Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MAP3K5 (mitogen-activated protein kinase kinase kinase 5) Homo sapiens
Symbol: MAP3K5
Name: mitogen-activated protein kinase kinase kinase 5
RGD ID: 1315043
Description: Exhibits several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including JNK cascade; cellular response to oxidative stress; and positive regulation of nitrogen compound metabolic process. Localizes to IRE1-TRAF2-ASK1 complex and protein kinase complex. Implicated in Huntington's disease. Biomarker of perinatal necrotizing enterocolitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK-1; ASK1; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; MEKK5
Mus musculus (house mouse) : Map3k5 (mitogen-activated protein kinase kinase kinase 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map3k5 (mitogen-activated protein kinase kinase kinase 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map3k5 (mitogen-activated protein kinase kinase kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP3K5 (mitogen-activated protein kinase kinase kinase 5)
Canis lupus familiaris (dog) : MAP3K5 (mitogen-activated protein kinase kinase kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map3k5 (mitogen-activated protein kinase kinase kinase 5)
Sus scrofa (pig) : MAP3K5 (mitogen-activated protein kinase kinase kinase 5)
Chlorocebus sabaeus (African green monkey) : MAP3K5 (mitogen-activated protein kinase kinase kinase 5)
Heterocephalus glaber (naked mole-rat) : Map3k5 (mitogen-activated protein kinase kinase kinase 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl6136,557,046 - 136,792,477 (-)EnsemblGRCh38hg38GRCh38
GRCh386136,557,046 - 136,793,098 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376136,878,184 - 137,113,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366136,919,880 - 137,155,349 (-)NCBINCBI36hg18NCBI36
Build 346136,919,880 - 137,155,349NCBI
Celera6137,618,672 - 137,854,128 (-)NCBI
Cytogenetic Map6q23.3NCBI
HuRef6134,442,506 - 134,677,689 (-)NCBIHuRef
CHM1_16137,140,796 - 137,376,381 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAP3K5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315043
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.