Cx3cr1 (C-X3-C motif chemokine receptor 1) - Rat Genome Database

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Gene: Cx3cr1 (C-X3-C motif chemokine receptor 1) Mus musculus
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Symbol: Cx3cr1
Name: C-X3-C motif chemokine receptor 1
RGD ID: 1552004
MGI Page MGI
Description: Enables C-X3-C chemokine binding activity and C-X3-C chemokine receptor activity. Involved in several processes, including antifungal innate immune response; central nervous system development; and synapse organization. Located in cell surface. Is expressed in several structures, including brain; colon; genitourinary system; head mesenchyme; and meninges. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X3-C chemokine receptor 1; C-X3-C CKR-1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CX3C chemokine receptor 1; fractalkine receptor; mCX3CR1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,877,749 - 119,897,362 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,877,749 - 119,898,945 (-)EnsemblGRCm39 Ensembl
GRCm389120,048,683 - 120,068,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,901,616 - 120,069,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,957,811 - 119,977,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,897,391 - 119,916,980 (-)NCBIMGSCv36mm8
Celera9120,518,248 - 120,537,939 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 12  (IAGP,ISO)
anti-basement membrane glomerulonephritis  (ISO)
arteriosclerosis  (IMP)
arthus reaction  (IMP)
asthma  (IMP,ISO)
atherosclerosis  (IMP)
atopic dermatitis  (IMP,ISO)
borna disease  (ISO)
Chloracne  (ISO)
Chronic Mesangial Proliferative Glomerulonephritis  (ISO)
congestive heart failure  (ISO)
conjunctivitis  (IMP)
corneal neovascularization  (IMP)
Coronary Disease  (ISO)
cystitis  (ISO)
diabetes mellitus  (IMP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (IMP,ISO)
Experimental Diabetes Mellitus  (ISO)
glaucoma  (IMP)
glomerulonephritis  (ISO)
graft-versus-host disease  (ISO)
Hearing Loss  (IEP)
hepatopulmonary syndrome  (ISO)
Herpes Simplex Encephalitis  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (IMP,ISO)
Inflammation  (IMP,ISO)
Intervertebral Disc Displacement  (ISO)
Intimal Hyperplasia  (IMP)
macular degeneration  (IGI,ISO)
Memory Disorders  (ISO)
Microscopic Polyangiitis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
optic nerve glioma  (IMP)
otitis media  (ISO)
Pain  (ISO)
Parkinsonism  (ISO)
portal hypertension  (ISO)
prion disease  (ISO)
psoriasis  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (IEP,IMP)
retinal degeneration  (IMP,ISO)
retinal vasculitis  (ISO)
retinitis  (IMP)
sciatic neuropathy  (IMP,ISO)
Sepsis  (ISO)
status epilepticus  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (IMP,ISO)
transient cerebral ischemia  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
ceric oxide  (ISO)
choline  (EXP,ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ferric oxide  (EXP)
folic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
glycidol  (ISO)
GW 501516  (ISO)
ketamine  (EXP)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mechlorethamine  (ISO)
methamphetamine  (ISO)
methimazole  (ISO)
monosodium L-glutamate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentane-2,3-dione  (ISO)
phenobarbital  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
succimer  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IMP)
antifungal innate immune response  (IMP,ISO)
autocrine signaling  (IEA,ISO)
brain development  (IMP)
calcium-mediated signaling  (IBA)
cell adhesion  (IPI,ISO)
cell chemotaxis  (IBA,ISO)
cell-cell adhesion  (ISO)
cellular response to lipopolysaccharide  (IGI,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
central nervous system maturation  (IMP)
chemokine-mediated signaling pathway  (IEA,ISO)
chemotaxis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
host-mediated regulation of intestinal microbiota composition  (IMP)
immune response  (IBA,IMP)
innate immune response  (IC)
leukocyte chemotaxis  (IMP)
leukocyte tethering or rolling  (IGI)
memory  (IEA,ISO)
microglial cell activation  (ISO)
microglial cell activation involved in immune response  (IMP)
modulation of chemical synaptic transmission  (IMP)
multiple spine synapse organization, single dendrite  (IMP)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of chronic inflammatory response to non-antigenic stimulus  (ISO)
negative regulation of hippocampal neuron apoptotic process  (IEA,ISO)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of microglial cell mediated cytotoxicity  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of I-kappaB phosphorylation  (ISO)
positive regulation of microglial cell migration  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IMP)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of nitric oxide biosynthetic process  (IGI)
regulation of tumor necrosis factor production  (IGI)
response to ischemia  (IEA,ISO)
social behavior  (IMP)
synapse maturation  (IMP)
synapse pruning  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amacrine cell morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal caudal vertebrae morphology  (IEA)
abnormal corticosterone level  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal leukocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal ocular fundus morphology  (IAGP)
abnormal photoreceptor connecting cilium morphology  (IAGP)
abnormal photoreceptor inner segment morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal response to transplant  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina outer nuclear layer morphology  (IAGP)
abnormal retina photoreceptor layer morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
brain inflammation  (IAGP)
brainstem hemorrhage  (IAGP)
choroidal neovascularization  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased colon length  (IAGP)
decreased grip strength  (IAGP)
decreased inflammatory response  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased litter size  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased neuron number  (IAGP)
decreased NK cell number  (IAGP)
decreased retina cone cell number  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased vascular smooth muscle cell proliferation  (IAGP)
demyelination  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
enlarged kidney  (IEA)
impaired behavioral response to xenobiotic  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased dendritic cell number  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased macrophage cell number  (IAGP)
increased microglial cell activation  (IAGP)
increased neuron apoptosis  (IAGP)
increased susceptibility to age-related retinal degeneration  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased transforming growth factor beta level  (IAGP)
microgliosis  (IAGP)
neuron degeneration  (IAGP)
paralysis  (IAGP)
paresis  (IAGP)
premature death  (IAGP)
retina cone cell degeneration  (IAGP)
retina degeneration  (IAGP)
retina deposits  (IAGP)
retina gliosis  (IAGP)
retina outer nuclear layer degeneration  (IAGP)
retina photoreceptor degeneration  (IAGP)
retina pigment epithelium atrophy  (IAGP)
retina pigment epithelium hyperplasia  (IAGP)
short photoreceptor outer segment  (IAGP)
small kidney  (IEA)
thin retina outer nuclear layer  (IAGP)
variable depigmentation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Amanatidou V, etal., Pediatr Infect Dis J. 2006 May;25(5):410-4.
2. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
3. Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population. Anastasopoulos E, etal., Curr Eye Res. 2012 Dec;37(12):1148-55. doi: 10.3109/02713683.2012.705413. Epub 2012 Jul 20.
4. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Andre F, etal., Ann Oncol. 2006 Jun;17(6):945-51. Epub 2006 Apr 20.
5. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
6. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
7. Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. Briones TL, etal., J Neuroinflammation. 2014 Jan 22;11:13. doi: 10.1186/1742-2094-11-13.
8. Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Cepika AM, etal., Pediatr Allergy Immunol. 2008 Mar;19(2):148-56. doi: 10.1111/j.1399-3038.2007.00611.x.
9. Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Chan CC, etal., Histol Histopathol. 2005 Jul;20(3):857-63.
10. Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation. Chen M, etal., Invest Ophthalmol Vis Sci. 2013 Jan 23;54(1):682-90. doi: 10.1167/iovs.12-10888.
11. Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats. Chen YM, etal., Nephrol Dial Transplant. 2003 Dec;18(12):2505-14.
12. Expression of fractalkine (CX3CL1) and its receptor in endotoxin-induced uveitis. Chu L, etal., Ophthalmic Res. 2009;42(3):160-6. Epub 2009 Jul 31.
13. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Combadiere C, etal., Circulation. 2003 Feb 25;107(7):1009-16.
14. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Dagkalis A, etal., Immunology. 2009 Sep;128(1):25-33. doi: 10.1111/j.1365-2567.2009.03046.x.
15. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Denoyer A, etal., Mucosal Immunol. 2012 Nov;5(6):702-11. doi: 10.1038/mi.2012.43. Epub 2012 Jun 13.
16. CX3CR1 polymorphisms are associated with atopy but not asthma in German children. Depner M, etal., Int Arch Allergy Immunol. 2007;144(1):91-4. Epub 2007 May 15.
17. Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation. Echigo T, etal., J Allergy Clin Immunol. 2004 May;113(5):940-8.
18. Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis. Fang IM, etal., Mol Vis. 2005 Jul 1;11:443-51.
19. Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication. Feng L, etal., Kidney Int. 1999 Aug;56(2):612-20.
20. Study of Polymorphisms in CX3CR1, PLEKHA1 and VEGF Genes as Risk Factors for Age-related Macular Degeneration in Indian Patients. Gupta D, etal., Arch Med Res. 2014 Jul 19. pii: S0188-4409(14)00161-1. doi: 10.1016/j.arcmed.2014.07.005.
21. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. Harcourt J, etal., J Immunol. 2006 Feb 1;176(3):1600-8.
22. Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis. Hasegawa M, etal., Ann Rheum Dis. 2005 Jan;64(1):21-8.
23. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P. Haynes LM, etal., J Virol. 2003 Sep;77(18):9831-44.
24. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Hughes PM, etal., Glia. 2002 Mar 15;37(4):314-27.
25. Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. Ito Y, etal., Kidney Int. 2002 Jun;61(6):2044-57.
26. Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation. Jerath MR, etal., Thromb J. 2010 Sep 13;8:14. doi: 10.1186/1477-9560-8-14.
27. Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus. Katsuyama K, etal., Nephron Exp Nephrol. 2009;113(2):e45-56. Epub 2009 Jul 10.
28. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. Kezic JM, etal., Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):854-63. doi: 10.1167/iovs.12-10876.
29. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Kikuchi Y, etal., Nephron Exp Nephrol. 2004;97(1):e17-25.
30. Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK. Lee KM, etal., Eur J Pain. 2010 Aug;14(7):682.e1-12. Epub 2009 Dec 2.
31. mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
32. Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. Lu P, etal., J Immunol. 2008 Mar 15;180(6):4283-91.
33. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. Luhmann UF, etal., PLoS One. 2012;7(4):e35551. doi: 10.1371/journal.pone.0035551. Epub 2012 Apr 24.
34. Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome. Luongo L, etal., Neurosci Lett. 2008 May 30;437(2):98-102. Epub 2008 Apr 10.
35. Polymorphism of the fractalkine receptor CX3CR1 and systemic sclerosis-associated pulmonary arterial hypertension. Marasini B, etal., Clin Dev Immunol. 2005 Dec;12(4):275-9.
36. Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis. Matsunawa M, etal., Clin Exp Rheumatol. 2009 Jan-Feb;27(1):72-8.
37. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis. McDermott DH, etal., Circ Res. 2001 Aug 31;89(5):401-7.
38. Gut-brain chemokine changes in portal hypertensive rats. Merino J, etal., Dig Dis Sci. 2011 Aug;56(8):2309-17. doi: 10.1007/s10620-011-1625-y. Epub 2011 Feb 24.
39. MGDs mouse GO annotations MGD data from the GO Consortium
40. MGD IEA MGD IEA
41. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Milligan E, etal., Eur J Neurosci. 2005 Dec;22(11):2775-82.
42. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Mionnet C, etal., Nat Med. 2010 Nov;16(11):1305-12. Epub 2010 Oct 31.
43. Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. Morimura S, etal., Am J Pathol. 2013 May;182(5):1640-7. doi: 10.1016/j.ajpath.2013.01.023. Epub 2013 Mar 5.
44. Predominant infiltration of monocytes in chronic graft-versus-host disease. Namba N, etal., Transplantation. 2007 Jan 27;83(2):220-4.
45. Polymorphisms of immunity genes and susceptibility to otitis media in children. Nokso-Koivisto J, etal., PLoS One. 2014 Apr 9;9(4):e93930. doi: 10.1371/journal.pone.0093930. eCollection 2014.
46. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Intrathecal infusion of pyrrolidine dithiocarbamate for the prevention and reversal of neuropathic pain in rats using a sciatic chronic constriction injury model. Pan YD, etal., Reg Anesth Pain Med. 2010 May-Jun;35(3):231-7. doi: 10.1097/AAP.0b013e3181df245b.
49. Changes in spinal cord expression of fractalkine and its receptor in a rat model of disc herniation by autologous nucleus pulposus. Park HW, etal., Spine (Phila Pa 1976). 2011 Jan 8.
50. Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Perros F, etal., Eur Respir J. 2007 May;29(5):937-43. Epub 2006 Dec 20.
51. The CX3CL1-CX3CR1 system and psoriasis. Plant D, etal., Exp Dermatol. 2006 Nov;15(11):900-3.
52. Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Pong WW, etal., Ann Neurol. 2013 Feb;73(2):303-8. doi: 10.1002/ana.23813. Epub 2013 Feb 19.
53. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice. Poupel L, etal., Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2297-305. doi: 10.1161/ATVBAHA.112.300930. Epub 2013 Jul 25.
54. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. Rauer M, etal., J Neurovirol. 2002 Jan;8(3):168-79.
55. Mouse MP Annotation Import Pipeline RGD automated import pipeline
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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58. The cardiovascular actions of fractalkine/CX3CL1 in the hypothalamic paraventricular nucleus are attenuated in rats with heart failure. Ruchaya PJ, etal., Exp Physiol. 2014 Jan;99(1):111-22. doi: 10.1113/expphysiol.2013.075432. Epub 2013 Sep 13.
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PMID:30541565   PMID:30541786   PMID:30552020   PMID:30582448   PMID:30588668   PMID:30598527   PMID:30606613   PMID:30627652   PMID:30634998   PMID:30643263   PMID:30643265   PMID:30647151  
PMID:30650375   PMID:30654821   PMID:30666961   PMID:30671738   PMID:30675063   PMID:30679343   PMID:30692259   PMID:30737131   PMID:30746765   PMID:30760484   PMID:30760929   PMID:30769286  
PMID:30783017   PMID:30811995   PMID:30833511   PMID:30842418   PMID:30846482   PMID:30850344   PMID:30866963   PMID:30872165   PMID:30890724   PMID:30897213   PMID:30909963   PMID:30910011  
PMID:30930171   PMID:30948201   PMID:30951142   PMID:30959277   PMID:30988524   PMID:30996332   PMID:30996341   PMID:31023885   PMID:31036641   PMID:31039135   PMID:31045582   PMID:31048318  
PMID:31053503   PMID:31058213   PMID:31061494   PMID:31071093   PMID:31086203   PMID:31091440   PMID:31091450   PMID:31112137   PMID:31116973   PMID:31138703   PMID:31150565   PMID:31167129  
PMID:31167136   PMID:31169521   PMID:31178352   PMID:31182576   PMID:31189971   PMID:31201094   PMID:31201215   PMID:31208274   PMID:31209379   PMID:31219699   PMID:31222056   PMID:31231364  
PMID:31235930   PMID:31237618   PMID:31238788   PMID:31239386   PMID:31242418   PMID:31246581   PMID:31251389   PMID:31257024   PMID:31257151   PMID:31262353   PMID:31263146   PMID:31263278  
PMID:31263398   PMID:31272490   PMID:31278348   PMID:31300648   PMID:31316515   PMID:31324779   PMID:31325968   PMID:31350310   PMID:31356156   PMID:31375314   PMID:31378907   PMID:31391580  
PMID:31400163   PMID:31426806   PMID:31446159   PMID:31467036   PMID:31471472   PMID:31481690   PMID:31489403   PMID:31491389   PMID:31495690   PMID:31501473   PMID:31540356   PMID:31541001  
PMID:31586069   PMID:31618637   PMID:31619539   PMID:31619589   PMID:31626642   PMID:31636449   PMID:31636451   PMID:31652020   PMID:31676809   PMID:31692106   PMID:31697805   PMID:31712428  
PMID:31727842   PMID:31732166   PMID:31744815   PMID:31762013   PMID:31765724   PMID:31771656   PMID:31775156   PMID:31776203   PMID:31778536   PMID:31785096   PMID:31792059   PMID:31799746  
PMID:31803182   PMID:31825829   PMID:31840109   PMID:31862977   PMID:31866067   PMID:31873194   PMID:31879345   PMID:31896673   PMID:31907410   PMID:31915267   PMID:31923400   PMID:31935195  
PMID:31937758   PMID:31944217   PMID:31951251   PMID:31967645   PMID:31983537   PMID:31996456   PMID:32003140   PMID:32003282   PMID:32016488   PMID:32023471   PMID:32023844   PMID:32027825  
PMID:32030804   PMID:32039516   PMID:32066806   PMID:32066949   PMID:32080187   PMID:32082318   PMID:32094172   PMID:32102934   PMID:32112058   PMID:32119994   PMID:32130903   PMID:32142677  
PMID:32150307   PMID:32165624   PMID:32170061   PMID:32179066   PMID:32188932   PMID:32219160   PMID:32220118   PMID:32229332   PMID:32236410   PMID:32239625   PMID:32240765   PMID:32242005  
PMID:32259484   PMID:32269105   PMID:32276965   PMID:32281691   PMID:32284594   PMID:32284604   PMID:32286273   PMID:32290105   PMID:32296307   PMID:32296422   PMID:32301704   PMID:32320664  
PMID:32325694   PMID:32341550   PMID:32348754   PMID:32349774   PMID:32389572   PMID:32393787   PMID:32400390   PMID:32413556   PMID:32417340   PMID:32418612   PMID:32425929   PMID:32434046  
PMID:32437334   PMID:32438398   PMID:32439942   PMID:32444476   PMID:32451485   PMID:32452062   PMID:32453801   PMID:32457369   PMID:32459864   PMID:32466726   PMID:32483169   PMID:32488990  
PMID:32513210   PMID:32541832   PMID:32542737   PMID:32562599   PMID:32567735   PMID:32568214   PMID:32573436   PMID:32579923   PMID:32601313   PMID:32611727   PMID:32615087   PMID:32621847  
PMID:32624353   PMID:32639068   PMID:32648893   PMID:32659044   PMID:32662924   PMID:32703941   PMID:32716294   PMID:32717023   PMID:32720752   PMID:32723480   PMID:32747526   PMID:32755573  
PMID:32783928   PMID:32795398   PMID:32795415   PMID:32797195   PMID:32808923   PMID:32810508   PMID:32814050   PMID:32814243   PMID:32814898   PMID:32863951   PMID:32865286   PMID:32866728  
PMID:32873797   PMID:32895539   PMID:32915783   PMID:32923620   PMID:32923636   PMID:32937105   PMID:32937134   PMID:32959911   PMID:32963013   PMID:32994410   PMID:32999463   PMID:33020472  
PMID:33020661   PMID:33027640   PMID:33029008   PMID:33034881   PMID:33038331   PMID:33039355   PMID:33045062   PMID:33049219   PMID:33052099   PMID:33054973   PMID:33059703   PMID:33060175  
PMID:33068332   PMID:33079443   PMID:33081841   PMID:33086061   PMID:33095507   PMID:33108405   PMID:33113353   PMID:33119934   PMID:33122426   PMID:33127853   PMID:33133103   PMID:33147450  
PMID:33172841   PMID:33177990   PMID:33183319   PMID:33187533   PMID:33190798   PMID:33207209   PMID:33214681   PMID:33220232   PMID:33238121   PMID:33239787   PMID:33241604   PMID:33258449  
PMID:33316453   PMID:33318667   PMID:33323383   PMID:33333014   PMID:33360827   PMID:33363534   PMID:33364241   PMID:33371336   PMID:33373623   PMID:33378678   PMID:33402196   PMID:33407903  
PMID:33408187   PMID:33411754   PMID:33414187   PMID:33423699   PMID:33428140   PMID:33434616   PMID:33462113   PMID:33462481   PMID:33476547   PMID:33495636   PMID:33519804   PMID:33523920  
PMID:33535035   PMID:33539767   PMID:33547295   PMID:33555074   PMID:33556431   PMID:33568812   PMID:33588074   PMID:33592194   PMID:33593983   PMID:33602265   PMID:33603230   PMID:33606320  
PMID:33606969   PMID:33620118   PMID:33624376   PMID:33626909   PMID:33627648   PMID:33627843   PMID:33637522   PMID:33662668   PMID:33672319   PMID:33710283   PMID:33731355   PMID:33731931  
PMID:33739978   PMID:33754166   PMID:33762004   PMID:33765141   PMID:33766097   PMID:33773107   PMID:33785644   PMID:33797066   PMID:33811906   PMID:33815067   PMID:33823533   PMID:33830019  
PMID:33846230   PMID:33849645   PMID:33855305   PMID:33859199   PMID:33859405   PMID:33932339   PMID:33934399   PMID:33951432   PMID:33972447   PMID:33998138   PMID:34007995   PMID:34013588  
PMID:34015256   PMID:34021136   PMID:34038728   PMID:34038733   PMID:34099706   PMID:34101346   PMID:34108686   PMID:34115982   PMID:34130712   PMID:34133945   PMID:34135508   PMID:34138470  
PMID:34196465   PMID:34210853   PMID:34223817   PMID:34224823   PMID:34233151   PMID:34233165   PMID:34250902   PMID:34253764   PMID:34258598   PMID:34262178   PMID:34270934   PMID:34283971  
PMID:34292944   PMID:34298846   PMID:34320366   PMID:34321229   PMID:34321999   PMID:34343616   PMID:34343617   PMID:34343619   PMID:34363749   PMID:34385589   PMID:34407943   PMID:34411753  
PMID:34413303   PMID:34417326   PMID:34423781   PMID:34433021   PMID:34433553   PMID:34433559   PMID:34440631   PMID:34446062   PMID:34452924   PMID:34459015   PMID:34484224   PMID:34484228  
PMID:34487590   PMID:34488442   PMID:34489419   PMID:34489438   PMID:34490521   PMID:34520571   PMID:34526403   PMID:34526998   PMID:34544421   PMID:34544431   PMID:34551296   PMID:34551300  
PMID:34555357   PMID:34555433   PMID:34556874   PMID:34561487   PMID:34618685   PMID:34630039   PMID:34636034   PMID:34642249   PMID:34654439   PMID:34661337   PMID:34673570   PMID:34677124  
PMID:34678150   PMID:34685628   PMID:34707603   PMID:34744631   PMID:34772739   PMID:34782623   PMID:34788631   PMID:34793707   PMID:34819341   PMID:34819664   PMID:34826234   PMID:34836549  
PMID:34851693   PMID:34875233   PMID:34887354   PMID:34887504   PMID:34911964   PMID:34916658   PMID:34982959   PMID:34983562   PMID:34995099   PMID:35017526   PMID:35019164   PMID:35021079  
PMID:35045285   PMID:35062962   PMID:35085235   PMID:35086862   PMID:35090578   PMID:35110420   PMID:35115536   PMID:35119218   PMID:35121993   PMID:35132709   PMID:35148456   PMID:35173711  
PMID:35185378   PMID:35195906   PMID:35201268   PMID:35222638   PMID:35228700   PMID:35236374   PMID:35245123   PMID:35250464   PMID:35296717   PMID:35296858   PMID:35303081   PMID:35303422  
PMID:35328354   PMID:35342016   PMID:35343899   PMID:35347900   PMID:35352285   PMID:35354026   PMID:35357926   PMID:35359928   PMID:35366396   PMID:35379828   PMID:35384838   PMID:35385340  
PMID:35388142   PMID:35396327   PMID:35408803   PMID:35413950   PMID:35414012   PMID:35431801   PMID:35443157   PMID:35444273   PMID:35452096   PMID:35476440   PMID:35478937   PMID:35481836  
PMID:35488301   PMID:35504893   PMID:35526014   PMID:35544642   PMID:35545672   PMID:35560167   PMID:35567352   PMID:35581352   PMID:35599331   PMID:35599984   PMID:35609421   PMID:35613577  
PMID:35624490   PMID:35636458   PMID:35669512   PMID:35672148   PMID:35705045   PMID:35705491   PMID:35749158   PMID:35750050   PMID:35757750   PMID:35764973   PMID:35795142   PMID:35809029  
PMID:35863346   PMID:35870427   PMID:35871167   PMID:35884958   PMID:35909315   PMID:35909564   PMID:35914622   PMID:35933343   PMID:35948630   PMID:35966584   PMID:35972072   PMID:35977543  
PMID:35985835   PMID:35986378   PMID:35988637   PMID:36034743   PMID:36037380   PMID:36037587   PMID:36067217   PMID:36076283   PMID:36103829   PMID:36107206   PMID:36130488   PMID:36142366  
PMID:36173678   PMID:36180790   PMID:36184639   PMID:36203331   PMID:36228615   PMID:36231129   PMID:36241997   PMID:36253375   PMID:36257314   PMID:36266311   PMID:36280666   PMID:36306735  
PMID:36321865   PMID:36323311   PMID:36343752   PMID:36368316   PMID:36375656   PMID:36375694   PMID:36379210   PMID:36384110   PMID:36384142   PMID:36400250   PMID:36426712   PMID:36438480  
PMID:36446385   PMID:36450771   PMID:36462493   PMID:36473461   PMID:36473468   PMID:36497130   PMID:36511337   PMID:36515584   PMID:36517889   PMID:36541061   PMID:36543959   PMID:36550225  
PMID:36563662   PMID:36563667   PMID:36577069   PMID:36577999   PMID:36591296   PMID:36603072   PMID:36638785   PMID:36640306   PMID:36652438   PMID:36672219   PMID:36681359   PMID:36683435  
PMID:36697258   PMID:36701202   PMID:36703006   PMID:36705667   PMID:36706180   PMID:36725904   PMID:36726454   PMID:36736320   PMID:36747024   PMID:36749020   PMID:36753421   PMID:36763532  
PMID:36787231   PMID:36787740   PMID:36795751   PMID:36810227   PMID:36827982   PMID:36845109   PMID:36852927   PMID:36857453   PMID:36859544   PMID:36868219   PMID:36878712   PMID:36879007  
PMID:36879321   PMID:36890539   PMID:36890580   PMID:36893254   PMID:36906075   PMID:36906076   PMID:36909184   PMID:36922518   PMID:36928411   PMID:36928635   PMID:36989353   PMID:36994950  
PMID:37012245   PMID:37033925   PMID:37060359   PMID:37065770   PMID:37084991   PMID:37086405   PMID:37099424   PMID:37101546   PMID:37115585   PMID:37117599   PMID:37118341   PMID:37130522  
PMID:37146150   PMID:37167975   PMID:37169859   PMID:37175391   PMID:37178688   PMID:37179295   PMID:37199240   PMID:37204925   PMID:37211968   PMID:37214408   PMID:37217677   PMID:37224917  
PMID:37231161   PMID:37234176   PMID:37234914   PMID:37248420   PMID:37256130   PMID:37256881   PMID:37261911   PMID:37268417   PMID:37289588   PMID:37289590   PMID:37300531   PMID:37315234  
PMID:37315555   PMID:37322178   PMID:37328088   PMID:37332598   PMID:37340860   PMID:37348508   PMID:37353182   PMID:37353538   PMID:37365181   PMID:37402168   PMID:37414907   PMID:37426658  
PMID:37426748   PMID:37428916   PMID:37440641   PMID:37466391   PMID:37490909   PMID:37516311   PMID:37516803   PMID:37516843   PMID:37527036   PMID:37527657   PMID:37528070   PMID:37566453  
PMID:37572655   PMID:37572666   PMID:37578861   PMID:37590143   PMID:37615937   PMID:37635351   PMID:37638037   PMID:37640194   PMID:37648036   PMID:37652021   PMID:37680624   PMID:37689689  
PMID:37691936   PMID:37717033   PMID:37724398   PMID:37729919   PMID:37731609   PMID:37737058   PMID:37742194   PMID:37746760   PMID:37749326   PMID:37751892   PMID:37771579   PMID:37771779  
PMID:37773430   PMID:37777475   PMID:37779150   PMID:37808470   PMID:37814796   PMID:37820974   PMID:37838079   PMID:37863874   PMID:37880248   PMID:37901245   PMID:37903620   PMID:37908731  
PMID:37914098   PMID:37918358   PMID:37924268   PMID:37926132   PMID:37926818   PMID:37942288   PMID:37952151   PMID:37967660   PMID:37980559   PMID:37985764   PMID:37989592   PMID:37993717  
PMID:38045056   PMID:38049944   PMID:38057428   PMID:38057662   PMID:38064171   PMID:38086903   PMID:38089576   PMID:38096370   PMID:38100356   PMID:38101413   PMID:38131301   PMID:38134473  
PMID:38141840   PMID:38145872   PMID:38159573   PMID:38167258   PMID:38175754   PMID:38177340   PMID:38180236   PMID:38180982   PMID:38200023   PMID:38217856   PMID:38258906   PMID:38261512  
PMID:38279130   PMID:38295790   PMID:38309258   PMID:38311721   PMID:38320455   PMID:38326613   PMID:38331051   PMID:38347225   PMID:38352874   PMID:38355793   PMID:38362011   PMID:38367237  
PMID:38367239   PMID:38368612   PMID:38383567   PMID:38407952   PMID:38409076   PMID:38427731   PMID:38448581   PMID:38468308   PMID:38472515   PMID:38474350   PMID:38489263   PMID:38489366  
PMID:38490196   PMID:38505603   PMID:38505607   PMID:38510113   PMID:38537684   PMID:38561421   PMID:38565291   PMID:38587075   PMID:38596358   PMID:38600569   PMID:38614103   PMID:38616340  
PMID:38625796   PMID:38632402   PMID:38636518   PMID:38646596   PMID:38660801   PMID:38670239   PMID:38697107   PMID:38700011   PMID:38701781   PMID:38715939   PMID:38735403   PMID:38749446  
PMID:38750507   PMID:38777288   PMID:38786041   PMID:38802940   PMID:38831312   PMID:38894655   PMID:38906887   PMID:38909126   PMID:38925413   PMID:38935500   PMID:38941274   PMID:38942014  
PMID:38951525   PMID:38961498   PMID:39002124   PMID:39021836   PMID:39043941   PMID:39047106   PMID:39048565   PMID:39082371   PMID:39088319   PMID:39089253   PMID:39089257   PMID:39095477  
PMID:39116878   PMID:39142282   PMID:39154007   PMID:39184441   PMID:39198639   PMID:39215356   PMID:39218233   PMID:39236241   PMID:39237613   PMID:39334471   PMID:39362935   PMID:39424804  
PMID:39435149  


Genomics

Comparative Map Data
Cx3cr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,877,749 - 119,897,362 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,877,749 - 119,898,945 (-)EnsemblGRCm39 Ensembl
GRCm389120,048,683 - 120,068,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,901,616 - 120,069,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,957,811 - 119,977,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,897,391 - 119,916,980 (-)NCBIMGSCv36mm8
Celera9120,518,248 - 120,537,939 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.37NCBI
CX3CR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38339,263,494 - 39,292,966 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl339,263,495 - 39,281,735 (-)EnsemblGRCh38hg38GRCh38
GRCh37339,304,985 - 39,323,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,279,989 - 39,296,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 34339,279,990 - 39,296,526NCBI
Celera339,246,596 - 39,264,836 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef339,347,466 - 39,365,706 (-)NCBIHuRef
CHM1_1339,256,125 - 39,274,344 (-)NCBICHM1_1
T2T-CHM13v2.0339,276,418 - 39,305,868 (-)NCBIT2T-CHM13v2.0
Cx3cr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,661,294 - 128,679,048 (-)NCBIGRCr8
mRatBN7.28119,785,726 - 119,799,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,782,595 - 119,800,014 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8125,366,943 - 125,380,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,565,979 - 123,579,659 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,406,569 - 121,420,231 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,740,756 - 128,754,514 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,740,756 - 128,754,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,941,653 - 127,955,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,033,630 - 125,047,335 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,053,366 - 125,067,072 (-)NCBI
Celera8118,932,179 - 118,945,873 (-)NCBICelera
Cytogenetic Map8q32NCBI
Cx3cr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,701,073 - 24,707,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,691,206 - 24,705,599 (+)NCBIChiLan1.0ChiLan1.0
CX3CR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2239,213,724 - 39,231,983 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1339,218,486 - 39,235,054 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0339,158,346 - 39,176,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,439,009 - 39,456,797 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,440,955 - 39,457,219 (-)Ensemblpanpan1.1panPan2
CX3CR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,937,069 - 8,954,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,938,906 - 8,952,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,974,330 - 8,988,240 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,221,526 - 9,239,150 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,221,526 - 9,237,271 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,036,770 - 9,050,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,179,594 - 9,193,497 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,172,979 - 9,186,888 (-)NCBIUU_Cfam_GSD_1.0
Cx3cr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,370,137 - 195,397,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,510,523 - 28,535,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,508,726 - 28,535,640 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CX3CR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,944,369 - 23,957,486 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,944,386 - 23,957,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,204,842 - 26,218,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CX3CR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115136,757 - 153,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15150,718 - 151,785 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660638,861,161 - 8,878,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cx3cr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,706,043 - 1,719,452 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,705,953 - 1,719,452 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cx3cr1
676 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1656
Count of miRNA genes:505
Interacting mature miRNAs:616
Transcripts:ENSMUST00000064165, ENSMUST00000177637
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse

Markers in Region
PMC209384P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,051,562 - 120,052,175UniSTSGRCm38
MGSCv379119,960,680 - 119,961,293UniSTSGRCm37
Celera9120,521,122 - 120,521,735UniSTS
Cytogenetic Map9F4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000064165   ⟹   ENSMUSP00000063986
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,877,749 - 119,897,362 (-)Ensembl
GRCm38.p6 Ensembl9120,048,683 - 120,068,296 (-)Ensembl
Ensembl Acc Id: ENSMUST00000177637   ⟹   ENSMUSP00000136413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,730,682 - 119,897,349 (-)Ensembl
GRCm38.p6 Ensembl9119,901,616 - 120,068,283 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215016   ⟹   ENSMUSP00000150463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,877,749 - 119,898,945 (-)Ensembl
GRCm38.p6 Ensembl9120,048,683 - 120,069,879 (-)Ensembl
RefSeq Acc Id: NM_009987   ⟹   NP_034117
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,877,749 - 119,897,362 (-)NCBI
GRCm389120,048,683 - 120,068,296 (-)NCBI
MGSCv379119,957,811 - 119,977,400 (-)RGD
Celera9120,518,238 - 120,537,953 (-)NCBI
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034117   ⟸   NM_009987
- UniProtKB: Q9Z0D9 (UniProtKB/Swiss-Prot),   Q543X3 (UniProtKB/TrEMBL),   Q8BR50 (UniProtKB/TrEMBL),   Q8CBJ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000136413   ⟸   ENSMUST00000177637
Ensembl Acc Id: ENSMUSP00000063986   ⟸   ENSMUST00000064165
Ensembl Acc Id: ENSMUSP00000150463   ⟸   ENSMUST00000215016
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0D9-F1-model_v2 AlphaFold Q9Z0D9 1-354 view protein structure

Promoters
RGD ID:6844381
Promoter ID:MM_KWN:59158
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_009987
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,977,231 - 119,977,731 (-)MPROMDB
RGD ID:8671216
Promoter ID:EPDNEW_M13639
Type:multiple initiation site
Name:Cx3cr1_1
Description:Mus musculus chemokine (C-X3-C motif) receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,068,270 - 120,068,330EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333815 AgrOrtholog
Ensembl Genes ENSMUSG00000052336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064165 ENTREZGENE
  ENSMUST00000064165.5 UniProtKB/Swiss-Prot
  ENSMUST00000215016.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CX3CR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13051 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333815 ENTREZGENE
NCBI Gene 13051 ENTREZGENE
PANTHER CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CX3C CHEMOKINE RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cx3cr1 PhenoGen
PRINTS FRACTALKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CX3C1_MOUSE UniProtKB/Swiss-Prot
  Q543X3 ENTREZGENE, UniProtKB/TrEMBL
  Q8BR50 ENTREZGENE, UniProtKB/TrEMBL
  Q8CBJ0 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0D9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Cx3cr1  C-X3-C motif chemokine receptor 1  Cx3cr1  chemokine (C-X3-C motif) receptor 1  Symbol and/or name change 5135510 APPROVED
2013-11-26 Cx3cr1  chemokine (C-X3-C motif) receptor 1    chemokine (C-X3-C) receptor 1  Symbol and/or name change 5135510 APPROVED