Fto (FTO alpha-ketoglutarate dependent dioxygenase) - Rat Genome Database

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Gene: Fto (FTO alpha-ketoglutarate dependent dioxygenase) Mus musculus
Analyze
Symbol: Fto
Name: FTO alpha-ketoglutarate dependent dioxygenase (Ensembl:fat mass and obesity associated)
RGD ID: 1621572
MGI Page MGI
Description: Enables broad specificity oxidative DNA demethylase activity and oxidative RNA demethylase activity. Involved in several processes, including nucleic acid metabolic process; regulation of respiratory system process; and regulation of white fat cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; cerebral cortex; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-ketoglutarate-dependent dioxygenase FTO; AW743446; fat mass and obesity associated; fat mass and obesity-associated protein; m6A(m)-demethylase FTO; mKIAA1752; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; protein fatso; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39892,039,995 - 92,395,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl892,040,153 - 92,395,067 (+)EnsemblGRCm39 Ensembl
GRCm38891,313,367 - 91,668,433 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,313,525 - 91,668,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37893,837,424 - 94,192,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36894,203,644 - 94,558,535 (+)NCBIMGSCv36mm8
Celera895,629,636 - 95,973,782 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute myocardial infarction  (ISO)
aortic valve disease 2  (ISO)
atherosclerosis  (IGI)
Body Weight  (ISO)
Breast Neoplasms  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Atherosclerosis  (ISO)
Cerebral Hemorrhage  (IEP)
clear cell renal cell carcinoma  (ISO)
congestive heart failure  (IEP,IMP,ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
essential hypertension  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Growth Retardation, Developmental Delay, Coarse Facies, and Early Death  (ISO)
heart transplant rejection  (ISO)
Hyperalgesia  (IMP)
hypertension  (IMP,ISO)
Insulin Resistance  (ISO)
Joubert syndrome  (ISO)
Joubert syndrome 1  (ISO)
Meckel syndrome  (ISO)
Meckel syndrome 1  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (IEP,IMP,ISO)
nephronophthisis  (ISO)
nephronophthisis 1  (ISO)
nuclear senile cataract  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Pediatric Obesity  (ISO)
Premature Birth  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary embolism  (ISO)
renal cell carcinoma  (ISO)
sciatic neuropathy  (ISO)
silicosis  (ISO)
Testicular Injury  (ISO)
transient cerebral ischemia  (IEP,ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue morphology  (IAGP)
abnormal carbon dioxide production  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal eating behavior  (IAGP)
abnormal metabolism  (IAGP)
abnormal oxygen consumption  (IAGP)
abnormal urine catecholamine level  (IAGP)
cachexia  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased carbon dioxide production  (IAGP)
decreased circulating alanine transaminase level  (IEA)
decreased circulating aspartate transaminase level  (IEA)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating iron level  (IEA)
decreased circulating LDL cholesterol level  (IEA)
decreased circulating leptin level  (IAGP)
decreased food intake  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased lactate dehydrogenase level  (IEA)
decreased lean body mass  (IAGP)
decreased locomotor activity  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased total body fat amount  (IAGP)
decreased white fat cell size  (IAGP)
dermatitis  (IAGP)
enlarged pancreatic islets  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IEA)
improved glucose tolerance  (IAGP)
increased basal metabolism  (IAGP)
increased body weight  (IAGP)
increased carbon dioxide production  (IAGP)
increased circulating adrenaline level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucagon level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased energy expenditure  (IAGP)
increased fat cell size  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased interscapular fat pad weight  (IAGP)
increased lean body mass  (IAGP)
increased liver weight  (IAGP)
increased oxygen consumption  (IAGP)
increased percent body fat/body weight  (IAGP)
increased respiratory quotient  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
polyphagia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Fat mass and obesity-associated gene rs9939609 polymorphism is a potential biomarker of recurrent venous thromboembolism in male but not in female patients. Ahmad A, etal., Gene. 2018 Mar 20;647:136-142. doi: 10.1016/j.gene.2018.01.013. Epub 2018 Jan 9.
2. The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors. Aijala M, etal., Ann Med. 2015;47(8):655-63. doi: 10.3109/07853890.2015.1091088. Epub 2015 Nov 11.
3. The obesity associated FTO gene variant and the risk of adverse pregnancy outcomes: Evidence from the SCOPE study. Andraweera PH, etal., Obesity (Silver Spring). 2016 Dec;24(12):2600-2607. doi: 10.1002/oby.21662. Epub 2016 Oct 21.
4. Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats. Dabeer S and Raisuddin S, Environ Sci Pollut Res Int. 2023 Jan;30(2):3146-3165. doi: 10.1007/s11356-022-22246-y. Epub 2022 Aug 9.
5. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Doney AS, etal., Circ Cardiovasc Genet. 2009 Jun;2(3):255-9. doi: 10.1161/CIRCGENETICS.108.822320. Epub 2009 Mar 30.
6. Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies. Elekofehinti OO, etal., J Diabetes Metab Disord. 2020 Mar 12;19(1):197-204. doi: 10.1007/s40200-020-00491-7. eCollection 2020 Jun.
7. FTO (Fat-Mass and Obesity-Associated Protein) Participates in Hemorrhage-Induced Thalamic Pain by Stabilizing Toll-Like Receptor 4 Expression in Thalamic Neurons. Fu G, etal., Stroke. 2021 Jul;52(7):2393-2403. doi: 10.1161/STROKEAHA.121.034173. Epub 2021 Jun 9.
8. Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder. Gao L, etal., Ecotoxicol Environ Saf. 2022 Jun 1;237:113534. doi: 10.1016/j.ecoenv.2022.113534. Epub 2022 Apr 21.
9. Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. Guo J, etal., Dig Dis Sci. 2013 Apr;58(4):1004-9. doi: 10.1007/s10620-012-2516-6. Epub 2013 Jan 18.
10. FTO genotype, physical activity, and coronary heart disease risk in Swedish men and women. Gustavsson J, etal., Circ Cardiovasc Genet. 2014 Apr;7(2):171-7. doi: 10.1161/CIRCGENETICS.111.000007. Epub 2014 Mar 12.
11. Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm. He Y, etal., Ann Transl Med. 2019 Dec;7(24):797. doi: 10.21037/atm.2019.12.65.
12. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. Hotta K, etal., J Hum Genet. 2011 Sep;56(9):647-51. doi: 10.1038/jhg.2011.74. Epub 2011 Jul 28.
13. A FTO variant and risk of acute coronary syndrome. Hubacek JA, etal., Clin Chim Acta. 2010 Aug 5;411(15-16):1069-72. doi: 10.1016/j.cca.2010.03.037. Epub 2010 Apr 1.
14. Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men. Hubacek JA, etal., Clin Chim Acta. 2016 Feb 15;454:119-23. doi: 10.1016/j.cca.2016.01.005. Epub 2016 Jan 7.
15. The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients. Hubacek JA, etal., Clin Transplant. 2018 Dec;32(12):e13443. doi: 10.1111/ctr.13443. Epub 2018 Nov 22.
16. The FTO variant is associated with chronic complications of diabetes mellitus in Czech population. Hubacek JA, etal., Gene. 2018 Feb 5;642:220-224. doi: 10.1016/j.gene.2017.11.040. Epub 2017 Nov 14.
17. Higher prevalence of FTO gene risk genotypes AA rs9939609, CC rs1421085, and GG rs17817449 and saliva containing Staphylococcus aureus in obese women in Croatia. Huđek A, etal., Nutr Res. 2017 Dec 18;50:94-103. doi: 10.1016/j.nutres.2017.12.005.
18. Obesity as a causal risk factor for deep venous thrombosis: a Mendelian randomization study. Klovaite J, etal., J Intern Med. 2015 May;277(5):573-84. doi: 10.1111/joim.12299. Epub 2014 Sep 15.
19. Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. Krüger N, etal., Circ Res. 2020 Jan 17;126(2):232-242. doi: 10.1161/CIRCRESAHA.119.315531. Epub 2019 Dec 5.
20. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. Kumar R, etal., PLoS One. 2013 May 14;8(5):e63934. doi: 10.1371/journal.pone.0063934. Print 2013.
21. Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study. Lappalainen T, etal., Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):691-8. doi: 10.1016/j.numecd.2010.01.006. Epub 2010 Apr 18.
22. Intrathecal administration of the fat-mass and obesity-associated protein inhibitor mitigates neuropathic pain in female rats. Li X and Tao YX, Transl Perioper Pain Med. 2022;9(4):478-487. doi: 10.31480/2330-4871/163. Epub 2022 Nov 30.
23. Diagnosis, clustering, and immune cell infiltration analysis of m6A-related genes in patients with acute myocardial infarction-a bioinformatics analysis. Liang C, etal., J Thorac Dis. 2022 May;14(5):1607-1619. doi: 10.21037/jtd-22-569.
24. Relation of age-related cataract with obesity and obesity genes in an Asian population. Lim LS, etal., Am J Epidemiol. 2009 May 15;169(10):1267-74. doi: 10.1093/aje/kwp045. Epub 2009 Mar 27.
25. Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study. Lindström S, etal., Hum Genet. 2017 Jul;136(7):897-902. doi: 10.1007/s00439-017-1811-x. Epub 2017 May 20.
26. Exercise training ameliorates myocardial phenotypes in heart failure with preserved ejection fraction by changing N6-methyladenosine modification in mice model. Liu K, etal., Front Cell Dev Biol. 2022 Sep 2;10:954769. doi: 10.3389/fcell.2022.954769. eCollection 2022.
27. Relationship between the FTO Genotype and Early Chronic Kidney Disease in Type 2 Diabetes: The Mediating Role of Central Obesity, Hypertension, and High Albuminuria. Marchetti J, etal., Lifestyle Genom. 2021;14(3):73-80. doi: 10.1159/000516118. Epub 2021 Jun 16.
28. FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair. Mathiyalagan P, etal., Circulation. 2019 Jan 22;139(4):518-532. doi: 10.1161/CIRCULATIONAHA.118.033794.
29. Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans. Mayeur S, etal., J Dev Orig Health Dis. 2013 Apr;4(2):134-8. doi: 10.1017/S2040174412000748.
30. Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. Mo C, etal., J Hypertens. 2017 Apr;35(4):810-821. doi: 10.1097/HJH.0000000000001255.
31. Genes associated with Type 2 Diabetes and vascular complications. Montesanto A, etal., Aging (Albany NY). 2018 Feb 4;10(2):178-196. doi: 10.18632/aging.101375.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Clinical correlations and genetic associations of metabolic syndrome in the United Arab Emirates. Osman WM, etal., Gene. 2020 May 15;738:144476. doi: 10.1016/j.gene.2020.144476. Epub 2020 Feb 18.
34. A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians. Pausova Z, etal., Circ Cardiovasc Genet. 2009 Jun;2(3):260-9. doi: 10.1161/CIRCGENETICS.109.857359. Epub 2009 Mar 31.
35. Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population. Prakash J, etal., Ann Hum Biol. 2011 Nov;38(6):760-3. doi: 10.3109/03014460.2011.614278. Epub 2011 Sep 15.
36. The Alteration of M6A-Tagged Transcript Profiles in the Retina of Rats After Traumatic Optic Neuropathy. Qu X, etal., Front Genet. 2021 Feb 16;12:628841. doi: 10.3389/fgene.2021.628841. eCollection 2021.
37. The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals. Ramos AV, etal., BMC Med Genet. 2012 Nov 7;13:101. doi: 10.1186/1471-2350-13-101.
38. Association between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Genes Polymorphism and Type 2 Diabetes with Dyslipidemia. Raza ST, etal., Int J Mol Cell Med. 2017 Spring;6(2):121-130. doi: 10.22088/acadpub.BUMS.6.2.6. Epub 2017 Jul 4.
39. An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference. Rees SD, etal., Diabet Med. 2011 Jun;28(6):673-80. doi: 10.1111/j.1464-5491.2011.03257.x.
40. Mouse MP Annotation Import Pipeline RGD automated import pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. The FTO rs9939609 "A" allele is associated with impaired fasting glucose and insulin resistance in Emirati population. Saber-Ayad M, etal., Gene. 2019 Jan 10;681:93-98. doi: 10.1016/j.gene.2018.09.053. Epub 2018 Sep 29.
44. Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. Shahid SU, etal., Atherosclerosis. 2017 Mar;258:1-7. doi: 10.1016/j.atherosclerosis.2017.01.024. Epub 2017 Jan 22.
45. N6-methyladenosine-modified lncRNA and mRNA modification profiles in cerebral ischemia-reperfusion injury. Shao L, etal., Front Genet. 2022 Nov 21;13:973979. doi: 10.3389/fgene.2022.973979. eCollection 2022.
46. Decreased N(6)-methyladenosine in peripheral blood RNA from diabetic patients is associated with FTO expression rather than ALKBH5. Shen F, etal., J Clin Endocrinol Metab. 2015 Jan;100(1):E148-54. doi: 10.1210/jc.2014-1893.
47. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Shimaoka I, etal., Hypertens Res. 2010 Mar;33(3):214-8. doi: 10.1038/hr.2009.215. Epub 2010 Jan 15.
48. IDH2 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in multiple myeloma. Song S, etal., Oncogene. 2021 Sep;40(35):5393-5402. doi: 10.1038/s41388-021-01939-7. Epub 2021 Jul 17.
49. Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Su X, etal., Front Pharmacol. 2021 Aug 3;12:654316. doi: 10.3389/fphar.2021.654316. eCollection 2021.
50. FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study. Thron C, etal., PLoS One. 2015 Oct 2;10(10):e0139419. doi: 10.1371/journal.pone.0139419. eCollection 2015.
51. Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women. Wang MH, etal., Meta Gene. 2014 May 21;2:384-91. doi: 10.1016/j.mgene.2014.04.010. eCollection 2014 Dec.
52. Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case-control study. Wu TW, etal., Cardiovasc Diabetol. 2023 Mar 9;22(1):51. doi: 10.1186/s12933-023-01787-7.
53. The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children. Xi B, etal., Mol Biol Rep. 2013 Feb;40(2):773-8. doi: 10.1007/s11033-012-2113-y. Epub 2012 Oct 31.
54. The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Xiao Y, etal., Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21441-21449. doi: 10.1073/pnas.2000516117. Epub 2020 Aug 19.
55. N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury. Xu K, etal., Ther Adv Chronic Dis. 2020 Apr 29;11:2040622320916024. doi: 10.1177/2040622320916024. eCollection 2020.
56. Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury. Yu J, etal., Mol Brain. 2020 Jan 28;13(1):11. doi: 10.1186/s13041-020-0554-0.
57. Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension. Zeng Y, etal., Aging (Albany NY). 2021 Jul 26;13(14):18238-18256. doi: 10.18632/aging.203230. Epub 2021 Jul 26.
58. Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction. Zhang B, etal., Front Cardiovasc Med. 2021 Mar 5;8:647806. doi: 10.3389/fcvm.2021.647806. eCollection 2021.
59. m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure. Zhang B, etal., Signal Transduct Target Ther. 2021 Nov 2;6(1):377. doi: 10.1038/s41392-021-00699-w.
60. Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury. Zhao TX, etal., Environ Pollut. 2020 Apr;259:113911. doi: 10.1016/j.envpol.2020.113911. Epub 2020 Jan 6.
61. Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities. Zheng BX, etal., Neurotherapeutics. 2021 Jul;18(3):1995-2007. doi: 10.1007/s13311-021-01053-2. Epub 2021 Apr 7.
62. N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. Zhuang C, etal., J Cell Mol Med. 2019 Mar;23(3):2163-2173. doi: 10.1111/jcmm.14128. Epub 2019 Jan 16.
63. The Impact of Physical Activity and Dietary Measures on the Biochemical and Anthropometric Parameters in Obese Children. Is There Any Genetic Predisposition? Zlatohlavek L, etal., Cent Eur J Public Health. 2015 Nov;23 Suppl:S62-6.
Additional References at PubMed
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PMID:30305247   PMID:30728336   PMID:30730976   PMID:30809304   PMID:30973865   PMID:30996080   PMID:31189104   PMID:31239444   PMID:31434789   PMID:31451060   PMID:31709454   PMID:31751468  
PMID:32018056   PMID:32325033   PMID:32500354   PMID:32522250   PMID:32531187   PMID:32766784   PMID:32956847   PMID:33548009   PMID:33761320   PMID:33783988   PMID:33826069   PMID:33846348  
PMID:33947842   PMID:34017338   PMID:34134995   PMID:34262022   PMID:34321999   PMID:34462564   PMID:34569703   PMID:34836959   PMID:35085712   PMID:35176940   PMID:35282837   PMID:35511947  
PMID:35721711   PMID:35874829   PMID:35878734   PMID:36058192   PMID:36227651   PMID:36321453   PMID:36458690   PMID:36465115   PMID:36469784   PMID:36717587   PMID:36878272   PMID:37269288  
PMID:37408034   PMID:37478845   PMID:37698901   PMID:37734910   PMID:37781923   PMID:37795886   PMID:37907171   PMID:37972699   PMID:37979906   PMID:38044851   PMID:38193628   PMID:38297099  
PMID:38321831   PMID:38325270   PMID:38365111   PMID:38403011   PMID:38430221   PMID:38430461  


Genomics

Comparative Map Data
Fto
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39892,039,995 - 92,395,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl892,040,153 - 92,395,067 (+)EnsemblGRCm39 Ensembl
GRCm38891,313,367 - 91,668,433 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,313,525 - 91,668,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37893,837,424 - 94,192,332 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36894,203,644 - 94,558,535 (+)NCBIMGSCv36mm8
Celera895,629,636 - 95,973,782 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.34NCBI
FTO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,703,963 - 54,121,941 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,701,692 - 54,158,512 (+)EnsemblGRCh38hg38GRCh38
GRCh371653,737,875 - 54,155,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,295,376 - 52,705,882 (+)NCBINCBI36Build 36hg18NCBI36
Celera1638,252,466 - 38,662,847 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1639,624,702 - 40,035,200 (+)NCBIHuRef
CHM1_11655,145,011 - 55,555,415 (+)NCBICHM1_1
T2T-CHM13v2.01659,501,796 - 59,919,950 (+)NCBIT2T-CHM13v2.0
Fto
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81931,456,749 - 31,865,011 (-)NCBIGRCr8
mRatBN7.21915,284,898 - 15,692,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,349,696 - 15,692,083 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1917,040,780 - 17,381,004 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,235,585 - 22,575,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,181,005 - 25,521,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01916,774,549 - 17,115,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1916,772,744 - 17,115,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01927,803,098 - 28,182,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41916,514,746 - 16,858,800 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11916,517,774 - 16,845,431 (-)NCBI
Celera1915,258,617 - 15,598,740 (-)NCBICelera
Cytogenetic Map19p11NCBI
Fto
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543311,424,176 - 11,813,771 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543311,424,069 - 11,834,955 (+)NCBIChiLan1.0ChiLan1.0
FTO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21863,133,875 - 63,537,984 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11669,052,529 - 69,456,636 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01633,939,300 - 34,343,419 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11653,023,203 - 53,451,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1653,023,425 - 53,490,231 (+)Ensemblpanpan1.1panPan2
FTO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,699,864 - 62,080,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,652,236 - 62,080,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,284,508 - 58,713,282 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0262,193,054 - 62,621,914 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,226,376 - 62,622,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,017,676 - 59,445,579 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0260,044,508 - 60,472,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0260,919,844 - 61,348,533 (-)NCBIUU_Cfam_GSD_1.0
Fto
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934952,899,665 - 53,267,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364756,321,711 - 6,689,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364756,321,725 - 6,689,410 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,174,569 - 31,564,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1631,177,112 - 31,564,674 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FTO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1539,487,304 - 39,900,238 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl539,487,418 - 39,725,747 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604736,477,673 - 36,894,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fto
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247572,675,671 - 3,080,480 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247572,675,810 - 3,081,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fto
12936 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1468
Count of miRNA genes:699
Interacting mature miRNAs:869
Transcripts:ENSMUST00000069718, ENSMUST00000125471, ENSMUST00000128081, ENSMUST00000136802, ENSMUST00000140276, ENSMUST00000149913, ENSMUST00000166548
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse

Markers in Region
43.MMHAP10FRG10.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,320,523 - 91,320,674UniSTSGRCm38
MGSCv37893,844,422 - 93,844,573UniSTSGRCm37
Celera895,636,625 - 95,636,775UniSTS
Cytogenetic Map8C5UniSTS
cM Map841.9UniSTS
Whitehead_YAC8 UniSTS
D8Mit196  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,628,533 - 91,628,620UniSTSGRCm38
MGSCv37894,152,432 - 94,152,519UniSTSGRCm37
Celera895,933,960 - 95,934,043UniSTS
Cytogenetic Map8C5UniSTS
cM Map843.0UniSTS
Whitehead Genetic842.6UniSTS
Whitehead_YAC8 UniSTS
UniSTS:235963  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,367,161 - 91,367,241UniSTSGRCm38
MGSCv37893,891,060 - 93,891,140UniSTSGRCm37
Celera895,683,350 - 95,683,430UniSTS
Cytogenetic Map8C5UniSTS
cM Map841.9UniSTS
Fto  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map841.9UniSTS
cM Map841.9UniSTS
Fto  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map841.9UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC139351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC151713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ237917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK016860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY290198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA321822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000069718   ⟹   ENSMUSP00000068380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,040,153 - 92,395,067 (+)Ensembl
GRCm38.p6 Ensembl891,313,525 - 91,668,439 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125471   ⟹   ENSMUSP00000147563
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,040,163 - 92,171,394 (+)Ensembl
GRCm38.p6 Ensembl891,313,535 - 91,444,766 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128081   ⟹   ENSMUSP00000147548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,040,186 - 92,252,858 (+)Ensembl
GRCm38.p6 Ensembl891,313,558 - 91,526,230 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136802   ⟹   ENSMUSP00000147603
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,040,196 - 92,214,419 (+)Ensembl
GRCm38.p6 Ensembl891,313,568 - 91,487,791 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,194,313 - 92,393,574 (+)Ensembl
GRCm38.p6 Ensembl891,467,685 - 91,666,946 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149913   ⟹   ENSMUSP00000123142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,117,183 - 92,136,092 (+)Ensembl
GRCm38.p6 Ensembl891,390,555 - 91,409,464 (+)Ensembl
RefSeq Acc Id: ENSMUST00000166548   ⟹   ENSMUSP00000127680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,040,242 - 92,195,019 (+)Ensembl
GRCm38.p6 Ensembl891,313,614 - 91,468,391 (+)Ensembl
RefSeq Acc Id: NM_011936   ⟹   NP_036066
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39892,040,153 - 92,395,061 (+)NCBI
GRCm38891,313,525 - 91,668,433 (+)NCBI
MGSCv37893,837,424 - 94,192,332 (+)RGD
Celera895,629,636 - 95,973,782 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531036   ⟹   XP_006531099
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39892,039,995 - 92,137,319 (+)NCBI
GRCm38891,313,367 - 91,410,691 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036066   ⟸   NM_011936
- UniProtKB: Q8R250 (UniProtKB/Swiss-Prot),   Q8CB66 (UniProtKB/Swiss-Prot),   Q8BR68 (UniProtKB/Swiss-Prot),   Q6ZPI7 (UniProtKB/Swiss-Prot),   Q3TTZ5 (UniProtKB/Swiss-Prot),   Q9QZ13 (UniProtKB/Swiss-Prot),   Q8BGW1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531099   ⟸   XM_006531036
- Peptide Label: isoform X1
- UniProtKB: E9Q1E4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000147563   ⟸   ENSMUST00000125471
RefSeq Acc Id: ENSMUSP00000127680   ⟸   ENSMUST00000166548
RefSeq Acc Id: ENSMUSP00000123142   ⟸   ENSMUST00000149913
RefSeq Acc Id: ENSMUSP00000147548   ⟸   ENSMUST00000128081
RefSeq Acc Id: ENSMUSP00000068380   ⟸   ENSMUST00000069718
RefSeq Acc Id: ENSMUSP00000147603   ⟸   ENSMUST00000136802
Protein Domains
Alpha-ketoglutarate-dependent dioxygenase FTO

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BGW1-F1-model_v2 AlphaFold Q8BGW1 1-502 view protein structure

Promoters
RGD ID:8667849
Promoter ID:EPDNEW_M11955
Type:initiation region
Name:Fto_1
Description:Mus musculus fat mass and obesity associated , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38891,313,549 - 91,313,609EPDNEW
RGD ID:6843177
Promoter ID:MM_KWN:55250
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000047783,   OTTMUST00000059886,   OTTMUST00000063364,   OTTMUST00000063365,   UC009MSR.1,   UC009MSS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36893,837,214 - 93,837,714 (+)MPROMDB
RGD ID:6843170
Promoter ID:MM_KWN:55252
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000063369
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36893,914,306 - 93,914,806 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347093 AgrOrtholog
Ensembl Genes ENSMUSG00000055932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069718 ENTREZGENE
  ENSMUST00000069718.15 UniProtKB/Swiss-Prot
  ENSMUST00000125471.8 UniProtKB/Swiss-Prot
  ENSMUST00000128081.8 UniProtKB/Swiss-Prot
  ENSMUST00000136802.8 UniProtKB/Swiss-Prot
  ENSMUST00000149913.2 UniProtKB/TrEMBL
  ENSMUST00000166548.9 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1470 UniProtKB/Swiss-Prot
  2.60.120.590 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AlkB-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FTO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FTO_C UniProtKB/Swiss-Prot
  FTO_C_sf UniProtKB/Swiss-Prot
  FTO_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26383 UniProtKB/Swiss-Prot
MGD MGI:1347093 ENTREZGENE
NCBI Gene 26383 ENTREZGENE
PANTHER ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31291 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FTO_CTD UniProtKB/Swiss-Prot
  FTO_NTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fto PhenoGen
SMART FTO_NTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z127_MOUSE UniProtKB/TrEMBL
  E9Q1E4 ENTREZGENE, UniProtKB/TrEMBL
  FTO_MOUSE UniProtKB/Swiss-Prot
  Q3TTZ5 ENTREZGENE
  Q6ZPI7 ENTREZGENE
  Q8BGW1 ENTREZGENE
  Q8BR68 ENTREZGENE
  Q8CB66 ENTREZGENE
  Q8R250 ENTREZGENE
  Q9QZ13 ENTREZGENE
UniProt Secondary Q3TTZ5 UniProtKB/Swiss-Prot
  Q6ZPI7 UniProtKB/Swiss-Prot
  Q8BR68 UniProtKB/Swiss-Prot
  Q8CB66 UniProtKB/Swiss-Prot
  Q8R250 UniProtKB/Swiss-Prot
  Q9QZ13 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-15 Fto  FTO alpha-ketoglutarate dependent dioxygenase  Fto  fat mass and obesity associated  Symbol and/or name change 5135510 APPROVED