JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
Analyze
Symbol: JUNB
Name: JunB proto-oncogene, AP-1 transcription factor subunit
RGD ID: 737195
HGNC Page HGNC:6205
Description: Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in RNA polymerase II transcription regulator complex and nucleoplasm. Part of transcription factor AP-1 complex. Implicated in head and neck squamous cell carcinoma and melanoma. Biomarker of gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and lymphoma (multiple).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activator protein 1; AP-1; jun B proto-oncogene; transcription factor AP-1 subunit JunB; transcription factor jun-B; transcription factor JunB
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,791,486 - 12,793,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)EnsemblGRCh38hg38GRCh38
GRCh371912,902,300 - 12,904,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,763,310 - 12,765,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 341912,763,309 - 12,765,124NCBI
Celera1912,792,018 - 12,793,833 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,474,046 - 12,475,861 (+)NCBIHuRef
CHM1_11912,902,786 - 12,904,601 (+)NCBICHM1_1
T2T-CHM13v2.01912,915,978 - 12,917,807 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-citrinin  (EXP)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(E)-thiamethoxam  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
8-OH-DPAT  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atropine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzoyl peroxide  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calcitriol  (EXP)
camostat  (ISO)
capecitabine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
D-glucose  (ISO)
DDT  (ISO)
deguelin  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichromium trioxide  (EXP)
dieldrin  (EXP,ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
eticlopride(1+)  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-linolenic acid  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (EXP)
glafenine  (ISO)
gliotoxin  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (ISO)
indometacin  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
kainic acid  (ISO)
kenpaullone  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
luteolin  (EXP)
mechlorethamine  (EXP,ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
Mezerein  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosomorpholine  (ISO)
naphthalenes  (ISO)
neurotensin  (EXP)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (EXP,ISO)
nilotinib  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
organoselenium compound  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxazepam  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
pirenzepine  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
quinomethionate  (EXP)
quinpirole  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saccharin  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
scopolamine  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sulfadimethoxine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiabendazole  (ISO)
thiamethoxam  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
torcetrapib  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (EXP,ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
zebularine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA,ISO)
cellular response to calcium ion  (IEA,ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
decidualization  (IEA,ISO)
embryonic process involved in female pregnancy  (IEA,ISO)
female pregnancy  (ISO)
in utero embryonic development  (IEA,ISO)
integrated stress response signaling  (NAS)
labyrinthine layer blood vessel development  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoblast proliferation  (IEA)
osteoblast proliferation  (IEA)
osteoblast proliferation  (ISO)
osteoclast differentiation  (IEA,ISO)
osteoclast proliferation  (IEA,ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA)
regulation of cell cycle  (IBA)
regulation of cell cycle  (IBA)
regulation of cell cycle  (IEA)
regulation of cell cycle  (ISO)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of T-helper 17 cell differentiation  (NAS)
regulation of transcription by RNA polymerase II  (IBA,NAS,TAS)
response to 4-nitroquinoline N-oxide  (ISO)
response to cAMP  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to light stimulus  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
RNA catabolic process  (IEA)
RNA metabolic process  (IEA)
RNA phosphodiester bond hydrolysis, endonucleolytic  (IEA)
transcription by RNA polymerase II  (ISO)
trophectodermal cell differentiation  (IEA,ISO)
vasculogenesis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A Seven-NF-κB-Related Gene Signature May Distinguish Patients with Ulcerative Colitis-Associated Colorectal Carcinoma. Ge CY, etal., Pharmgenomics Pers Med. 2020 Dec 2;13:707-718. doi: 10.2147/PGPM.S274258. eCollection 2020.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
4. Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human Papillomavirus infection. Hussain S, etal., BMC Cancer. 2009 Sep 16;9:329. doi: 10.1186/1471-2407-9-329.
5. JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma. Hyakusoku H, etal., J Exp Clin Cancer Res. 2016 Jan 12;35:6. doi: 10.1186/s13046-016-0284-4.
6. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Kong X, etal., Nature. 2017 Oct 12;550(7675):270-274. doi: 10.1038/nature24037. Epub 2017 Oct 4.
7. PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer. Lian S, etal., Oncotarget. 2015 Oct 6;6(30):29076-86. doi: 10.18632/oncotarget.4931.
8. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. Mathas S, etal., EMBO J 2002 Aug 1;21(15):4104-13.
9. Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers. Ohyama M, etal., Pathol Int. 2004 Jan;54(1):35-40.
10. RAC2 promotes abnormal proliferation of quiescent cells by enhanced JUNB expression via the MAL-SRF pathway. Pei H, etal., Cell Cycle. 2018;17(9):1115-1123. doi: 10.1080/15384101.2018.1480217. Epub 2018 Jul 9.
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. LINC00657 played oncogenic roles in esophageal squamous cell carcinoma by targeting miR-615-3p and JunB. Sun Y, etal., Biomed Pharmacother. 2018 Dec;108:316-324. doi: 10.1016/j.biopha.2018.09.003. Epub 2018 Sep 15.
14. Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. Tice DA, etal., J Biol Chem. 2002 Feb 22;277(8):6118-23. doi: 10.1074/jbc.M111255200. Epub 2001 Dec 18.
15. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
16. Characterization of key transcription factors as molecular signatures of HPV-positive and HPV-negative oral cancers. Verma G, etal., Cancer Med. 2017 Mar;6(3):591-604. doi: 10.1002/cam4.983. Epub 2017 Feb 3.
17. Expression of Jun family members in human colorectal adenocarcinoma. Wang H, etal., Carcinogenesis. 2000 Jul;21(7):1313-7.
Additional References at PubMed
PMID:1406655   PMID:1633872   PMID:1899335   PMID:2112242   PMID:2513129   PMID:8125298   PMID:8432525   PMID:8530030   PMID:8570175   PMID:8617242   PMID:8649827   PMID:8654373  
PMID:8917518   PMID:8945519   PMID:8954125   PMID:9128241   PMID:9154808   PMID:9405416   PMID:9872330   PMID:9889198   PMID:10220381   PMID:10508860   PMID:10764760   PMID:10777209  
PMID:10903323   PMID:11036094   PMID:11053448   PMID:11477071   PMID:11726656   PMID:12080089   PMID:12165517   PMID:12371906   PMID:12393503   PMID:12477932   PMID:12506033   PMID:12522006  
PMID:12592382   PMID:12907453   PMID:12907627   PMID:14499865   PMID:14673171   PMID:15025563   PMID:15231748   PMID:15240010   PMID:15302935   PMID:15308641   PMID:15489334   PMID:15507668  
PMID:15867431   PMID:16189514   PMID:16511568   PMID:16552541   PMID:16880520   PMID:17081983   PMID:17204476   PMID:17306025   PMID:17495958   PMID:17510411   PMID:17601350   PMID:17681951  
PMID:17690253   PMID:17965727   PMID:18029348   PMID:18042260   PMID:18259752   PMID:18391017   PMID:18424718   PMID:18628455   PMID:18671972   PMID:18692475   PMID:18843287   PMID:18977241  
PMID:19064921   PMID:19151755   PMID:19274049   PMID:19321746   PMID:19409613   PMID:19666408   PMID:19923172   PMID:20006998   PMID:20030915   PMID:20056077   PMID:20102225   PMID:20132737  
PMID:20195357   PMID:20200942   PMID:20211142   PMID:21225234   PMID:21289643   PMID:21326808   PMID:21393445   PMID:21423810   PMID:21516116   PMID:21822216   PMID:21873635   PMID:21937452  
PMID:21988832   PMID:22020339   PMID:22082156   PMID:22242598   PMID:22252121   PMID:22328780   PMID:22710716   PMID:23259178   PMID:23297064   PMID:23308222   PMID:23661758   PMID:23749999  
PMID:23858473   PMID:24029232   PMID:24107296   PMID:24136993   PMID:24200694   PMID:24551192   PMID:24780198   PMID:24858691   PMID:24952347   PMID:25117710   PMID:25145835   PMID:25184681  
PMID:25416956   PMID:25609649   PMID:25613138   PMID:25662951   PMID:25753664   PMID:25798074   PMID:26186194   PMID:26217035   PMID:26264872   PMID:26344197   PMID:26496610   PMID:26658840  
PMID:26725775   PMID:26747248   PMID:26860974   PMID:26926107   PMID:27147707   PMID:27245101   PMID:27591797   PMID:27609421   PMID:27637333   PMID:27890927   PMID:28089446   PMID:28192407  
PMID:28473536   PMID:28514442   PMID:28566324   PMID:28747490   PMID:29083110   PMID:29186616   PMID:29234109   PMID:29899166   PMID:29997244   PMID:30021884   PMID:30804502   PMID:30833792  
PMID:31180492   PMID:31467278   PMID:31527615   PMID:31575873   PMID:31586073   PMID:31641227   PMID:31806366   PMID:31982139   PMID:32281291   PMID:32296183   PMID:32299901   PMID:32382040  
PMID:32406953   PMID:32416067   PMID:32510596   PMID:32538781   PMID:32582999   PMID:32814053   PMID:32945523   PMID:33450132   PMID:33961781   PMID:34007044   PMID:34186245   PMID:34519628  
PMID:34921867   PMID:35013218   PMID:35140242   PMID:35271311   PMID:35320721   PMID:35616875   PMID:35726195   PMID:35831314   PMID:36183833  


Genomics

Comparative Map Data
JUNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,791,486 - 12,793,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)EnsemblGRCh38hg38GRCh38
GRCh371912,902,300 - 12,904,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,763,310 - 12,765,125 (+)NCBINCBI36Build 36hg18NCBI36
Build 341912,763,309 - 12,765,124NCBI
Celera1912,792,018 - 12,793,833 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,474,046 - 12,475,861 (+)NCBIHuRef
CHM1_11912,902,786 - 12,904,601 (+)NCBICHM1_1
T2T-CHM13v2.01912,915,978 - 12,917,807 (+)NCBIT2T-CHM13v2.0
Junb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,703,538 - 85,705,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,701,113 - 85,705,347 (-)EnsemblGRCm39 Ensembl
GRCm38884,976,909 - 84,978,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,976,910 - 84,978,718 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl884,974,484 - 84,978,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,500,811 - 87,502,617 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,867,037 - 87,868,853 (-)NCBIMGSCv36mm8
Celera889,271,597 - 89,273,403 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.41NCBI
Junb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,176,265 - 23,178,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,176,294 - 23,178,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1929,999,230 - 30,001,014 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01930,653,592 - 30,655,376 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01932,876,269 - 32,878,053 (+)NCBIRnor_WKY
Rnor_6.01926,092,972 - 26,094,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,092,974 - 26,094,756 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,068,595 - 37,070,379 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,831,536 - 24,833,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,836,361 - 24,838,144 (+)NCBI
Celera1922,733,824 - 22,735,608 (+)NCBICelera
Cytogenetic Map19q11NCBI
Junb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,876,793 - 31,877,836 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,876,508 - 31,878,289 (+)NCBIChiLan1.0ChiLan1.0
JUNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,097,640 - 13,099,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,097,931 - 13,098,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,353,760 - 12,355,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JUNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,358,904 - 49,360,746 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,359,399 - 49,360,442 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,232,549 - 49,234,383 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,877,333 - 49,879,167 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,877,347 - 49,879,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,088,428 - 49,090,262 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,514,724 - 49,516,558 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,757,409 - 49,759,245 (-)NCBIUU_Cfam_GSD_1.0
Junb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,462,083 - 208,463,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,891,080 - 1,892,123 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366591,890,786 - 1,892,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,214,138 - 66,217,002 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,214,086 - 66,219,435 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,505,351 - 66,507,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUNB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,479,108 - 11,480,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,479,407 - 11,480,450 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,315,355 - 8,317,197 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Junb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901403,235 - 404,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901402,969 - 404,741 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-13.13(chr19:8831147-13331227)x3 copy number gain See cases [RCV000052908] Chr19:8831147..13331227 [GRCh38]
Chr19:8941823..13442041 [GRCh37]
Chr19:8802823..13303041 [NCBI36]
Chr19:19p13.2-13.13
likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:11517825-13225287)x1 copy number loss See cases [RCV000053945] Chr19:11517825..13225287 [GRCh38]
Chr19:11628640..13336101 [GRCh37]
Chr19:11489640..13197101 [NCBI36]
Chr19:19p13.2-13.13
pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:10319474-13777860)x1 copy number loss See cases [RCV000141568] Chr19:10319474..13777860 [GRCh38]
Chr19:10430150..13888674 [GRCh37]
Chr19:10291150..13749674 [NCBI36]
Chr19:19p13.2-13.13
pathogenic
GRCh37/hg19 19p13.2(chr19:12204632-13497073)x1 copy number loss See cases [RCV000449161] Chr19:12204632..13497073 [GRCh37]
Chr19:19p13.2
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:11608072-14543046)x3 copy number gain See cases [RCV000511013] Chr19:11608072..14543046 [GRCh37]
Chr19:19p13.2-13.12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.2(chr19:12354642-13424014)x1 copy number loss not provided [RCV000846538] Chr19:12354642..13424014 [GRCh37]
Chr19:19p13.2
pathogenic
NC_000019.9:g.(?_11277234)_(13249220_?)dup duplication not provided [RCV003105511] Chr19:11277234..13249220 [GRCh37]
Chr19:19p13.2
uncertain significance
NC_000019.9:g.(?_10828919)_(13482613_?)dup duplication Charcot-Marie-Tooth disease dominant intermediate B [RCV003109233]|Deficiency of alpha-mannosidase [RCV003109232]|Episodic ataxia type 2 [RCV003109234]|Glutaric aciduria, type 1 [RCV003122092] Chr19:10828919..13482613 [GRCh37]
Chr19:19p13.2
uncertain significance
NC_000019.9:g.(?_12757434)_(13617038_?)del deletion Episodic ataxia type 2 [RCV001953618]|Glutaric aciduria, type 1 [RCV001947065] Chr19:12757434..13617038 [GRCh37]
Chr19:19p13.2
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12697728-14111313)x1 copy number loss not provided [RCV001834482] Chr19:12697728..14111313 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
NC_000019.9:g.(?_12757434)_(13373667_?)del deletion Aicardi-Goutieres syndrome 4 [RCV001923352]|Episodic ataxia type 2 [RCV001923351]|not provided [RCV001923353] Chr19:12757434..13373667 [GRCh37]
Chr19:19p13.2
pathogenic|uncertain significance
NM_002229.3(JUNB):c.985A>C (p.Met329Leu) single nucleotide variant Inborn genetic diseases [RCV002864728] Chr19:12792756 [GRCh38]
Chr19:12903570 [GRCh37]
Chr19:19p13.13
uncertain significance
NM_002229.3(JUNB):c.679C>T (p.Pro227Ser) single nucleotide variant Inborn genetic diseases [RCV002855345] Chr19:12792450 [GRCh38]
Chr19:12903264 [GRCh37]
Chr19:19p13.13
uncertain significance
NM_002229.3(JUNB):c.200G>C (p.Ser67Thr) single nucleotide variant Inborn genetic diseases [RCV002674289] Chr19:12791971 [GRCh38]
Chr19:12902785 [GRCh37]
Chr19:19p13.13
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR663Ahsa-miR-663aMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20622002

Predicted Target Of
Summary Value
Count of predictions:552
Count of miRNA genes:287
Interacting mature miRNAs:301
Transcripts:ENST00000302754
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
A005B41  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371912,903,846 - 12,904,044UniSTSGRCh37
Build 361912,764,846 - 12,765,044RGDNCBI36
Celera1912,793,554 - 12,793,752RGD
Cytogenetic Map19p13.2UniSTS
HuRef1912,475,582 - 12,475,780UniSTS
GeneMap99-GB4 RH Map1972.87UniSTS
PMC186344P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371912,902,623 - 12,902,700UniSTSGRCh37
Build 361912,763,623 - 12,763,700RGDNCBI36
Celera1912,792,331 - 12,792,408RGD
Cytogenetic Map19p13.2UniSTS
HuRef1912,474,359 - 12,474,436UniSTS
G32220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371912,903,846 - 12,904,044UniSTSGRCh37
Celera1912,793,554 - 12,793,752UniSTS
Cytogenetic Map19p13.2UniSTS
HuRef1912,475,582 - 12,475,780UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 190 931 148 131 2 1027 53 164 17 207 227 313 702
Medium 2247 2046 1577 623 1812 462 3262 2125 3525 400 1247 1385 175 1 891 2084 6 2
Low 2 14 1 1 8 1 68 18 45 2 6 1 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC018761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY751746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ650707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X51345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000302754   ⟹   ENSP00000303315
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1912,791,486 - 12,793,315 (+)Ensembl
RefSeq Acc Id: NM_002229   ⟹   NP_002220
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381912,791,486 - 12,793,315 (+)NCBI
GRCh371912,902,310 - 12,904,125 (+)ENTREZGENE
Build 361912,763,310 - 12,765,125 (+)NCBI Archive
HuRef1912,474,046 - 12,475,861 (+)ENTREZGENE
CHM1_11912,902,786 - 12,904,601 (+)NCBI
T2T-CHM13v2.01912,915,978 - 12,917,807 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002220   ⟸   NM_002229
- UniProtKB: Q96GH3 (UniProtKB/Swiss-Prot),   P17275 (UniProtKB/Swiss-Prot),   Q5U079 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000303315   ⟸   ENST00000302754
Protein Domains
bZIP   RNase H type-2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17275-F1-model_v2 AlphaFold P17275 1-347 view protein structure

Promoters
RGD ID:6795685
Promoter ID:HG_KWN:29028
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC002MVB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361912,762,286 - 12,764,537 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6205 AgrOrtholog
COSMIC JUNB COSMIC
Ensembl Genes ENSG00000171223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000303315 ENTREZGENE
  ENSP00000303315.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000302754 ENTREZGENE
  ENST00000302754.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.460 UniProtKB/TrEMBL
  1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
GTEx ENSG00000171223 GTEx
HGNC ID HGNC:6205 ENTREZGENE
Human Proteome Map JUNB Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_H2_suA UniProtKB/TrEMBL
  RNase_HII/HIII UniProtKB/TrEMBL
  RNase_HII/HIII_dom UniProtKB/TrEMBL
  RNase_HII_hlx-loop-hlx_cap_dom UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3726 ENTREZGENE
OMIM 165161 OMIM
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10954 UniProtKB/TrEMBL
  PTHR11462:SF37 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBONUCLEASE H2 SUBUNIT A UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_HII UniProtKB/TrEMBL
PharmGKB PA30007 PharmGKB
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNASE_H_2 UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
  SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00729 UniProtKB/TrEMBL
UniProt JUNB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U079 ENTREZGENE, UniProtKB/TrEMBL
  Q6IBG3_HUMAN UniProtKB/TrEMBL
  Q96GH3 ENTREZGENE
UniProt Secondary Q96GH3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-10 JUNB  JunB proto-oncogene, AP-1 transcription factor subunit    jun B proto-oncogene  Symbol and/or name change 5135510 APPROVED