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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735945
Species: Homo sapiens
RGD Object: Gene
Symbol: CPT1A
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CPT1Amultiple interactionsISOCpt1a (Rattus norvegicus)15036816RGDObeticholic acid inhibits the reaction [ethanol decreases expression of CPT1a mRNA and protein in liver] 
CPT1Aincreases expressionEXP 6480464CTDobeticholic acid results in increased expression of CPT1A mRNAPMID:27939613
CPT1Amultiple interactionsEXP 6480464CTDobeticholic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]PMID:27939985
CPT1Aincreases expressionISOCpt1a (Mus musculus)6480464CTDobeticholic acid results in increased expression of CPT1A mRNAPMID:26655953
CPT1Aincreases expressionISOCpt1a (Rattus norvegicus)6480464CTDobeticholic acid results in increased expression of CPT1A proteinPMID:32738331
CPT1Amultiple interactionsISOCpt1a (Mus musculus)6480464CTDobeticholic acid promotes the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]PMID:26655953
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