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Gene: MAP2K3 (mitogen-activated protein kinase kinase 3) Homo sapiens
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Symbol: MAP2K3
Name: mitogen-activated protein kinase kinase 3
Description: Exhibits protein kinase binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of blood vessel endothelial cell migration; and positive regulation of macromolecule metabolic process. Localizes to the membrane. Implicated in cervical cancer and restrictive cardiomyopathy. Biomarker of astrocytoma; breast cancer; colon cancer; glioblastoma multiforme; and liver benign neoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen activated protein kinase kinase 3; MKK3; PRKMK3; SAPK kinase 2; SAPKK-2; SAPKK2; stress-activated protein kinase kinase 2
Orthologs:
Mus musculus (house mouse) : Map2k3 (mitogen-activated protein kinase kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map2k3 (mitogen activated protein kinase kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k3 (mitogen-activated protein kinase kinase 3)
Canis lupus familiaris (dog) : MAP2K3 (mitogen-activated protein kinase kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k3 (mitogen-activated protein kinase kinase 3)
Sus scrofa (pig) : MAP2K3 (mitogen-activated protein kinase kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381721,284,679 - 21,315,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371721,187,968 - 21,218,552 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361721,128,561 - 21,159,145 (+)NCBINCBI36hg18NCBI36
Build 341721,141,910 - 21,158,870NCBI
Cytogenetic Map17p11.2NCBI
HuRef1720,389,899 - 20,420,519 (+)NCBIHuRef
CHM1_11721,197,569 - 21,228,147 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MAP2K3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315342
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.