Il27 (interleukin 27) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Il27 (interleukin 27) Mus musculus
Analyze
Symbol: Il27
Name: interleukin 27
RGD ID: 1615620
MGI Page MGI
Description: Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il; IL-; IL-27; IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL-27p28; IL27-A; Il30; interleukin 30; interleukin-27 subunit alpha; p2; p28
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,188,181 - 126,194,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387126,589,009 - 126,595,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)Ensemblmm10GRCm38
MGSCv377133,732,809 - 133,738,424 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367126,380,443 - 126,386,058 (-)NCBIMGSCv36mm8
Celera7126,438,423 - 126,444,039 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.18NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytosol  (IEA,TAS)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IL-27 enhances Leishmania amazonensis infection via ds-RNA dependent kinase (PKR) and IL-10 signaling. Barreto-de-Souza V, etal., Immunobiology. 2015 Apr;220(4):437-44. doi: 10.1016/j.imbio.2014.11.006. Epub 2014 Nov 15.
2. Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. Cao J, etal., EMBO Mol Med. 2014 Jan;6(1):120-40. doi: 10.1002/emmm.201302890.
3. IL-27 controls sepsis-induced impairment of lung antibacterial host defence. Cao J, etal., Thorax. 2014 Oct;69(10):926-37. doi: 10.1136/thoraxjnl-2014-205777. Epub 2014 Jul 29.
4. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. Chae SC, etal., J Hum Genet. 2007;52(4):355-61. Epub 2007 Feb 22.
5. Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence. Clement M, etal., PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.
6. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. Dibra D, etal., PLoS One. 2018 Mar 1;13(3):e0193485. doi: 10.1371/journal.pone.0193485. eCollection 2018.
7. Association of Interleukin-27 rs 153109 Single Nucleotide Polymorphism with Spontaneous Resolution of Hepatitis C Virus - Genotype 4a Infection in Egyptian Patients. Fawzy MM, etal., Asian Pac J Cancer Prev. 2016;17(4):2093-7. doi: 10.7314/apjcp.2016.17.4.2093.
8. Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. Fazalul Rahiman SS, etal., Trop Biomed. 2013 Dec;30(4):663-80.
9. Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model. Fujita H, etal., J Immunol. 2009 Jul 1;183(1):254-60.
10. Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4. Garg A, etal., Sci Rep. 2017 Mar 24;7:44485. doi: 10.1038/srep44485.
11. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Hall AO, etal.
12. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. Harker JA, etal., J Virol. 2018 May 29;92(12). pii: JVI.02196-17. doi: 10.1128/JVI.02196-17. Print 2018 Jun 15.
13. Relationship of IL27 gene polymorphisms with the risk of pulmonary tuberculosis in Chinese Han population. He C and Liu J, Int J Clin Exp Pathol. 2018 Aug 1;11(8):4147-4152. eCollection 2018.
14. The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis. He J, etal., Crit Care. 2018 Sep 30;22(1):248. doi: 10.1186/s13054-018-2180-0.
15. Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese. He L, etal., PLoS One. 2014 May 9;9(5):e96792. doi: 10.1371/journal.pone.0096792. eCollection 2014.
16. Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. Hirase T, etal., Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
17. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Huang M, etal., Mediators Inflamm. 2016;2016:4025167. doi: 10.1155/2016/4025167. Epub 2016 Jun 15.
18. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. Huang N, etal., DNA Cell Biol. 2008 Sep;27(9):527-31.
19. Circulating interleukin-27 levels in Helicobacter pylori-infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin-associated gene A virulence factor. Jafarzadeh A, etal., J Dig Dis. 2011 Aug;12(4):302-7. doi: 10.1111/j.1751-2980.2011.00510.x.
20. Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in naïve hepatitis B infection patients. Kao JT, etal., Liver Int. 2012 Jul;32(6):928-36. doi: 10.1111/j.1478-3231.2011.02742.x. Epub 2012 Jan 9.
21. Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection. Kimura D, etal., Immunity. 2016 Mar 15;44(3):672-82. doi: 10.1016/j.immuni.2016.02.011. Epub 2016 Mar 8.
22. IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Li JJ, etal., J Immunol. 2010 Oct 1;185(7):4401-9. Epub 2010 Sep 3.
23. Diagnostic Accuracy of Interleukin-27 in Bronchoalveolar Lavage Fluids for Pulmonary Tuberculosis. Lin S, etal., Infect Drug Resist. 2019 Dec 2;12:3755-3763. doi: 10.2147/IDR.S231215. eCollection 2019.
24. Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. Liu L, etal., J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
25. Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome. Lucchesi D, etal., Arthritis Rheumatol. 2020 Sep;72(9):1559-1570. doi: 10.1002/art.41289. Epub 2020 Jul 21.
26. Anti-inflammatory Activity of Caspian Cobra (Naja naja oxiana) Snake Venom on the Serum Level of Interleukin-27 and Histopathological Changes in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitisinduced Mice. Mohammadnejad L, etal., Arch Razi Inst. 2021 Jan;75(4):491-500. doi: 10.22092/ari.2019.126151.1333. Epub 2021 Jan 1.
27. Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Moro K, etal., Nat Immunol. 2016 Jan;17(1):76-86. doi: 10.1038/ni.3309. Epub 2015 Nov 23.
28. Interleukin-27 expression following infection with the murine gammaherpesvirus 68. Nelson DA, etal., Cytokine. 2010 Aug;51(2):184-94. doi: 10.1016/j.cyto.2010.04.015. Epub 2010 May 20.
29. The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. O'Dwyer MJ, etal., Intensive Care Med. 2008 Apr;34(4):683-91. doi: 10.1007/s00134-007-0968-5. Epub 2008 Jan 29.
30. Deficiency in the frequency and function of Tr1 cells in IgAV and the possible role of IL-27. Pan L, etal., Rheumatology (Oxford). 2020 Dec 6. pii: 6024785. doi: 10.1093/rheumatology/keaa752.
31. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Park J, etal., Infect Immun. 2019 Nov 18;87(12). pii: IAI.00455-19. doi: 10.1128/IAI.00455-19. Print 2019 Dec.
32. Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. Pinto MT, etal., AIDS Res Hum Retroviruses. 2014 Jun;30(6):610-22. doi: 10.1089/aid.2013.0109. Epub 2013 Oct 16.
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response. Quirino GFS, etal., Infect Immun. 2016 Jul 21;84(8):2289-2298. doi: 10.1128/IAI.00283-16. Print 2016 Aug.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Rinchai D, etal., Eur J Immunol. 2012 Dec;42(12):3280-90. doi: 10.1002/eji.201242526. Epub 2012 Oct 25.
39. Interleukin-27 is abrogated in gastric cancer, but highly expressed in other Helicobacter pylori-associated gastroduodenal diseases. Rocha GA, etal., Helicobacter. 2020 Feb;25(1):e12667. doi: 10.1111/hel.12667. Epub 2019 Nov 8.
40. Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis. Seman BG, etal., Infect Immun. 2020 Feb 20;88(3). pii: IAI.00828-19. doi: 10.1128/IAI.00828-19. Print 2020 Feb 20.
41. Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. Skouras VS, etal., Infect Dis (Lond). 2015 Jul;47(7):477-83. doi: 10.3109/23744235.2015.1019919. Epub 2015 Mar 10.
42. [Diagnostic value of interleukin-27 in tuberculous pleural effusion]. Sun M, etal., Zhonghua Yi Xue Za Zhi. 2014 Sep 16;94(34):2641-4.
43. IL-27 Suppresses Antimicrobial Activity in Human Leprosy. Teles RMB, etal., J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.
44. Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis. Tong X, etal., Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19.
45. Association between polymorphisms of cytokine genes and secretion of IL-12p70, IL-18, and IL-27 by dendritic cells in patients with pulmonary tuberculosis. Urazova OI, etal., Tuberculosis (Edinb). 2019 Mar;115:56-62. doi: 10.1016/j.tube.2019.02.003. Epub 2019 Feb 6.
46. Interleukin 27 could be useful in the diagnosis of tuberculous pleural effusions. Valdés L, etal., Respir Care. 2014 Mar;59(3):399-405. doi: 10.4187/respcare.02749. Epub 2013 Aug 20.
47. Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7. Vultaggio A, etal., J Immunol. 2009 Jan 15;182(2):880-9.
48. The correlation between hepatitis B virus infection and IL-27. Wang HL, etal., Biomed Mater Eng. 2012;22(1-3):187-93. doi: 10.3233/BME-2012-0706.
49. IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis. Wang L, etal., J Infect Dis. 2018 Jan 4;217(2):198-207. doi: 10.1093/infdis/jix581.
50. Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. Wang W, etal., Thorax. 2018 Mar;73(3):240-247. doi: 10.1136/thoraxjnl-2016-209718. Epub 2017 Aug 26.
51. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. Wirtz S, etal., J Exp Med. 2006 Aug 7;203(8):1875-81. doi: 10.1084/jem.20060471. Epub 2006 Jul 31.
52. Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Yan J, etal., J Hepatol. 2016 May;64(5):1128-1136. doi: 10.1016/j.jhep.2015.12.020. Epub 2016 Jan 6.
53. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. Yoshimoto T, etal., J Immunol. 2007 Oct 1;179(7):4415-23.
54. Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation. Yoshizaki A, etal., Ann Rheum Dis. 2011 Jan;70(1):194-200. Epub 2010 Aug 12.
55. Association of the Interleukin-27 Gene Expression and Hepatitis B Virus Infection in Liver Transplanted Patients. Zare A, etal., Exp Clin Transplant. 2017 Oct;15(5):554-560. doi: 10.6002/ect.2015.0243. Epub 2016 Feb 26.
56. Comparison of the interleukin 27 expression for the acute and chronic phase of mononucleosis in children. Zelazowska-Rutkowska B, etal., Cytokine. 2021 May;141:155395. doi: 10.1016/j.cyto.2020.155395. Epub 2021 Feb 8.
57. Interleukin-27 inhibits vaccine-enhanced pulmonary disease following respiratory syncytial virus infection by regulating cellular memory responses. Zeng R, etal., J Virol. 2012 Apr;86(8):4505-17. doi: 10.1128/JVI.07091-11. Epub 2012 Feb 1.
58. Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure. Zhang GL, etal., J Immunol Res. 2019 May 6;2019:1538439. doi: 10.1155/2019/1538439. eCollection 2019.
59. High level of IL-27 positively correlated with Th17 cells may indicate liver injury in patients infected with HBV. Zhang GL, etal., Liver Int. 2014 Feb;34(2):266-73. doi: 10.1111/liv.12268. Epub 2013 Jul 25.
60. Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. Zhang J, etal., J Biol Chem. 2010 Jul 9;285(28):21269-81. doi: 10.1074/jbc.M110.100818. Epub 2010 Apr 30.
61. Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Zhu C, etal., Clin Immunol. 2009 Apr;131(1):92-7. doi: 10.1016/j.clim.2008.10.011. Epub 2008 Dec 9.
62. Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. Zhu H, etal., Virol J. 2015 Nov 14;12:189. doi: 10.1186/s12985-015-0418-x.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12121660   PMID:12466851   PMID:12477932   PMID:12646495   PMID:12734330   PMID:14610273   PMID:14657353   PMID:15253382  
PMID:15294962   PMID:15308705   PMID:15356135   PMID:15528388   PMID:15585838   PMID:15585875   PMID:15607729   PMID:15850576   PMID:15944269   PMID:16034109   PMID:16081786   PMID:16141072  
PMID:16141073   PMID:16493033   PMID:16751375   PMID:16906166   PMID:16906167   PMID:16979593   PMID:17015723   PMID:17114427   PMID:17227910   PMID:17549733   PMID:17609432   PMID:17675254  
PMID:17709543   PMID:17961512   PMID:17994022   PMID:17994023   PMID:18086375   PMID:18096999   PMID:18156621   PMID:18178832   PMID:18292228   PMID:18292493   PMID:18292512   PMID:18336386  
PMID:18453571   PMID:18931971   PMID:19060371   PMID:19299021   PMID:19380822   PMID:19446579   PMID:19549909   PMID:19570826   PMID:19596985   PMID:19608294   PMID:19668220   PMID:19740343  
PMID:19748991   PMID:19933857   PMID:20083668   PMID:20139275   PMID:20360853   PMID:20468050   PMID:20534530   PMID:20952070   PMID:20974977   PMID:21041726   PMID:21057510   PMID:21098093  
PMID:21173106   PMID:21294722   PMID:21297642   PMID:21420486   PMID:21482740   PMID:21677750   PMID:21844391   PMID:21873635   PMID:21930967   PMID:22045869   PMID:22069308   PMID:22116827  
PMID:22205023   PMID:22479310   PMID:22491257   PMID:22508931   PMID:22678896   PMID:22790384   PMID:22825627   PMID:22837488   PMID:22925810   PMID:22927332   PMID:22936807   PMID:22951728  
PMID:23029250   PMID:23091017   PMID:23125412   PMID:23175475   PMID:23209286   PMID:23225163   PMID:23335749   PMID:23390294   PMID:23455508   PMID:23464355   PMID:23522926   PMID:23554861  
PMID:23583238   PMID:23593003   PMID:23630250   PMID:23733881   PMID:23904441   PMID:24021664   PMID:24129161   PMID:24337375   PMID:24434636   PMID:24443555   PMID:24604832   PMID:24700119  
PMID:24809349   PMID:24890725   PMID:25088998   PMID:25092334   PMID:25187652   PMID:25267651   PMID:25268627   PMID:25614966   PMID:25651926   PMID:25658840   PMID:25888222   PMID:26013006  
PMID:26142823   PMID:26176652   PMID:26222157   PMID:26347474   PMID:26638127   PMID:26900987   PMID:26979394   PMID:26982595   PMID:26991425   PMID:27259855   PMID:27469302   PMID:27488350  
PMID:27525353   PMID:27579860   PMID:27619997   PMID:27721424   PMID:27799314   PMID:27881708   PMID:28062696   PMID:28129374   PMID:28132857   PMID:28377398   PMID:28508429   PMID:28685820  
PMID:28758191   PMID:28835457   PMID:28874534   PMID:28928459   PMID:28953978   PMID:29021521   PMID:29167232   PMID:29218601   PMID:29354801   PMID:29487200   PMID:29500240   PMID:30037367  
PMID:30038376   PMID:30044874   PMID:30483251   PMID:30515838   PMID:30541887   PMID:30575117   PMID:30700587   PMID:30718407   PMID:30880234   PMID:30899058   PMID:30944247   PMID:31164392  
PMID:31216373   PMID:31366386   PMID:31426028   PMID:31634628   PMID:31786500   PMID:31801074   PMID:31871021   PMID:31991091   PMID:32849596   PMID:33049000   PMID:33381604   PMID:33593983  
PMID:33863788   PMID:34003734   PMID:34108491   PMID:34234781   PMID:34554189   PMID:34559883   PMID:34819664   PMID:35022243   PMID:35064029   PMID:35258318   PMID:35436657   PMID:35695698  
PMID:35973751   PMID:36064575   PMID:36109504   PMID:36405994   PMID:36515659   PMID:36725904   PMID:36762954   PMID:36860682   PMID:36868324   PMID:36869378   PMID:36891292   PMID:36927528  
PMID:37153622   PMID:37345470   PMID:37636037   PMID:37725438   PMID:37756334   PMID:37756640   PMID:37855243   PMID:37932457   PMID:37944428   PMID:37948192   PMID:38085267   PMID:38117410  
PMID:38224627   PMID:38355793   PMID:38360199   PMID:38376210   PMID:38390338   PMID:39171524   PMID:39276693   PMID:39365874  


Genomics

Comparative Map Data
Il27
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,188,181 - 126,194,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387126,589,009 - 126,595,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)Ensemblmm10GRCm38
MGSCv377133,732,809 - 133,738,424 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367126,380,443 - 126,386,058 (-)NCBIMGSCv36mm8
Celera7126,438,423 - 126,444,039 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.18NCBI
IL27
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,499,362 - 28,506,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,499,362 - 28,512,051 (-)Ensemblhg38GRCh38
GRCh371628,510,683 - 28,518,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,418,184 - 28,425,656 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341628,418,472 - 28,425,633NCBI
Celera1627,685,614 - 27,693,084 (+)NCBICelera
Cytogenetic Map16p12.1-p11.2NCBI
HuRef1626,536,601 - 26,544,073 (-)NCBIHuRef
CHM1_11629,522,293 - 29,529,765 (-)NCBICHM1_1
T2T-CHM13v2.01628,869,090 - 28,896,415 (+)NCBIT2T-CHM13v2.0
Il27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,603,684 - 190,609,292 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,603,522 - 190,609,258 (-)EnsemblGRCr8
mRatBN7.21181,173,108 - 181,178,720 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,173,372 - 181,178,582 (-)EnsemblmRatBN7.2
Rnor_6.01198,003,615 - 198,010,112 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,003,683 - 198,008,893 (-)Ensemblrn6Rnor6.0
Rnor_5.01204,981,789 - 204,987,782 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41185,730,394 - 185,735,604 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1178,831,320 - 178,837,817 (-)NCBICelera
Cytogenetic Map1q36NCBI
Il27
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,712,005 - 6,717,417 (-)Ensembl
ChiLan1.0NW_0049554936,712,005 - 6,717,417 (-)NCBIChiLan1.0ChiLan1.0
IL27
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,104,366 - 31,111,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11634,982,084 - 34,989,328 (+)NCBINHGRI_mPanPan1
PanPan1.11628,979,717 - 28,984,655 (-)NCBIPanPan1.1PanPan1.1panPan2
IL27
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,243,988 - 18,248,369 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,244,040 - 18,247,635 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha619,822,685 - 19,827,046 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0618,380,027 - 18,384,391 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,380,086 - 18,384,093 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,179,035 - 18,183,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,094,139 - 18,098,496 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,410,212 - 18,414,571 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,875,494 - 123,879,941 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,973,385 - 11,976,583 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,972,715 - 11,978,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL27
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,421,981 - 18,427,915 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1318,421,962 - 18,427,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL27
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,348,559 - 26,358,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,348,848 - 26,356,360 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660683,217,584 - 3,222,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il27
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,009,564 - 13,015,440 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478213,009,450 - 13,015,548 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Il27
240 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:132
Interacting mature miRNAs:142
Transcripts:ENSMUST00000058429
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
38501066Tip2_mtuberculosis immunophenotype 2, spleen CFU (mouse)7124299223126899172Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse

Markers in Region
UniSTS:235779  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387126,588,804 - 126,589,030UniSTSGRCm38
MGSCv377133,732,318 - 133,732,544UniSTSGRCm37
Celera7126,437,932 - 126,438,158UniSTS
Cytogenetic Map7F3UniSTS
Ebi3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17DUniSTS
Cytogenetic Map7F3UniSTS
cM Map1729.08UniSTS
Il27  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17DUniSTS
Cytogenetic Map7F3UniSTS
cM Map769.18UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000058429   ⟹   ENSMUSP00000054637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7126,188,182 - 126,194,113 (-)Ensembl
GRCm38.p6 Ensembl7126,589,010 - 126,594,941 (-)Ensembl
RefSeq Acc Id: NM_145636   ⟹   NP_663611
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,188,181 - 126,194,194 (-)NCBI
GRCm387126,589,009 - 126,595,022 (-)NCBI
MGSCv377133,732,809 - 133,738,424 (-)RGD
Celera7126,438,423 - 126,444,039 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006507857   ⟹   XP_006507920
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,188,181 - 126,194,197 (-)NCBI
GRCm387126,589,009 - 126,595,035 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153130   ⟹   XP_036009023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397126,188,181 - 126,192,033 (-)NCBI
Sequence:
RefSeq Acc Id: NP_663611   ⟸   NM_145636
- Peptide Label: precursor
- UniProtKB: Q8K3I6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006507920   ⟸   XM_006507857
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000054637   ⟸   ENSMUST00000058429
RefSeq Acc Id: XP_036009023   ⟸   XM_036153130
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3I6-F1-model_v2 AlphaFold Q8K3I6 1-234 view protein structure

Promoters
RGD ID:8665559
Promoter ID:EPDNEW_M10811
Type:multiple initiation site
Name:Il27_1
Description:Mus musculus interleukin 27 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387126,594,931 - 126,594,991EPDNEW
RGD ID:6841329
Promoter ID:MM_KWN:52685
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000072967
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367133,738,331 - 133,738,831 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384409 AgrOrtholog
Ensembl Genes ENSMUSG00000044701 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058429 ENTREZGENE
  ENSMUST00000058429.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-27_alpha UniProtKB/Swiss-Prot
KEGG Report mmu:246779 UniProtKB/Swiss-Prot
MGD MGI:2384409 ENTREZGENE
NCBI Gene 246779 ENTREZGENE
PANTHER INTERLEUKIN-27 SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR20879 UniProtKB/Swiss-Prot
PhenoGen Il27 PhenoGen
UniProt IL27A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE