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Gene: BAD (BCL2 associated agonist of cell death) Homo sapiens
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Symbol: BAD
Name: BCL2 associated agonist of cell death
Description: Exhibits cysteine-type endopeptidase activator activity involved in apoptotic process; phospholipid binding activity; and protein kinase binding activity. Involved in several processes, including apoptotic signaling pathway; cellular response to mechanical stimulus; and positive regulation of cysteine-type endopeptidase activity. Localizes to the cytosol and mitochondrial outer membrane. Implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Biomarker of several diseases, including Alzheimer's disease; carcinoma (multiple); macular degeneration; osteoarthritis; and prostate disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BBC2; bcl-2 associated death agonist; bcl-2-binding component 6; bcl-2-like protein 8; BCL-X/BCL-2 binding protein; bcl-XL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; BCL2-antagonist of cell death; BCL2-associated agonist of cell death; BCL2-binding component 6; BCL2-binding protein; bcl2-L-8; BCL2L8
Orthologs:
Mus musculus (house mouse) : Bad (BCL2-associated agonist of cell death)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bad (BCL2-associated agonist of cell death)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bad (BCL2 associated agonist of cell death)
Pan paniscus (bonobo/pygmy chimpanzee) : BAD (BCL2 associated agonist of cell death)
Canis lupus familiaris (dog) : BAD (BCL2 associated agonist of cell death)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bad (BCL2 associated agonist of cell death)
Sus scrofa (pig) : BAD (BCL2 associated agonist of cell death)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,269,828 - 64,284,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,037,300 - 64,052,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,793,878 - 63,808,740 (-)NCBINCBI36hg18NCBI36
Build 341163,793,877 - 63,808,740NCBI
Celera1161,364,184 - 61,379,075 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,365,093 - 60,379,900 (-)NCBIHuRef
CHM1_11163,920,295 - 63,935,173 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BAD
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735541
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.