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Gene: CYP21A2 (cytochrome P450 family 21 subfamily A member 2) Homo sapiens
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Symbol: CYP21A2
Name: cytochrome P450 family 21 subfamily A member 2
Description: Exhibits heme binding activity and steroid 21-monooxygenase activity. Involved in steroid biosynthetic process. Predicted to localize to the endoplasmic reticulum membrane. Implicated in congenital adrenal hyperplasia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 21-hydroxylase; 21-OHase; CA21H; CAH1; CPS1; CYP21; CYP21B; cytochrome P-450c21; cytochrome P450 21; cytochrome P450 XXI; cytochrome P450, family 21, subfamily A, polypeptide 2; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; cytochrome P450-C21; cytochrome P450-C21B; MGC150536; MGC150537; P450c21B; steroid 21 hydroxylase; steroid 21-hydroxylase; steroid 21-monooxygenase
Orthologs:
Mus musculus (house mouse) : Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102008255 (steroid 21-hydroxylase)
Canis lupus familiaris (dog) : CYP21A2 (cytochrome P450c21)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101977414 (steroid 21-hydroxylase)
Sus scrofa (pig) : CYP21A2 (cytochrome P450, family 21, subfamily A, polypepide 2)
more info ...
Related Pseudogenes: CYP21A1P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,038,306 - 32,041,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,006,093 - 32,009,447 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,114,061 - 32,117,398 (+)NCBINCBI36hg18NCBI36
Build 34632,114,060 - 32,117,396NCBI
Celera633,573,108 - 33,576,445 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,760,372 - 31,763,726 (+)NCBIHuRef
CHM1_1632,008,304 - 32,011,658 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CYP21A2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346271
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.