MAP2K6 (mitogen-activated protein kinase kinase 6) - Rat Genome Database

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Gene: MAP2K6 (mitogen-activated protein kinase kinase 6) Homo sapiens
Analyze
Symbol: MAP2K6
Name: mitogen-activated protein kinase kinase 6
RGD ID: 732805
HGNC Page HGNC:6846
Description: Enables MAP kinase kinase activity; identical protein binding activity; and protein kinase binding activity. Involved in p38MAPK cascade and stress-activated MAPK cascade. Located in nucleoplasm. Is active in cytosol. Implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Biomarker of prostate carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; MKK6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 3; SAPKK-3; SAPKK3; stress-activated protein kinase kinase 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,414,697 - 69,553,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,414,697 - 69,553,865 (+)EnsemblGRCh38hg38GRCh38
GRCh371767,410,838 - 67,550,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,922,433 - 65,050,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 341765,010,164 - 65,051,067NCBI
Celera1763,982,421 - 64,110,030 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1762,796,464 - 62,924,594 (+)NCBIHuRef
CHM1_11767,475,265 - 67,603,400 (+)NCBICHM1_1
T2T-CHM13v2.01770,291,653 - 70,430,810 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
alpha-phellandrene  (EXP)
amino acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (EXP)
atrazine  (ISO)
azathioprine  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucan  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
bromoacetate  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
cisplatin  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corn oil  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP)
DDT  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (EXP)
diclofenac  (EXP)
dicrotophos  (EXP)
Didecyldimethylammonium  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
filipin III  (ISO)
folic acid  (EXP)
FR900359  (EXP)
fulvestrant  (EXP)
gemcitabine  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (EXP)
iron atom  (ISO)
iron dichloride  (EXP)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
maneb  (ISO)
melatonin  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (EXP)
methimazole  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
mevinphos  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (EXP)
organoselenium compound  (EXP)
ouabain  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
progesterone  (EXP)
Ptaquiloside  (EXP)
quercetin  (EXP)
raloxifene  (EXP)
ritodrine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
Salinomycin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
Securinine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulfates  (EXP)
sulforaphane  (EXP)
Sunset Yellow FCF  (EXP)
tanespimycin  (EXP)
tartrazine  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
trichostatin A  (EXP,ISO)
triclosan  (EXP)
trimethyltin  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,TAS)
cytoskeleton  (IEA)
cytosol  (IDA,TAS)
nucleoplasm  (IDA,TAS)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. Braz JC, etal., J Clin Invest. 2003 May;111(10):1475-86. doi: 10.1172/JCI17295.
2. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. Chang AY J Biomed Sci. 2012 Nov 17;19:96. doi: 10.1186/1423-0127-19-96.
3. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
4. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Demidov ON, etal., Oncogene. 2007 Apr 12;26(17):2502-6. Epub 2006 Oct 2.
5. Active kinase proteome screening reveals novel signal complexity in cardiomyopathy. Fernando P, etal., Mol Cell Proteomics. 2005 May;4(5):673-82. Epub 2005 Feb 18.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Hartzler AW, etal., Neurobiol Aging. 2002 Sep-Oct;23(5):855-9.
8. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Hickson JA, etal., Cancer Res. 2006 Feb 15;66(4):2264-70.
9. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. Kaiser RA, etal., J Biol Chem. 2004 Apr 9;279(15):15524-30. Epub 2004 Jan 28.
10. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kang SW, etal., Kidney Int. 2001 Aug;60(2):543-52.
11. p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Kumar V, etal., Cancer Res. 2010 Dec 15;70(24):10381-91. doi: 10.1158/0008-5472.CAN-10-1470. Epub 2010 Oct 27.
12. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
13. Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. Lotan TL, etal., J Pathol. 2007 Aug;212(4):386-94.
14. Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. Martindale JJ, etal., J Biol Chem. 2005 Jan 7;280(1):669-76. Epub 2004 Oct 18.
15. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Vander Griend DJ, etal., Cancer Res. 2005 Dec 1;65(23):10984-91.
Additional References at PubMed
PMID:7750576   PMID:8125298   PMID:8621675   PMID:8622669   PMID:8626699   PMID:8663074   PMID:8663524   PMID:8861944   PMID:9218798   PMID:9430721   PMID:9768359   PMID:9808624  
PMID:9841871   PMID:10094049   PMID:10497253   PMID:10512765   PMID:10570156   PMID:10702308   PMID:10838074   PMID:10848581   PMID:10961885   PMID:11035004   PMID:11062067   PMID:11062068  
PMID:11104681   PMID:11279118   PMID:11460167   PMID:11562357   PMID:11689443   PMID:11727828   PMID:11836244   PMID:11971971   PMID:12052864   PMID:12054652   PMID:12242293   PMID:12477932  
PMID:12482967   PMID:12509443   PMID:12556533   PMID:12589052   PMID:12609980   PMID:12624112   PMID:12697810   PMID:12761180   PMID:12820963   PMID:14633987   PMID:14702039   PMID:15229216  
PMID:15276183   PMID:15375157   PMID:15489334   PMID:15516490   PMID:15550393   PMID:15590691   PMID:15677464   PMID:15717329   PMID:15764709   PMID:15778394   PMID:15790570   PMID:15866172  
PMID:15923648   PMID:16142216   PMID:16157600   PMID:16313339   PMID:16342939   PMID:16344560   PMID:16498455   PMID:16728640   PMID:16893890   PMID:16960152   PMID:17079228   PMID:17255097  
PMID:17255949   PMID:17325029   PMID:17363905   PMID:17363973   PMID:17384642   PMID:17719230   PMID:17726008   PMID:18327563   PMID:19047046   PMID:19141286   PMID:19234473   PMID:19302196  
PMID:19672773   PMID:19675569   PMID:19846005   PMID:19913121   PMID:20067578   PMID:20162623   PMID:20213747   PMID:20364819   PMID:20628086   PMID:20706999   PMID:20805296   PMID:20869211  
PMID:20932476   PMID:21078955   PMID:21308746   PMID:21368234   PMID:21873635   PMID:21926646   PMID:22095282   PMID:22154358   PMID:22164285   PMID:22383536   PMID:22569225   PMID:23535064  
PMID:23606331   PMID:23744074   PMID:23825189   PMID:24085465   PMID:24554482   PMID:24742347   PMID:24936062   PMID:25019214   PMID:25098452   PMID:25214442   PMID:25241761   PMID:25633196  
PMID:26038599   PMID:26186194   PMID:27181679   PMID:27432908   PMID:27503909   PMID:27526785   PMID:28205554   PMID:28514442   PMID:29021624   PMID:29669288   PMID:30245131   PMID:30305582  
PMID:30663248   PMID:30837379   PMID:31091453   PMID:31839598   PMID:32296183   PMID:32344865   PMID:32707033   PMID:32814053   PMID:32911434   PMID:33554397   PMID:33961781   PMID:34709743  
PMID:34857952   PMID:35192930   PMID:35689709   PMID:35857590   PMID:36205565   PMID:36349938   PMID:36736316   PMID:36897256   PMID:38334954  


Genomics

Comparative Map Data
MAP2K6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,414,697 - 69,553,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,414,697 - 69,553,865 (+)EnsemblGRCh38hg38GRCh38
GRCh371767,410,838 - 67,550,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,922,433 - 65,050,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 341765,010,164 - 65,051,067NCBI
Celera1763,982,421 - 64,110,030 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1762,796,464 - 62,924,594 (+)NCBIHuRef
CHM1_11767,475,265 - 67,603,400 (+)NCBICHM1_1
T2T-CHM13v2.01770,291,653 - 70,430,810 (+)NCBIT2T-CHM13v2.0
Map2k6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,289,928 - 110,416,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,289,948 - 110,416,348 (+)EnsemblGRCm39 Ensembl
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11110,399,122 - 110,525,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBIMGSCv36mm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11E1- E2NCBI
cM Map1173.6NCBI
Map2k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,872,747 - 95,987,747 (+)NCBIGRCr8
mRatBN7.21095,373,304 - 95,490,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1095,373,204 - 95,488,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10100,429,713 - 100,544,144 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,892,740 - 100,007,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01095,301,015 - 95,415,445 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01098,707,160 - 98,823,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1098,706,960 - 98,823,287 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01098,413,927 - 98,527,709 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41099,859,684 - 99,974,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11099,873,953 - 99,989,003 (+)NCBI
Celera1094,024,106 - 94,137,678 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Map2k6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554783,331,607 - 3,448,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554783,331,607 - 3,448,840 (-)NCBIChiLan1.0ChiLan1.0
MAP2K6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21985,434,352 - 85,573,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11790,255,171 - 90,400,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01763,342,720 - 63,483,926 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11768,730,011 - 68,870,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1768,730,011 - 68,870,454 (+)Ensemblpanpan1.1panPan2
MAP2K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,840,714 - 15,962,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,840,983 - 15,952,026 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha916,731,937 - 16,853,765 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0917,501,891 - 17,623,440 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl917,501,897 - 17,614,738 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1916,445,924 - 16,567,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0910,966,413 - 11,088,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0910,965,262 - 11,086,973 (-)NCBIUU_Cfam_GSD_1.0
MAP2K6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1210,894,966 - 11,018,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11210,891,445 - 11,018,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,145,143 - 11,264,150 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11652,045,398 - 52,188,416 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1652,057,784 - 52,187,997 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607722,937,949 - 23,081,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248704,287,835 - 4,416,559 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248704,224,108 - 4,420,217 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP2K6
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002758.3(MAP2K6):c.83+202T>G single nucleotide variant Lung cancer [RCV000100620] Chr17:69506048 [GRCh38]
Chr17:67502189 [GRCh37]
Chr17:17q24.3
uncertain significance
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q24.2-24.3(chr17:67833866-70085854)x1 copy number loss See cases [RCV000053452] Chr17:67833866..70085854 [GRCh38]
Chr17:65829982..68081995 [GRCh37]
Chr17:63260444..65593590 [NCBI36]
Chr17:17q24.2-24.3
pathogenic
NM_002758.3(MAP2K6):c.17-20C>T single nucleotide variant Malignant melanoma [RCV000071641] Chr17:69505760 [GRCh38]
Chr17:67501901 [GRCh37]
Chr17:65013496 [NCBI36]
Chr17:17q24.3
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q24.2-24.3(chr17:68420514-71351235)x1 copy number loss See cases [RCV000143113] Chr17:68420514..71351235 [GRCh38]
Chr17:66416655..69347376 [GRCh37]
Chr17:63928250..66858971 [NCBI36]
Chr17:17q24.2-24.3
pathogenic
GRCh37/hg19 17q24.2-24.3(chr17:65343022-69344022)x3 copy number gain See cases [RCV000446484] Chr17:65343022..69344022 [GRCh37]
Chr17:17q24.2-24.3
uncertain significance
GRCh37/hg19 17q24.2-25.3(chr17:64241326-81041938)x3 copy number gain See cases [RCV000447577] Chr17:64241326..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_002758.4(MAP2K6):c.82A>G (p.Thr28Ala) single nucleotide variant not specified [RCV004305133] Chr17:69505845 [GRCh38]
Chr17:67501986 [GRCh37]
Chr17:17q24.3
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:67002415-81041938)x3 copy number gain See cases [RCV000512573] Chr17:67002415..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:63689671-81041938)x3 copy number gain not provided [RCV000683952] Chr17:63689671..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.1-25.2(chr17:64159738-74891024)x3 copy number gain not provided [RCV000762750] Chr17:64159738..74891024 [GRCh37]
Chr17:17q24.1-25.2
likely pathogenic
GRCh37/hg19 17q24.3(chr17:67426611-67633034)x1 copy number loss not provided [RCV001006914] Chr17:67426611..67633034 [GRCh37]
Chr17:17q24.3
uncertain significance
NM_002758.4(MAP2K6):c.820C>T (p.Pro274Ser) single nucleotide variant not specified [RCV004317703] Chr17:69526648 [GRCh38]
Chr17:67522789 [GRCh37]
Chr17:17q24.3
uncertain significance
GRCh37/hg19 17q24.1-25.3(chr17:62778720-81041938)x3 copy number gain not provided [RCV000849900] Chr17:62778720..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
NM_002758.4(MAP2K6):c.568C>A (p.Leu190Ile) single nucleotide variant not specified [RCV004313433] Chr17:69523546 [GRCh38]
Chr17:67519687 [GRCh37]
Chr17:17q24.3
uncertain significance
NM_002758.4(MAP2K6):c.761G>A (p.Arg254Gln) single nucleotide variant not specified [RCV004184585] Chr17:69526589 [GRCh38]
Chr17:67522730 [GRCh37]
Chr17:17q24.3
uncertain significance
NM_002758.4(MAP2K6):c.556C>G (p.Leu186Val) single nucleotide variant not specified [RCV004111302] Chr17:69523534 [GRCh38]
Chr17:67519675 [GRCh37]
Chr17:17q24.3
uncertain significance
NM_002758.4(MAP2K6):c.166A>G (p.Ile56Val) single nucleotide variant not specified [RCV004266144] Chr17:69517533 [GRCh38]
Chr17:67513674 [GRCh37]
Chr17:17q24.3
uncertain significance
NM_002758.4(MAP2K6):c.430A>G (p.Ile144Val) single nucleotide variant not specified [RCV004416176] Chr17:69520333 [GRCh38]
Chr17:67516474 [GRCh37]
Chr17:17q24.3
uncertain significance
NM_002758.4(MAP2K6):c.200T>C (p.Val67Ala) single nucleotide variant not specified [RCV004642814] Chr17:69517567 [GRCh38]
Chr17:67513708 [GRCh37]
Chr17:17q24.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2438
Count of miRNA genes:890
Interacting mature miRNAs:1046
Transcripts:ENST00000359094, ENST00000586641, ENST00000588110, ENST00000589295, ENST00000589647, ENST00000590474, ENST00000591445, ENST00000592348
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597249049GWAS1345123_Hserum albumin measurement QTL GWAS1345123 (human)8e-64serum albumin measurementserum albumin level (CMO:0000550)176942836769428368Human
597023446GWAS1119520_Hblood osmolality measurement QTL GWAS1119520 (human)0.000009blood molecular composition trait (VT:0010931)plasma osmolality (CMO:0002923)176951572869515729Human
597244061GWAS1340135_Hblood protein measurement QTL GWAS1340135 (human)1e-19blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)176942836769428368Human
597243678GWAS1339752_Hlow density lipoprotein cholesterol measurement QTL GWAS1339752 (human)4e-63low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)176942836769428368Human
597196307GWAS1292381_Hfasting blood glucose measurement QTL GWAS1292381 (human)4e-10fasting blood glucose measurementblood glucose level (CMO:0000046)176954684869546849Human
597252821GWAS1348895_Hcalcium measurement QTL GWAS1348895 (human)9e-15calcium measurementblood calcium level (CMO:0000502)176942836769428368Human
597323030GWAS1419104_Heducational attainment QTL GWAS1419104 (human)2e-09educational attainment176943047169430472Human
597341078GWAS1437152_Hcartilage thickness measurement QTL GWAS1437152 (human)1e-08cartilage morphology trait (VT:0000163)176950751269507513Human
597232598GWAS1328672_Happendicular lean mass QTL GWAS1328672 (human)1e-21appendicular lean mass176943808469438085Human
597128965GWAS1225039_Hbody height QTL GWAS1225039 (human)4e-09body height (VT:0001253)body height (CMO:0000106)176952683469526835Human
407050135GWAS699111_HNG-monomethyl-arginine measurement QTL GWAS699111 (human)0.0000003NG-monomethyl-arginine measurement176954921369549214Human
597029248GWAS1125322_Hosteoarthritis, hip QTL GWAS1125322 (human)0.0000002osteoarthritis, hip176950736069507361Human
597068940GWAS1165014_Hwaist-hip ratio QTL GWAS1165014 (human)0.000003waist-hip ratiowaist to hip ratio (WHR) (CMO:0000020)176948612269486123Human
597254595GWAS1350669_Hapolipoprotein B measurement QTL GWAS1350669 (human)5e-15apolipoprotein B measurementblood apoliprotein B level (CMO:0000522)176955106069551061Human
597254594GWAS1350668_Hapolipoprotein B measurement QTL GWAS1350668 (human)1e-15apolipoprotein B measurementblood apoliprotein B level (CMO:0000522)176948581369485814Human
597250821GWAS1346895_Hapolipoprotein A 1 measurement QTL GWAS1346895 (human)7e-11apolipoprotein A 1 measurementblood apolipoprotein AI level (CMO:0000520)176942836769428368Human
597354886GWAS1450960_Hbody height QTL GWAS1450960 (human)1e-116body height (VT:0001253)body height (CMO:0000106)176950357669503577Human
597354885GWAS1450959_Hbody height QTL GWAS1450959 (human)8e-70body height (VT:0001253)body height (CMO:0000106)176941734369417344Human
597219322GWAS1315396_Hserum albumin measurement QTL GWAS1315396 (human)5e-11serum albumin measurementserum albumin level (CMO:0000550)176955106069551061Human
597203391GWAS1299465_Heye color QTL GWAS1299465 (human)5e-09eye color176950122669501227Human
597171967GWAS1268041_Hosteoarthritis, hip QTL GWAS1268041 (human)1e-16osteoarthritis, hip176950751269507513Human
597252721GWAS1348795_Hapolipoprotein B measurement QTL GWAS1348795 (human)1e-51apolipoprotein B measurementblood apoliprotein B level (CMO:0000522)176942836769428368Human
406974121GWAS623097_Hresponse to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy QTL GWAS623097 (human)0.000003response to viral infection trait (VT:0010439)176943624469436245Human
597245424GWAS1341498_Hlow density lipoprotein cholesterol measurement QTL GWAS1341498 (human)4e-15low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)176948581369485814Human
597252147GWAS1348221_Htotal cholesterol measurement QTL GWAS1348221 (human)6e-45total cholesterol measurementblood total cholesterol level (CMO:0000051)176942836769428368Human
597077882GWAS1173956_Hosteoarthritis, hip, osteoarthritis, knee QTL GWAS1173956 (human)0.000001osteoarthritis, hip, osteoarthritis, knee176950736069507361Human
597224693GWAS1320767_Htotal cholesterol measurement QTL GWAS1320767 (human)1e-09total cholesterol measurementblood total cholesterol level (CMO:0000051)176948581369485814Human
597245046GWAS1341120_Hlow density lipoprotein cholesterol measurement QTL GWAS1341120 (human)4e-18low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)176955106069551061Human
597135207GWAS1231281_Hbody height QTL GWAS1231281 (human)3e-12body height (VT:0001253)body height (CMO:0000106)176953229069532291Human
597035175GWAS1131249_Hbody height QTL GWAS1131249 (human)2e-19body height (VT:0001253)body height (CMO:0000106)176949982269499823Human
597221675GWAS1317749_HBMI-adjusted waist circumference QTL GWAS1317749 (human)2e-08body size trait (VT:0100005)176948032969480330Human
597077669GWAS1173743_Hosteoarthritis, hip QTL GWAS1173743 (human)1e-09osteoarthritis, hip176950736069507361Human
597221676GWAS1317750_HBMI-adjusted waist circumference QTL GWAS1317750 (human)3e-08body size trait (VT:0100005)176950122669501227Human
597126562GWAS1222636_Htotal hip arthroplasty, osteoarthritis QTL GWAS1222636 (human)4e-10total hip arthroplasty, osteoarthritis176950751269507513Human
597143201GWAS1239275_Hlow density lipoprotein cholesterol measurement QTL GWAS1239275 (human)0.000003low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)176949755369497554Human
597220064GWAS1316138_Htotal cholesterol measurement QTL GWAS1316138 (human)8e-13total cholesterol measurementblood total cholesterol level (CMO:0000051)176955106069551061Human
597315555GWAS1411629_Hattention function measurement QTL GWAS1411629 (human)0.000002attention function measurement176951100269511003Human

Markers in Region
D17S1786  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371767,494,737 - 67,494,897UniSTSGRCh37
Build 361765,006,332 - 65,006,492RGDNCBI36
Celera1764,066,297 - 64,066,451RGD
Cytogenetic Map17q24.3UniSTS
HuRef1762,880,843 - 62,881,023UniSTS
Marshfield Genetic Map1789.32RGD
Marshfield Genetic Map1789.32UniSTS
Genethon Genetic Map1790.2UniSTS
Whitehead-YAC Contig Map17 UniSTS
D17S1471E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371767,537,948 - 67,538,131UniSTSGRCh37
Build 361765,049,543 - 65,049,726RGDNCBI36
Celera1764,109,508 - 64,109,691RGD
Cytogenetic Map17q24.3UniSTS
HuRef1762,924,072 - 62,924,255UniSTS
D17S1526  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371767,517,013 - 67,517,169UniSTSGRCh37
Build 361765,028,608 - 65,028,764RGDNCBI36
Celera1764,088,568 - 64,088,724RGD
Cytogenetic Map17q24.3UniSTS
HuRef1762,903,148 - 62,903,304UniSTS
Whitehead-YAC Contig Map17 UniSTS
G20292  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371767,537,883 - 67,538,104UniSTSGRCh37
Build 361765,049,478 - 65,049,699RGDNCBI36
Celera1764,109,443 - 64,109,664RGD
Cytogenetic Map17q24.3UniSTS
HuRef1762,924,007 - 62,924,228UniSTS
A005K40  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371767,537,883 - 67,538,104UniSTSGRCh37
Build 361765,049,478 - 65,049,699RGDNCBI36
Celera1764,109,443 - 64,109,664RGD
Cytogenetic Map17q24.3UniSTS
HuRef1762,924,007 - 62,924,228UniSTS
GeneMap99-GB4 RH Map17444.59UniSTS
MARC_24286-24287:1044369540:1  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef1762,901,641 - 62,902,634UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2431 2788 2250 4970 1723 2332 5 624 1939 465 2267 7283 6459 52 3733 1 848 1741 1598 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005257516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011525027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA932919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC002546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC015920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB111443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX512448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000359094   ⟹   ENSP00000351997
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,414,834 - 69,542,510 (+)Ensembl
Ensembl Acc Id: ENST00000586641
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,414,711 - 69,521,833 (+)Ensembl
Ensembl Acc Id: ENST00000588110   ⟹   ENSP00000464916
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,502,266 - 69,520,278 (+)Ensembl
Ensembl Acc Id: ENST00000589295   ⟹   ENSP00000466143
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,502,154 - 69,520,324 (+)Ensembl
Ensembl Acc Id: ENST00000589647   ⟹   ENSP00000467213
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,502,429 - 69,542,019 (+)Ensembl
Ensembl Acc Id: ENST00000590474   ⟹   ENSP00000468348
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,414,697 - 69,553,865 (+)Ensembl
Ensembl Acc Id: ENST00000591445
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,505,448 - 69,521,826 (+)Ensembl
Ensembl Acc Id: ENST00000592348
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,536,066 - 69,542,011 (+)Ensembl
Ensembl Acc Id: ENST00000613873   ⟹   ENSP00000477701
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1769,502,429 - 69,542,017 (+)Ensembl
RefSeq Acc Id: NM_001330450   ⟹   NP_001317379
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,502,262 - 69,553,865 (+)NCBI
T2T-CHM13v2.01770,379,205 - 70,430,810 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002758   ⟹   NP_002749
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,414,697 - 69,553,865 (+)NCBI
GRCh371767,410,838 - 67,538,470 (+)ENTREZGENE
GRCh371767,410,838 - 67,538,470 (+)NCBI
Build 361764,922,433 - 65,050,065 (+)NCBI Archive
HuRef1762,796,464 - 62,924,594 (+)ENTREZGENE
CHM1_11767,475,265 - 67,603,400 (+)NCBI
T2T-CHM13v2.01770,291,653 - 70,430,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005257516   ⟹   XP_005257573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,502,364 - 69,553,865 (+)NCBI
GRCh371767,410,838 - 67,538,470 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006721975   ⟹   XP_006722038
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,504,619 - 69,553,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011525027   ⟹   XP_011523329
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,502,177 - 69,553,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047436410   ⟹   XP_047292366
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,502,262 - 69,553,865 (+)NCBI
RefSeq Acc Id: XM_047436411   ⟹   XP_047292367
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,415,249 - 69,553,865 (+)NCBI
RefSeq Acc Id: XM_054316685   ⟹   XP_054172660
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01770,379,205 - 70,430,810 (+)NCBI
RefSeq Acc Id: XM_054316686   ⟹   XP_054172661
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01770,292,014 - 70,430,810 (+)NCBI
RefSeq Acc Id: XM_054316687   ⟹   XP_054172662
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01770,379,142 - 70,430,810 (+)NCBI
RefSeq Acc Id: XM_054316688   ⟹   XP_054172663
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01770,381,562 - 70,430,810 (+)NCBI
RefSeq Acc Id: XM_054316689   ⟹   XP_054172664
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01770,379,273 - 70,430,810 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001317379 (Get FASTA)   NCBI Sequence Viewer  
  NP_002749 (Get FASTA)   NCBI Sequence Viewer  
  XP_005257573 (Get FASTA)   NCBI Sequence Viewer  
  XP_006722038 (Get FASTA)   NCBI Sequence Viewer  
  XP_011523329 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292366 (Get FASTA)   NCBI Sequence Viewer  
  XP_047292367 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172660 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172661 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172662 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172663 (Get FASTA)   NCBI Sequence Viewer  
  XP_054172664 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03705 (Get FASTA)   NCBI Sequence Viewer  
  AAB03708 (Get FASTA)   NCBI Sequence Viewer  
  AAB05035 (Get FASTA)   NCBI Sequence Viewer  
  AAC50388 (Get FASTA)   NCBI Sequence Viewer  
  AAC50389 (Get FASTA)   NCBI Sequence Viewer  
  AAH12009 (Get FASTA)   NCBI Sequence Viewer  
  ABY87539 (Get FASTA)   NCBI Sequence Viewer  
  AGC09595 (Get FASTA)   NCBI Sequence Viewer  
  BAA13496 (Get FASTA)   NCBI Sequence Viewer  
  BAF83436 (Get FASTA)   NCBI Sequence Viewer  
  BAG70066 (Get FASTA)   NCBI Sequence Viewer  
  BAG70190 (Get FASTA)   NCBI Sequence Viewer  
  CAA65532 (Get FASTA)   NCBI Sequence Viewer  
  CAE46056 (Get FASTA)   NCBI Sequence Viewer  
  EAW89084 (Get FASTA)   NCBI Sequence Viewer  
  EAW89085 (Get FASTA)   NCBI Sequence Viewer  
  EAW89086 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000351997.3
  ENSP00000464916.1
  ENSP00000466143.1
  ENSP00000467213
  ENSP00000467213.1
  ENSP00000468348
  ENSP00000468348.1
GenBank Protein P52564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_002749   ⟸   NM_002758
- Peptide Label: isoform 1
- UniProtKB: P52564 (UniProtKB/Swiss-Prot),   A8K3Y2 (UniProtKB/TrEMBL),   B5BU16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005257573   ⟸   XM_005257516
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006722038   ⟸   XM_006721975
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011523329   ⟸   XM_011525027
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317379   ⟸   NM_001330450
- Peptide Label: isoform 2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000351997   ⟸   ENST00000359094
Ensembl Acc Id: ENSP00000477701   ⟸   ENST00000613873
Ensembl Acc Id: ENSP00000464916   ⟸   ENST00000588110
Ensembl Acc Id: ENSP00000466143   ⟸   ENST00000589295
Ensembl Acc Id: ENSP00000467213   ⟸   ENST00000589647
Ensembl Acc Id: ENSP00000468348   ⟸   ENST00000590474
RefSeq Acc Id: XP_047292367   ⟸   XM_047436411
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047292366   ⟸   XM_047436410
- Peptide Label: isoform X1
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172661   ⟸   XM_054316686
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172662   ⟸   XM_054316687
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172660   ⟸   XM_054316685
- Peptide Label: isoform X1
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172664   ⟸   XM_054316689
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054172663   ⟸   XM_054316688
- Peptide Label: isoform X2
- UniProtKB: B5BU16 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52564-F1-model_v2 AlphaFold P52564 1-334 view protein structure

Promoters
RGD ID:6794299
Promoter ID:HG_KWN:26969
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_002758,   UC002JII.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361764,922,261 - 64,922,912 (+)MPROMDB
RGD ID:7236151
Promoter ID:EPDNEW_H23820
Type:initiation region
Name:MAP2K6_1
Description:mitogen-activated protein kinase kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23822  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,414,718 - 69,414,778EPDNEW
RGD ID:7236153
Promoter ID:EPDNEW_H23822
Type:initiation region
Name:MAP2K6_2
Description:mitogen-activated protein kinase kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23820  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381769,502,383 - 69,502,443EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6846 AgrOrtholog
COSMIC MAP2K6 COSMIC
Ensembl Genes ENSG00000108984 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000359094.7 UniProtKB/TrEMBL
  ENST00000588110.5 UniProtKB/TrEMBL
  ENST00000589295.5 UniProtKB/TrEMBL
  ENST00000589647 ENTREZGENE
  ENST00000589647.5 UniProtKB/Swiss-Prot
  ENST00000590474 ENTREZGENE
  ENST00000590474.7 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000108984 GTEx
HGNC ID HGNC:6846 ENTREZGENE
Human Proteome Map MAP2K6 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5608 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5608 ENTREZGENE
OMIM 601254 OMIM
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30591 PharmGKB
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MRF7_HUMAN UniProtKB/TrEMBL
  A8K3Y2 ENTREZGENE, UniProtKB/TrEMBL
  B5BU16 ENTREZGENE, UniProtKB/TrEMBL
  K7EIW3_HUMAN UniProtKB/TrEMBL
  K7ELM6_HUMAN UniProtKB/TrEMBL
  MP2K6_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE