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Gene: CYP8B1 (cytochrome P450 family 8 subfamily B member 1) Homo sapiens
Symbol: CYP8B1
Name: cytochrome P450 family 8 subfamily B member 1
Description: Predicted to have heme binding activity and sterol 12-alpha-hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and sterol metabolic process. Predicted to localize to endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CP8B; CYP12; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450, family 8, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1; FLJ17826; sterol 12-alpha-hydroxylase
Mus musculus (house mouse) : Cyp8b1 (cytochrome P450, family 8, subfamily b, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp8b1 (cytochrome P450 family 8 subfamily B member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102019604 (7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP8B1 (cytochrome P450 family 8 subfamily B member 1)
Canis lupus familiaris (dog) : CYP8B1 (cytochrome P450 family 8 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101977223 (7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase)
Sus scrofa (pig) : CYP8B1 (cytochrome P-450 8B1)
Chlorocebus sabaeus (African green monkey) : CYP8B1 (cytochrome P450 family 8 subfamily B member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl342,856,005 - 42,875,898 (-)EnsemblGRCh38hg38GRCh38
GRCh38342,872,192 - 42,875,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37342,913,684 - 42,917,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36342,888,688 - 42,892,637 (-)NCBINCBI36hg18NCBI36
Build 34342,888,687 - 42,892,637NCBI
Celera342,851,598 - 42,855,548 (-)NCBI
Cytogenetic Map3p22.1NCBI
HuRef342,956,837 - 42,960,786 (-)NCBIHuRef
CHM1_1342,863,684 - 42,867,633 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP8B1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736649
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.