RGD Reference Report - A functional relationship between trigeminal astroglial activation and NR1 expression in a rat model of temporomandibular joint inflammation. - Rat Genome Database

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A functional relationship between trigeminal astroglial activation and NR1 expression in a rat model of temporomandibular joint inflammation.

Authors: Wang, S  Song, L  Tan, Y  Ma, Y  Tian, Y  Jin, X  Lim, G  Zhang, S  Chen, L  Mao, J 
Citation: Wang S, etal., Pain Med. 2012 Dec;13(12):1590-600. doi: 10.1111/j.1526-4637.2012.01511.x. Epub 2012 Oct 30.
RGD ID: 9491768
Pubmed: PMID:23110394   (View Abstract at PubMed)
PMCID: PMC3527674   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1526-4637.2012.01511.x   (Journal Full-text)

OBJECTIVE: To examine the hypothesis that glial activation would regulate the expression of the N-methyl-D-aspartate receptor subunit 1 (NR1) in the trigeminal subnucleus caudalis (Sp5C) after temporomandibular joint (TMJ) inflammation. METHODS: Inflammation of TMJ was produced in rats by injecting 50 muL complete Freund's adjuvant (CFA) into unilateral TMJ space. Sham control rats received incomplete Freund's adjuvant injection. Mechanical nociception in the affected and non-affected TMJ site was tested by using a digital algometer. Fractalkine, fluorocitrate, and/or MK801 were intracisternally administrated to examine the relationship between astroglial activation and NR1 upregulation. RESULTS: CFA TMJ injection resulted in persistent ipsilateral mechanical hyperalgesia 1, 3, and 5 days after CFA injection. The inflammation also induced significant upregulation of CX3C chemokine receptor 1 and glial fibrillary acidic protein (GFAP) beginning on day 1 and of NR1 beginning on day 3 within the ipsilateral Sp5C. Intracisternal administration of fluorocitrate for 5 days blocked the development of mechanical hyperalgesia as well as the upregulation of GFAP and NR1 in the Sp5C. Conversely, intracisternal injection of fractalkine for 5 days exacerbated the expression of NR1 in Sp5C and mechanical hyperalgesia induced by TMJ inflammation. Moreover, once daily intracisternal fractalkine administration for 5 days in naive rats induced the upregulation of NR1 and mechanical hyperalgesia. CONCLUSIONS: These results suggest that astroglial activation contributes to the mechanism of TMJ pain through the regulation of NR1 expression in Sp5C.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CX3CR1HumanInflammation  ISOCx3cr1 (Rattus norvegicus)associated with Temporomandibular Joint DisordersRGD 
Cx3cr1RatInflammation  IEP associated with Temporomandibular Joint DisordersRGD 
Cx3cr1MouseInflammation  ISOCx3cr1 (Rattus norvegicus)associated with Temporomandibular Joint DisordersRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Mus musculus)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Homo sapiens)
CX3CR1  (C-X3-C motif chemokine receptor 1)


Additional Information