Il27 (interleukin 27) - Rat Genome Database

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Gene: Il27 (interleukin 27) Mus musculus
Symbol: Il27
Name: interleukin 27
RGD ID: 1615620
Description: Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il; IL-; IL-27; IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL-27p28; IL27-A; Il30; interleukin 30; interleukin-27 subunit alpha; p2; p28
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397126,188,181 - 126,194,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)EnsemblGRCm39 Ensembl
GRCm387126,589,009 - 126,595,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,732,809 - 133,738,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,380,443 - 126,386,058 (-)NCBIMGSCv36mm8
Celera7126,438,423 - 126,444,039 (-)NCBICelera
Cytogenetic Map7F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. IL-27 enhances Leishmania amazonensis infection via ds-RNA dependent kinase (PKR) and IL-10 signaling. Barreto-de-Souza V, etal., Immunobiology. 2015 Apr;220(4):437-44. doi: 10.1016/j.imbio.2014.11.006. Epub 2014 Nov 15.
2. Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. Cao J, etal., EMBO Mol Med. 2014 Jan;6(1):120-40. doi: 10.1002/emmm.201302890.
3. IL-27 controls sepsis-induced impairment of lung antibacterial host defence. Cao J, etal., Thorax. 2014 Oct;69(10):926-37. doi: 10.1136/thoraxjnl-2014-205777. Epub 2014 Jul 29.
4. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. Chae SC, etal., J Hum Genet. 2007;52(4):355-61. Epub 2007 Feb 22.
5. Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. Clement M, etal., PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.
6. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. Dibra D, etal., PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
7. Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients. Fawzy MM, etal., Asian Pac J Cancer Prev. 2016;17(4):2093-7. doi: 10.7314/apjcp.2016.17.4.2093.
8. Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. Fazalul Rahiman SS, etal., Trop Biomed. 2013 Dec;30(4):663-80.
9. Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. Fujita H, etal., J Immunol. 2009 Jul 1;183(1):254-60.
10. Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4. Garg A, etal., Sci Rep. 2017 Mar 24;7:44485. doi: 10.1038/srep44485.
11. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Hall AO, etal.
12. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. Harker JA, etal., J Virol. 2018 May 29;92(12). pii: JVI.02196-17. doi: 10.1128/JVI.02196-17. Print 2018 Jun 15.
13. Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population. He C and Liu J, Int J Clin Exp Pathol. 2018 Aug 1;11(8):4147-4152. eCollection 2018.
14. The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis. He J, etal., Crit Care. 2018 Sep 30;22(1):248. doi: 10.1186/s13054-018-2180-0.
15. Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese. He L, etal., PLoS One. 2014 May 9;9(5):e96792. doi: 10.1371/journal.pone.0096792. eCollection 2014.
16. Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. Hirase T, etal., Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
17. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Huang M, etal., Mediators Inflamm. 2016;2016:4025167. doi: 10.1155/2016/4025167. Epub 2016 Jun 15.
18. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. Huang N, etal., DNA Cell Biol. 2008 Sep;27(9):527-31.
19. Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor. Jafarzadeh A, etal., J Dig Dis. 2011 Aug;12(4):302-7. doi: 10.1111/j.1751-2980.2011.00510.x.
20. Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in naïve hepatitis B infection patients. Kao JT, etal., Liver Int. 2012 Jul;32(6):928-36. doi: 10.1111/j.1478-3231.2011.02742.x. Epub 2012 Jan 9.
21. Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection. Kimura D, etal., Immunity. 2016 Mar 15;44(3):672-82. doi: 10.1016/j.immuni.2016.02.011. Epub 2016 Mar 8.
22. IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Li JJ, etal., J Immunol. 2010 Oct 1;185(7):4401-9. Epub 2010 Sep 3.
23. Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis. Lin S, etal., Infect Drug Resist. 2019 Dec 2;12:3755-3763. doi: 10.2147/IDR.S231215. eCollection 2019.
24. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. Liu L, etal., J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
25. Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome. Lucchesi D, etal., Arthritis Rheumatol. 2020 Sep;72(9):1559-1570. doi: 10.1002/art.41289. Epub 2020 Jul 21.
26. Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. Mohammadnejad L, etal., Arch Razi Inst. 2021 Jan;75(4):491-500. doi: 10.22092/ari.2019.126151.1333. Epub 2021 Jan 1.
27. Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Moro K, etal., Nat Immunol. 2016 Jan;17(1):76-86. doi: 10.1038/ni.3309. Epub 2015 Nov 23.
28. Interleukin-27 expression following infection with the murine gammaherpesvirus 68. Nelson DA, etal., Cytokine. 2010 Aug;51(2):184-94. doi: 10.1016/j.cyto.2010.04.015. Epub 2010 May 20.
29. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. O'Dwyer MJ, etal., Intensive Care Med. 2008 Apr;34(4):683-91. doi: 10.1007/s00134-007-0968-5. Epub 2008 Jan 29.
30. Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27. Pan L, etal., Rheumatology (Oxford). 2020 Dec 6. pii: 6024785. doi: 10.1093/rheumatology/keaa752.
31. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Park J, etal., Infect Immun. 2019 Nov 18;87(12). pii: IAI.00455-19. doi: 10.1128/IAI.00455-19. Print 2019 Dec.
32. Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. Pinto MT, etal., AIDS Res Hum Retroviruses. 2014 Jun;30(6):610-22. doi: 10.1089/aid.2013.0109. Epub 2013 Oct 16.
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response. Quirino GFS, etal., Infect Immun. 2016 Jul 21;84(8):2289-2298. doi: 10.1128/IAI.00283-16. Print 2016 Aug.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Rinchai D, etal., Eur J Immunol. 2012 Dec;42(12):3280-90. doi: 10.1002/eji.201242526. Epub 2012 Oct 25.
39. Interleukin-27 is abrogated in gastric cancer, but highly expressed in other Helicobacter pylori-associated gastroduodenal diseases. Rocha GA, etal., Helicobacter. 2020 Feb;25(1):e12667. doi: 10.1111/hel.12667. Epub 2019 Nov 8.
40. Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis. Seman BG, etal., Infect Immun. 2020 Feb 20;88(3). pii: IAI.00828-19. doi: 10.1128/IAI.00828-19. Print 2020 Feb 20.
41. Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. Skouras VS, etal., Infect Dis (Lond). 2015 Jul;47(7):477-83. doi: 10.3109/23744235.2015.1019919. Epub 2015 Mar 10.
42. [Diagnostic value of interleukin-27 in tuberculous pleural effusion]. Sun M, etal., Zhonghua Yi Xue Za Zhi. 2014 Sep 16;94(34):2641-4.
43. IL-27 Suppresses Antimicrobial Activity in Human Leprosy. Teles RMB, etal., J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.
44. Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. Tong X, etal., Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19.
45. Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis. Urazova OI, etal., Tuberculosis (Edinb). 2019 Mar;115:56-62. doi: 10.1016/ Epub 2019 Feb 6.
46. Interleukin 27 could be useful in the diagnosis of tuberculous pleural effusions. Valdés L, etal., Respir Care. 2014 Mar;59(3):399-405. doi: 10.4187/respcare.02749. Epub 2013 Aug 20.
47. Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. Vultaggio A, etal., J Immunol. 2009 Jan 15;182(2):880-9.
48. The correlation between hepatitis B virus infection and IL-27. Wang HL, etal., Biomed Mater Eng. 2012;22(1-3):187-93. doi: 10.3233/BME-2012-0706.
49. IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis. Wang L, etal., J Infect Dis. 2018 Jan 4;217(2):198-207. doi: 10.1093/infdis/jix581.
50. Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. Wang W, etal., Thorax. 2018 Mar;73(3):240-247. doi: 10.1136/thoraxjnl-2016-209718. Epub 2017 Aug 26.
51. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. Wirtz S, etal., J Exp Med. 2006 Aug 7;203(8):1875-81. doi: 10.1084/jem.20060471. Epub 2006 Jul 31.
52. Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Yan J, etal., J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.
53. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. Yoshimoto T, etal., J Immunol. 2007 Oct 1;179(7):4415-23.
54. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
55. Association of the Interleukin-27 Gene Expression and Hepatitis B Virus Infection in Liver Transplanted Patients. Zare A, etal., Exp Clin Transplant. 2017 Oct;15(5):554-560. doi: 10.6002/ect.2015.0243. Epub 2016 Feb 26.
56. Comparison of the interleukin 27 expression for the acute and chronic phase of mononucleosis in children. Zelazowska-Rutkowska B, etal., Cytokine. 2021 May;141:155395. doi: 10.1016/j.cyto.2020.155395. Epub 2021 Feb 8.
57. Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. Zeng R, etal., J Virol. 2012 Apr;86(8):4505-17. doi: 10.1128/JVI.07091-11. Epub 2012 Feb 1.
58. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Zhang GL, etal., J Immunol Res. 2019 May 6;2019:1538439. doi: 10.1155/2019/1538439. eCollection 2019.
59. High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV. Zhang GL, etal., Liver Int. 2014 Feb;34(2):266-73. doi: 10.1111/liv.12268. Epub 2013 Jul 25.
60. Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. Zhang J, etal., J Biol Chem. 2010 Jul 9;285(28):21269-81. doi: 10.1074/jbc.M110.100818. Epub 2010 Apr 30.
61. Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Zhu C, etal., Clin Immunol. 2009 Apr;131(1):92-7. doi: 10.1016/j.clim.2008.10.011. Epub 2008 Dec 9.
62. Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. Zhu H, etal., Virol J. 2015 Nov 14;12:189. doi: 10.1186/s12985-015-0418-x.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12121660   PMID:12466851   PMID:12477932   PMID:12646495   PMID:12734330   PMID:14610273   PMID:14657353   PMID:15253382  
PMID:15294962   PMID:15308705   PMID:15356135   PMID:15528388   PMID:15585838   PMID:15585875   PMID:15607729   PMID:15850576   PMID:15944269   PMID:16034109   PMID:16081786   PMID:16141072  
PMID:16141073   PMID:16493033   PMID:16751375   PMID:16906166   PMID:16906167   PMID:16979593   PMID:17015723   PMID:17114427   PMID:17227910   PMID:17549733   PMID:17609432   PMID:17675254  
PMID:17709543   PMID:17961512   PMID:17994022   PMID:17994023   PMID:18086375   PMID:18096999   PMID:18156621   PMID:18178832   PMID:18292228   PMID:18292493   PMID:18292512   PMID:18336386  
PMID:18453571   PMID:18931971   PMID:19060371   PMID:19299021   PMID:19380822   PMID:19446579   PMID:19549909   PMID:19570826   PMID:19596985   PMID:19608294   PMID:19668220   PMID:19740343  
PMID:19748991   PMID:19933857   PMID:20083668   PMID:20139275   PMID:20360853   PMID:20468050   PMID:20534530   PMID:20952070   PMID:20974977   PMID:21041726   PMID:21057510   PMID:21098093  
PMID:21173106   PMID:21294722   PMID:21297642   PMID:21420486   PMID:21482740   PMID:21677750   PMID:21844391   PMID:21873635   PMID:21930967   PMID:22045869   PMID:22069308   PMID:22116827  
PMID:22205023   PMID:22479310   PMID:22491257   PMID:22508931   PMID:22678896   PMID:22790384   PMID:22825627   PMID:22837488   PMID:22925810   PMID:22927332   PMID:22936807   PMID:22951728  
PMID:23029250   PMID:23091017   PMID:23125412   PMID:23175475   PMID:23209286   PMID:23225163   PMID:23335749   PMID:23390294   PMID:23455508   PMID:23464355   PMID:23522926   PMID:23554861  
PMID:23583238   PMID:23593003   PMID:23630250   PMID:23733881   PMID:23904441   PMID:24021664   PMID:24129161   PMID:24337375   PMID:24434636   PMID:24443555   PMID:24604832   PMID:24700119  
PMID:24809349   PMID:24890725   PMID:25088998   PMID:25092334   PMID:25187652   PMID:25267651   PMID:25268627   PMID:25614966   PMID:25651926   PMID:25658840   PMID:25888222   PMID:26013006  
PMID:26142823   PMID:26176652   PMID:26222157   PMID:26347474   PMID:26638127   PMID:26900987   PMID:26979394   PMID:26982595   PMID:26991425   PMID:27259855   PMID:27469302   PMID:27488350  
PMID:27525353   PMID:27579860   PMID:27619997   PMID:27721424   PMID:27799314   PMID:27881708   PMID:28062696   PMID:28129374   PMID:28132857   PMID:28377398   PMID:28508429   PMID:28685820  
PMID:28758191   PMID:28835457   PMID:28874534   PMID:28928459   PMID:28953978   PMID:29021521   PMID:29167232   PMID:29218601   PMID:29354801   PMID:29487200   PMID:29500240   PMID:30037367  
PMID:30038376   PMID:30044874   PMID:30483251   PMID:30515838   PMID:30541887   PMID:30575117   PMID:30700587   PMID:30718407   PMID:30880234   PMID:30899058   PMID:30944247   PMID:31164392  
PMID:31216373   PMID:31366386   PMID:31426028   PMID:31634628   PMID:31786500   PMID:31801074   PMID:31871021   PMID:31991091   PMID:32849596   PMID:33049000   PMID:33381604   PMID:33593983  
PMID:33863788   PMID:34003734   PMID:34108491   PMID:34234781   PMID:34554189   PMID:34559883   PMID:34819664   PMID:35022243   PMID:35064029   PMID:35258318   PMID:35436657   PMID:35695698  
PMID:35973751   PMID:36064575   PMID:36109504  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397126,188,181 - 126,194,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)EnsemblGRCm39 Ensembl
GRCm387126,589,009 - 126,595,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,732,809 - 133,738,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,380,443 - 126,386,058 (-)NCBIMGSCv36mm8
Celera7126,438,423 - 126,444,039 (-)NCBICelera
Cytogenetic Map7F3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381628,499,362 - 28,506,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1628,499,362 - 28,512,051 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,510,683 - 28,518,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,418,184 - 28,425,656 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,418,472 - 28,425,633NCBI
Celera1627,685,614 - 27,693,084 (+)NCBICelera
Cytogenetic Map16p12.1-p11.2NCBI
HuRef1626,536,601 - 26,544,073 (-)NCBIHuRef
CHM1_11629,522,293 - 29,529,765 (-)NCBICHM1_1
T2T-CHM13v2.01628,888,944 - 28,896,415 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21181,173,108 - 181,178,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,173,372 - 181,178,582 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01198,003,615 - 198,010,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,003,683 - 198,008,893 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,981,789 - 204,987,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,730,394 - 185,735,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,831,320 - 178,837,817 (-)NCBICelera
Cytogenetic Map1q36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554936,712,005 - 6,717,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,712,005 - 6,717,417 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11628,979,717 - 28,984,655 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1618,243,988 - 18,248,369 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,244,040 - 18,247,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,822,685 - 19,827,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,380,027 - 18,384,391 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,380,086 - 18,384,093 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,179,035 - 18,183,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,094,139 - 18,098,496 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,410,212 - 18,414,571 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344123,875,494 - 123,879,941 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,973,385 - 11,976,583 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493650111,972,715 - 11,978,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl318,421,981 - 18,427,915 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,421,962 - 18,427,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1526,348,559 - 26,358,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,348,848 - 26,356,360 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,217,584 - 3,222,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478213,009,564 - 13,015,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,009,450 - 13,015,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:132
Interacting mature miRNAs:142
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124299223126899172Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387126,588,804 - 126,589,030UniSTSGRCm38
MGSCv377133,732,318 - 133,732,544UniSTSGRCm37
Celera7126,437,932 - 126,438,158UniSTS
Cytogenetic Map7F3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17DUniSTS
Cytogenetic Map7F3UniSTS
cM Map1729.08UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17DUniSTS
Cytogenetic Map7F3UniSTS
cM Map769.18UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000058429   ⟹   ENSMUSP00000054637
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)Ensembl
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)Ensembl
RefSeq Acc Id: NM_145636   ⟹   NP_663611
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm397126,188,181 - 126,194,194 (-)NCBI
GRCm387126,589,009 - 126,595,022 (-)NCBI
MGSCv377133,732,809 - 133,738,424 (-)RGD
Celera7126,438,423 - 126,444,039 (-)RGD
RefSeq Acc Id: XM_006507857   ⟹   XP_006507920
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,188,181 - 126,194,197 (-)NCBI
GRCm387126,589,009 - 126,595,035 (-)NCBI
RefSeq Acc Id: XM_036153130   ⟹   XP_036009023
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,188,181 - 126,192,033 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_663611   ⟸   NM_145636
- Peptide Label: precursor
- UniProtKB: Q8K3I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006507920   ⟸   XM_006507857
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000054637   ⟸   ENSMUST00000058429
RefSeq Acc Id: XP_036009023   ⟸   XM_036153130
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3I6-F1-model_v2 AlphaFold Q8K3I6 1-234 view protein structure

RGD ID:8665559
Promoter ID:EPDNEW_M10811
Type:multiple initiation site
Description:Mus musculus interleukin 27 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm387126,594,931 - 126,594,991EPDNEW
RGD ID:6841329
Promoter ID:MM_KWN:52685
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Mouse AssemblyChrPosition (strand)Source
MGSCv367133,738,331 - 133,738,831 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384409 AgrOrtholog
Ensembl Genes ENSMUSG00000044701 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000054637 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058429 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-27_alpha UniProtKB/Swiss-Prot
KEGG Report mmu:246779 UniProtKB/Swiss-Prot
PANTHER PTHR20879 UniProtKB/Swiss-Prot
PhenoGen Il27 PhenoGen
UniProt IL27A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE