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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:arteriosclerotic cardiovascular disease
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Accession:DOID:2348 term browser browse the term
Synonyms:exact_synonym: cardiovascular arteriosclerosis
 related_synonym: Atherosclerotic Cardiovascular disease;   cardiovascular arteriosclerosis unspecified
 primary_id: RDO:9002214
 xref: NCI:C34403
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
aortic atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 ISO mRNA,protein:decreased expression:aorta RGD PMID:33035679 RGD:401793744 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Apoe apolipoprotein E ISO RGD PMID:29459263 RGD:13703129 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Capn1 calpain 1 ISO protein:increased activity:aorta RGD PMID:23006733 RGD:13792498 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Edn1 endothelin 1 exacerbates ISO associated with type 1 diabetes mellitus; RGD PMID:32533834 RGD:329955566 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:artery: RGD PMID:31043075 RGD:267986209 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Ldlr low density lipoprotein receptor ISO RGD PMID:29459263 RGD:13703129 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Mir223 microRNA 223 IEP RNA:increased expression:serum,aorta RGD PMID:26065992 RGD:25824846 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Myocd myocardin exacerbates ISO
IMP		 protein:decreased expression:aorta RGD PMID:33035679 PMID:33035679 RGD:401793744, RGD:401793744 NCBI chr11:65,064,434...65,160,821
Ensembl chr11:65,067,387...65,160,815 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates IMP associated with type 1 diabetes mellitus; RGD PMID:32533834 RGD:329955566 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:thrombus,artery RGD PMID:17045893 RGD:401794448 NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ameliorates IGI associated with Hypercholesterolemia RGD PMID:30282838 RGD:126925208 NCBI chr 1:156,255,678...156,301,898
Ensembl chr 1:156,252,095...156,301,901 		JBrowse link
atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 treatment ISO
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22022523 PMID:29593532 RGD:401827839 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 treatment IDA RGD PMID:23650230 RGD:401842363 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 treatment ISO
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11138003 PMID:29593532 RGD:401827839 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 treatment IDA RGD PMID:29593532 RGD:401827839 NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha treatment IEP RGD PMID:33011372 RGD:401842381 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Add1 adducin 1 ISO DNA:missense mutation:cds:p.G460W (human) RGD PMID:17082469 RGD:5147995 NCBI chr 5:34,731,008...34,789,652
Ensembl chr 5:34,731,008...34,789,652 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:18931039 PMID:12451000 RGD:8694473 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IEP
ISO
IDA
IMP		 CTD Direct Evidence: marker/mechanism
associated with Kidney Failure, Chronic; protein:decreased expression:plasma (human)		 CTD
RGD		 PMID:19939336 PMID:20372816 PMID:22552116 PMID:23936343 PMID:22038096 More... RGD:6784514, RGD:8695994, RGD:7245947, RGD:6767557, RGD:6784516, RGD:6784515 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen treatment ISO associated with Hypertension
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21925196 PMID:22539767 PMID:22977667 RGD:8549467 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Ahr aryl-hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228805 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 severity IMP RGD PMID:18054314 RGD:5509083 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase IMP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:16303615 PMID:18206890 RGD:5509610 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16698924 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:16698924 NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963 		JBrowse link
G Apoa1 apolipoprotein A-I treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:33861588 PMID:18287885 PMID:23078847 RGD:7241575, RGD:7241852 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa4 apolipoprotein A-IV ISO CTD Direct Evidence: therapeutic CTD PMID:15822908 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Apoe apolipoprotein E treatment IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9169506 PMID:9409251 PMID:9649566 PMID:11095717 PMID:11231916 More... RGD:734968, RGD:7771549 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO associated with type 2 diabetes mellitus; mRNA, protein:increased expression:thoracic aorta (rat) RGD PMID:33889291 RGD:329849122 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25374339 NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695 		JBrowse link
G Carmn cardiac mesoderm enhancer-associated non-coding RNA disease_progression IEP
ISO		 RNA:decreased expression:carotid artery RGD PMID:34289702 PMID:34289702 RGD:155882579, RGD:155882579 NCBI chr18:61,778,947...61,798,481
Ensembl chr18:61,782,696...61,798,608 		JBrowse link
G Casp3 caspase 3 treatment ISO associated with type 2 diabetes mellitus RGD PMID:29213335 RGD:13792600 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casr calcium-sensing receptor ISO protein:decreased expression:tibial artery (human)
protein:increased expression:myocardium (rat)		 RGD PMID:18852253 PMID:22527939 RGD:7205454, RGD:7205672 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503 		JBrowse link
G Cav1 caveolin 1, caveolae protein treatment ISO RGD PMID:23675421 RGD:8662275 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment
severity		 IDA
IEP
ISO		 mRNA:increased expression:aorta (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12677255 PMID:12928151 PMID:20720404 PMID:11486244 PMID:15823270 More... RGD:8548896, RGD:7401235, RGD:401842363 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24370436 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24370436 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ameliorates IMP RGD PMID:19122657 RGD:329901820 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates IMP ApoE knockout mouse RGD PMID:30917686 RGD:329845559 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Ccnd1 cyclin D1 ISO associated with type 2 diabetes mellitus; mRNA, protein:increased expression:thoracic aorta (rat) RGD PMID:33889291 RGD:329849122 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 treatment IMP RGD PMID:16763157 RGD:8549763 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 IMP RGD PMID:24114205 RGD:7483610 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Cd36 CD36 molecule treatment IDA
ISO
IMP		 RGD PMID:19264766 PMID:26003171 PMID:20037584 RGD:6893502, RGD:11041151, RGD:6893559 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40 CD40 antigen treatment IEP
ISO		 associated with Gram-Negative Bacterial Infections;protein:increased expression:aorta
associated with Hypercholesterolemia		 RGD PMID:20505314 PMID:23984971 PMID:16317521 RGD:5490534, RGD:8547801, RGD:1582628 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand treatment IMP
ISO		 associated with Hypercholesterolemia
protein:increased expression:plasma		 RGD PMID:20705757 PMID:26261622 PMID:23984971 PMID:16317521 PMID:21817131 RGD:5490529, RGD:11344965, RGD:8547801, RGD:1582628, RGD:7248421 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cela2a chymotrypsin-like elastase family, member 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31358993 NCBI chr 4:141,542,265...141,553,316
Ensembl chr 4:141,542,273...141,553,471 		JBrowse link
G Clu clusterin treatment ISO RGD PMID:15961700 RGD:9068390 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:15815632 NCBI chr 4:135,622,500...135,647,530
Ensembl chr 4:135,622,705...135,647,518 		JBrowse link
G Col4a2 collagen, type IV, alpha 2 susceptibility ISO DNA:SNP: :rs72657934(human) RGD PMID:28642624 RGD:13450936 NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver treatment IDA RGD PMID:23650230 RGD:401842363 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Crp C-reactive protein, pentraxin-related disease_progression ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16931792 PMID:18535598 RGD:9491769 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) ISO
IEP		 associated with Kidney Failure, Chronic
protein:increased expression:plasma (mouse)		 RGD PMID:16166801 PMID:9637704 RGD:7257575, RGD:734837 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Ctnnb1 catenin beta 1 ameliorates IEP RGD PMID:35854140 RGD:242905195 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsb cathepsin B IGI RGD PMID:12213722 RGD:5687152 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Ctsd cathepsin D IGI RGD PMID:12213722 RGD:5687152 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctsl cathepsin L IGI RGD PMID:12213722 RGD:5687152 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Ctss cathepsin S IGI RGD PMID:12213722 RGD:5687152 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IMP RGD PMID:23887641 RGD:9479739 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:20720404 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11166758 PMID:19801147 NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051 		JBrowse link
G Dab2ip disabled 2 interacting protein ISO protein:alternative forms:coronary artery (human) RGD PMID:31619063 RGD:401938615 NCBI chr 2:35,448,285...35,621,006
Ensembl chr 2:35,448,278...35,621,006 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ameliorates
treatment		 IMP
IEP		 RGD PMID:22699504 PMID:30909142 RGD:155641244, RGD:155663380 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443 		JBrowse link
G Dusp5 dual specificity phosphatase 5 ameliorates IEP ApoE knockout mice RGD PMID:30529164 RGD:243048424 NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862 		JBrowse link
G Edn1 endothelin 1 treatment IDA RGD PMID:16806235 RGD:8661682 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 treatment IMP RGD PMID:26848160 RGD:11251766 NCBI chr 8:125,635,325...125,676,063
Ensembl chr 8:125,635,326...125,676,063 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 treatment IDA RGD PMID:29593532 RGD:401827839 NCBI chr 9:77,824,647...77,891,801
Ensembl chr 9:77,824,646...77,891,801 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic IMP RGD PMID:20224052 RGD:5688357 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) treatment IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11894143 PMID:11160157 RGD:8553067 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) IDA RGD PMID:21697723 RGD:5508792 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F11r F11 receptor IGI mRNA:increased expression:carotid artery RGD PMID:15681301 RGD:7488921 NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171 		JBrowse link
G F2 coagulation factor II treatment ISO RGD PMID:20979870 RGD:7387315 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO
IDA		 associated with type 2 diabetes mellitus RGD PMID:29213335 PMID:29593532 RGD:13792600, RGD:401827839 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:15063428 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb IMP RGD PMID:17053192 RGD:7240526 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116 		JBrowse link
G Fgf21 fibroblast growth factor 21 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:serum: RGD PMID:26047614 RGD:10401919 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 treatment IDA RGD PMID:24224032 RGD:155791446 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase sexual_dimorphism IGI RGD PMID:28253220 RGD:329812017 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:21300352 RGD:401827830 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Grn granulin ISO protein:increased expression:smooth muscle cell, macrophage RGD PMID:19321167 RGD:5509781 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19822795 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G H19 H19, imprinted maternally expressed transcript ameliorates ISO
IEP
IMP		 RNA:increased expression:blood serum (human)
ApoE knockout mice
ApoE���/��� mice
RNA:increased expression:blood plasm (human)		 RGD PMID:28165553 PMID:30529164 PMID:31757932 PMID:32945413 PMID:35854140 More... RGD:156430317, RGD:243048424, RGD:242905202, RGD:242905200, RGD:242905195, RGD:158013772, RGD:156430336 NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase treatment IMP Ldlr knockout mouse RGD PMID:31589306 RGD:243065123 NCBI chr17:84,138,777...84,157,589
Ensembl chr17:84,138,585...84,155,392 		JBrowse link
G Hdac4 histone deacetylase 4 ameliorates IEP RGD PMID:35854140 RGD:242905195 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421 		JBrowse link
G Hdac9 histone deacetylase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36322813 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 treatment IEP RGD PMID:30909142 RGD:155663380 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:20519084 RGD:10402182 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C ISO protein:increased expression:internal carotid artery, smooth muscle cell (human) RGD PMID:18508286 RGD:10054381 NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485 		JBrowse link
G Hp haptoglobin treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16597321 PMID:23665315 RGD:11041860 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Hrh1 histamine receptor H1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25020133 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257 		JBrowse link
G Hspa1a heat shock protein 1A ISO DNA:SNP:promoter:-110A>C(rs1008438) (human) RGD PMID:20490736 PMID:22328194 RGD:5147595, RGD:7257649 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16513158 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12677255 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:9169506 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11726660 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:29593532 RGD:401827839 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il17a interleukin 17A treatment IMP RGD PMID:21300351 RGD:9170237 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 treatment ISO
IMP		 RGD PMID:23685195 PMID:16732281 RGD:8655997, RGD:14695532 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ameliorates IDA
IEP		 associated with Renal Insufficiency, Chronic RGD PMID:21245127 PMID:35854140 RGD:7175328, RGD:242905195 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 IEP associated with Diabetes Mellitus, Type 1 RGD PMID:21606463 RGD:5147904 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il27 interleukin 27 ameliorates IMP RGD PMID:23729211 RGD:39456136 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
G Il6 interleukin 6 ameliorates
treatment		 ISO
IEP
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19330073 PMID:35854140 PMID:29593532 RGD:242905195, RGD:401827839 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgam integrin alpha M ameliorates IMP
ISO
IEP		 associated with Hypercholesterolemia;DNA:missense mutation:CDS:p.I332G (mouse)
mRNA:increased expression:peripheral blood mononuclear cell (human)
protein:increased expression:descending aorta (mouse)		 RGD PMID:32938725 PMID:24716741 PMID:30913515 RGD:329853755, RGD:329901833, RGD:329901661 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Jak2 Janus kinase 2 ISO associated with type 2 diabetes mellitus; mRNA, protein:increased expression, increased phosphorylation:aorta, blood serum (rat) RGD PMID:33889291 RGD:329849122 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 ameliorates IMP ApoE knockout mouse RGD PMID:18688283 RGD:329955454 NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115 		JBrowse link
G Kdr kinase insert domain protein receptor treatment IDA RGD PMID:17303776 RGD:8551768 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 ameliorates IEP ApoE knockout mice RGD PMID:30529164 RGD:243048424 NCBI chr 4:129,596,143...129,637,402
Ensembl chr 4:129,596,957...129,636,096 		JBrowse link
G Kl klotho IMP RGD PMID:11027545 RGD:10403056 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Ldlr low density lipoprotein receptor IMP
ISO		 DNA:mutation:exon:478T > A(rat)
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:11947894 PMID:18450471 PMID:22153697 PMID:25619500 PMID:28899902 More... RGD:5490255, RGD:12910105 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 8:71,124,663...71,131,402
Ensembl chr 8:71,125,898...71,131,402 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16698924 NCBI chr10:93,289,258...93,320,758
Ensembl chr10:93,289,273...93,320,737 		JBrowse link
G Mir126b microRNA 126b exacerbates IMP RGD PMID:24584117 RGD:401850548 NCBI chr 2:26,481,375...26,481,432
Ensembl chr 2:26,481,375...26,481,432 		JBrowse link
G Mir140 microRNA 140 IEP
ISO		 mRNA:increased expression:blood vessel (mouse)
miRNA:increased expression:artery (human)
miRNA:increased expression:peripheral monocytes (human)		 RGD PMID:30483753 PMID:33495827 PMID:32965005 RGD:329337368, RGD:329347823, RGD:329337370 NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945 		JBrowse link
G Mir145a microRNA 145a ameliorates IGI RGD PMID:29710501 RGD:155260303 NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965 		JBrowse link
G Mir146 microRNA 146 severity ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir155 microRNA 155 treatment
severity		 IMP
IEP
ISO		 associated with Bacteremia
miRNA:decreased expression:peripheral blood mononuclear cell, plasma		 RGD PMID:28970282 PMID:28646427 PMID:31866771 PMID:27856635 RGD:21079445, RGD:24922209, RGD:21081515, RGD:21079446 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir17 microRNA 17 treatment IMP RGD PMID:30850242 RGD:329349304 NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186 		JBrowse link
G Mir20a microRNA 20a ameliorates IDA RGD PMID:35854140 RGD:242905195 NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695 		JBrowse link
G Mir21a microRNA 21a severity ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:serum,artery RGD PMID:26065992 RGD:25824846 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) susceptibility ISO human gene in mouse model RGD PMID:11375412 RGD:7207025 NCBI chr 9:7,464,141...7,476,870
Ensembl chr 9:7,464,141...7,476,857 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) susceptibility ISO human gene in mouse model
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:11375412 PMID:21742783 RGD:7207025 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ameliorates
treatment		 ISO
IDA		 RGD PMID:16317521 PMID:31757932 PMID:20370796 RGD:1582628, RGD:242905202, RGD:8657031 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:33861588 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrpl45 mitochondrial ribosomal protein L45 ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr11:97,205,749...97,220,746
Ensembl chr11:97,206,542...97,220,746 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase severity ISO associated with Kidney Failure, Chronic; DNA:transversion:cds:g.1298A>C (human) RGD PMID:17899317 RGD:6893579 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ameliorates IEP ApoE knockout mice RGD PMID:30529164 RGD:243048424 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene treatment IEP RGD PMID:35854140 RGD:242905195 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Mylip myosin regulatory light chain interacting protein treatment IDA RGD PMID:29593532 RGD:401827839 NCBI chr13:45,543,197...45,565,498
Ensembl chr13:45,543,218...45,565,498 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28062492 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Ngf nerve growth factor ISO protein:decreased expression:coronary artery (human) RGD PMID:11689207 RGD:5508382 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO protein:increased expression:adventitia, vasa vasorum (human) RGD PMID:11689207 RGD:5508382 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nnmt nicotinamide N-methyltransferase disease_progression IEP protein:increased activity:liver (mouse) RGD PMID:19307695 RGD:401794447 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IMP RGD PMID:24324141 RGD:8158039 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nono non-POU-domain-containing, octamer binding protein severity IMP
ISO		 mRNA, protein:increased expression:coronary artery (human) RGD PMID:29673854 PMID:33626912 RGD:155882449, RGD:155900763 NCBI chr  X:100,473,295...100,492,193
Ensembl chr  X:100,472,924...100,492,197 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:20720404 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell susceptibility ISO
IMP		 DNA:snp:exon:c.894G>T (human)
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12677255 PMID:20720404 PMID:21114134 PMID:12163452 RGD:7771564, RGD:7771607 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Notch1 notch 1 treatment IEP RGD PMID:30909142 RGD:155663380 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18483620 NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457 		JBrowse link
G Nppb natriuretic peptide type B susceptibility ISO associated with Renal Insufficiency, chronic;protein:increased expression:blood:
associated with Hypertension,Renal; DNA:SNP:promoter: -381 T>C,rs198389 (human)		 RGD PMID:22863432 PMID:19413180 RGD:7247628, RGD:7248594 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Npy neuropeptide Y severity IEP RGD PMID:21468772 RGD:10448273 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP RGD PMID:21468772 RGD:10448273 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 IEP RGD PMID:21468772 RGD:10448273 NCBI chr 3:82,445,688...82,455,404
Ensembl chr 3:82,445,690...82,455,391 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 IEP RGD PMID:21468772 RGD:10448273 NCBI chr 8:67,132,617...67,140,746
Ensembl chr 8:67,132,617...67,140,780 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 treatment IDA
IEP		 RGD PMID:29593532 PMID:33011372 RGD:401827839, RGD:401842381 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 treatment IDA
IEP
ISO		 mRNA:increased expression:carotid artery segment (human) RGD PMID:29593532 PMID:33011372 PMID:15528463 RGD:401827839, RGD:401842381, RGD:401827901 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:30996006 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18093987 PMID:19124646 PMID:18093987 RGD:5683916 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850 		JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide treatment IMP RGD PMID:11413086 RGD:10449506 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 severity
resistance		 IDA
ISO
IMP		 protein:increased expression:carotid artery (human) RGD PMID:22053073 PMID:21960570 PMID:17659202 RGD:6771176, RGD:6771359, RGD:6771223 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Pf4 platelet factor 4 ameliorates IMP RGD PMID:19122657 RGD:329901820 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242 		JBrowse link
G Pgf placental growth factor IMP RGD PMID:19952000 RGD:6483589 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 exacerbates ISO mRNA:increased expression:carotid artery (human) RGD PMID:36091033 RGD:401900131 NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma severity IMP RGD PMID:17483449 RGD:1642394 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19237014 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) IMP
ISO		 associated with Diabetes Mellitus, type 2;DNA:missense mutation: :994G>T(human) RGD PMID:21970837 PMID:12590019 RGD:6482784, RGD:7248796 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Plat plasminogen activator, tissue ISO CTD Direct Evidence: therapeutic CTD PMID:12677255 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase ISO
IMP		 associated with Kidney Failure, Chronic; protein:increased expression:plasma (human) RGD PMID:17706748 PMID:15096455 RGD:7241201, RGD:7241203 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pltp phospholipid transfer protein ISO protein:increased expression:coronary artery (human) RGD PMID:12835223 RGD:1581039 NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631 		JBrowse link
G Polr1c polymerase (RNA) I polypeptide C ISO ClinVar Annotator: match by term: Atherosclerosis, susceptibility to ClinVar PMID:15732116 PMID:15937083 PMID:18413368 NCBI chr17:46,554,846...46,558,971
Ensembl chr17:46,554,846...46,558,980 		JBrowse link
G Pon1 paraoxonase 1 susceptibility
treatment		 ISO
IDA
IMP		 mRNA:altered expression::human transgene expression in ApoE-KO mice was protective
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Beta-Thalassemia;protein:decreased activity:serum (human)		 CTD
RGD		 PMID:16216721 PMID:16229851 PMID:16331452 PMID:19371607 PMID:21629682 More... RGD:5509927, RGD:11552582, RGD:8547574, RGD:8547562 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Pon3 paraoxonase 3 ISO mRNA:altered expression::human transgene expression in ApoE-KO mice was protective RGD PMID:20182519 RGD:5509927 NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma IEP
ISO		 protein:increased expression:aortic sinus, endothelium (mouse)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:18269830 PMID:15779851 RGD:8552894 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO protein:decreased expression:mammary arteries (human) RGD PMID:14736553 RGD:5688075 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase ISO mRNA:decreased expression:artery (human) RGD PMID:22112851 RGD:401959395 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20720404 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rbp4 retinol binding protein 4, plasma exacerbates
disease_progression		 IMP
ISO		 APOE knockout
associated with type 2 diabetes mellitus; mRNA,protein:increased expression:adipose tissue, blood serum (rat)		 RGD PMID:28122883 PMID:33889291 RGD:329845881, RGD:329849122 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 treatment IDA
IEP		 RGD PMID:29593532 PMID:33011372 PMID:23650230 RGD:401827839, RGD:401842381, RGD:401842363 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 treatment IDA RGD PMID:29593532 RGD:401827839 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Sell selectin, lymphocyte IMP RGD PMID:21760899 RGD:5685675 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Selp selectin, platelet IEP
ISO		 protein:increased expression:aorta RGD PMID:19834105 PMID:22340239 RGD:6478699, RGD:6480102 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Sergef secretion regulating guanine nucleotide exchange factor ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 7:46,092,583...46,289,254
Ensembl chr 7:46,092,578...46,289,231 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12677255 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sirt1 sirtuin 1 ISO associated with Diabetes Mellitus, Type 2;mRNA:decreased expression:abdominal aorta
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20068143 PMID:21810449 RGD:9585743 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ameliorates IMP myeloid knockout RGD PMID:31495784 RGD:126925203 NCBI chr 1:156,255,678...156,301,898
Ensembl chr 1:156,252,095...156,301,901 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19330073 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod1 superoxide dismutase 1, soluble severity IEP
ISO		 mRNA:decreased expression:thoracic aorta (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20720404 PMID:20347443 RGD:8655856 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12677255 PMID:20720404 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 treatment IDA
IEP		 RGD PMID:29593532 PMID:31601342 PMID:33011372 PMID:23650230 RGD:401827839, RGD:401850587, RGD:401842381, RGD:401842363 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 treatment IDA RGD PMID:23650230 RGD:401842363 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism
associated with type 2 diabetes mellitus; mRNA, protein:increased expression, increased phosphorylation:aorta, blood serum (rat)		 CTD
RGD		 PMID:19330073 PMID:33889291 RGD:329849122 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stau1 staufen double-stranded RNA binding protein 1 ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 2:166,789,469...166,838,253
Ensembl chr 2:166,789,469...166,838,219 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 ameliorates IDA RGD PMID:31757932 RGD:242905202 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tlr2 toll-like receptor 2 IMP RGD PMID:17466307 RGD:8552973 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12124407 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor ameliorates
treatment		 IMP
ISO
IEP
IDA		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20720404 PMID:15823270 PMID:35854140 PMID:29593532 RGD:7401235, RGD:242905195, RGD:401827839 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trim28 tripartite motif-containing 28 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31351049 NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962 		JBrowse link
G Trp53 transformation related protein 53 ameliorates IDA RGD PMID:31757932 RGD:242905202 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21908651 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B treatment IDA RGD PMID:29593532 RGD:401827839 NCBI chr 4:83,138,537...83,242,488
Ensembl chr 4:83,138,537...83,242,492 		JBrowse link
G Ttpa tocopherol (alpha) transfer protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:11095717 NCBI chr 4:20,007,889...20,030,823
Ensembl chr 4:20,007,938...20,030,785 		JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 2:120,690,753...120,801,246
Ensembl chr 2:120,690,750...120,801,196 		JBrowse link
G Ucn2 urocortin 2 ISO protein:increased expression:coronary artery, endothelium (human) RGD PMID:16026900 RGD:5508308 NCBI chr 9:108,815,231...108,816,232
Ensembl chr 9:108,815,078...108,816,232 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ameliorates ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12677255 PMID:35854140 RGD:242905195 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor IMP RGD PMID:25801026 RGD:14402022 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vegfa vascular endothelial growth factor A ameliorates ISO
IDA		 CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Atherosclerosis, susceptibility to		 CTD
ClinVar
RGD		 PMID:15732116 PMID:15937083 PMID:18413368 PMID:31757932 RGD:242905202 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vegfc vascular endothelial growth factor C IEP associated with hypercholesterolemia;protein:increased expression:serum: RGD PMID:22206010 RGD:7483588 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131 		JBrowse link
G Vim vimentin ISO associated with arthritis,rheumatoid RGD PMID:21362765 RGD:6480618 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Wiz widely-interspaced zinc finger motifs ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr17:32,573,021...32,608,463
Ensembl chr17:32,573,029...32,608,413 		JBrowse link
G Wnt1 wingless-type MMTV integration site family, member 1 ameliorates IEP RGD PMID:35854140 RGD:242905195 NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718 		JBrowse link
Carotid Atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agxt2 alanine-glyoxylate aminotransferase 2 ISO DNA:missense mutations:cds:multiple (human) RGD PMID:25620171 RGD:329961318 NCBI chr15:10,358,602...10,410,244
Ensembl chr15:10,358,618...10,410,239 		JBrowse link
G Ccn1 cellular communication network factor 1 ISO protein:increased expression:carotid artery segment (human) RGD PMID:16774841 RGD:329845567 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Fgf21 fibroblast growth factor 21 ISO protein:increased expression:serum: RGD PMID:23887638 RGD:10401924 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:SNP:intron:rs9937354 (human) RGD PMID:36894991 RGD:329901850 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Glul glutamate-ammonia ligase ISO RGD PMID:35667160 RGD:401793760 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO associated with type 2 diabetes mellitus RGD PMID:32862561 RGD:401827123 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Hrg histidine-rich glycoprotein disease_progression ISO protein:increased expression:carotid artery segment (human) RGD PMID:16774841 RGD:329845567 NCBI chr16:22,769,822...22,780,409
Ensembl chr16:22,769,822...22,780,406 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast ameliorates IDA RGD PMID:17466308 RGD:401854230 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Itln1 intelectin 1 (galactofuranose binding) severity ISO protein:decreased expression:blood serum (human) RGD PMID:24956535 RGD:329845846 NCBI chr 1:171,345,691...171,362,893
Ensembl chr 1:171,345,690...171,362,862 		JBrowse link
G Kmt2d lysine (K)-specific methyltransferase 2D severity ISO RGD PMID:26764138 RGD:155582215 NCBI chr15:98,729,550...98,771,958
Ensembl chr15:98,729,550...98,769,085 		JBrowse link
G Mmp9 matrix metallopeptidase 9 disease_progression ISO protein:increased expression:carotid artery segment (human) RGD PMID:16774841 RGD:329845567 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 exacerbates ISO DNA:silent mutation:exon 4:c.297C>T (rs2279238) (human) RGD PMID:35907563 RGD:401842367 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO protein:increased expression:myofibroblast: RGD PMID:14970114 RGD:11556214 NCBI chr19:17,409,678...17,815,076
Ensembl chr19:17,409,683...17,814,996 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 severity ISO DNA:SNPs, haplotype:intron 3: (rs9349379, rs2026458, rs2876300) (human) RGD PMID:31200082 RGD:401900133 NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002 		JBrowse link
G Rbp4 retinol binding protein 4, plasma severity ISO protein:increased expression:blood serum (human) RGD PMID:24956535 RGD:329845846 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Sirt1 sirtuin 1 ISO mRNA, protein:decreased expression:carotid artery segment RGD PMID:23224247 RGD:9495924 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
Carotid Intimal Medial Thickness 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Carotid intimal medial thickness 1		 OMIM
CTD
ClinVar		 PMID:25741868 PMID:27749844 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
cerebral atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kalrn kalirin, RhoGEF kinase susceptibility ISO DNA:SNP:intron: (rs6438833) (human) RGD PMID:30232674 RGD:329956416 NCBI chr16:33,789,443...34,393,647
Ensembl chr16:33,789,443...34,393,902 		JBrowse link
Peripheral Arterial Occlusive Disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B ISO ClinVar Annotator: match by term: Peripheral arterial occlusive disease 1 ClinVar PMID:1618300 PMID:9040504 PMID:11289720 PMID:25741868 NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804 		JBrowse link
peripheral artery disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:16321391 RGD:5686716 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G B2m beta-2 microglobulin severity ISO RGD PMID:21314441 RGD:6482704 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564 		JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27082954 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp8a bone morphogenetic protein 8a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27082954 NCBI chr 4:123,206,438...123,237,045
Ensembl chr 4:123,206,438...123,237,045 		JBrowse link
G Ccn1 cellular communication network factor 1 severity ISO associated with type 2 diabetes mellitus; protein:increased expression:blood serum (human) RGD PMID:33222686 RGD:329845552 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Dab2ip disabled 2 interacting protein ISO DNA:SNP:CDS:intron 1 (rs7025486) (human) RGD PMID:20622881 RGD:401901599 NCBI chr 2:35,448,285...35,621,006
Ensembl chr 2:35,448,278...35,621,006 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IEP associated with Experimental Diabetes Mellitus RGD PMID:31623833 RGD:329961326 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO associated with Diabetes Mellitus, Type 2;DNA:transition:cds:g.677C>T (human) RGD PMID:16274479 RGD:6893659 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Npy neuropeptide Y ISO RGD PMID:21468772 RGD:10448273 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO RGD PMID:21468772 RGD:10448273 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO RGD PMID:21468772 RGD:10448273 NCBI chr 3:82,445,688...82,455,404
Ensembl chr 3:82,445,690...82,455,391 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO RGD PMID:21468772 RGD:10448273 NCBI chr 8:67,132,617...67,140,746
Ensembl chr 8:67,132,617...67,140,780 		JBrowse link
G P2ry12 purinergic receptor P2Y, G-protein coupled 12 ISO RGD PMID:14662702 RGD:1580188 NCBI chr 3:59,123,692...59,170,408
Ensembl chr 3:59,123,693...59,170,292 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO associated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human) RGD PMID:9201602 RGD:8547710 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18297
    disease of anatomical entity 15629
      cardiovascular system disease 4562
        vascular disease 3237
          Arterial Occlusive Diseases 802
            arteriosclerosis 775
              arteriosclerotic cardiovascular disease 209
                atherosclerosis + 209
paths to the root