(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:621403 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of HEY1 mRNA CTD PMID:25729387 (S)-nicotine increases expression ISO RGD:735762 6480464 Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 1-naphthyl isothiocyanate decreases expression ISO RGD:621403 6480464 1-Naphthylisothiocyanate results in decreased expression of HEY1 mRNA CTD PMID:30723492 17beta-estradiol multiple interactions ISO RGD:735762 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNA CTD PMID:19619570 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of HEY1 mRNA CTD PMID:15598610 17beta-estradiol increases expression ISO RGD:735762 6480464 Estradiol results in increased expression of HEY1 mRNA CTD PMID:19619570 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:735762 6480464 Dihydrotestosterone results in increased expression of HEY1 mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of HEY1 mRNA CTD PMID:21570461 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735762 6480464 Tetrachlorodibenzodioxin results in increased expression of HEY1 mRNA CTD PMID:19619570 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735762 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNA CTD PMID:19619570 2-methylcholine affects expression ISO RGD:735762 6480464 beta-methylcholine affects the expression of HEY1 mRNA CTD PMID:21179406 4,4'-diaminodiphenylmethane decreases expression ISO RGD:621403 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of HEY1 mRNA CTD PMID:30723492 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of HEY1 mRNA CTD PMID:28973697 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide multiple interactions ISO RGD:621403 6480464 Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA] CTD PMID:28318631 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide multiple interactions ISO RGD:735762 6480464 Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] CTD PMID:27542212 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide multiple interactions EXP 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA] CTD PMID:28318631 aflatoxin B1 increases expression ISO RGD:735762 6480464 Aflatoxin B1 results in increased expression of HEY1 mRNA CTD PMID:22100608 all-trans-retinoic acid decreases expression ISO RGD:621403 6480464 Tretinoin results in decreased expression of HEY1 mRNA CTD PMID:20488242 all-trans-retinoic acid increases expression ISO RGD:735762 6480464 Tretinoin results in increased expression of HEY1 mRNA CTD PMID:21934132 , PMID:22906706 ammonium chloride affects expression ISO RGD:621403 6480464 Ammonium Chloride affects the expression of HEY1 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:735762 6480464 Antirheumatic Agents results in increased expression of HEY1 mRNA CTD PMID:24449571 Aroclor 1254 increases expression ISO RGD:735762 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of HEY1 mRNA CTD PMID:16934159 atrazine increases expression ISO RGD:735762 6480464 Atrazine results in increased expression of HEY1 mRNA CTD PMID:22378314 azathioprine increases expression ISO RGD:735762 6480464 Azathioprine results in increased expression of HEY1 mRNA CTD PMID:22623647 baicalein multiple interactions ISO RGD:735762 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA] CTD PMID:19160421 baicalein increases expression ISO RGD:735762 6480464 baicalein results in increased expression of HEY1 mRNA CTD PMID:19160421 baicalin increases expression ISO RGD:735762 6480464 baicalin results in increased expression of HEY1 mRNA CTD PMID:19160421 baicalin multiple interactions ISO RGD:735762 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA] CTD PMID:19160421 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of HEY1 mRNA CTD PMID:21569818 , PMID:22228805 benzo[a]pyrene increases expression ISO RGD:735762 6480464 Benzo(a)pyrene results in increased expression of HEY1 mRNA CTD PMID:26238291 benzo[b]fluoranthene decreases expression EXP 6480464 benzo(b)fluoranthene results in decreased expression of HEY1 mRNA CTD PMID:26377693 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of HEY1 mRNA CTD PMID:15674844 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:735762 6480464 Diethylhexyl Phthalate results in decreased expression of HEY1 mRNA CTD PMID:28412506 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:621403 6480464 Diethylhexyl Phthalate results in decreased expression of HEY1 mRNA CTD PMID:26472102 bisphenol A decreases expression ISO RGD:621403 6480464 bisphenol A results in decreased expression of HEY1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:621403 6480464 bisphenol A results in increased expression of HEY1 mRNA, bisphenol A results in increased expression of HEY1 protein CTD PMID:29438945 bisphenol A increases expression ISO RGD:735762 6480464 bisphenol A results in increased expression of HEY1 mRNA CTD PMID:29275510 butanal increases expression ISO RGD:735762 6480464 butyraldehyde results in increased expression of HEY1 mRNA CTD PMID:26079696 Butylbenzyl phthalate decreases expression ISO RGD:621403 6480464 butylbenzyl phthalate results in decreased expression of HEY1 mRNA CTD PMID:26472102 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of HEY1 mRNA, Nanotubes, Carbon results in decreased expression of HEY1 mRNA CTD PMID:25554681 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HEY1 gene CTD PMID:20938992 cisplatin increases expression ISO RGD:735762 6480464 Cisplatin results in increased expression of HEY1 mRNA CTD PMID:19561079 cisplatin decreases expression ISO RGD:735762 6480464 Cisplatin results in decreased expression of HEY1 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:735762 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of HEY1 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:621403 6480464 cobaltous chloride results in decreased expression of HEY1 mRNA CTD PMID:24386269 copper atom increases expression ISO RGD:621403 6480464 Copper deficiency results in increased expression of HEY1 mRNA CTD PMID:26033743 copper atom multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of HEY1 mRNA CTD PMID:15467011 copper atom multiple interactions ISO RGD:735762 6480464 [NSC 689534 binds to Copper] which results in increased expression of HEY1 mRNA CTD PMID:20971185 copper(0) increases expression ISO RGD:621403 6480464 Copper deficiency results in increased expression of HEY1 mRNA CTD PMID:26033743 copper(0) multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of HEY1 mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:735762 6480464 [NSC 689534 binds to Copper] which results in increased expression of HEY1 mRNA CTD PMID:20971185 copper(2+) multiple interactions ISO RGD:735762 6480464 [NSC 689534 binds to Copper] which results in increased expression of HEY1 mRNA CTD PMID:20971185 copper(2+) increases expression ISO RGD:621403 6480464 Copper deficiency results in increased expression of HEY1 mRNA CTD PMID:26033743 copper(2+) multiple interactions EXP 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of HEY1 mRNA CTD PMID:15467011 copper(II) sulfate decreases expression ISO RGD:735762 6480464 Copper Sulfate results in decreased expression of HEY1 mRNA CTD PMID:19549813 crocidolite asbestos decreases expression ISO RGD:735762 6480464 Asbestos, Crocidolite results in decreased expression of HEY1 mRNA CTD PMID:25351596 CU-O LINKAGE increases expression ISO RGD:735762 6480464 cupric oxide results in increased expression of HEY1 mRNA CTD PMID:22077320 cyclosporin A increases expression ISO RGD:735762 6480464 Cyclosporine results in increased expression of HEY1 mRNA CTD PMID:20106945 more ... DAPT multiple interactions ISO RGD:735762 6480464 N-(N-(3 more ... CTD PMID:19160421 diallyl trisulfide decreases expression ISO RGD:735762 6480464 diallyl trisulfide results in decreased expression of HEY1 mRNA CTD PMID:23430952 dibutyl phthalate decreases expression ISO RGD:621403 6480464 Dibutyl Phthalate results in decreased expression of HEY1 mRNA CTD PMID:26472102 dibutyl phthalate increases expression ISO RGD:621403 6480464 Dibutyl Phthalate results in increased expression of HEY1 mRNA, Dibutyl Phthalate results in increased expression of HEY1 protein CTD PMID:29438945 dipentyl phthalate decreases expression ISO RGD:621403 6480464 di-n-pentyl phthalate results in decreased expression of HEY1 mRNA CTD PMID:26472102 dorsomorphin multiple interactions ISO RGD:735762 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEY1 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:735762 6480464 Doxorubicin results in decreased expression of HEY1 mRNA CTD PMID:29803840 doxorubicin multiple interactions EXP 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA] CTD PMID:28318631 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of HEY1 mRNA CTD PMID:28318631 entinostat multiple interactions ISO RGD:735762 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEY1 mRNA CTD PMID:27188386 entinostat decreases expression ISO RGD:735762 6480464 entinostat results in decreased expression of HEY1 mRNA CTD PMID:26272509 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of HEY1 mRNA CTD PMID:30319688 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HEY1 gene CTD PMID:20938992 formaldehyde increases expression ISO RGD:735762 6480464 Formaldehyde results in increased expression of HEY1 mRNA CTD PMID:17938736 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HEY1 gene CTD PMID:20938992 leflunomide increases expression ISO RGD:735762 6480464 leflunomide results in increased expression of HEY1 mRNA CTD PMID:28988120 manganese(II) chloride increases expression ISO RGD:621403 6480464 manganese chloride results in increased expression of HEY1 mRNA CTD PMID:28801915 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of HEY1 mRNA CTD PMID:29104120 mitomycin C affects response to substance ISO RGD:735762 6480464 HEY1 protein affects the susceptibility to Mitomycin CTD PMID:16217747 nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of HEY1 mRNA CTD PMID:12540486 nicotine increases expression ISO RGD:735762 6480464 Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 ouabain increases expression ISO RGD:735762 6480464 Ouabain results in increased expression of HEY1 mRNA CTD PMID:28795476 oxaliplatin increases expression ISO RGD:621403 6480464 oxaliplatin results in increased expression of HEY1 mRNA CTD PMID:25729387 oxaliplatin decreases expression ISO RGD:735762 6480464 oxaliplatin results in decreased expression of HEY1 mRNA CTD PMID:17762391 oxaliplatin multiple interactions ISO RGD:621403 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of HEY1 mRNA CTD PMID:25729387 ozone decreases expression EXP 6480464 Ozone results in decreased expression of HEY1 mRNA CTD PMID:12763052 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of HEY1 mRNA CTD PMID:17562736 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of HEY1 mRNA CTD PMID:20813756 propanal increases expression ISO RGD:735762 6480464 propionaldehyde results in increased expression of HEY1 mRNA CTD PMID:26079696 pyrvinium multiple interactions ISO RGD:735762 6480464 pyrvinium inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA] CTD PMID:27542212 quercetin increases expression ISO RGD:621403 6480464 Quercetin results in increased expression of HEY1 mRNA CTD PMID:23117658 quinolin-8-ol decreases expression ISO RGD:735762 6480464 Oxyquinoline results in decreased expression of HEY1 mRNA CTD PMID:21632981 rifampicin multiple interactions ISO RGD:735762 6480464 [Rifampin co-treated with NR1I2 protein] results in increased expression of HEY1 mRNA CTD PMID:21127053 rotenone decreases expression ISO RGD:735762 6480464 Rotenone results in decreased expression of HEY1 mRNA CTD PMID:29955902 SB 431542 multiple interactions ISO RGD:735762 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEY1 mRNA CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:735762 6480464 Silicon Dioxide analog results in decreased expression of HEY1 mRNA, Silicon Dioxide results in decreased expression of HEY1 mRNA CTD PMID:22300531 more ... silicon dioxide increases expression ISO RGD:735762 6480464 Silicon Dioxide analog results in increased expression of HEY1 mRNA CTD PMID:23806026 sodium arsenite increases expression ISO RGD:735762 6480464 sodium arsenite results in increased expression of HEY1 mRNA CTD PMID:28595984 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of HEY1 mRNA CTD PMID:27862939 Soman decreases expression ISO RGD:621403 6480464 Soman results in decreased expression of HEY1 mRNA CTD PMID:19281266 sulforaphane decreases expression EXP 6480464 sulforafan results in decreased expression of HEY1 mRNA CTD PMID:30529165 thapsigargin decreases expression ISO RGD:735762 6480464 Thapsigargin results in decreased expression of HEY1 mRNA CTD PMID:22378314 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of HEY1 mRNA CTD PMID:23557971 topotecan multiple interactions ISO RGD:621403 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of HEY1 mRNA CTD PMID:25729387 trichostatin A increases expression ISO RGD:735762 6480464 trichostatin A results in increased expression of HEY1 mRNA CTD PMID:24935251 tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of HEY1 mRNA CTD PMID:22115781 tunicamycin decreases expression ISO RGD:735762 6480464 Tunicamycin results in decreased expression of HEY1 mRNA CTD PMID:22378314 urethane decreases expression ISO RGD:735762 6480464 Urethane results in decreased expression of HEY1 mRNA CTD PMID:28818685 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of HEY1 mRNA CTD PMID:19136453 valproic acid increases methylation ISO RGD:735762 6480464 Valproic Acid results in increased methylation of HEY1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:735762 6480464 Valproic Acid affects the expression of HEY1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:735762 6480464 Valproic Acid results in increased expression of HEY1 mRNA CTD PMID:24383497 , PMID:29154799 valproic acid decreases expression ISO RGD:735762 6480464 Valproic Acid results in decreased expression of HEY1 mRNA CTD PMID:23179753
Biological Process anterior/posterior axis specification IGI MGI:MGI:1341884 2290270 (MGI:MGI:3530185, PMID:15680351) MGI MGI:MGI:3530185 , PMID:15680351 anterior/posterior pattern specification IBA MGI:MGI:104853 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 anterior/posterior pattern specification IBA MGI:MGI:104853 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 arterial endothelial cell differentiation IGI UniProtKB:Q9QUS4 2290270 (MGI:MGI:3040159, PMID:15107403) BHF-UCL MGI:MGI:3040159 , PMID:15107403 artery development IGI MGI:MGI:1341884 2290270 (MGI:MGI:3530185, PMID:15680351) MGI MGI:MGI:3530185 , PMID:15680351 atrioventricular valve formation IMP 2290270 (MGI:MGI:3703467, PMID:17259303) BHF-UCL MGI:MGI:3703467 , PMID:17259303 atrioventricular valve morphogenesis IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 blood vessel development IGI MGI:MGI:1341884 2290270 (MGI:MGI:3530185, PMID:15680351) MGI MGI:MGI:3530185 , PMID:15680351 cardiac epithelial to mesenchymal transition IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 cardiac septum morphogenesis IMP 2290270 (MGI:MGI:3703467, PMID:17259303) BHF-UCL MGI:MGI:3703467 , PMID:17259303 cardiac ventricle morphogenesis IMP 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 cell differentiation IBA MGI:MGI:1859852 , PANTHER:PTN000105428 2290270 (PMID:21873635) GO_Central PMID:21873635 circulatory system development IBA MGI:MGI:1341800 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 circulatory system development IBA MGI:MGI:1341800 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 comma-shaped body morphogenesis IEP 2290270 (PMID:15821257) UniProtKB PMID:15821257 dorsal aorta morphogenesis IGI UniProtKB:Q9QUS4 2290270 (MGI:MGI:3040159, PMID:15107403) BHF-UCL MGI:MGI:3040159 , PMID:15107403 endocardial cushion morphogenesis IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 endocardial cushion to mesenchymal transition involved in heart valve formation IGI MGI:MGI:1341884 2290270 (MGI:MGI:3530185, PMID:15680351) MGI MGI:MGI:3530185 , PMID:15680351 epithelial to mesenchymal transition involved in endocardial cushion formation IGI MGI:MGI:1860511 2290270 (MGI:MGI:3783952, PMID:17303760) MGI MGI:MGI:3783952 , PMID:17303760 establishment of epithelial cell polarity IGI MGI:MGI:104853 , MGI:MGI:104876 2290270 (MGI:MGI:4949990, PMID:21300049) MGI MGI:MGI:4949990 , PMID:21300049 inner ear receptor cell stereocilium organization IGI MGI:MGI:104853 , MGI:MGI:104876 2290270 (MGI:MGI:4949990, PMID:21300049) MGI MGI:MGI:4949990 , PMID:21300049 labyrinthine layer blood vessel development IGI UniProtKB:Q9QUS4 2290270 (MGI:MGI:3040159, PMID:15107403) BHF-UCL MGI:MGI:3040159 , PMID:15107403 mesenchymal cell development IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 multicellular organism development IEA UniProtKB-KW:KW-0217 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 negative regulation of biomineral tissue development IDA 2290270 (MGI:MGI:6158746, PMID:22110751) BHF-UCL MGI:MGI:6158746 , PMID:22110751 negative regulation of gene expression IMP 2290270 (MGI:MGI:5427763, PMID:22615585) MGI MGI:MGI:5427763 , PMID:22615585 negative regulation of gene expression IDA 2290270 (MGI:MGI:3604167, PMID:16025100) BHF-UCL MGI:MGI:3604167 , PMID:16025100 negative regulation of neuron differentiation IMP 2290270 (MGI:MGI:4365702, PMID:19631204) UniProtKB MGI:MGI:4365702 , PMID:19631204 negative regulation of neuron differentiation IBA MGI:MGI:1341800 , PANTHER:PTN000105777 2290270 (PMID:21873635) GO_Central PMID:21873635 negative regulation of Notch signaling pathway ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:3604167 more ... UniProtKB MGI:MGI:3604167 more ... negative regulation of transcription by RNA polymerase II IBA FB:FBgn0001168 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 negative regulation of transcription by RNA polymerase II ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription by RNA polymerase II IMP 2290270 (MGI:MGI:3703467, PMID:17259303) BHF-UCL MGI:MGI:3703467 , PMID:17259303 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription regulatory region DNA binding ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription, DNA-templated ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription, DNA-templated IMP 2290270 (MGI:MGI:3603871, PMID:16199874) UniProtKB MGI:MGI:3603871 , PMID:16199874 Notch signaling involved in heart development IC GO:0060411 2290270 (MGI:MGI:3703467, PMID:17259303) BHF-UCL MGI:MGI:3703467 , PMID:17259303 Notch signaling pathway IBA MGI:MGI:1341800 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Notch signaling pathway IBA MGI:MGI:1341800 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Notch signaling pathway IDA 2290270 (MGI:MGI:1889175, PMID:10964718) UniProtKB MGI:MGI:1889175 , PMID:10964718 Notch signaling pathway TAS 2290270 (MGI:MGI:3576186, PMID:15821257) UniProtKB MGI:MGI:3576186 , PMID:15821257 Notch signaling pathway ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Notch signaling pathway ISO RGD:621403 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 osteoblast development IGI MGI:MGI:99829 2290270 (MGI:MGI:3836510, PMID:18986983) MGI MGI:MGI:3836510 , PMID:18986983 outflow tract morphogenesis IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 positive regulation of gene expression IDA 2290270 (MGI:MGI:6158746, PMID:22110751) BHF-UCL MGI:MGI:6158746 , PMID:22110751 positive regulation of osteoblast differentiation IGI MGI:MGI:1321394 , MGI:MGI:99829 2290270 (MGI:MGI:3836510, PMID:18986983) MGI MGI:MGI:3836510 , PMID:18986983 positive regulation of transcription by RNA polymerase II IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 positive regulation of transcription by RNA polymerase II IMP 2290270 (MGI:MGI:3040159, PMID:15107403) BHF-UCL MGI:MGI:3040159 , PMID:15107403 pulmonary valve morphogenesis IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 regulation of epithelial cell proliferation IGI MGI:MGI:104853 , MGI:MGI:104876 2290270 (MGI:MGI:4949990, PMID:21300049) MGI MGI:MGI:4949990 , PMID:21300049 regulation of inner ear auditory receptor cell differentiation IGI MGI:MGI:104853 , MGI:MGI:104876 2290270 (MGI:MGI:4949990, PMID:21300049) MGI MGI:MGI:4949990 , PMID:21300049 regulation of neurogenesis IBA MGI:MGI:104853 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of transcription, DNA-templated IEA InterPro:IPR003650 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 regulation of vasculogenesis IGI UniProtKB:Q9QUS4 2290270 (MGI:MGI:3040159, PMID:15107403) BHF-UCL MGI:MGI:3040159 , PMID:15107403 renal vesicle development IEP 2290270 (PMID:15821257) UniProtKB PMID:15821257 S-shaped body morphogenesis IEP 2290270 (PMID:15821257) UniProtKB PMID:15821257 umbilical cord morphogenesis IGI UniProtKB:Q9QUS4 2290270 (MGI:MGI:3040159, PMID:15107403) BHF-UCL MGI:MGI:3040159 , PMID:15107403 ureteric bud morphogenesis IEP 2290270 (PMID:15821257) UniProtKB PMID:15821257 vasculogenesis IGI MGI:MGI:1341884 2290270 (MGI:MGI:3040159, PMID:15107403) MGI MGI:MGI:3040159 , PMID:15107403 ventricular septum morphogenesis IGI UniProtKB:Q9DBX7 2290270 (MGI:MGI:3783952, PMID:17303760) BHF-UCL MGI:MGI:3783952 , PMID:17303760 ventricular trabecula myocardium morphogenesis IGI MGI:MGI:1341884 2290270 (MGI:MGI:3530185, PMID:15680351) MGI MGI:MGI:3530185 , PMID:15680351 Cellular Component cytoplasm IDA 2290270 (MGI:MGI:5285133, PMID:21290414) UniProtKB MGI:MGI:5285133 , PMID:21290414 nucleus ISO RGD:621403 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus IBA FB:FBgn0002631 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 nucleus ISS UniProtKB:Q9I8A3 2290270 (MGI:MGI:3809308, PMID:14648848) MGI MGI:MGI:3809308 , PMID:14648848 nucleus IDA 2290270 (MGI:MGI:2148334 more ... MGI MGI:MGI:2148334 more ... Molecular Function DNA binding IEA UniProtKB-KW:KW-0238 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 DNA binding IEA InterPro:IPR003650 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 DNA-binding transcription factor activity ISS 2290270 (MGI:MGI:1859988, PMID:10860664) MGI MGI:MGI:1859988 , PMID:10860664 DNA-binding transcription factor activity ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA-binding transcription factor activity, RNA polymerase II-specific IDA 2290270 (MGI:MGI:5285133, PMID:21290414) UniProtKB MGI:MGI:5285133 , PMID:21290414 DNA-binding transcription factor activity, RNA polymerase II-specific ISO UniProtKB:Q9Y5J3 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 2290270 (MGI:MGI:3603871 more ... UniProt MGI:MGI:3603871 more ... DNA-binding transcription repressor activity, RNA polymerase II-specific IBA FB:FBgn0000591 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein binding IPI UniProtKB:P20067 2290270 (MGI:MGI:4453908, PMID:20231428) MGI MGI:MGI:4453908 , PMID:20231428 protein binding IPI UniProtKB:P15806 , UniProtKB:Q60722 2290270 (MGI:MGI:1927044, PMID:11076679) MGI MGI:MGI:1927044 , PMID:11076679 protein binding IPI UniProtKB:Q9DA73 2290270 (MGI:MGI:3809308, PMID:14648848) UniProtKB MGI:MGI:3809308 , PMID:14648848 protein binding IPI UniProtKB:P43694 , UniProtKB:Q92908 2290270 (MGI:MGI:3603871, PMID:16199874) UniProtKB MGI:MGI:3603871 , PMID:16199874 protein binding IPI UniProtKB:Q62440 , UniProtKB:Q9DBX7 2290270 (MGI:MGI:5285519, PMID:21259317) UniProtKB MGI:MGI:5285519 , PMID:21259317 protein binding IPI UniProtKB:Q15327 2290270 (MGI:MGI:5294529, PMID:20599664) BHF-UCL MGI:MGI:5294529 , PMID:20599664 protein dimerization activity IEA InterPro:IPR011598 , InterPro:IPR036638 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein heterodimerization activity IDA 2290270 (MGI:MGI:1927044, PMID:11076679) MGI MGI:MGI:1927044 , PMID:11076679 protein homodimerization activity IDA 2290270 (MGI:MGI:1927044, PMID:11076679) MGI MGI:MGI:1927044 , PMID:11076679 RNA polymerase II regulatory region sequence-specific DNA binding IBA MGI:MGI:1859852 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 sequence-specific DNA binding IDA 2290270 (MGI:MGI:5427763, PMID:22615585) MGI MGI:MGI:5427763 , PMID:22615585
Gene-Chemical Interaction Annotations
