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Gene: CASP4 (caspase 4) Homo sapiens
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Symbol: CASP4
Name: caspase 4
Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptotic cysteine protease Mih1/TX; CASP-4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; protease ICH-2; protease TX; TX
Orthologs:
Mus musculus (house mouse) : Casp4 (caspase 4, apoptosis-related cysteine peptidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp4 (caspase 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CASP4 (caspase 4)
Canis lupus familiaris (dog) : CASP4 (caspase 4, apoptosis-related cysteine peptidase)
Sus scrofa (pig) : LOC100522887 (caspase-13)
more info ...
Related Pseudogenes: CASP17P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811104,942,866 - 104,968,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711104,813,594 - 104,839,325 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,318,804 - 104,344,535 (-)NCBINCBI36hg18NCBI36
Build 3411104,318,804 - 104,344,503NCBI
Celera11101,977,781 - 102,003,518 (-)NCBI
Cytogenetic Map11q22.3NCBI
HuRef11100,744,534 - 100,770,269 (-)NCBIHuRef
CHM1_111104,696,522 - 104,722,254 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CASP4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343162
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.