1. |
IL-27 enhances Leishmania amazonensis infection via ds-RNA dependent kinase (PKR) and IL-10 signaling. |
Barreto-de-Souza V, etal., Immunobiology. 2015 Apr;220(4):437-44. doi: 10.1016/j.imbio.2014.11.006. Epub 2014 Nov 15.
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2. |
Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. |
Cao J, etal., EMBO Mol Med. 2014 Jan;6(1):120-40. doi: 10.1002/emmm.201302890.
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3. |
IL-27 controls sepsis-induced impairment of lung antibacterial host defence. |
Cao J, etal., Thorax. 2014 Oct;69(10):926-37. doi: 10.1136/thoraxjnl-2014-205777. Epub 2014 Jul 29.
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4. |
Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. |
Chae SC, etal., J Hum Genet. 2007;52(4):355-61. Epub 2007 Feb 22.
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5. |
Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. |
Clement M, etal., PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.
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6. |
A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. |
Dibra D, etal., PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
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7. |
Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients. |
Fawzy MM, etal., Asian Pac J Cancer Prev. 2016;17(4):2093-7. doi: 10.7314/apjcp.2016.17.4.2093.
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8. |
Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. |
Fazalul Rahiman SS, etal., Trop Biomed. 2013 Dec;30(4):663-80.
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9. |
Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. |
Fujita H, etal., J Immunol. 2009 Jul 1;183(1):254-60.
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10. |
Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4. |
Garg A, etal., Sci Rep. 2017 Mar 24;7:44485. doi: 10.1038/srep44485.
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11. |
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. |
Hall AO, etal.
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12. |
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. |
Harker JA, etal., J Virol. 2018 May 29;92(12). pii: JVI.02196-17. doi: 10.1128/JVI.02196-17. Print 2018 Jun 15.
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13. |
Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population. |
He C and Liu J, Int J Clin Exp Pathol. 2018 Aug 1;11(8):4147-4152. eCollection 2018.
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14. |
The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis. |
He J, etal., Crit Care. 2018 Sep 30;22(1):248. doi: 10.1186/s13054-018-2180-0.
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15. |
Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese. |
He L, etal., PLoS One. 2014 May 9;9(5):e96792. doi: 10.1371/journal.pone.0096792. eCollection 2014.
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16. |
Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. |
Hirase T, etal., Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
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17. |
Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. |
Huang M, etal., Mediators Inflamm. 2016;2016:4025167. doi: 10.1155/2016/4025167. Epub 2016 Jun 15.
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18. |
Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. |
Huang N, etal., DNA Cell Biol. 2008 Sep;27(9):527-31.
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19. |
Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor. |
Jafarzadeh A, etal., J Dig Dis. 2011 Aug;12(4):302-7. doi: 10.1111/j.1751-2980.2011.00510.x.
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20. |
Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in naïve hepatitis B infection patients. |
Kao JT, etal., Liver Int. 2012 Jul;32(6):928-36. doi: 10.1111/j.1478-3231.2011.02742.x. Epub 2012 Jan 9.
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21. |
Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection. |
Kimura D, etal., Immunity. 2016 Mar 15;44(3):672-82. doi: 10.1016/j.immuni.2016.02.011. Epub 2016 Mar 8.
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22. |
IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. |
Li JJ, etal., J Immunol. 2010 Oct 1;185(7):4401-9. Epub 2010 Sep 3.
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23. |
Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis. |
Lin S, etal., Infect Drug Resist. 2019 Dec 2;12:3755-3763. doi: 10.2147/IDR.S231215. eCollection 2019.
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24. |
Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. |
Liu L, etal., J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
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25. |
Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome. |
Lucchesi D, etal., Arthritis Rheumatol. 2020 Sep;72(9):1559-1570. doi: 10.1002/art.41289. Epub 2020 Jul 21.
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26. |
Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. |
Mohammadnejad L, etal., Arch Razi Inst. 2021 Jan;75(4):491-500. doi: 10.22092/ari.2019.126151.1333. Epub 2021 Jan 1.
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27. |
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. |
Moro K, etal., Nat Immunol. 2016 Jan;17(1):76-86. doi: 10.1038/ni.3309. Epub 2015 Nov 23.
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28. |
Interleukin-27 expression following infection with the murine gammaherpesvirus 68. |
Nelson DA, etal., Cytokine. 2010 Aug;51(2):184-94. doi: 10.1016/j.cyto.2010.04.015. Epub 2010 May 20.
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29. |
The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. |
O'Dwyer MJ, etal., Intensive Care Med. 2008 Apr;34(4):683-91. doi: 10.1007/s00134-007-0968-5. Epub 2008 Jan 29.
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30. |
Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27. |
Pan L, etal., Rheumatology (Oxford). 2020 Dec 6. pii: 6024785. doi: 10.1093/rheumatology/keaa752.
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31. |
Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. |
Park J, etal., Infect Immun. 2019 Nov 18;87(12). pii: IAI.00455-19. doi: 10.1128/IAI.00455-19. Print 2019 Dec.
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32. |
Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. |
Pinto MT, etal., AIDS Res Hum Retroviruses. 2014 Jun;30(6):610-22. doi: 10.1089/aid.2013.0109. Epub 2013 Oct 16.
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33. |
PID Annotation Import Pipeline |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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34. |
Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response. |
Quirino GFS, etal., Infect Immun. 2016 Jul 21;84(8):2289-2298. doi: 10.1128/IAI.00283-16. Print 2016 Aug.
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35. |
Mouse MP Annotation Import Pipeline |
RGD automated import pipeline
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36. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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37. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
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38. |
Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. |
Rinchai D, etal., Eur J Immunol. 2012 Dec;42(12):3280-90. doi: 10.1002/eji.201242526. Epub 2012 Oct 25.
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39. |
Interleukin-27 is abrogated in gastric cancer, but highly expressed in other Helicobacter pylori-associated gastroduodenal diseases. |
Rocha GA, etal., Helicobacter. 2020 Feb;25(1):e12667. doi: 10.1111/hel.12667. Epub 2019 Nov 8.
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40. |
Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis. |
Seman BG, etal., Infect Immun. 2020 Feb 20;88(3). pii: IAI.00828-19. doi: 10.1128/IAI.00828-19. Print 2020 Feb 20.
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41. |
Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. |
Skouras VS, etal., Infect Dis (Lond). 2015 Jul;47(7):477-83. doi: 10.3109/23744235.2015.1019919. Epub 2015 Mar 10.
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42. |
[Diagnostic value of interleukin-27 in tuberculous pleural effusion]. |
Sun M, etal., Zhonghua Yi Xue Za Zhi. 2014 Sep 16;94(34):2641-4.
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43. |
IL-27 Suppresses Antimicrobial Activity in Human Leprosy. |
Teles RMB, etal., J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.
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44. |
Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. |
Tong X, etal., Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19.
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45. |
Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis. |
Urazova OI, etal., Tuberculosis (Edinb). 2019 Mar;115:56-62. doi: 10.1016/j.tube.2019.02.003. Epub 2019 Feb 6.
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46. |
Interleukin 27 could be useful in the diagnosis of tuberculous pleural effusions. |
Valdés L, etal., Respir Care. 2014 Mar;59(3):399-405. doi: 10.4187/respcare.02749. Epub 2013 Aug 20.
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47. |
Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. |
Vultaggio A, etal., J Immunol. 2009 Jan 15;182(2):880-9.
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48. |
The correlation between hepatitis B virus infection and IL-27. |
Wang HL, etal., Biomed Mater Eng. 2012;22(1-3):187-93. doi: 10.3233/BME-2012-0706.
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49. |
IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis. |
Wang L, etal., J Infect Dis. 2018 Jan 4;217(2):198-207. doi: 10.1093/infdis/jix581.
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50. |
Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. |
Wang W, etal., Thorax. 2018 Mar;73(3):240-247. doi: 10.1136/thoraxjnl-2016-209718. Epub 2017 Aug 26.
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51. |
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. |
Wirtz S, etal., J Exp Med. 2006 Aug 7;203(8):1875-81. doi: 10.1084/jem.20060471. Epub 2006 Jul 31.
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52. |
Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. |
Yan J, etal., J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.
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53. |
IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. |
Yoshimoto T, etal., J Immunol. 2007 Oct 1;179(7):4415-23.
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54. |
Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. |
Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
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55. |
Association of the Interleukin-27 Gene Expression and Hepatitis B Virus Infection in Liver Transplanted Patients. |
Zare A, etal., Exp Clin Transplant. 2017 Oct;15(5):554-560. doi: 10.6002/ect.2015.0243. Epub 2016 Feb 26.
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56. |
Comparison of the interleukin 27 expression for the acute and chronic phase of mononucleosis in children. |
Zelazowska-Rutkowska B, etal., Cytokine. 2021 May;141:155395. doi: 10.1016/j.cyto.2020.155395. Epub 2021 Feb 8.
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57. |
Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. |
Zeng R, etal., J Virol. 2012 Apr;86(8):4505-17. doi: 10.1128/JVI.07091-11. Epub 2012 Feb 1.
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58. |
Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. |
Zhang GL, etal., J Immunol Res. 2019 May 6;2019:1538439. doi: 10.1155/2019/1538439. eCollection 2019.
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59. |
High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV. |
Zhang GL, etal., Liver Int. 2014 Feb;34(2):266-73. doi: 10.1111/liv.12268. Epub 2013 Jul 25.
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60. |
Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. |
Zhang J, etal., J Biol Chem. 2010 Jul 9;285(28):21269-81. doi: 10.1074/jbc.M110.100818. Epub 2010 Apr 30.
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61. |
Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. |
Zhu C, etal., Clin Immunol. 2009 Apr;131(1):92-7. doi: 10.1016/j.clim.2008.10.011. Epub 2008 Dec 9.
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62. |
Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. |
Zhu H, etal., Virol J. 2015 Nov 14;12:189. doi: 10.1186/s12985-015-0418-x.
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