Cx3cr1 (chemokine (C-X3-C motif) receptor 1) - Rat Genome Database

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Gene: Cx3cr1 (chemokine (C-X3-C motif) receptor 1) Mus musculus
Symbol: Cx3cr1
Name: chemokine (C-X3-C motif) receptor 1
RGD ID: 1552004
Description: Enables C-X3-C chemokine binding activity and C-X3-C chemokine receptor activity. Involved in several processes, including central nervous system development; leukocyte migration; and synapse organization. Acts upstream of or within several processes, including macrophage chemotaxis; microglial cell activation involved in immune response; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cell surface. Is expressed in several structures, including colon; genitourinary system; and liver. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X3-C chemokine receptor 1; C-X3-C CKR-1; chemokine (C-X3-C) receptor 1; CX3C chemokine receptor 1; fractalkine receptor; mCX3CR1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399119,877,749 - 119,897,362 (-)NCBIGRCm39mm39
GRCm39 Ensembl9119,730,682 - 119,898,945 (-)Ensembl
GRCm389120,048,683 - 120,068,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,901,616 - 120,069,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,957,811 - 119,977,400 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,897,391 - 119,916,980 (-)NCBImm8
Celera9120,518,248 - 120,537,939 (-)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 12  (IEA,ISO)
anti-basement membrane glomerulonephritis  (ISO)
arteriosclerosis  (IMP)
arthus reaction  (IMP)
asthma  (IMP,ISO)
atherosclerosis  (IMP)
atopic dermatitis  (IMP,ISO)
borna disease  (ISO)
Chloracne  (ISO)
Chronic Mesangial Proliferative Glomerulonephritis  (ISO)
congestive heart failure  (ISO)
conjunctivitis  (IMP)
corneal neovascularization  (IMP)
coronary artery disease  (ISS)
Coronary Disease  (ISO)
cystitis  (ISO)
diabetes mellitus  (IMP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (IMP,ISO)
Experimental Diabetes Mellitus  (ISO)
glaucoma  (IMP)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Hearing Loss  (IEP)
hepatopulmonary syndrome  (ISO)
Herpes Simplex Encephalitis  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (IMP,ISO)
Inflammation  (IMP,ISO)
Intervertebral Disc Displacement  (ISO)
Intimal Hyperplasia  (IMP)
macular degeneration  (IGI,ISO)
Memory Disorders  (ISO)
Microscopic Polyangiitis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
optic nerve glioma  (IMP)
otitis media  (ISO)
Pain  (ISO)
Parkinsonism  (ISO)
portal hypertension  (ISO)
prion disease  (ISO)
psoriasis  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (IEP,IMP)
retinal degeneration  (IMP,ISO)
retinal vasculitis  (ISO)
retinitis  (IMP)
sciatic neuropathy  (IMP,ISO)
Sepsis  (ISO)
status epilepticus  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (IMP,ISO)
transient cerebral ischemia  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
ceric oxide  (ISO)
choline  (EXP,ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
dextran sulfate  (EXP)
diazinon  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ferric oxide  (EXP)
folic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
GW 501516  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mechlorethamine  (ISO)
methamphetamine  (ISO)
monosodium L-glutamate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentane-2,3-dione  (ISO)
phenobarbital  (ISO)
quercetin  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
succimer  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IMP)
antifungal innate immune response  (IMP,ISO)
autocrine signaling  (ISO)
brain development  (IMP)
calcium-mediated signaling  (IBA)
cell adhesion  (IPI,ISO)
cell chemotaxis  (IBA,ISO)
cellular response to lipopolysaccharide  (IGI,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
central nervous system maturation  (IMP)
cerebral cortex cell migration  (IMP)
chemokine-mediated signaling pathway  (ISO)
chemotaxis  (ISO)
cytokine-mediated signaling pathway  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
host-mediated regulation of intestinal microbiota composition  (IMP)
immune response  (IBA,IMP)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IC)
leukocyte chemotaxis  (IMP)
leukocyte tethering or rolling  (IGI)
macrophage chemotaxis  (IMP)
memory  (ISO)
microglial cell activation  (ISO)
microglial cell activation involved in immune response  (IMP)
microglial cell migration  (IMP)
modulation of chemical synaptic transmission  (IMP)
multiple spine synapse organization, single dendrite  (IMP)
negative regulation of angiogenesis  (IMP)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of chronic inflammatory response to non-antigenic stimulus  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
negative regulation of hippocampal neuron apoptotic process  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of microglial cell mediated cytotoxicity  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of angiogenesis  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of I-kappaB phosphorylation  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of monocyte chemotaxis  (IMP)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
regulation of nitric oxide biosynthetic process  (IGI)
regulation of tumor necrosis factor production  (IGI)
response to ischemia  (ISO)
signal transduction  (IEA)
social behavior  (IMP)
synapse maturation  (IMP)
synapse pruning  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amacrine cell morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal leukocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal ocular fundus morphology  (IAGP)
abnormal photoreceptor connecting cilium morphology  (IAGP)
abnormal photoreceptor inner segment morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal response to transplant  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina outer nuclear layer morphology  (IAGP)
abnormal retina photoreceptor layer morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
brain inflammation  (IAGP)
brainstem hemorrhage  (IAGP)
choroidal neovascularization  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased colon length  (IAGP)
decreased grip strength  (IAGP)
decreased inflammatory response  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased litter size  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased neuron number  (IAGP)
decreased NK cell number  (IAGP)
decreased retina cone cell number  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
demyelination  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
enlarged kidney  (IEA)
impaired behavioral response to xenobiotic  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased dendritic cell number  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased macrophage cell number  (IAGP)
increased microglial cell activation  (IAGP)
increased neuron apoptosis  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased transforming growth factor beta level  (IAGP)
microgliosis  (IAGP)
neuron degeneration  (IAGP)
paralysis  (IAGP)
paresis  (IAGP)
premature death  (IAGP)
retina cone cell degeneration  (IAGP)
retina degeneration  (IAGP)
retina deposits  (IAGP)
retina gliosis  (IAGP)
retina outer nuclear layer degeneration  (IAGP)
retina photoreceptor degeneration  (IAGP)
retina pigment epithelium atrophy  (IAGP)
retina pigment epithelium hyperplasia  (IAGP)
short photoreceptor outer segment  (IAGP)
small kidney  (IEA)
thin retina outer nuclear layer  (IAGP)
variable depigmentation  (IAGP)

References - curated
# Reference Title Reference Citation
1. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Amanatidou V, etal., Pediatr Infect Dis J. 2006 May;25(5):410-4.
2. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
3. Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population. Anastasopoulos E, etal., Curr Eye Res. 2012 Dec;37(12):1148-55. doi: 10.3109/02713683.2012.705413. Epub 2012 Jul 20.
4. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Andre F, etal., Ann Oncol. 2006 Jun;17(6):945-51. Epub 2006 Apr 20.
5. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
6. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
7. Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. Briones TL, etal., J Neuroinflammation. 2014 Jan 22;11:13. doi: 10.1186/1742-2094-11-13.
8. Expression of chemokine receptor CX3CR1 in infants with respiratory syncytial virus bronchiolitis. Cepika AM, etal., Pediatr Allergy Immunol. 2008 Mar;19(2):148-56. doi: 10.1111/j.1399-3038.2007.00611.x.
9. Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Chan CC, etal., Histol Histopathol. 2005 Jul;20(3):857-63.
10. Paraquat-induced retinal degeneration is exaggerated in CX3CR1-deficient mice and is associated with increased retinal inflammation. Chen M, etal., Invest Ophthalmol Vis Sci. 2013 Jan 23;54(1):682-90. doi: 10.1167/iovs.12-10888.
11. Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats. Chen YM, etal., Nephrol Dial Transplant. 2003 Dec;18(12):2505-14.
12. Expression of fractalkine (CX3CL1) and its receptor in endotoxin-induced uveitis. Chu L, etal., Ophthalmic Res. 2009;42(3):160-6. Epub 2009 Jul 31.
13. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Combadiere C, etal., Circulation. 2003 Feb 25;107(7):1009-16.
14. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Dagkalis A, etal., Immunology. 2009 Sep;128(1):25-33. doi: 10.1111/j.1365-2567.2009.03046.x.
15. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Denoyer A, etal., Mucosal Immunol. 2012 Nov;5(6):702-11. doi: 10.1038/mi.2012.43. Epub 2012 Jun 13.
16. CX3CR1 polymorphisms are associated with atopy but not asthma in German children. Depner M, etal., Int Arch Allergy Immunol. 2007;144(1):91-4. Epub 2007 May 15.
17. Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation. Echigo T, etal., J Allergy Clin Immunol. 2004 May;113(5):940-8.
18. Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis. Fang IM, etal., Mol Vis. 2005 Jul 1;11:443-51.
19. Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication. Feng L, etal., Kidney Int. 1999 Aug;56(2):612-20.
20. Study of Polymorphisms in CX3CR1, PLEKHA1 and VEGF Genes as Risk Factors for Age-related Macular Degeneration in Indian Patients. Gupta D, etal., Arch Med Res. 2014 Jul 19. pii: S0188-4409(14)00161-1. doi: 10.1016/j.arcmed.2014.07.005.
21. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. Harcourt J, etal., J Immunol. 2006 Feb 1;176(3):1600-8.
22. Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis. Hasegawa M, etal., Ann Rheum Dis. 2005 Jan;64(1):21-8.
23. Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P. Haynes LM, etal., J Virol. 2003 Sep;77(18):9831-44.
24. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Hughes PM, etal., Glia. 2002 Mar 15;37(4):314-27.
25. Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. Ito Y, etal., Kidney Int. 2002 Jun;61(6):2044-57.
26. Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation. Jerath MR, etal., Thromb J. 2010 Sep 13;8:14. doi: 10.1186/1477-9560-8-14.
27. Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus. Katsuyama K, etal., Nephron Exp Nephrol. 2009;113(2):e45-56. Epub 2009 Jul 10.
28. The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. Kezic JM, etal., Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):854-63. doi: 10.1167/iovs.12-10876.
29. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Kikuchi Y, etal., Nephron Exp Nephrol. 2004;97(1):e17-25.
30. Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK. Lee KM, etal., Eur J Pain. 2010 Aug;14(7):682.e1-12. Epub 2009 Dec 2.
31. mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients. Li YM, etal., Chin Med Sci J. 2010 Sep;25(3):162-8.
32. Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. Lu P, etal., J Immunol. 2008 Mar 15;180(6):4283-91.
33. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. Luhmann UF, etal., PLoS One. 2012;7(4):e35551. doi: 10.1371/journal.pone.0035551. Epub 2012 Apr 24.
34. Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome. Luongo L, etal., Neurosci Lett. 2008 May 30;437(2):98-102. Epub 2008 Apr 10.
35. Polymorphism of the fractalkine receptor CX3CR1 and systemic sclerosis-associated pulmonary arterial hypertension. Marasini B, etal., Clin Dev Immunol. 2005 Dec;12(4):275-9.
36. Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis. Matsunawa M, etal., Clin Exp Rheumatol. 2009 Jan-Feb;27(1):72-8.
37. Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis. McDermott DH, etal., Circ Res. 2001 Aug 31;89(5):401-7.
38. Gut-brain chemokine changes in portal hypertensive rats. Merino J, etal., Dig Dis Sci. 2011 Aug;56(8):2309-17. doi: 10.1007/s10620-011-1625-y. Epub 2011 Feb 24.
39. MGDs mouse GO annotations MGD data from the GO Consortium
41. An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Milligan E, etal., Eur J Neurosci. 2005 Dec;22(11):2775-82.
42. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Mionnet C, etal., Nat Med. 2010 Nov;16(11):1305-12. Epub 2010 Oct 31.
43. Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. Morimura S, etal., Am J Pathol. 2013 May;182(5):1640-7. doi: 10.1016/j.ajpath.2013.01.023. Epub 2013 Mar 5.
44. Predominant infiltration of monocytes in chronic graft-versus-host disease. Namba N, etal., Transplantation. 2007 Jan 27;83(2):220-4.
45. Polymorphisms of immunity genes and susceptibility to otitis media in children. Nokso-Koivisto J, etal., PLoS One. 2014 Apr 9;9(4):e93930. doi: 10.1371/journal.pone.0093930. eCollection 2014.
46. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Intrathecal infusion of pyrrolidine dithiocarbamate for the prevention and reversal of neuropathic pain in rats using a sciatic chronic constriction injury model. Pan YD, etal., Reg Anesth Pain Med. 2010 May-Jun;35(3):231-7. doi: 10.1097/AAP.0b013e3181df245b.
49. Changes in spinal cord expression of fractalkine and its receptor in a rat model of disc herniation by autologous nucleus pulposus. Park HW, etal., Spine (Phila Pa 1976). 2011 Jan 8.
50. Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. Perros F, etal., Eur Respir J. 2007 May;29(5):937-43. Epub 2006 Dec 20.
51. The CX3CL1-CX3CR1 system and psoriasis. Plant D, etal., Exp Dermatol. 2006 Nov;15(11):900-3.
52. Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Pong WW, etal., Ann Neurol. 2013 Feb;73(2):303-8. doi: 10.1002/ana.23813. Epub 2013 Feb 19.
53. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice. Poupel L, etal., Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2297-305. doi: 10.1161/ATVBAHA.112.300930. Epub 2013 Jul 25.
54. Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. Rauer M, etal., J Neurovirol. 2002 Jan;8(3):168-79.
55. Mouse MP Annotation Import Pipeline RGD automated import pipeline
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis. Ridderstad Wollberg A, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5409-14. doi: 10.1073/pnas.1316510111. Epub 2014 Mar 25.
58. The cardiovascular actions of fractalkine/CX3CL1 in the hypothalamic paraventricular nucleus are attenuated in rats with heart failure. Ruchaya PJ, etal., Exp Physiol. 2014 Jan;99(1):111-22. doi: 10.1113/expphysiol.2013.075432. Epub 2013 Sep 13.
59. Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Ruth JH, etal., Arthritis Rheum. 2001 Jul;44(7):1568-81.
60. Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation. Sbrana S, etal., Cytometry B Clin Cytom. 2005 May;65(1):14-21.
61. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
62. NEW evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Shan S, etal., Neurobiol Aging. 2009 Apr 14.
63. Association of common polymorphisms in the fractalkine receptor (CX3CR1) with obesity. Sirois-Gagnon D, etal., Obesity (Silver Spring). 2011 Jan;19(1):222-7. Epub 2010 Jun 3.
64. Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. Staniland AA, etal., J Neurochem. 2010 Aug;114(4):1143-57. doi: 10.1111/j.1471-4159.2010.06837.x. Epub 2010 May 28.
65. CX(3)CL1 (fractalkine) and its receptor CX(3)CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. Staumont-Salle D, etal., J Exp Med. 2014 Jun 2;211(6):1185-96. doi: 10.1084/jem.20121350. Epub 2014 May 12.
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67. Inhibition of the Activation and Recruitment of Microglia-Like Cells Protects Against Neomycin-Induced Ototoxicity. Sun S, etal., Mol Neurobiol. 2014 May 1.
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PMID:31586069   PMID:31618637   PMID:31619539   PMID:31619589   PMID:31626642   PMID:31636449   PMID:31636451   PMID:31652020   PMID:31676809   PMID:31692106   PMID:31697805   PMID:31712428  
PMID:31727842   PMID:31732166   PMID:31744815   PMID:31765724   PMID:31771656   PMID:31776203   PMID:31778536   PMID:31792059   PMID:31799746   PMID:31803182   PMID:31825829   PMID:31862977  
PMID:31866067   PMID:31873194   PMID:31879345   PMID:31896673   PMID:31907410   PMID:31923400   PMID:31935195   PMID:31937758   PMID:31944217   PMID:31951251   PMID:31967645   PMID:31983537  
PMID:31996456   PMID:32003282   PMID:32016488   PMID:32023471   PMID:32023844   PMID:32027825   PMID:32030804   PMID:32039516   PMID:32066806   PMID:32066949   PMID:32080187   PMID:32082318  
PMID:32094172   PMID:32112058   PMID:32119994   PMID:32130903   PMID:32142677   PMID:32150307   PMID:32165624   PMID:32170061   PMID:32179066   PMID:32188932   PMID:32236410   PMID:32239625  
PMID:32242005   PMID:32259484   PMID:32269105   PMID:32276965   PMID:32281691   PMID:32284594   PMID:32284604   PMID:32286273   PMID:32290105   PMID:32296307   PMID:32296422   PMID:32320664  
PMID:32325694   PMID:32341550   PMID:32348754   PMID:32389572   PMID:32393787   PMID:32400390   PMID:32417340   PMID:32418612   PMID:32434046   PMID:32437334   PMID:32438398   PMID:32439942  
PMID:32444476   PMID:32451485   PMID:32452062   PMID:32453801   PMID:32457369   PMID:32483169   PMID:32488990   PMID:32513210   PMID:32541832   PMID:32542737   PMID:32562599   PMID:32567735  
PMID:32568214   PMID:32573436   PMID:32579923   PMID:32601313   PMID:32611727   PMID:32615087   PMID:32621847   PMID:32624353   PMID:32639068   PMID:32659044   PMID:32662924   PMID:32703941  
PMID:32716294   PMID:32720752   PMID:32723480   PMID:32747526   PMID:32755573   PMID:32783928   PMID:32795398   PMID:32797195   PMID:32808923   PMID:32810508   PMID:32814243   PMID:32814898  
PMID:32865286   PMID:32866728   PMID:32873797   PMID:32895539   PMID:32923620   PMID:32923636   PMID:32937105   PMID:32937134   PMID:32959911   PMID:32963013   PMID:32999463   PMID:33020472  
PMID:33020661   PMID:33027640   PMID:33029008   PMID:33034881   PMID:33045062   PMID:33049219   PMID:33054973   PMID:33059703   PMID:33060175   PMID:33068332   PMID:33079443   PMID:33086061  
PMID:33095507   PMID:33108405   PMID:33113353   PMID:33122426   PMID:33147450   PMID:33172841   PMID:33187533   PMID:33190798   PMID:33207209   PMID:33214681   PMID:33220232   PMID:33238121  
PMID:33241604   PMID:33258449   PMID:33318667   PMID:33333014   PMID:33363534   PMID:33373623   PMID:33407903   PMID:33408187   PMID:33411754   PMID:33414187   PMID:33428140   PMID:33462113  
PMID:33462481   PMID:33476547   PMID:33495636   PMID:33523920   PMID:33535035   PMID:33555074   PMID:33556431   PMID:33568812   PMID:33588074   PMID:33593983   PMID:33602265   PMID:33603230  
PMID:33606969   PMID:33620118   PMID:33627648   PMID:33662668   PMID:33672319   PMID:33731355   PMID:33731931   PMID:33739978   PMID:33754166   PMID:33762004   PMID:33765141   PMID:33773107  
PMID:33797066   PMID:33811906   PMID:33823533   PMID:33830019   PMID:33846230   PMID:33849645   PMID:33859199   PMID:33859405   PMID:33932339   PMID:33934399   PMID:33951432   PMID:33972447  
PMID:33998138   PMID:34007995   PMID:34021136   PMID:34038728   PMID:34038733   PMID:34099706   PMID:34101346   PMID:34108686   PMID:34133945   PMID:34138470   PMID:34196465   PMID:34210853  
PMID:34223817   PMID:34224823   PMID:34233151   PMID:34233165   PMID:34250902   PMID:34253764   PMID:34270934   PMID:34283971   PMID:34298846   PMID:34320366   PMID:34321229   PMID:34343617  
PMID:34343619   PMID:34363749   PMID:34385589   PMID:34413303   PMID:34417326   PMID:34423781   PMID:34433021   PMID:34433553   PMID:34433559   PMID:34440631   PMID:34446062   PMID:34484224  
PMID:34484228   PMID:34487590   PMID:34488442   PMID:34489419   PMID:34489438   PMID:34520571   PMID:34526403   PMID:34526998   PMID:34544421   PMID:34544431   PMID:34551300   PMID:34555433  
PMID:34556874   PMID:34561487   PMID:34618685   PMID:34630039   PMID:34654439   PMID:34661337   PMID:34673570   PMID:34685628   PMID:34707603   PMID:34782623   PMID:34788631   PMID:34826234  
PMID:34851693   PMID:34887504   PMID:34911964   PMID:34982959   PMID:34983562   PMID:35045285   PMID:35062962   PMID:35086862   PMID:35090578   PMID:35110420   PMID:35115536   PMID:35119218  
PMID:35121993   PMID:35132709   PMID:35148456   PMID:35185378   PMID:35236374   PMID:35250464   PMID:35296717   PMID:35328354   PMID:35342016   PMID:35343899   PMID:35357926   PMID:35359928  
PMID:35379828   PMID:35388142   PMID:35408803   PMID:35414012   PMID:35431801   PMID:35443157   PMID:35452096   PMID:35476440   PMID:35478937   PMID:35526014   PMID:35544642   PMID:35613577  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399119,877,749 - 119,897,362 (-)NCBIGRCm39mm39
GRCm39 Ensembl9119,730,682 - 119,898,945 (-)Ensembl
GRCm389120,048,683 - 120,068,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,901,616 - 120,069,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,957,811 - 119,977,400 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,897,391 - 119,916,980 (-)NCBImm8
Celera9120,518,248 - 120,537,939 (-)NCBICelera
Cytogenetic Map9F4NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38339,263,494 - 39,292,966 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl339,263,495 - 39,281,735 (-)EnsemblGRCh38hg38GRCh38
GRCh37339,304,985 - 39,323,226 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,279,989 - 39,296,531 (-)NCBINCBI36hg18NCBI36
Build 34339,279,990 - 39,296,526NCBI
Celera339,246,596 - 39,264,836 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef339,347,466 - 39,365,706 (-)NCBIHuRef
CHM1_1339,256,125 - 39,274,344 (-)NCBICHM1_1
T2T-CHM13v2.0339,276,418 - 39,294,663 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.28119,785,726 - 119,799,431 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl8119,782,595 - 119,800,014 (-)Ensembl
Rnor_6.08128,740,756 - 128,754,514 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,740,756 - 128,754,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,941,653 - 127,955,411 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,033,630 - 125,047,335 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18125,053,366 - 125,067,072 (-)NCBI
Celera8118,932,179 - 118,945,873 (-)NCBICelera
Cytogenetic Map8q32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542724,701,073 - 24,707,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,691,206 - 24,705,599 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1339,439,009 - 39,456,797 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,440,955 - 39,457,219 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0339,158,346 - 39,176,604 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1238,937,069 - 8,954,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,938,906 - 8,952,808 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,974,330 - 8,988,240 (-)NCBI
ROS_Cfam_1.0239,221,526 - 9,239,150 (-)NCBI
ROS_Cfam_1.0 Ensembl239,221,526 - 9,237,271 (-)Ensembl
UMICH_Zoey_3.1239,036,770 - 9,050,661 (-)NCBI
UNSW_CanFamBas_1.0239,179,594 - 9,193,497 (-)NCBI
UU_Cfam_GSD_1.0239,172,979 - 9,186,888 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118195,370,137 - 195,397,149 (-)NCBI
SpeTri2.0NW_00493647328,508,726 - 28,535,640 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1323,944,369 - 23,957,486 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,944,386 - 23,957,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,204,842 - 26,218,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.115136,757 - 153,316 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl15150,718 - 151,785 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660638,861,161 - 8,878,212 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247311,706,043 - 1,719,452 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247311,705,953 - 1,719,452 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,051,562 - 120,052,175UniSTSGRCm38
MGSCv379119,960,680 - 119,961,293UniSTSGRCm37
Celera9120,521,122 - 120,521,735UniSTS
Cytogenetic Map9F4UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1656
Count of miRNA genes:505
Interacting mature miRNAs:616
Transcripts:ENSMUST00000064165, ENSMUST00000177637
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000064165   ⟹   ENSMUSP00000063986
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,877,749 - 119,897,362 (-)Ensembl
GRCm38.p6 Ensembl9120,048,683 - 120,068,296 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177637   ⟹   ENSMUSP00000136413
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,730,682 - 119,897,349 (-)Ensembl
GRCm38.p6 Ensembl9119,901,616 - 120,068,283 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215016   ⟹   ENSMUSP00000150463
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,877,749 - 119,898,945 (-)Ensembl
GRCm38.p6 Ensembl9120,048,683 - 120,069,879 (-)Ensembl
RefSeq Acc Id: NM_009987   ⟹   NP_034117
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm399119,877,749 - 119,897,362 (-)NCBI
GRCm389120,048,683 - 120,068,296 (-)NCBI
MGSCv379119,957,811 - 119,977,400 (-)RGD
Celera9120,518,238 - 120,537,953 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_034117   ⟸   NM_009987
- UniProtKB: Q9Z0D9 (UniProtKB/Swiss-Prot),   Q543X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136413   ⟸   ENSMUST00000177637
RefSeq Acc Id: ENSMUSP00000063986   ⟸   ENSMUST00000064165
RefSeq Acc Id: ENSMUSP00000150463   ⟸   ENSMUST00000215016
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0D9-F1-model_v2 AlphaFold Q9Z0D9 1-354 view protein structure

RGD ID:6844381
Promoter ID:MM_KWN:59158
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv369119,977,231 - 119,977,731 (-)MPROMDB
RGD ID:8671216
Promoter ID:EPDNEW_M13639
Type:multiple initiation site
Description:Mus musculus chemokine (C-X3-C motif) receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm389120,068,270 - 120,068,330EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333815 AgrOrtholog
Ensembl Genes ENSMUSG00000052336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000063986 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000136413 UniProtKB/Swiss-Prot
  ENSMUSP00000150463 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064165 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000177637 UniProtKB/Swiss-Prot
  ENSMUST00000215016 UniProtKB/Swiss-Prot
InterPro Chemokine_CX3CR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13051 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cx3cr1 PhenoGen
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CX3C1_MOUSE UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Cx3cr1  chemokine (C-X3-C motif) receptor 1    chemokine (C-X3-C) receptor 1  Symbol and/or name change 5135510 APPROVED