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Gene: CYP21A2 (cytochrome P450 family 21 subfamily A member 2) Homo sapiens
Symbol: CYP21A2
Name: cytochrome P450 family 21 subfamily A member 2
Description: Exhibits heme binding activity and steroid 21-monooxygenase activity. Involved in steroid biosynthetic process. Predicted to localize to the endoplasmic reticulum membrane. Implicated in congenital adrenal hyperplasia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 21-hydroxylase; 21-OHase; CA21H; CAH1; CPS1; CYP21; CYP21B; cytochrome P-450c21; cytochrome P450 21; cytochrome P450 XXI; cytochrome P450, family 21, subfamily A, polypeptide 2; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; cytochrome P450-C21; cytochrome P450-C21B; MGC150536; MGC150537; P450c21B; steroid 21 hydroxylase; steroid 21-hydroxylase; steroid 21-monooxygenase
Mus musculus (house mouse) : Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102008255 (steroid 21-hydroxylase)
Canis lupus familiaris (dog) : CYP21A2 (cytochrome P450c21)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101977414 (steroid 21-hydroxylase)
Sus scrofa (pig) : CYP21A2 (cytochrome P450, family 21, subfamily A, polypepide 2)
more info ...
Related Pseudogenes: CYP21A1P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38632,038,306 - 32,041,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,006,093 - 32,009,447 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,114,061 - 32,117,398 (+)NCBINCBI36hg18NCBI36
Build 34632,114,060 - 32,117,396NCBI
Celera633,573,108 - 33,576,445 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,760,372 - 31,763,726 (+)NCBIHuRef
CHM1_1632,008,304 - 32,011,658 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP21A2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346271
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.