellular membrane-bounded organelle	located_in	ISO	TGFB3 (Homo sapiens)	9068941		HPA	GO_REF:0000052
Tgfb3	Chinchilla	neuronal cell body		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:15214860 and REF_RGD_ID:1601584
Tgfb3	Chinchilla	secretory granule		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:15214860 and REF_RGD_ID:1601584
Tgfb3	Chinchilla	T-tubule		ISO	Tgfb3 (Rattus norvegicus)	9068941		RGD	PMID:9281452 and REF_RGD_ID:1625705

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	identical protein binding	enables	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18243111	BHF-UCL	PMID:18243111
Tgfb3	Chinchilla	identical protein binding	enables	ISO	UniProtKB:P10600	9068941	PMID:19073914 and PMID:21423151	IntAct	PMID:19073914 and PMID:21423151
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:Q99MQ4	9068941	PMID:17827158	UniProt	PMID:17827158
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:G3XA59	9068941	PMID:28912269	UniProt	PMID:28912269
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:Q14766 and UniProtKB:Q9NS15	9068941	PMID:10930463	UniProt	PMID:10930463
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:P36897 and UniProtKB:P37173	9068941	PMID:18243111	BHF-UCL	PMID:18243111
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:P37173-1 and UniProtKB:P37173-2	9068941	PMID:11157754	BHF-UCL	PMID:11157754
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:P37173	9068941	PMID:11850637 more ...	IntAct	PMID:11850637 more ...
Tgfb3	Chinchilla	protein binding	enables	ISO	UniProtKB:P17813	9068941	PMID:1326540 and PMID:9872992	BHF-UCL	PMID:1326540 and PMID:9872992
Tgfb3	Chinchilla	protein-containing complex binding		ISO	Tgfb3 (Rattus norvegicus)	9068941	heterodimerization	RGD	PMID:18406405 and REF_RGD_ID:2302086
Tgfb3	Chinchilla	transforming growth factor beta binding	enables	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18243111	BHF-UCL	PMID:18243111
Tgfb3	Chinchilla	type I transforming growth factor beta receptor binding	enables	ISO	TGFB3 (Homo sapiens)	9068941	PMID:18243111	BHF-UCL	PMID:18243111
Tgfb3	Chinchilla	type II transforming growth factor beta receptor binding	enables	ISO	TGFB3 (Homo sapiens)	9068941	PMID:11157754 and PMID:18243111	BHF-UCL	PMID:11157754 and PMID:18243111
Tgfb3	Chinchilla	type II transforming growth factor beta receptor binding	enables	ISO	UniProtKB:P37173	9068941	PMID:1333888	BHF-UCL	PMID:1333888
Tgfb3	Chinchilla	type II transforming growth factor beta receptor binding	enables	ISO	UniProtKB:Q90999	9068941	PMID:8167376	AgBase	PMID:8167376
Tgfb3	Chinchilla	type III transforming growth factor beta receptor binding	enables	ISO	UniProtKB:Q90998	9068941	PMID:8167376	AgBase	PMID:8167376

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	transforming growth factor-beta Smad dependent signaling pathway		ISO	TGFB3 (Homo sapiens)	9068941		RGD	PMID:12809600 and REF_RGD_ID:2298922

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Tgfb3	Chinchilla	glypican signaling pathway		ISO	TGFB3 (Homo sapiens)	9068941		PID	PID:200026
Tgfb3	Chinchilla	transforming growth factor-beta Smad dependent signaling pathway		ISO	TGFB3 (Homo sapiens)	9068941		PID	PID:200227

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

PMID:22301074	PMID:30032202

Tgfb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	29,415 - 55,180 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	33,129 - 55,180 (-)	NCBI	ChiLan1.0	ChiLan1.0

TGFB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	75,958,097 - 75,983,011 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	75,958,097 - 75,983,011 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	76,424,440 - 76,449,354 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	75,494,195 - 75,517,242 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	75,494,194 - 75,517,242	NCBI
Celera	14	56,462,579 - 56,486,236 (-)	NCBI		Celera
Cytogenetic Map	14	q24.3	NCBI
HuRef	14	56,593,103 - 56,616,766 (-)	NCBI		HuRef
CHM1_1	14	76,362,235 - 76,385,896 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	70,167,287 - 70,192,202 (-)	NCBI		T2T-CHM13v2.0

Tgfb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	86,103,517 - 86,125,815 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	86,103,519 - 86,125,815 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	86,056,743 - 86,079,041 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	86,056,745 - 86,079,041 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	87,397,693 - 87,419,991 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	86,945,847 - 86,967,637 (-)	NCBI		MGSCv36	mm8
Celera	12	87,516,891 - 87,539,154 (-)	NCBI		Celera
Cytogenetic Map	12	D2	NCBI
cM Map	12	40.09	NCBI

Tgfb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	111,435,170 - 111,457,646 (-)	NCBI		GRCr8
mRatBN7.2	6	105,704,058 - 105,726,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	105,704,236 - 105,726,564 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	105,874,132 - 105,895,952 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	106,173,012 - 106,194,830 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	105,542,654 - 105,564,473 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	109,913,757 - 109,936,217 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	109,913,757 - 109,935,533 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	119,222,052 - 119,244,512 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	110,173,443 - 110,195,215 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	110,176,974 - 110,198,746 (-)	NCBI
Celera	6	103,530,785 - 103,552,563 (-)	NCBI		Celera
RH 3.4 Map	6	742.1	RGD
Cytogenetic Map	6	q31	NCBI

TGFB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	77,047,367 - 77,072,727 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	76,263,873 - 76,289,264 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	56,516,697 - 56,542,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	75,359,505 - 75,382,412 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	75,359,505 - 75,382,412 (-)	Ensembl	panpan1.1		panPan2

TGFB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	48,920,874 - 48,946,037 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	48,923,423 - 48,945,816 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	48,603,511 - 48,629,028 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	49,145,129 - 49,170,643 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	49,147,212 - 49,170,366 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	48,817,670 - 48,843,148 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	48,839,598 - 48,865,116 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	49,235,714 - 49,261,227 (-)	NCBI		UU_Cfam_GSD_1.0

Tgfb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	27,060,257 - 27,083,429 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	4,986,748 - 5,008,496 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	4,986,712 - 5,008,728 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TGFB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	99,133,879 - 99,162,232 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	99,133,873 - 99,162,239 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	105,178,639 - 105,208,968 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TGFB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	53,203,593 - 53,227,483 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	53,203,301 - 53,227,325 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	41,419,765 - 41,443,760 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tgfb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	25,716,972 - 25,739,199 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	25,717,011 - 25,739,942 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005390146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01034940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01098971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000012354 ⟹ ENSCLAP00000012212

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955438	29,415 - 55,180 (-)	Ensembl

RefSeq Acc Id:

XM_005390146 ⟹ XP_005390203

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955438	33,129 - 55,180 (-)	NCBI

Sequence:

show sequence

TGTAGCCGGAGTGACTCCAAGAGGGGAAAAAAGTTCAGTTACCACGTCGAATGAGAGGGCTCGCAAAGTATTTTTCAAACGGGCTCGGCTTTTCCTGTGCCTGTTTAAAACATTAAAAATCGTGCAGC
AAAAGAGGCTGCGTGCGCTGGTCCCTCCCTCGCTCCCTCCCCCACCCCAGGCCCGAGACGTCATGGGAGGGAGGTATAAAATTTCAGCAGGGAAATAGAGAAAGCAGTGTGTGTGCATGTGTGTGTGT
GAGAGAGGGAGAGCAGCGAGAAGGAGAGAAAGGGAGGGAAGCAGAGAGCCAAGTTCAAGGCAAGGAGCGAGAGAGGCAGAGCTAGGAGAAGACACGCATGGGAACGAAGGAATAACCGCTTTCCGGAG
CAGGCTGCAGTGAACTGGCTTCTATTTTCTTTTCCTTTTGGTTTTTTAAAAAACGAAGCAAGGGATAGAAGCCATGGCCGAGGGAGAAGACAAGCTGAGGCGCTGGTGACCGTGGGCGTTCGAGTGGA
TTATTGGGGCCCTTCTCCAGAGGCCTGGCCTGCCTGCGCTCCAGTTGCACATAACCCCACATCCCAGCCAATGAAGACGGGAGGCAGCGTGAACAAAGTCATTTAGAAACCCCTGAGGAAGTGTAAAC
AAAAGGGAAAGCATGAATGGAGTGCCCGAGAGACAAGTGTGTCCTGTACTGCCCCCACCTTTAGCCAGGCCAGCAGCTGCCCAGACCTGCCTCTCCCCACCTACTCACTGGTGATTCGATTTTTTTAA
AAAAGCTTTTTTCCTTTTCTTTTCCATTCTCTTTTTTTATTCTCCTTCAGGGCAAGGCGAGGATTTTGATTTTGGGACCTAGCCATGGTCCTTCTGCACCTTCTTTAAAATACCCACTTTCTCCCCAT
TGCCAAACGGTGTTTGGCAATATCAGATATCTGCTCTATTTATTTTTACCTAAGGAGAAACTCCAGCTCCCTTTCCACTCCCAGCTGCCTGGCCACCCCTCCCAGCCCTCTGCTTGCCCTCCACCTGG
GCTGCTGGGAGTCAGAGCCCAGCAAAACCTGTTTAGACACATGGACAAGAATCCCAGCACTACAAGGCACACAGTCTGCTTCTTCGTCCTCAGGGCTGCCAGCGCTTCCTGGAAGTCCTGAAGCTCTC
GCCGTGCAGTGAGTTCATGCACCCTGTTGCCAAGCCTCAGTCTTTGGGATCTGGGGAGGCTGCCTGGTTTTTCTCCCTCTTTCTGCACGTCTGCCGGGGTCTCCTCCTCGCCAAGACTCACCGCCCCC
TGGCCTCTCTTCCCGGCTTGCACATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACCTTGCCACGGTCAGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTTGGCCACATC
AAGAAGAAGAGGGTGGAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGACTCACCAGCCCCCCTGAGCCATCGGTGATGACCCACGTCCCCTATCAAGTCTTAGCCCTGTATAACAGCACCCGGGA
GCTGCTGGAAGAGATGCAAGGGGAGAAGGAGGAAGGCTGCACTCAGGAAAACACCGAATCAGAGTACTATGCCAAAGAGATCCATAAGTTCGACATGATCCAGGGGCTGGCGGAGCACAATGAACTGG
CTGTCTGCCCTAAAGGAATTACCTCCAAGATTTTCCGCTTCAACGTGTCCTCAGTGGAGAAAAATAGAACCAACTTGTTCCGGGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGCTCCAAGCGC
ACTGAGCAGAGGATTGAGCTCTTCCAGATTCTCCGGCCAGATGAGCACATCGCCAAACAGCGCTATATCGGTGGCAAGAATCTGCCCACACGGGGCACCGCCGAGTGGCTCTCTTTTGATGTCACTGA
CACTGTGCGTGAGTGGCTGTTGCGAAGAGAGTCCAATTTAGGTCTGGAAATCAGCATCCACTGTCCATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAAAACATTCAAGAGGTGATGGAAATCA
AATTCAAAGGGGTGGACAATGAGGATGACCATGGCCGTGGAGACCTGGGACGCCTTAAGAAGCAGAAGGATCACCACAACCCTCATCTAATCCTAATGATGATTCCCCCACACCGGCTTGACAACCCT
GGCCAAGGGGGTCAGAGAAAGAAGCGGGCCCTGGACACCAACTACTGCTTCCGCAACTTGGAGGAGAACTGCTGTGTGCGTCCCCTCTACATTGACTTCCGACAGGATCTGGGCTGGAAATGGGTCCA
CGAACCTAAGGGCTACTATGCCAACTTCTGCTCAGGCCCCTGCCCGTACCTCCGAAGTGCAGACACGACTCACAGCACGGTGCTGGGACTGTATAACACCCTGAATCCGGAAGCGTCTGCCTCACCTT
GCTGTGTGCCCCAGGACTTGGAGCCCCTGACCATTCTGTACTATGTCGGGAGGACCCCAAAGGTGGAGCAGCTCTCCAACATGGTGGTGAAGTCATGTAAGTGTAGCTGAGGCCTGCGTGTGTGCGAC
GGAGGAGGGAGAACCGCCACCATCCGACTGACAGCTCATCGAGAAGCCAATGTGACAGACGTAATTTAGAGGCCTGGGGCCTTCAACCCTTGGCTCCCAGTATGGCCAAGATGGAGGCTTCCTTCTGG
AACATTTCCCTTTCTTGCTGGCTCTGAGAATCACTGTGGTAAAGAAAGTGTGGGTTGGTAGGGGAAGGTGAACTCTTCAGAACACAGGTTTCCTGTGGTACAGACAGAGGTGGTGGAGATGGAGGAAG
AGGGATGGCTAGTTGACATGGCATGTGGCAATGGGACTTGGGCTACCTTTGGGAGGAGGAAGGGCTGAGGATGGCCGGATCAGGGCCAGGCTGGAAGACACTTTGGATCTGAGGTCAGCTTTGTGCAT
TGCTGTGCCACATCTGCCCTAAGGAACTGGGATGACATCTTATGAGGCAAGCATTTTTCTTCAGATAGGTTACCAAGACAAAGTCCCAGAATTGTATTTTGCACTACCTGGGATTAAGGACAAATCTG
TTACTTTTGCAACCTGTGCCCTCTCCATCAATCAGCATCATGGGTTGTTACAGGAAATGTAATGTAGTTCCTGGGCTAGCAACTATATTGGACCCCATGGAGAGCAGAAATCAGAAGCCAAGGATGGG
AATTAACCCTCTCCTGTTCGCCCTCTGGGTCCCTCCTCTTGCCTTCTTCCCTGATCACATATCGCCTTGGACATCTGGCTAGACACCTTCCAGGTCAGGGTGTGCACATTTGGATTTTGGTCCATGCA
GCCTCAGGGCATCGGGGGTTCCTTCCCGCCTACCCCCCAAGACCCTGTGTTCAGTTGGCGCTCCTGAAAGCAGGTGCTACATATGTGGTACTGGGTGGGGGGATGATGACTTGGCCCCAGGCATGGAG
ACTGAGGTATAAGACAAGTACAAATATTACTCTCAAAATCTTTGTATAAATAAATATTTTTGGGGAATTATGGATGATTTCATCTTCTGGAAGGCTGTTTCTAGAACAGTAAAAGCCTAACTCTAAGG
TGTA

hide sequence


Protein RefSeqs	XP_005390203	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012212
	ENSCLAP00000012212.1

RefSeq Acc Id:

XP_005390203 ⟸ XM_005390146

- UniProtKB:

A0A8C2VEL2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHPVAKPQSLGSGEAAWFFSLFLHVCRGLLLAKTHRPLASLPGLHMKMHLQRALVVLALLNLATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPSVMTHVPYQVLALYNSTRELLEEM
QGEKEEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKIFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRTEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREW
LLRRESNLGLEISIHCPCHTFQPNGDILENIQEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGY
YANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS

hide sequence

Ensembl Acc Id:

ENSCLAP00000012212 ⟸ ENSCLAT00000012354

Protein Domains

TGF-beta family profile

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008424	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012354	ENTREZGENE
	ENSCLAT00000012354.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_propeptide	UniProtKB/TrEMBL
	TGF-beta	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFB3	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
NCBI Gene	Tgfb3	ENTREZGENE
PANTHER	PTHR11848	UniProtKB/TrEMBL
	TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PIRSF	TGF-beta	UniProtKB/TrEMBL
PRINTS	TGFBETA	UniProtKB/TrEMBL
	TGFBETA3	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A8C2VEL2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Tgfb3	transforming growth factor beta 3		transforming growth factor, beta 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)