RGD Reference Report - Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. - Rat Genome Database

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Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation.

Authors: Pong, WW  Higer, SB  Gianino, SM  Emnett, RJ  Gutmann, DH 
Citation: Pong WW, etal., Ann Neurol. 2013 Feb;73(2):303-8. doi: 10.1002/ana.23813. Epub 2013 Feb 19.
RGD ID: 9491391
Pubmed: PMID:23424002   (View Abstract at PubMed)
PMCID: PMC3608848   (View Article at PubMed Central)
DOI: DOI:10.1002/ana.23813   (Journal Full-text)

Although traditional models of carcinogenesis have largely focused on neoplastic cells, converging data have revealed the importance of non-neoplastic stromal cells in influencing tumor growth and progression. Leveraging a genetically engineered mouse model of neurofibromatosis type 1 (NF1)-associated optic glioma, we now demonstrate that stromal microglia express the CX3CR1 chemokine receptor, such that reduced CX3CR1 expression decreases optic nerve microglia. Moreover, genetic reduction of Cx3cr1 expression in Nf1 optic glioma mice delays optic glioma formation. Coupled with previous findings demonstrating that microglia maintain optic glioma growth, these new findings provide a strong preclinical rationale for the development of future stroma-directed glioma therapies in children.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
optic nerve glioma onsetISOCx3cr1 (Mus musculus)9491391; 9491391associated with Neurofibromatosis 1RGD 
optic nerve glioma onsetIMP 9491391associated with Neurofibromatosis 1RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Mus musculus)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Homo sapiens)
CX3CR1  (C-X3-C motif chemokine receptor 1)


Additional Information