Gene: Cx3cr1 (chemokine (C-X3-C motif) receptor 1) Mus musculus
Analyze
Symbol:
Cx3cr1
Name:
chemokine (C-X3-C motif) receptor 1
Description:
ENCODES a protein that exhibits C-X3-C chemokine binding; cytokine receptor activity; G protein-coupled receptor activity; INVOLVED IN cell adhesion; cellular response to lipopolysaccharide; central nervous system maturation; ASSOCIATED WITH abnormal amacrine cell morphology; abnormal Bruch membrane morphology; abnormal dendritic cell physiology; ASSOCIATED WITH arteriosclerosis; arthus reaction; asthma; FOUND IN cell surface; dendritic tree (ortholog); neuron projection (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; 3,4-methylenedioxymethamphetamine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
C-X3-C chemokine receptor 1; C-X3-C CKR-1; chemokine (C-X3-C) receptor 1; CX3C chemokine receptor 1; fractalkine receptor
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CX3CR1 (C-X3-C motif chemokine receptor 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Cx3cr1 (C-X3-C motif chemokine receptor 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cx3cr1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cx3cr1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cx3cr1 (C-X3-C motif chemokine receptor 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
CX3CR1 (C-X3-C motif chemokine receptor 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 120,048,683 - 120,068,296 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 119,957,811 - 119,977,400 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 119,897,391 - 119,916,980 (-) NCBI mm8 Celera 9 120,518,238 - 120,537,953 (-) NCBI Celera Cytogenetic Map 9 F4 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
anti-basement membrane glomerulonephritis ISO RGD:620137 4891946 mRNA, protein:increased expression:glomerulus RGD arteriosclerosis IMP 4891900 RGD arthus reaction IMP 9068463 RGD asthma IMP 4891882 RGD asthma no_association ISO RGD:1352124 4891904 DNA:polymorphisms: :p.V249I, p.T280M (human) RGD asthma ISO RGD:1352124 4891895 DNA:SNPs: :p.V249I, rs2669849 (human) RGD atherosclerosis IMP 9479739 RGD atopic dermatitis ISO RGD:1352124 9491761 protein:decreased expression:blood, leukocyte RGD atopic dermatitis IMP 9491393 RGD borna disease ISO RGD:620137 4891998 mRNA:increased expression:brain RGD Chronic Mesangial Proliferative Glomerulonephritis ISO RGD:620137 9491783 RGD congestive heart failure ISO RGD:620137 9491792 mRNA, protein:increased expression: paraventricular nucleus of hypothalamus RGD conjunctivitis IMP 9491751 RGD corneal neovascularization IMP 9365153 RGD Coronary Disease ISO RGD:1352124 4891901 DNA:polymorphism: :p.V249I (human) RGD cystitis ISO RGD:620137 4891972 protein:increased expression:urinary bladder urothelium RGD diabetes mellitus IMP 9491759 RGD Diabetes Mellitus, Experimental ISO RGD:620137 4891992 mRNA:increased expression:kidney RGD Experimental Arthritis ISO RGD:620137 4892002 RGD Experimental Arthritis ISO RGD:620137 4891969 protein:increased expression:spinal cord RGD Experimental Autoimmune Encephalomyelitis ISO RGD:620137 9491767 ; 4891973 RGD Experimental Autoimmune Neuritis ISO RGD:620137 4891968 RGD Experimental Autoimmune Uveitis ISO RGD:620137 9479740 RGD Experimental Autoimmune Uveitis IMP 9491397 RGD glaucoma IMP 9384823 RGD glomerulonephritis ISO RGD:620137 4891995 mRNA:increased expression:glomerulus RGD glomerulonephritis ISO RGD:620137 4892027 RGD Graft vs Host Disease severity ISO RGD:1352124 4892014 RGD Hearing Loss IEP 9491762 mRNA, protein:increased expression:cochlea RGD hepatopulmonary syndrome treatment ISO RGD:620137 9491778 RGD Herpes Simplex Encephalitis IMP 8661752 RGD Hyperalgesia ISO RGD:620137 9491779 associated with Arthritis, Experimental, protein:increased expression:lumbar spinal cord RGD Hyperalgesia ISO RGD:620137 9387859 RGD Hyperalgesia IMP 9354422 associated with Inflammation RGD Hyperalgesia ISO RGD:620137 4892020 associated with Bone Neoplasms RGD Hyperalgesia IMP 4891885 RGD Hyperalgesia ISO RGD:620137 4891942 associated with Sciatic Neuropathy RGD Inflammation ISO RGD:620137 9491768 associated with Temporomandibular Joint Disorders RGD Inflammation IMP 9375525 RGD Intervertebral Disc Displacement ISO RGD:620137 4891907 protein:increased expression:spinal cord RGD Intimal Hyperplasia IMP 8661636 RGD macular degeneration IGI RGD:11275 9491385 RGD macular degeneration ISO RGD:1352124 9479078 DNA:missense mutation:cds:p.T280M (human) RGD macular degeneration no_association ISO RGD:1352124 9491392 DNA:missense mutations:cds:p.V249I, p.T280M (rs3732379, rs3732378) (human) RGD macular degeneration ISO RGD:1352124 9491390 DNA:missense mutations:cds:p.V249I, p.T280M (human) RGD macular degeneration no_association ISO RGD:1352124 9491395 DNA:missense mutation:cds:p.V249I (human) RGD macular degeneration ISO RGD:1352124 9491395 DNA:missense mutation:cds:p.V249I (human) RGD Memory Disorders ISO RGD:620137 9491766 RGD Microscopic Polyangiitis ISO RGD:1352124 9491765 protein:increased expression:blood, T cell RGD Myocardial Reperfusion Injury ISO RGD:1352124 4892017 protein:decreased expression:blood, monocyte RGD Neoplasm Metastasis susceptibility ISO RGD:1352124 4892015 associated with Breast Neoplasms RGD nephrosis ISO RGD:620137 4891946 RGD obesity ISO RGD:1352124 4891903 DNA:SNP: :p.T280M (human) RGD optic nerve glioma onset IMP 9491391 associated with Neurofibromatosis 1 RGD otitis media susceptibility ISO RGD:1352124 9491764 DNA:missense mutation:cds:p.T280M (human) RGD Pain ISO RGD:620137 4892020 associated with Bone Neoplasms RGD Parkinsonian Disorders ISO RGD:620137 4891964 RGD portal hypertension ISO RGD:620137 9491791 RGD prion disease ISO RGD:620137 4892001 protein:increased expression:microglial cell RGD psoriasis ISO RGD:1352124 9491384 DNA:SNP, missense mutation:intron, cds: , p.T280M (human) RGD pulmonary embolism treatment ISO RGD:620137 9491777 RGD pulmonary hypertension ISO RGD:620137 4891893 mRNA, protein:increased expression:lung RGD pulmonary hypertension ISO RGD:1352124 4891896 associated with Scleroderma, Systemic, DNA:polymorphisms: :p.V249I, p.T280M (human) RGD respiratory syncytial virus infectious disease severity IMP 4892018 RGD respiratory syncytial virus infectious disease IEP 4892016 RGD retinal degeneration IMP 9479077 RGD retinal vasculitis ISO RGD:1352124 9491394 DNA:missense mutations, haplotypes:cds:p.V249I, p.T280M (human) RGD retinitis IMP 8661224 RGD sciatic neuropathy treatment ISO RGD:620137 9491396 RGD sciatic neuropathy ISO RGD:620137 1358720 RGD sciatic neuropathy IMP 9354422 RGD Sepsis ISO RGD:1352124 4144897 protein:increased expression:lung, macrophage RGD status epilepticus treatment ISO RGD:620137 9491789 RGD systemic lupus erythematosus severity ISO RGD:1352124 6893428 mRNA:increased expression:blood, mononuclear cell RGD systemic scleroderma IMP 9479741 RGD systemic scleroderma ISO RGD:1352124 4891898 protein:increased expression:lung, skin RGD systemic scleroderma ISO RGD:1352124 4891896 DNA:polymorphisms: :p.V249I, p.T280M (human) RGD transient cerebral ischemia ISO RGD:620137 9491776 mRNA, protein:decreased expression:hippocampus RGD uveitis ISO RGD:620137 4891945 associated with Endotoxemia, mRNA, protein:increased expression:retina RGD Viral Bronchiolitis ISO RGD:1352124 4891891 RGD Viral Bronchiolitis ISO RGD:1352124 4891905 DNA:SNP: :p.T280M (human) RGD
Imported Annotations - CTD
Chloracne ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17101203 Coronary Disease ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD human immunodeficiency virus infectious disease ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD retinal degeneration ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20361964
Imported Annotations - MGI
acquired immunodeficiency syndrome ISS RGD:1352124 13592920 OMIM:609423 MouseDO age related macular degeneration 12 IEA 13592920 OMIM:613784 MouseDO coronary artery disease ISS RGD:1352124 13592920 OMIM:300464 more ... MouseDO Imported Annotations - OMIM
age related macular degeneration 12 ISO RGD:1352124 7240710 OMIM Coronary Disease susceptibility ISO RGD:1352124 7240710 OMIM human immunodeficiency virus infectious disease susceptibility ISO RGD:1352124 7240710 OMIM
(RS)-amphetamine decreases expression ISO RGD:620137 6480464 Amphetamine results in decreased expression of CX3CR1 mRNA CTD PMID:30779732 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CX3CR1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CX3CR1 mRNA CTD PMID:26377647 , PMID:29673856 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine increases expression ISO RGD:1352124 6480464 Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 2-butoxyethanol decreases expression EXP 6480464 n-butoxyethanol results in decreased expression of CX3CR1 mRNA CTD PMID:19812364 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CX3CR1 mRNA CTD PMID:20188158 6-propyl-2-thiouracil decreases expression ISO RGD:620137 6480464 Propylthiouracil results in decreased expression of CX3CR1 mRNA CTD PMID:24780913 aflatoxin B1 increases expression ISO RGD:620137 6480464 Aflatoxin B1 results in increased expression of CX3CR1 mRNA CTD PMID:25378103 ammonium chloride affects expression ISO RGD:620137 6480464 Ammonium Chloride affects the expression of CX3CR1 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CX3CR1 mRNA CTD PMID:21569818 benzo[b]fluoranthene affects expression EXP 6480464 benzo(b)fluoranthene affects the expression of CX3CR1 mRNA CTD PMID:26377693 Benzo[ghi]perylene increases expression EXP 6480464 1, 12-benzoperylene results in increased expression of CX3CR1 mRNA CTD PMID:26377693 Benzo[k]fluoranthene increases expression EXP 6480464 benzo(k)fluoranthene results in increased expression of CX3CR1 mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of CX3CR1 mRNA CTD PMID:28085963 bisphenol A affects expression ISO RGD:620137 6480464 bisphenol A affects the expression of CX3CR1 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CX3CR1 mRNA CTD PMID:29248573 buta-1,3-diene decreases expression EXP 6480464 1, 3-butadiene results in decreased expression of CX3CR1 mRNA CTD PMID:29038090 cadmium atom decreases expression ISO RGD:1352124 6480464 Cadmium results in decreased expression of CX3CR1 mRNA CTD PMID:24376830 cannabidiol decreases expression EXP 6480464 Cannabidiol results in decreased expression of CX3CR1 mRNA CTD PMID:21542829 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon affects the expression of CX3CR1 mRNA, Nanotubes, Carbon analog affects the expression of CX3CR1 mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of CX3CR1 mRNA CTD PMID:25620056 ceric oxide affects expression ISO RGD:620137 6480464 ceric oxide affects the expression of CX3CR1 mRNA CTD PMID:29463257 choline affects expression ISO RGD:1352124 6480464 Choline affects the expression of CX3CR1 mRNA CTD PMID:17616785 choline multiple interactions EXP 6480464 [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA CTD PMID:20938992 , PMID:23439872 cyclophosphamide increases expression ISO RGD:620137 6480464 Cyclophosphamide results in increased expression of CX3CR1 protein CTD PMID:16651033 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CX3CR1 mRNA CTD PMID:29950665 diazinon decreases expression ISO RGD:1352124 6480464 Diazinon results in decreased expression of CX3CR1 mRNA CTD PMID:24356939 dioxygen increases expression ISO RGD:1352124 6480464 Oxygen deficiency results in increased expression of CX3CR1 mRNA, Oxygen deficiency results in increased expression of CX3CR1 protein CTD PMID:17476338 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of CX3CR1 mRNA CTD PMID:24205000 disodium selenite decreases expression ISO RGD:1352124 6480464 Sodium Selenite results in decreased expression of CX3CR1 mRNA CTD PMID:18175754 divanadium pentaoxide increases expression ISO RGD:1352124 6480464 vanadium pentoxide results in increased expression of CX3CR1 mRNA CTD PMID:17459161 doxorubicin decreases expression ISO RGD:1352124 6480464 Doxorubicin results in decreased expression of CX3CR1 mRNA CTD PMID:29803840 entinostat increases expression ISO RGD:1352124 6480464 entinostat results in increased expression of CX3CR1 mRNA CTD PMID:27188386 ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of CX3CR1 mRNA CTD PMID:30517762 ethanol increases expression EXP 6480464 Ethanol results in increased expression of CX3CR1 mRNA CTD PMID:30319688 ethanol affects expression EXP 6480464 Ethanol affects the expression of CX3CR1 mRNA CTD PMID:30319688 ferric oxide decreases expression EXP 6480464 ferric oxide analog results in decreased expression of CX3CR1 mRNA CTD PMID:25086211 folic acid multiple interactions EXP 6480464 [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA CTD PMID:20938992 , PMID:23439872 gamma-hexachlorocyclohexane decreases expression ISO RGD:1352124 6480464 Hexachlorocyclohexane results in decreased expression of CX3CR1 mRNA CTD PMID:24356939 GW 501516 decreases expression ISO RGD:1352124 6480464 GW 501516 results in decreased expression of CX3CR1 mRNA CTD PMID:19850645 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA CTD PMID:20938992 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of CX3CR1 mRNA CTD PMID:21829687 lipopolysaccharide increases expression ISO RGD:620137 6480464 Lipopolysaccharides results in increased expression of CX3CR1 mRNA CTD PMID:21846543 mechlorethamine increases expression ISO RGD:620137 6480464 Mechlorethamine results in increased expression of CX3CR1 mRNA, Mechlorethamine results in increased expression of CX3CR1 protein CTD PMID:26273949 , PMID:28184907 mechlorethamine multiple interactions ISO RGD:620137 6480464 Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA] CTD PMID:28184907 methamphetamine decreases expression ISO RGD:620137 6480464 Methamphetamine results in decreased expression of CX3CR1 mRNA CTD PMID:19564919 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO RGD:1352124 6480464 N more ... CTD PMID:19013360 nickel atom decreases expression ISO RGD:1352124 6480464 Nickel results in decreased expression of CX3CR1 mRNA CTD PMID:23195993 nickel atom increases expression ISO RGD:1352124 6480464 Nickel results in increased expression of CX3CR1 mRNA CTD PMID:25583101 ochratoxin A increases expression ISO RGD:1352124 6480464 ochratoxin A metabolite results in increased expression of CX3CR1 mRNA, ochratoxin A results in increased expression of CX3CR1 mRNA CTD PMID:24356939 paracetamol multiple interactions EXP 6480464 [MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CR1 mRNA CTD PMID:22575169 paracetamol increases expression ISO RGD:1352124 6480464 Acetaminophen results in increased expression of CX3CR1 mRNA CTD PMID:26690555 paraquat decreases response to substance EXP 6480464 CX3CR1 protein results in decreased susceptibility to Paraquat CTD PMID:23299473 pentane-2,3-dione increases expression ISO RGD:620137 6480464 2, 3-pentanedione results in increased expression of CX3CR1 mRNA CTD PMID:25710175 phenobarbital increases expression ISO RGD:1352124 6480464 Phenobarbital results in increased expression of CX3CR1 mRNA CTD PMID:19084549 quercetin multiple interactions EXP 6480464 Quercetin affects the reaction [CX3CR1 protein affects the activity of PTGS2 protein] more ... CTD PMID:20361964 silicon dioxide decreases expression ISO RGD:1352124 6480464 Silicon Dioxide analog results in decreased expression of CX3CR1 mRNA CTD PMID:25895662 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of CX3CR1 mRNA CTD PMID:19073995 simvastatin decreases expression ISO RGD:1352124 6480464 Simvastatin results in decreased expression of CX3CR1 mRNA CTD PMID:18359719 sodium arsenite affects methylation ISO RGD:1352124 6480464 sodium arsenite affects the methylation of CX3CR1 gene CTD PMID:28589171 Soman increases expression ISO RGD:620137 6480464 Soman results in increased expression of CX3CR1 mRNA CTD PMID:19281266 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CX3CR1 mRNA CTD PMID:21641980 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CX3CR1 mRNA CTD PMID:23288052 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of CX3CR1 mRNA CTD PMID:30517762 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CX3CR1 mRNA CTD PMID:29950665 trichloroethene multiple interactions EXP 6480464 PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of CX3CR1 mRNA] CTD PMID:15363585 valproic acid increases methylation ISO RGD:1352124 6480464 Valproic Acid results in increased methylation of CX3CR1 gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:620137 6480464 Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA] CTD PMID:28184907
Biological Process autocrine signaling ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 calcium-mediated signaling IBA PANTHER:PTN001200797 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cell adhesion IPI UniProtKB:P78423 2290270 (MGI:MGI:6162594, PMID:10187784) ARUK-UCL MGI:MGI:6162594 , PMID:10187784 cell chemotaxis IBA PANTHER:PTN001200797 , UniProtKB:P51684 2290270 (PMID:21873635) GO_Central PMID:21873635 cellular response to lipopolysaccharide IGI UniProtKB:P05067 2290270 (MGI:MGI:6162390, PMID:23499256) ARUK-UCL MGI:MGI:6162390 , PMID:23499256 central nervous system maturation IMP 2290270 (MGI:MGI:5576986, PMID:24487234) ARUK-UCL MGI:MGI:5576986 , PMID:24487234 cerebral cortex cell migration IMP MGI:MGI:2670351 2290270 (MGI:MGI:3639805, PMID:16732273) MGI MGI:MGI:3639805 , PMID:16732273 chemotaxis ISO UniProtKB:P49238 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chemotaxis IBA MGI:MGI:103011 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytokine-mediated signaling pathway IMP 2290270 (MGI:MGI:3833195, PMID:18971423) MGI MGI:MGI:3833195 , PMID:18971423 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 G protein-coupled receptor signaling pathway IEA InterPro:IPR000276 , InterPro:IPR005387 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 immune response IBA MGI:MGI:103011 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 innate immune response IC GO:0071222 2290270 (MGI:MGI:6162390, PMID:23499256) ARUK-UCL MGI:MGI:6162390 , PMID:23499256 leukocyte tethering or rolling IGI UniProtKB:O00585 , UniProtKB:P19320 2290270 (MGI:MGI:6162594, PMID:10187784) ARUK-UCL MGI:MGI:6162594 , PMID:10187784 macrophage chemotaxis IMP MGI:MGI:3608773 2290270 (MGI:MGI:3777228, PMID:18322241) MGI MGI:MGI:3777228 , PMID:18322241 memory ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 microglial cell activation ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 microglial cell activation involved in immune response IMP MGI:MGI:2670351 2290270 (MGI:MGI:3639805, PMID:16732273) MGI MGI:MGI:3639805 , PMID:16732273 modulation of chemical synaptic transmission IMP 2290270 (MGI:MGI:5576986, PMID:24487234) ARUK-UCL MGI:MGI:5576986 , PMID:24487234 multiple spine synapse organization, single dendrite IMP 2290270 (MGI:MGI:5576986, PMID:24487234) ARUK-UCL MGI:MGI:5576986 , PMID:24487234 negative regulation of angiogenesis IMP MGI:MGI:3608773 2290270 (MGI:MGI:3777228, PMID:18322241) MGI MGI:MGI:3777228 , PMID:18322241 negative regulation of apoptotic signaling pathway ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 negative regulation of cell migration ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of chronic inflammatory response to non-antigenic stimulus ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP MGI:MGI:2670351 2290270 (MGI:MGI:3833195, PMID:18971423) MGI MGI:MGI:3833195 , PMID:18971423 negative regulation of hippocampal neuron apoptotic process ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 negative regulation of interleukin-1 beta production ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 negative regulation of long-term synaptic potentiation ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 phospholipase C-activating G protein-coupled receptor signaling pathway IMP 2290270 (MGI:MGI:6162594, PMID:10187784) ARUK-UCL MGI:MGI:6162594 , PMID:10187784 positive regulation of angiogenesis ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of cytosolic calcium ion concentration IBA MGI:MGI:1096320 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 positive regulation of I-kappaB phosphorylation ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 positive regulation of neuroblast proliferation ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of neurogenesis IMP 2290270 (MGI:MGI:6189288, PMID:20018408) ARUK-UCL MGI:MGI:6189288 , PMID:20018408 positive regulation of NF-kappaB transcription factor activity ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 positive regulation of protein kinase B signaling ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 regulation of nitric oxide biosynthetic process IGI UniProtKB:P05067 2290270 (MGI:MGI:6162390, PMID:23499256) ARUK-UCL MGI:MGI:6162390 , PMID:23499256 regulation of tumor necrosis factor biosynthetic process IGI UniProtKB:P05067 2290270 (MGI:MGI:6162390, PMID:23499256) ARUK-UCL MGI:MGI:6162390 , PMID:23499256 response to ischemia ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 signal transduction IEA UniProtKB-KW:KW-0807 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 social behavior IMP 2290270 (MGI:MGI:5576986, PMID:24487234) ARUK-UCL MGI:MGI:5576986 , PMID:24487234 synapse maturation IMP 2290270 (MGI:MGI:5576986, PMID:24487234) ARUK-UCL MGI:MGI:5576986 , PMID:24487234 Cellular Component cell surface ISO UniProtKB:P49238 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cell surface ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 cell surface IDA 2290270 (MGI:MGI:6162594, PMID:10187784) ARUK-UCL MGI:MGI:6162594 , PMID:10187784 dendritic tree ISO RGD:620137 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 external side of plasma membrane IBA MGI:MGI:103011 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 integral component of membrane IEA InterPro:IPR000276 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 neuron projection ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuronal cell body membrane ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleoplasm ISO UniProtKB:P49238 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus ISO UniProtKB:P49238 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 perinuclear region of cytoplasm ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane IEA UniProtKB-KW:KW-1003 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Molecular Function C-C chemokine binding IBA MGI:MGI:104616 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 C-C chemokine receptor activity IBA MGI:MGI:103011 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 C-X3-C chemokine binding ISO UniProtKB:P49238 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 C-X3-C chemokine binding IPI UniProtKB:P78423 2290270 (MGI:MGI:6162594, PMID:10187784) ARUK-UCL MGI:MGI:6162594 , PMID:10187784 C-X3-C chemokine receptor activity ISO RGD:620137 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 chemokine binding IBA PANTHER:PTN001200797 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytokine receptor activity IMP 2290270 (MGI:MGI:3833195, PMID:18971423) MGI MGI:MGI:3833195 , PMID:18971423 G protein-coupled receptor activity IMP 2290270 (MGI:MGI:6162594, PMID:10187784) ARUK-UCL MGI:MGI:6162594 , PMID:10187784
Gene-Chemical Interaction Annotations
