Hey1 (hairy/enhancer-of-split related with YRPW motif 1) - Rat Genome Database

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Gene: Hey1 (hairy/enhancer-of-split related with YRPW motif 1) Mus musculus
Analyze
Symbol: Hey1
Name: hairy/enhancer-of-split related with YRPW motif 1
RGD ID: 735763
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; nephron development; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; osteoblast development; and positive regulation of osteoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; jaw; and sensory organ. Orthologous to human HEY1 (hes related family bHLH transcription factor with YRPW motif 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI316788; AI414254; bHLHb3; bHLHb31; CHF2; hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; Her; Herp2; Hes; hesr; hesr-1; Hesr1; HRT; HRT-1; HRT1; mHRT1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3938,728,419 - 8,732,098 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl38,728,419 - 8,732,316 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3838,663,359 - 8,667,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl38,663,359 - 8,667,256 (-)Ensemblmm10GRCm38
MGSCv3738,663,359 - 8,667,038 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3638,646,432 - 8,650,059 (-)NCBIMGSCv36mm8
Celera38,666,683 - 8,670,362 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.15NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-methylfuran  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DAPT  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dipentyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
loliolide  (ISO)
manganese(II) chloride  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (ISO)
nickel atom  (EXP)
niclosamide  (EXP,ISO)
nicotine  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
propanal  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sotorasib  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tacedinaline  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IEA)
angiogenesis  (ISO)
anterior/posterior axis specification  (IGI)
anterior/posterior pattern specification  (IBA)
aortic valve morphogenesis  (IDA)
arterial endothelial cell differentiation  (IGI)
artery development  (IGI)
atrioventricular valve formation  (IMP)
atrioventricular valve morphogenesis  (IEA,IGI)
blood vessel development  (IGI)
blood vessel endothelial cell differentiation  (IGI)
cardiac epithelial to mesenchymal transition  (IEA,IGI)
cardiac septum morphogenesis  (IMP)
cardiac ventricle morphogenesis  (IEA,IMP)
cellular response to glucocorticoid stimulus  (ISO)
circulatory system development  (IBA)
comma-shaped body morphogenesis  (IEP)
dorsal aorta morphogenesis  (IGI)
endocardial cushion morphogenesis  (IGI)
endocardial cushion to mesenchymal transition involved in heart valve formation  (IGI)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IGI)
establishment of epithelial cell polarity  (IGI)
inner ear receptor cell stereocilium organization  (IGI)
labyrinthine layer blood vessel development  (IGI)
mesenchymal cell development  (IEA,IGI)
muscle organ development  (IEA)
negative regulation of biomineral tissue development  (IDA)
negative regulation of DNA-templated transcription  (IMP,ISO)
negative regulation of gene expression  (IDA,IEA,IMP)
negative regulation of neuron differentiation  (IBA,IMP)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of smooth muscle cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
Notch signaling pathway  (IBA,IDA,IEA,IMP,ISO,TAS)
osteoblast development  (IGI)
outflow tract morphogenesis  (IEA,IGI)
positive regulation of osteoblast differentiation  (IGI)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
pulmonary valve morphogenesis  (IEA,IGI)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IGI)
regulation of inner ear auditory receptor cell differentiation  (IGI)
regulation of neurogenesis  (IBA)
regulation of neuron differentiation  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of vasculogenesis  (IGI)
renal vesicle development  (IEP)
S-shaped body morphogenesis  (IEP)
striated muscle tissue development  (IEA)
tissue morphogenesis  (IEA)
umbilical cord morphogenesis  (IGI)
ureteric bud morphogenesis  (IEP)
vasculogenesis  (IGI)
ventricular septum morphogenesis  (IEA,IGI)
ventricular trabecula myocardium morphogenesis  (IGI)

Cellular Component
cytoplasm  (IDA)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,IEA,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal artery development  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardinal vein morphology  (IAGP)
abnormal conotruncal ridge morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skeletal muscle satellite cell proliferation  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal umbilical cord morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent myocardial trabeculae  (IAGP)
common atrium  (IAGP)
common ventricle  (IAGP)
decreased angiogenesis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased muscle weight  (IAGP)
decreased satellite cell number  (IAGP)
decreased skeletal muscle fiber number  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
hemorrhage  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
incomplete somite formation  (IAGP)
increased heart ventricle size  (IAGP)
increased sensory neuron number  (IAGP)
no abnormal phenotype detected  (IAGP)
pale yolk sac  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary valve stenosis  (IAGP)
small first pharyngeal arch  (IAGP)
small second pharyngeal arch  (IAGP)
thick pulmonary valve  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
trabecula carnea hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
2. HERP1 is a cell type-specific primary target of Notch. Iso T, etal., J Biol Chem 2002 Feb 22;277(8):6598-607.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
8. Study of angiogenic signaling pathways in hemangioblastoma. Pierscianek D, etal., Neuropathology. 2017 Feb;37(1):3-11. doi: 10.1111/neup.12316. Epub 2016 Jul 7.
9. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
14. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
15. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
16. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
Additional References at PubMed
PMID:10349636   PMID:10403790   PMID:10415358   PMID:10588864   PMID:10692439   PMID:10860664   PMID:10924525   PMID:10964718   PMID:11042159   PMID:11076679   PMID:11076861   PMID:11095750  
PMID:11160397   PMID:11279181   PMID:11486044   PMID:11572777   PMID:11784028   PMID:11923214   PMID:12223415   PMID:12424520   PMID:12466851   PMID:12477932   PMID:12947105   PMID:12971992  
PMID:14648848   PMID:14660441   PMID:14672936   PMID:14701881   PMID:14766969   PMID:15073150   PMID:15107403   PMID:15618518   PMID:15659488   PMID:15680351   PMID:15689374   PMID:15821257  
PMID:15837802   PMID:15843414   PMID:15875024   PMID:16000382   PMID:16025100   PMID:16061358   PMID:16079153   PMID:16141072   PMID:16141073   PMID:16169709   PMID:16199874   PMID:16452096  
PMID:16554359   PMID:16840533   PMID:17015435   PMID:17021042   PMID:17079689   PMID:17095659   PMID:17194759   PMID:17259303   PMID:17273555   PMID:17303760   PMID:17336907   PMID:17392792  
PMID:17476283   PMID:17584735   PMID:17709399   PMID:18043734   PMID:18093989   PMID:18206867   PMID:18234727   PMID:18267097   PMID:18287559   PMID:18291358   PMID:18297083   PMID:18302773  
PMID:18528438   PMID:18547789   PMID:18557763   PMID:18559979   PMID:18579678   PMID:18617694   PMID:18694942   PMID:18804439   PMID:18976936   PMID:18986983   PMID:19030180   PMID:19084512  
PMID:19087347   PMID:19154719   PMID:19161597   PMID:19369401   PMID:19386638   PMID:19433762   PMID:19501159   PMID:19502490   PMID:19521566   PMID:19590010   PMID:19631204   PMID:19644017  
PMID:19666558   PMID:19723774   PMID:19917614   PMID:20007915   PMID:20059953   PMID:20231428   PMID:20335360   PMID:20336138   PMID:20346184   PMID:20371769   PMID:20412781   PMID:20568246  
PMID:20599664   PMID:20610746   PMID:20627076   PMID:20733081   PMID:20798046   PMID:20890042   PMID:20947685   PMID:21084383   PMID:21205794   PMID:21252157   PMID:21259317   PMID:21267068  
PMID:21270765   PMID:21282332   PMID:21290414   PMID:21300049   PMID:21311046   PMID:21349854   PMID:21352545   PMID:21402699   PMID:21420948   PMID:21606200   PMID:21632926   PMID:21633169  
PMID:21781958   PMID:21791528   PMID:21793101   PMID:21839733   PMID:21873635   PMID:21909072   PMID:21983003   PMID:21989910   PMID:22069191   PMID:22096492   PMID:22110751   PMID:22147907  
PMID:22279058   PMID:22323600   PMID:22331706   PMID:22432025   PMID:22457635   PMID:22536403   PMID:22615585   PMID:22675208   PMID:22696295   PMID:22711842   PMID:22783020   PMID:22819676  
PMID:22865640   PMID:22988430   PMID:23197712   PMID:23213461   PMID:23314057   PMID:23362348   PMID:23362349   PMID:23431145   PMID:23454273   PMID:23526992   PMID:23560082   PMID:23571217  
PMID:23676271   PMID:23946445   PMID:24019535   PMID:24146773   PMID:24148613   PMID:24153254   PMID:24167636   PMID:24227653   PMID:24337118   PMID:24391519   PMID:24431082   PMID:24491691  
PMID:24496616   PMID:24583261   PMID:24583262   PMID:24586749   PMID:24673559   PMID:24741061   PMID:24755984   PMID:24927569   PMID:24952961   PMID:25005473   PMID:25232121   PMID:25264302  
PMID:25336743   PMID:25401743   PMID:25406395   PMID:25446183   PMID:25497097   PMID:25535917   PMID:25546423   PMID:25691540   PMID:25715395   PMID:25733872   PMID:25804738   PMID:25830332  
PMID:25848000   PMID:25916881   PMID:26002917   PMID:26051942   PMID:26209882   PMID:26276819   PMID:26552887   PMID:26553930   PMID:26577899   PMID:26598619   PMID:26641715   PMID:26647760  
PMID:26651607   PMID:26657772   PMID:26689699   PMID:26719988   PMID:26791579   PMID:26856660   PMID:26856890   PMID:26932672   PMID:27122169   PMID:27160681   PMID:27166947   PMID:27922003  
PMID:27930960   PMID:27991863   PMID:28139517   PMID:28334989   PMID:28402857   PMID:28455376   PMID:28526753   PMID:28530678   PMID:28538179   PMID:28942923   PMID:29033846   PMID:29107558  
PMID:29138798   PMID:29140246   PMID:29155305   PMID:29409032   PMID:29540665   PMID:29567677   PMID:29578405   PMID:29853617   PMID:30201295   PMID:30347193   PMID:30418981   PMID:30428088  
PMID:30504829   PMID:30538222   PMID:30596653   PMID:30745427   PMID:30796970   PMID:30862661   PMID:30991836   PMID:31276493   PMID:31412026   PMID:31420575   PMID:31434798   PMID:31488567  
PMID:31545169   PMID:31550547   PMID:31591643   PMID:31636950   PMID:31789590   PMID:31845891   PMID:31988190   PMID:32141129   PMID:32554463   PMID:32857879   PMID:33454003   PMID:33591268  
PMID:33730615   PMID:33773996   PMID:33898448   PMID:34099102   PMID:34157307   PMID:34189436   PMID:34321999   PMID:34510201   PMID:34772946   PMID:35103284   PMID:35247391   PMID:35297995  
PMID:35575074   PMID:35864959   PMID:36064547   PMID:36194632   PMID:36239412   PMID:37200191   PMID:37212282   PMID:37385754   PMID:37471646   PMID:37555328   PMID:37681879   PMID:37702066  
PMID:37818607   PMID:38166414   PMID:38374152   PMID:38923264   PMID:39373109   PMID:39699962  


Genomics

Comparative Map Data
Hey1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3938,728,419 - 8,732,098 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl38,728,419 - 8,732,316 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3838,663,359 - 8,667,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl38,663,359 - 8,667,256 (-)Ensemblmm10GRCm38
MGSCv3738,663,359 - 8,667,038 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3638,646,432 - 8,650,059 (-)NCBIMGSCv36mm8
Celera38,666,683 - 8,670,362 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.15NCBI
HEY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38879,764,010 - 79,767,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl879,762,371 - 79,767,857 (-)Ensemblhg38GRCh38
GRCh37880,676,245 - 80,680,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36880,838,800 - 80,842,653 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34880,838,800 - 80,842,559NCBI
Celera876,680,512 - 76,684,366 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef876,165,779 - 76,169,632 (-)NCBIHuRef
CHM1_1880,728,484 - 80,732,338 (-)NCBICHM1_1
T2T-CHM13v2.0880,195,346 - 80,199,104 (-)NCBIT2T-CHM13v2.0
Hey1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8295,003,935 - 95,006,457 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl295,002,943 - 95,007,624 (+)EnsemblGRCr8
mRatBN7.2293,096,605 - 93,100,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl293,095,498 - 93,100,312 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx299,620,837 - 99,623,361 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0297,741,864 - 97,744,388 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0292,798,743 - 92,801,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0295,320,147 - 95,322,701 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl295,320,283 - 95,322,696 (+)Ensemblrn6Rnor6.0
Rnor_5.02115,062,450 - 115,064,660 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4295,174,030 - 95,176,430 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera288,672,179 - 88,674,351 (+)NCBICelera
RGSC_v3.1295,119,909 - 95,121,344 (+)NCBI
Cytogenetic Map2q23NCBI
Hey1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554441,498,675 - 1,500,945 (+)Ensembl
ChiLan1.0NW_0049554441,498,444 - 1,502,099 (+)NCBIChiLan1.0ChiLan1.0
HEY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2795,499,395 - 95,503,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1871,129,371 - 71,133,453 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0876,286,433 - 76,290,507 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1877,917,206 - 77,921,062 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl877,913,761 - 77,921,201 (-)EnsemblpanPan2panpan1.1
HEY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12927,185,191 - 27,188,121 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2927,185,191 - 27,188,121 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2927,458,786 - 27,461,729 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02927,308,721 - 27,311,675 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2927,307,758 - 27,311,736 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12927,354,259 - 27,357,186 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02927,393,148 - 27,396,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02927,749,711 - 27,752,657 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hey1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530351,893,528 - 51,897,480 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936871666,938 - 670,916 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936871666,961 - 670,910 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl456,859,663 - 56,863,788 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1456,859,640 - 56,863,807 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2462,080,177 - 62,084,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1875,225,081 - 75,228,941 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl875,224,769 - 75,228,896 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603965,971,543 - 65,975,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hey1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474411,462,847 - 11,467,870 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474411,462,865 - 11,466,559 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Hey1
152 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:273
Interacting mature miRNAs:303
Transcripts:ENSMUST00000042412
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
1301256Skmw1_mskeletal muscle weight 1 (mouse)Not determined3125786432Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
12798540Scvg2_msubcutaneous vessel growth QTL 2 (mouse)3744981526249645Mouse

Markers in Region
RH136115  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3838,663,691 - 8,663,886UniSTSGRCm38
MGSCv3738,663,691 - 8,663,886UniSTSGRCm37
Celera38,667,015 - 8,667,210UniSTS
Cytogenetic Map3A1UniSTS
cM Map32.4UniSTS
AI414254  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3838,663,553 - 8,663,670UniSTSGRCm38
MGSCv3738,663,553 - 8,663,670UniSTSGRCm37
Celera38,666,877 - 8,666,994UniSTS
Cytogenetic Map3A1UniSTS
cM Map32.4UniSTS
Whitehead/MRC_RH3138.15UniSTS
Hey1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3738,663,782 - 8,664,426UniSTSGRCm37
Celera38,667,106 - 8,667,750UniSTS
Cytogenetic Map3A1UniSTS
cM Map32.4UniSTS
cM Map32.4UniSTS
Hey1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3838,663,782 - 8,664,426UniSTSGRCm38
MGSCv3738,663,782 - 8,664,426UniSTSGRCm37
Celera38,667,106 - 8,667,750UniSTS
Cytogenetic Map3A1UniSTS
cM Map32.4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000042412   ⟹   ENSMUSP00000038014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl38,728,419 - 8,732,316 (-)Ensembl
GRCm38.p6 Ensembl38,663,359 - 8,667,256 (-)Ensembl
Ensembl Acc Id: ENSMUST00000192102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl38,729,856 - 8,731,685 (-)Ensembl
GRCm38.p6 Ensembl38,664,796 - 8,666,625 (-)Ensembl
Ensembl Acc Id: ENSMUST00000192550
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl38,729,759 - 8,732,044 (-)Ensembl
GRCm38.p6 Ensembl38,664,699 - 8,666,984 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194299
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl38,730,602 - 8,732,024 (-)Ensembl
GRCm38.p6 Ensembl38,665,542 - 8,666,964 (-)Ensembl
RefSeq Acc Id: NM_010423   ⟹   NP_034553
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3938,728,419 - 8,732,098 (-)NCBI
GRCm3838,663,359 - 8,667,038 (-)ENTREZGENE
MGSCv3738,663,359 - 8,667,038 (-)RGD
Celera38,666,683 - 8,670,362 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530053   ⟹   XP_006530116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3938,728,419 - 8,730,935 (-)NCBI
GRCm3838,663,359 - 8,665,882 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034553   ⟸   NM_010423
- UniProtKB: Q9WV93 (UniProtKB/Swiss-Prot),   Q9QUM5 (UniProtKB/TrEMBL),   Q9D0R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006530116   ⟸   XM_006530053
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000038014   ⟸   ENSMUST00000042412
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WV93-F1-model_v2 AlphaFold Q9WV93 1-299 view protein structure

Promoters
RGD ID:6848770
Promoter ID:MM_TRO:6026
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:MTR001407.3.47.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3638,665,789 - 8,666,289 (-)MPROMDB
RGD ID:6833945
Promoter ID:MM_KWN:33724
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   MEF_B6
Transcripts:ENSMUST00000042412
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3638,666,791 - 8,667,887 (-)MPROMDB
RGD ID:6880208
Promoter ID:EPDNEW_M3555
Type:initiation region
Name:Hey1_1
Description:Mus musculus hairy/enhancer-of-split related with YRPW motif1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3838,666,970 - 8,667,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341800 AgrOrtholog
Ensembl Genes ENSMUSG00000040289 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000042412 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  6.10.250.980 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HES_HEY UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
MGD MGI:1341800 ENTREZGENE
NCBI Gene 15213 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot
Pfam Hairy_orange UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
PhenoGen Hey1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot
  SSF47459 UniProtKB/Swiss-Prot
UniProt HEY1_MOUSE UniProtKB/Swiss-Prot
  Q9D0R0 ENTREZGENE, UniProtKB/TrEMBL
  Q9QUM5 ENTREZGENE, UniProtKB/TrEMBL
  Q9WV93 ENTREZGENE