JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database
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Gene: JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
Analyze
Symbol: JUNB
Name: JunB proto-oncogene, AP-1 transcription factor subunit
RGD ID: 737195
Description: Exhibits sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Localizes to nucleoplasm and transcription factor AP-1 complex. Biomarker of Hodgkin's lymphoma and anaplastic large cell lymphoma; PARTICIPATES IN interleukin-6 signaling pathway; INTERACTS WITH (-)-citrinin; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activator protein 1; AP-1; jun B proto-oncogene; transcription factor jun-B
Orthologs:
Mus musculus (house mouse) : Junb (jun B proto-oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Junb (JunB proto-oncogene, AP-1 transcription factor subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Junb (JunB proto-oncogene, AP-1 transcription factor subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : JUNB (JunB proto-oncogene, AP-1 transcription factor subunit)
Canis lupus familiaris (dog) : JUNB (JunB proto-oncogene, AP-1 transcription factor subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Junb (JunB proto-oncogene, AP-1 transcription factor subunit)
Sus scrofa (pig) : JUNB (JunB proto-oncogene, AP-1 transcription factor subunit)
Chlorocebus sabaeus (African green monkey) : JUNB (JunB proto-oncogene, AP-1 transcription factor subunit)
Heterocephalus glaber (naked mole-rat) : Junb (JunB proto-oncogene, AP-1 transcription factor subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,791,486 - 12,793,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,902,310 - 12,904,125 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,763,310 - 12,765,125 (+)NCBINCBI36hg18NCBI36
Build 341912,763,309 - 12,765,124NCBI
Celera1912,792,018 - 12,793,833 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,474,046 - 12,475,861 (+)NCBIHuRef
CHM1_11912,902,786 - 12,904,601 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-citrinin  (EXP)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8-OH-DPAT  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzoyl peroxide  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
camostat  (ISO)
capecitabine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
D-glucose  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichromium trioxide  (EXP)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
gamma-linolenic acid  (EXP)
genistein  (ISO)
geraniol  (EXP)
glafenine  (ISO)
gliotoxin  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
kainic acid  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
luteolin  (EXP)
mechlorethamine  (EXP,ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
Mezerein  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosomorpholine  (ISO)
naphthalenes  (ISO)
neurotensin  (EXP)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
nilotinib  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
organoselenium compound  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxazepam  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
quinomethionate  (EXP)
quinpirole  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saccharin  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
scopolamine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sulfadimethoxine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
torcetrapib  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (EXP,ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
zebularine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)


Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1406655   PMID:1633872   PMID:1899335   PMID:2112242   PMID:2513129   PMID:8125298   PMID:8432525   PMID:8530030   PMID:8570175   PMID:8617242   PMID:8649827   PMID:8654373  
PMID:8917518   PMID:8945519   PMID:8954125   PMID:9128241   PMID:9154808   PMID:9405416   PMID:9872330   PMID:9889198   PMID:10220381   PMID:10508860   PMID:10764760   PMID:10777209  
PMID:10903323   PMID:11036094   PMID:11053448   PMID:11477071   PMID:11726656   PMID:12080089   PMID:12165517   PMID:12371906   PMID:12393503   PMID:12477932   PMID:12506033   PMID:12522006  
PMID:12592382   PMID:12907453   PMID:12907627   PMID:14499865   PMID:14673171   PMID:15025563   PMID:15231748   PMID:15240010   PMID:15302935   PMID:15308641   PMID:15489334   PMID:15507668  
PMID:15867431   PMID:16189514   PMID:16511568   PMID:16552541   PMID:16880520   PMID:17081983   PMID:17204476   PMID:17306025   PMID:17495958   PMID:17510411   PMID:17601350   PMID:17681951  
PMID:17690253   PMID:17965727   PMID:18029348   PMID:18042260   PMID:18259752   PMID:18391017   PMID:18424718   PMID:18628455   PMID:18692475   PMID:18843287   PMID:18977241   PMID:19064921  
PMID:19151755   PMID:19274049   PMID:19321746   PMID:19409613   PMID:19666408   PMID:19923172   PMID:20006998   PMID:20030915   PMID:20056077   PMID:20102225   PMID:20132737   PMID:20195357  
PMID:20200942   PMID:21225234   PMID:21289643   PMID:21326808   PMID:21393445   PMID:21423810   PMID:21516116   PMID:21822216   PMID:21873635   PMID:21937452   PMID:21988832   PMID:22020339  
PMID:22082156   PMID:22242598   PMID:22252121   PMID:22328780   PMID:22710716   PMID:23259178   PMID:23297064   PMID:23308222   PMID:23661758   PMID:23749999   PMID:24029232   PMID:24107296  
PMID:24136993   PMID:24200694   PMID:24551192   PMID:24780198   PMID:24858691   PMID:24952347   PMID:25117710   PMID:25145835   PMID:25184681   PMID:25416956   PMID:25609649   PMID:25613138  
PMID:25662951   PMID:25753664   PMID:26186194   PMID:26217035   PMID:26264872   PMID:26318166   PMID:26344197   PMID:26496610   PMID:26658840   PMID:26725775   PMID:26747248   PMID:26754630  
PMID:26860974   PMID:26926107   PMID:27147707   PMID:27245101   PMID:27591797   PMID:27609421   PMID:27637333   PMID:27890927   PMID:28089446   PMID:28192407   PMID:28473536   PMID:28514442  
PMID:28747490   PMID:29083110   PMID:29186616   PMID:29895215   PMID:29899166   PMID:29997244   PMID:30021884   PMID:30227324   PMID:30804502   PMID:30833792   PMID:31180492   PMID:31527615  
PMID:31575873   PMID:31641227   PMID:31806366   PMID:31982139   PMID:32296183  


Genomics

Comparative Map Data
JUNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,791,486 - 12,793,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,902,310 - 12,904,125 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,763,310 - 12,765,125 (+)NCBINCBI36hg18NCBI36
Build 341912,763,309 - 12,765,124NCBI
Celera1912,792,018 - 12,793,833 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,474,046 - 12,475,861 (+)NCBIHuRef
CHM1_11912,902,786 - 12,904,601 (+)NCBICHM1_1
Junb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,703,538 - 85,705,377 (-)NCBI
GRCm38884,976,909 - 84,978,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,976,910 - 84,978,718 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl884,974,484 - 84,978,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,500,811 - 87,502,617 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,867,037 - 87,868,853 (-)NCBImm8
Celera889,271,597 - 89,273,403 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.41NCBI
Junb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01926,092,972 - 26,094,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,092,974 - 26,094,756 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,068,595 - 37,070,379 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,831,536 - 24,833,320 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,836,361 - 24,838,144 (+)NCBI
Celera1922,733,824 - 22,735,608 (+)NCBICelera
Cytogenetic Map19q11NCBI
Junb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,876,793 - 31,877,836 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,876,508 - 31,878,289 (+)NCBIChiLan1.0ChiLan1.0
JUNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,097,640 - 13,099,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,097,931 - 13,098,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,353,760 - 12,355,598 (+)NCBI
JUNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,359,399 - 49,360,442 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,358,904 - 49,360,746 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Junb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,890,786 - 1,892,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,214,594 - 66,215,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,214,086 - 66,219,435 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,505,351 - 66,507,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUNB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl611,479,407 - 11,480,450 (+)Ensembl
ChlSab1.1611,479,108 - 11,480,942 (+)NCBI
Junb
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
A005B41  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371912,903,846 - 12,904,044UniSTSGRCh37
Build 361912,764,846 - 12,765,044RGDNCBI36
Celera1912,793,554 - 12,793,752RGD
Cytogenetic Map19p13.2UniSTS
HuRef1912,475,582 - 12,475,780UniSTS
GeneMap99-GB4 RH Map1972.87UniSTS
PMC186344P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371912,902,623 - 12,902,700UniSTSGRCh37
Build 361912,763,623 - 12,763,700RGDNCBI36
Celera1912,792,331 - 12,792,408RGD
Cytogenetic Map19p13.2UniSTS
HuRef1912,474,359 - 12,474,436UniSTS
G32220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371912,903,846 - 12,904,044UniSTSGRCh37
Celera1912,793,554 - 12,793,752UniSTS
Cytogenetic Map19p13.2UniSTS
HuRef1912,475,582 - 12,475,780UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR663Ahsa-miR-663aMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20622002

Predicted Target Of
Summary Value
Count of predictions:552
Count of miRNA genes:287
Interacting mature miRNAs:301
Transcripts:ENST00000302754
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 190 931 148 131 2 1027 53 164 17 207 227 313 702
Medium 2247 2046 1577 623 1812 462 3262 2125 3525 400 1247 1385 175 1 891 2084 6 2
Low 2 14 1 1 8 1 68 18 45 2 6 1 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000302754   ⟹   ENSP00000303315
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)Ensembl
RefSeq Acc Id: NM_002229   ⟹   NP_002220
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381912,791,486 - 12,793,315 (+)NCBI
GRCh371912,902,310 - 12,904,125 (+)ENTREZGENE
Build 361912,763,310 - 12,765,125 (+)NCBI Archive
HuRef1912,474,046 - 12,475,861 (+)ENTREZGENE
CHM1_11912,902,786 - 12,904,601 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002220   ⟸   NM_002229
- UniProtKB: P17275 (UniProtKB/Swiss-Prot),   Q5U079 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000303315   ⟸   ENST00000302754
Protein Domains
bZIP   RNase_HII

Promoters
RGD ID:6795685
Promoter ID:HG_KWN:29028
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC002MVB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361912,762,286 - 12,764,537 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-13.13(chr19:8831147-13331227)x3 copy number gain See cases [RCV000052908] Chr19:8831147..13331227 [GRCh38]
Chr19:8941823..13442041 [GRCh37]
Chr19:8802823..13303041 [NCBI36]
Chr19:19p13.2-13.13
likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:11517825-13225287)x1 copy number loss See cases [RCV000053945] Chr19:11517825..13225287 [GRCh38]
Chr19:11628640..13336101 [GRCh37]
Chr19:11489640..13197101 [NCBI36]
Chr19:19p13.2-13.13
pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:10319474-13777860)x1 copy number loss See cases [RCV000141568] Chr19:10319474..13777860 [GRCh38]
Chr19:10430150..13888674 [GRCh37]
Chr19:10291150..13749674 [NCBI36]
Chr19:19p13.2-13.13
pathogenic
GRCh37/hg19 19p13.2(chr19:12204632-13497073)x1 copy number loss See cases [RCV000449161] Chr19:12204632..13497073 [GRCh37]
Chr19:19p13.2
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:11608072-14543046)x3 copy number gain See cases [RCV000511013] Chr19:11608072..14543046 [GRCh37]
Chr19:19p13.2-13.12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.2(chr19:12354642-13424014)x1 copy number loss not provided [RCV000846538] Chr19:12354642..13424014 [GRCh37]
Chr19:19p13.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6205 AgrOrtholog
COSMIC JUNB COSMIC
Ensembl Genes ENSG00000171223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000303315 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000302754 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.460 UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
GTEx ENSG00000171223 GTEx
HGNC ID HGNC:6205 ENTREZGENE
Human Proteome Map JUNB Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JunB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_H2_suA UniProtKB/TrEMBL
  RNase_HII/HIII UniProtKB/TrEMBL
  RNase_HII/HIII_dom UniProtKB/TrEMBL
  RNase_HII_hlx-loop-hlx_cap_dom UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3726 ENTREZGENE
OMIM 165161 OMIM
PANTHER PTHR10954 UniProtKB/TrEMBL
  PTHR11462:SF37 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_HII UniProtKB/TrEMBL
PharmGKB PA30007 PharmGKB
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
TIGRFAMs TIGR00729 UniProtKB/TrEMBL
UniGene Hs.25292 ENTREZGENE
UniProt JUNB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U079 ENTREZGENE, UniProtKB/TrEMBL
  Q6IBG3_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q96GH3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-10 JUNB  JunB proto-oncogene, AP-1 transcription factor subunit    jun B proto-oncogene  Symbol and/or name change 5135510 APPROVED

 



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