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Gene: CLDN5 (claudin 5) Homo sapiens
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Symbol: CLDN5
Name: claudin 5
Description: Predicted to have identical protein binding activity. Involved in several processes, including establishment of blood-retinal barrier; positive regulation of bicellular tight junction assembly; and regulation of gene expression. Localizes to apicolateral plasma membrane and bicellular tight junction. Colocalizes with cortical actin cytoskeleton. Implicated in schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: androgen withdrawal and apoptosis induced protein RVP1-like; AWAL; BEC1; claudin-5; CPETRL1; TMDVCF; TMVCF; transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
Orthologs:
Mus musculus (house mouse) : Cldn5 (claudin 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cldn5 (claudin 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cldn5 (claudin 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CLDN5 (claudin 5)
Canis lupus familiaris (dog) : CLDN5 (claudin 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cldn5 (claudin 5)
Sus scrofa (pig) : CLDN5 (claudin 5)
Chlorocebus sabaeus (African green monkey) : CLDN5 (claudin 5)
Heterocephalus glaber (naked mole-rat) : Cldn5 (claudin 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2219,523,024 - 19,527,545 (-)EnsemblGRCh38hg38GRCh38
GRCh382219,523,024 - 19,525,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,510,547 - 19,515,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,890,550 - 17,892,860 (-)NCBINCBI36hg18NCBI36
Build 342217,885,103 - 17,887,414NCBI
Celera223,362,807 - 3,365,120 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,131,378 - 3,133,692 (-)NCBIHuRef
CHM1_12219,510,114 - 19,512,427 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CLDN5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68644
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.