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Gene: MAP2K3 (mitogen-activated protein kinase kinase 3) Homo sapiens
Symbol: MAP2K3
Name: mitogen-activated protein kinase kinase 3
Description: Exhibits protein kinase binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of blood vessel endothelial cell migration; and positive regulation of macromolecule metabolic process. Localizes to the membrane. Implicated in cervical cancer and restrictive cardiomyopathy. Biomarker of astrocytoma; breast cancer; colon cancer; glioblastoma multiforme; and liver benign neoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen activated protein kinase kinase 3; MKK3; PRKMK3; SAPK kinase 2; SAPKK-2; SAPKK2; stress-activated protein kinase kinase 2
Mus musculus (house mouse) : Map2k3 (mitogen-activated protein kinase kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map2k3 (mitogen activated protein kinase kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k3 (mitogen-activated protein kinase kinase 3)
Canis lupus familiaris (dog) : MAP2K3 (mitogen-activated protein kinase kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k3 (mitogen-activated protein kinase kinase 3)
Sus scrofa (pig) : MAP2K3 (mitogen-activated protein kinase kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381721,284,679 - 21,315,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371721,187,968 - 21,218,552 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361721,128,561 - 21,159,145 (+)NCBINCBI36hg18NCBI36
Build 341721,141,910 - 21,158,870NCBI
Cytogenetic Map17p11.2NCBI
HuRef1720,389,899 - 20,420,519 (+)NCBIHuRef
CHM1_11721,197,569 - 21,228,147 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAP2K3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315342
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.