H2BC11 (H2B clustered histone 11) - Rat Genome Database

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Gene: H2BC11 (H2B clustered histone 11) Homo sapiens
Analyze
Symbol: H2BC11
Name: H2B clustered histone 11
RGD ID: 1348596
HGNC Page HGNC:4761
Description: Enables lipopolysaccharide binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response in mucosa; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in several cellular components, including CENP-A containing nucleosome; extracellular space; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: H2B histone family, member R; H2B/r; H2BFR; H2BJ; HIST1H2BJ; histone 1, H2bj; histone cluster 1 H2B family member j; histone cluster 1, H2bj; histone H2B type 1-J; histone H2B.1; histone H2B.r
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Related Pseudogenes: H2BP3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38627,132,316 - 27,132,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl627,125,897 - 27,132,795 (-)EnsemblGRCh38hg38GRCh38
GRCh37627,100,095 - 27,100,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36627,208,074 - 27,208,554 (-)NCBINCBI36Build 36hg18NCBI36
Build 34627,208,073 - 27,208,554NCBI
Celera628,706,094 - 28,706,574 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef626,908,156 - 26,908,636 (-)NCBIHuRef
CHM1_1627,102,417 - 27,102,897 (-)NCBICHM1_1
T2T-CHM13v2.0627,001,131 - 27,001,610 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP)
alpha-pinene  (EXP)
aristolochic acid A  (EXP)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
Diisodecyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
enniatin  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ferric oxide  (ISO)
folic acid  (EXP,ISO)
gentamycin  (ISO)
iron dichloride  (EXP)
isoflurane  (ISO)
ivermectin  (EXP)
leflunomide  (EXP)
Licochalcone B  (EXP)
methyl methacrylate  (ISO)
Monobutylphthalate  (ISO)
N-Nitrosopyrrolidine  (EXP)
obeticholic acid  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
tetrachloromethane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2917990   PMID:6647026   PMID:8620898   PMID:9439656   PMID:9566873   PMID:10064132   PMID:10384058   PMID:11080476   PMID:11689053   PMID:11709551   PMID:11799066   PMID:11859126  
PMID:12408966   PMID:12477932   PMID:12686141   PMID:12757711   PMID:12860195   PMID:14574404   PMID:14657027   PMID:15019208   PMID:16283522   PMID:16307923   PMID:16319397   PMID:16627869  
PMID:16713563   PMID:16916647   PMID:19084217   PMID:19571809   PMID:19738201   PMID:20211142   PMID:20498094   PMID:21081503   PMID:21630459   PMID:21743476   PMID:21812398   PMID:21873635  
PMID:22488895   PMID:22586326   PMID:23455924   PMID:23463506   PMID:24311584   PMID:24981860   PMID:25609649   PMID:25963833   PMID:26186194   PMID:26446488   PMID:26479788   PMID:26694698  
PMID:26974126   PMID:27248496   PMID:27976729   PMID:28330616   PMID:28514442   PMID:28846114   PMID:28902428   PMID:29128334   PMID:29507755   PMID:29509190   PMID:29676528   PMID:29845934  
PMID:30462309   PMID:30745168   PMID:31142837   PMID:31180492   PMID:31300519   PMID:31409639   PMID:31586073   PMID:31790919   PMID:31980649   PMID:32296183   PMID:32416067   PMID:32433965  
PMID:32552912   PMID:32687490   PMID:32780723   PMID:32812023   PMID:33022573   PMID:33194618   PMID:33417871   PMID:33644029   PMID:33838681   PMID:33903120   PMID:33961781   PMID:34373451  
PMID:34537242   PMID:34709727   PMID:35122331   PMID:35568845   PMID:35777956   PMID:35944360   PMID:36057605   PMID:36168627   PMID:36215168   PMID:36526897   PMID:36574265   PMID:36736316  
PMID:36912080   PMID:38172120  


Genomics

Comparative Map Data
H2BC11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38627,132,316 - 27,132,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl627,125,897 - 27,132,795 (-)EnsemblGRCh38hg38GRCh38
GRCh37627,100,095 - 27,100,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36627,208,074 - 27,208,554 (-)NCBINCBI36Build 36hg18NCBI36
Build 34627,208,073 - 27,208,554NCBI
Celera628,706,094 - 28,706,574 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef626,908,156 - 26,908,636 (-)NCBIHuRef
CHM1_1627,102,417 - 27,102,897 (-)NCBICHM1_1
T2T-CHM13v2.0627,001,131 - 27,001,610 (-)NCBIT2T-CHM13v2.0
H2bc21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,128,435 - 96,131,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,128,435 - 96,131,054 (+)EnsemblGRCm39 Ensembl
GRCm38396,221,072 - 96,223,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,221,119 - 96,223,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,025,044 - 96,027,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,306,526 - 96,309,143 (+)NCBIMGSCv36mm8
Celera397,651,223 - 97,653,841 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.67NCBI
Hist2h2be
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,469,452 - 186,471,899 (+)NCBIGRCr8
mRatBN7.22183,780,583 - 183,783,030 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.02198,360,837 - 198,363,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,360,998 - 198,361,378 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,846,629 - 217,849,158 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,024,190 - 191,026,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2176,308,071 - 176,310,633 (+)NCBICelera
Cytogenetic Map2q34NCBI
LOC100981494
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2541,771,668 - 41,778,598 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1637,779,601 - 37,780,067 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0626,958,944 - 26,966,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1627,620,306 - 27,627,777 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl627,627,323 - 27,627,703 (-)Ensemblpanpan1.1panPan2
H2BC11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,540,629 - 24,543,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3524,398,133 - 24,399,997 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03524,724,421 - 24,726,416 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13524,505,366 - 24,507,369 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03524,557,553 - 24,559,418 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03526,022,425 - 26,024,476 (-)NCBIUU_Cfam_GSD_1.0
H2BC11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl721,220,123 - 21,220,503 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1721,219,729 - 21,220,563 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in H2BC11
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33		 pathogenic
GRCh38/hg38 6p22.2-22.1(chr6:26280579-28727313)x3 copy number gain See cases [RCV000133692] Chr6:26280579..28727313 [GRCh38]
Chr6:26280807..28695090 [GRCh37]
Chr6:26388786..28803069 [NCBI36]
Chr6:6p22.2-22.1		 uncertain significance
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p22.2-22.1(chr6:26545571-27115102)x3 copy number gain Breast ductal adenocarcinoma [RCV000207103] Chr6:26545571..27115102 [GRCh37]
Chr6:6p22.2-22.1		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_021058.4(H2BC11):c.59C>T (p.Thr20Ile) single nucleotide variant Inborn genetic diseases [RCV003261904] Chr6:27132692 [GRCh38]
Chr6:27100471 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_021058.4(H2BC11):c.152C>A (p.Pro51His) single nucleotide variant Inborn genetic diseases [RCV003266364] Chr6:27132599 [GRCh38]
Chr6:27100378 [GRCh37]
Chr6:6p22.1		 uncertain significance
GRCh37/hg19 6p22.2-22.1(chr6:26928203-27344831)x3 copy number gain not provided [RCV000682658] Chr6:26928203..27344831 [GRCh37]
Chr6:6p22.2-22.1		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1(chr6:27093821-27158033)x3 copy number gain not provided [RCV000745567] Chr6:27093821..27158033 [GRCh37]
Chr6:6p22.1		 benign
NM_021058.4(H2BC11):c.89G>A (p.Arg30His) single nucleotide variant Inborn genetic diseases [RCV003173379] Chr6:27132662 [GRCh38]
Chr6:27100441 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_021058.4(H2BC11):c.239G>A (p.Arg80His) single nucleotide variant Inborn genetic diseases [RCV003304133] Chr6:27132512 [GRCh38]
Chr6:27100291 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_021058.4(H2BC11):c.137T>A (p.Leu46Gln) single nucleotide variant Inborn genetic diseases [RCV003193053] Chr6:27132614 [GRCh38]
Chr6:27100393 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_021058.4(H2BC11):c.52G>A (p.Ala18Thr) single nucleotide variant Inborn genetic diseases [RCV003355253] Chr6:27132699 [GRCh38]
Chr6:27100478 [GRCh37]
Chr6:6p22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:743
Count of miRNA genes:446
Interacting mature miRNAs:481
Transcripts:ENST00000339812, ENST00000541790, ENST00000606923, ENST00000607124
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SGC35270  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37627,101,275 - 27,101,481UniSTSGRCh37
Build 36627,209,254 - 27,209,460RGDNCBI36
Celera628,707,274 - 28,707,480RGD
Cytogenetic Map6p22.1UniSTS
HuRef626,909,336 - 26,909,542UniSTS
GeneMap99-GB4 RH Map6114.95UniSTS
Whitehead-RH Map6162.1UniSTS
NCBI RH Map6353.4UniSTS
PMC162237P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37627,100,530 - 27,100,729UniSTSGRCh37
Build 36627,208,509 - 27,208,708RGDNCBI36
Celera628,706,529 - 28,706,728RGD
Cytogenetic Map6p22.1UniSTS
HuRef626,908,591 - 26,908,790UniSTS
PMC316937P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37627,100,530 - 27,100,710UniSTSGRCh37
Build 36627,208,509 - 27,208,689RGDNCBI36
Celera628,706,529 - 28,706,709RGD
Cytogenetic Map6p22.1UniSTS
HuRef626,908,591 - 26,908,771UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map13q14.1-q14.3UniSTS
Cytogenetic Map3q22-q24UniSTS
Cytogenetic Map3q13.1-q13.2UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map17p13.1-p12UniSTS
Cytogenetic Map18q21.33UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map17p12-p11.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map1q24UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2q32UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map14q31-q32UniSTS
Cytogenetic Map5p15.33UniSTS
Cytogenetic Map1q23.2UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map4q32.2UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map5q14.2UniSTS
Cytogenetic Map4q32.1UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map3p21.1UniSTS
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Cytogenetic Map4q13.3UniSTS
Cytogenetic Map4q35.2UniSTS
Cytogenetic Map3p26.1UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map2q21.2UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map18p11.3UniSTS
Cytogenetic Map17q11.1UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q32-q34UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map2p15-p13UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map19q13.33-q13.41UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map6q23-q24UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map6p12.3-p11.2UniSTS
Cytogenetic Map6q16.1-q16.3UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map7q31.2UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map3q25.2UniSTS
Cytogenetic Map3p21.1-p14.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map3q12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map3q22.3UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map22q12-q13UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1q24.3UniSTS
Cytogenetic Map9q33.1UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map2p16.2UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 85 411 53 33 891 34 49 41 41 18 636 261 9 23 18 3
Low 2136 2410 1334 461 1036 314 3730 1919 2041 275 735 1301 149 890 2502 1
Below cutoff 206 162 324 124 19 112 564 232 1558 118 76 43 12 283 265

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000339812   ⟹   ENSP00000342886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl627,132,316 - 27,132,795 (-)Ensembl
RefSeq Acc Id: ENST00000606923   ⟹   ENSP00000475213
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl627,126,079 - 27,132,548 (-)Ensembl
RefSeq Acc Id: ENST00000607124   ⟹   ENSP00000476136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl627,125,897 - 27,132,750 (-)Ensembl
RefSeq Acc Id: NM_021058   ⟹   NP_066402
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38627,132,316 - 27,132,795 (-)NCBI
GRCh37627,093,912 - 27,100,743 (-)NCBI
Build 36627,208,074 - 27,208,554 (-)NCBI Archive
HuRef626,908,156 - 26,908,636 (-)ENTREZGENE
CHM1_1627,102,417 - 27,102,897 (-)NCBI
T2T-CHM13v2.0627,001,131 - 27,001,610 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_066402   ⟸   NM_021058
- UniProtKB: B2R4J4 (UniProtKB/Swiss-Prot),   O60816 (UniProtKB/Swiss-Prot),   P06899 (UniProtKB/Swiss-Prot),   Q0D2M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000342886   ⟸   ENST00000339812
RefSeq Acc Id: ENSP00000475213   ⟸   ENST00000606923
RefSeq Acc Id: ENSP00000476136   ⟸   ENST00000607124
Protein Domains
Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06899-F1-model_v2 AlphaFold P06899 1-126 view protein structure

Promoters
RGD ID:6872278
Promoter ID:EPDNEW_H9304
Type:initiation region
Name:HIST1H2BJ_1
Description:histone cluster 1 H2B family member j
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38627,132,793 - 27,132,853EPDNEW
RGD ID:6803805
Promoter ID:HG_KWN:52628
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000406237,   NM_021064,   UC003NIU.1,   UC003NIW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36627,207,726 - 27,209,687 (-)MPROMDB
RGD ID:6849364
Promoter ID:EP11070
Type:single initiation site
Name:HS_HIST1H2BJ
Description:Histone 1, H2B.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:[S]
Experiment Methods:Nuclease protection; Nuclease protection; transfected or transformed cells
Position:
Human AssemblyChrPosition (strand)Source
Build 36627,208,551 - 27,208,611EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4761 AgrOrtholog
COSMIC H2BC11 COSMIC
Ensembl Genes ENSG00000124635 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000339812 ENTREZGENE
  ENST00000339812.3 UniProtKB/Swiss-Prot
  ENST00000606923.1 UniProtKB/TrEMBL
  ENST00000607124.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000124635 GTEx
HGNC ID HGNC:4761 ENTREZGENE
Human Proteome Map H2BC11 Human Proteome Map
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8970 UniProtKB/Swiss-Prot
NCBI Gene 8970 ENTREZGENE
OMIM 615044 OMIM
PANTHER HISTONE H2B TYPE 1-J UniProtKB/Swiss-Prot
  HISTONE H2B TYPE 1-J UniProtKB/TrEMBL
  PTHR23428 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Histone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HISTONEH2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H2B UniProtKB/Swiss-Prot
SMART H2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R4J4 ENTREZGENE
  H2B1J_HUMAN UniProtKB/Swiss-Prot
  O60816 ENTREZGENE
  P06899 ENTREZGENE
  Q0D2M2 ENTREZGENE, UniProtKB/TrEMBL
  U3KPT8_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R4J4 UniProtKB/Swiss-Prot
  O60816 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-30 H2BC11  H2B clustered histone 11  HIST1H2BJ  histone cluster 1 H2B family member j  Symbol and/or name change 5135510 APPROVED
2016-08-23 HIST1H2BJ  histone cluster 1 H2B family member j  HIST1H2BJ  histone cluster 1, H2bj  Symbol and/or name change 5135510 APPROVED