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Gene: TGFB2 (transforming growth factor beta 2) Homo sapiens
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Symbol: TGFB2
Name: transforming growth factor beta 2
RGD ID: 730953
Description: Exhibits amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of macromolecule metabolic process. Localizes to collagen-containing extracellular matrix and extracellular space. Implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Biomarker of colon carcinoma; colorectal cancer; and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BSC-1 cell growth inhibitor; cetermin; G-TSF; glioblastoma-derived T-cell suppressor factor; LDS4; MGC116892; polyergin; prepro-transforming growth factor beta-2; TGF-beta-2; TGF-beta2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein; transforming growth factor, beta 2
Orthologs:
Mus musculus (house mouse) : Tgfb2 (transforming growth factor, beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgfb2 (transforming growth factor, beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfb2 (transforming growth factor beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFB2 (transforming growth factor beta 2)
Canis lupus familiaris (dog) : TGFB2 (transforming growth factor beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfb2 (transforming growth factor beta 2)
Sus scrofa (pig) : TGFB2 (transforming growth factor beta 2)
Chlorocebus sabaeus (African green monkey) : TGFB2 (transforming growth factor beta 2)
Heterocephalus glaber (naked mole-rat) : Tgfb2 (transforming growth factor beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371218,518,676 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBI
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
 
More on TGFB2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730953
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.