Fcgr2b (Fc receptor, IgG, low affinity IIb) - Rat Genome Database

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Gene: Fcgr2b (Fc receptor, IgG, low affinity IIb) Mus musculus
Analyze
Symbol: Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
RGD ID: 1332447
MGI Page MGI
Description: Enables IgG binding activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; nervous system development; and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; liver; lung; and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc gamma receptor IIb).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI528646; CD32; F630109E10Rik; fc gamma receptor IIB; Fc gamma RIIB; fc-gamma RII; Fc-gamma-RII; fc-gamma-RIIB; Fc[g]; Fc[g]RII; Fcg; Fcgamm; FcgammaRIIB; Fcgr; Fcgr2; Fcgr2a; FcgRII; Fcr-; Fcr-2; Fcr-3; fcRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-1; Ly-17; Ly-m2; Ly-m20; LyM-; LyM-1; lymphocyte antigen 17
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,786,186 - 170,804,141 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,786,186 - 170,804,116 (-)EnsemblGRCm39 Ensembl
GRCm381170,960,558 - 170,976,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,958,617 - 170,976,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,890,689 - 172,906,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,797,258 - 172,812,708 (-)NCBIMGSCv36mm8
Celera1173,410,273 - 173,425,760 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
cefaloridine  (ISO)
chloroethene  (EXP)
clofibric acid  (ISO)
cocaine  (ISO)
Cuprizon  (ISO)
dexamethasone  (EXP)
dexamethasone phosphate  (ISO)
dextran sulfate  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doramapimod  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
eugenol  (ISO)
fipronil  (ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
graphene oxide  (EXP)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (EXP)
menadione  (EXP)
mercury dichloride  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phenacetin  (ISO)
phenylhydrazine  (ISO)
pirinixic acid  (EXP)
quartz  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
sulpiride  (EXP)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
undecane  (ISO)
ursolic acid  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibody-dependent cellular cytotoxicity  (IBA)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IMP)
B cell proliferation  (IMP)
cell surface receptor signaling pathway  (IBA,IMP)
cellular response to amyloid-beta  (IMP,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to molecule of bacterial origin  (IMP)
cerebellum development  (IMP)
defense response  (IMP)
dendrite development  (IMP)
endocytic recycling  (ISO)
establishment of localization in cell  (IMP)
Fc receptor-mediated immune complex endocytosis  (IDA)
Fc-gamma receptor signaling pathway  (ISO)
immune complex clearance  (ISO)
immune effector process  (ISO)
immunoglobulin mediated immune response  (IMP)
mast cell activation  (IDA)
negative regulation of acute inflammatory response to antigenic stimulus  (IMP)
negative regulation of B cell proliferation  (IMP)
negative regulation of B cell receptor signaling pathway  (ISO)
negative regulation of humoral immune response mediated by circulating immunoglobulin  (IMP)
negative regulation of immune response  (IMP)
negative regulation of immunoglobulin production  (IMP)
negative regulation of inflammatory response to antigenic stimulus  (IMP)
negative regulation of interleukin-10 production  (IMP)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of phagocytosis  (IMP)
negative regulation of type I hypersensitivity  (IMP)
phagocytosis  (IMP,ISO)
phagocytosis, engulfment  (IDA)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of JNK cascade  (IMP)
positive regulation of phagocytosis  (IBA,IDA)
positive regulation of response to endoplasmic reticulum stress  (IMP,ISO)
positive regulation of tumor necrosis factor production  (IBA)
receptor-mediated endocytosis  (ISO)
regulation of dendritic spine maintenance  (IMP)
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (IMP,ISO)
regulation of long-term neuronal synaptic plasticity  (IMP)
response to bacterium  (IMP)
response to estradiol  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal cytokine level  (IAGP)
abnormal glomerular capillary thrombosis  (IAGP)
abnormal hypersensitivity reaction  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal seizure response to electrical stimulation  (IAGP)
abnormal splenocyte physiology  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal urine cytokine level  (IAGP)
albuminuria  (IAGP)
anemia  (IAGP)
autoimmune response  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased body weight  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased susceptibility to systemic lupus erythematosus  (IAGP)
dehydration  (IAGP)
edema  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
hunched posture  (IAGP)
impaired macrophage phagocytosis  (IAGP)
increased anti-chromatin antibody level  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-histone antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased double-negative T cell number  (IAGP)
increased germinal center B cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased inflammatory response  (IAGP)
increased memory T cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased myeloid dendritic cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased plasma cell number  (IAGP)
increased plasmacytoid dendritic cell number  (IAGP)
increased single-positive T cell number  (IAGP)
increased spleen germinal center number  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased urine protein level  (IAGP)
kidney inflammation  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
maximal tonic hindlimb extension seizures  (IAGP)
no abnormal phenotype detected  (IAGP)
oliguria  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
renal glomerular protein deposits  (IAGP)
salivary gland inflammation  (IAGP)
spleen hyperplasia  (IAGP)
tonic-clonic seizures  (IAGP)
urinary bladder inflammation  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus. Blank MC, etal., Hum Genet 2005 Jul;117(2-3):220-7. Epub 2005 May 14.
2. Molecular biomarkers of phospholipidosis in rat blood and heart after amiodarone treatment. Bocchini N, etal., J Appl Toxicol. 2015 Jan;35(1):90-103.
3. IGG and complement receptor expression on peripheral white blood cells in uraemic children. Bouts AH, etal., Nephrol Dial Transplant. 2004 Sep;19(9):2296-301. Epub 2004 Jul 20.
4. Platelet count, previous infection and FCGR2B genotype predict development of chronic disease in newly diagnosed idiopathic thrombocytopenia in childhood: results of a prospective study. Bruin M, etal., Br J Haematol. 2004 Dec;127(5):561-7.
5. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Crow AR, etal., Blood. 2011 Jan 20;117(3):971-4. doi: 10.1182/blood-2010-05-280115. Epub 2010 Nov 2.
6. FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma. Dharajiya N, etal., PLoS One. 2010 Feb 22;5(2):e9337. doi: 10.1371/journal.pone.0009337.
7. Target silencing of disease-associated B-lymphocytes by chimeric molecules in SCID model of pristane-induced autoimmunity. Dimitrova I, etal., Lupus. 2010 Oct;19(11):1261-71. doi: 10.1177/0961203310371153. Epub 2010 Jun 8.
8. Effect of FCGR2A and FCGR3A variants on CLL outcome. Dornan D, etal., Blood. 2010 Nov 18;116(20):4212-22. doi: 10.1182/blood-2010-03-272765. Epub 2010 Aug 12.
9. [Relationship between polymorphisms of FCGR2B and susceptibility of children idiopathic thrombocytopenic purpura]. He LY, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Jun;17(3):729-33.
10. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice. Hernandez-Vargas P, etal., Circ Res. 2006 Nov 24;99(11):1188-96. Epub 2006 Oct 19.
11. FcgammaRIIB Gene Polymorphisms Are Associated with Disease Risk and Clinical Manifestations of Systemic Lupus Erythematosus in Koreans. Jeon JY, etal., Tohoku J Exp Med. 2015;236(3):185-91. doi: 10.1620/tjem.236.185.
12. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. Kowalewska J, etal., Am J Pathol. 2007 Mar;170(3):981-9.
13. Inhibition of hyperacute transplant rejection by soluble proteins with the functional domains of CD46 and FcgammaRII. Lanteri MB, etal., Transplantation. 2000 Mar 27;69(6):1128-36.
14. Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcgammaRIIb expression and monocyte homeostasis. Lawlor KE, etal., J Leukoc Biol. 2013 Apr;93(4):585-97. doi: 10.1189/jlb.0412190. Epub 2013 Jan 22.
15. Fcgamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. Lee YH, etal., Lupus. 2009 Jul;18(8):727-34. doi: 10.1177/0961203309104020.
16. Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin. Leontyev D, etal., Transfusion. 2012 Aug;52(8):1799-805. doi: 10.1111/j.1537-2995.2011.03517.x. Epub 2012 Jan 18.
17. High-dose dexamethasone shifts the balance of stimulatory and inhibitory Fcgamma receptors on monocytes in patients with primary immune thrombocytopenia. Liu XG, etal., Blood. 2011 Feb 10;117(6):2061-9. doi: 10.1182/blood-2010-07-295477. Epub 2010 Dec 3.
18. FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. McGaha TL, etal., J Immunol. 2008 Apr 15;180(8):5670-9.
19. Restoration of tolerance in lupus by targeted inhibitory receptor expression. McGaha TL, etal., Science. 2005 Jan 28;307(5709):590-3.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Selective silencing of disease-associated B-lymphocytes by chimeric molecules targeting their Fc gamma IIb receptor. Mihaylova N, etal., Int Immunol. 2008 Feb;20(2):165-75. Epub 2007 Dec 21.
24. Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by FcgammaRIIb2. Mousavi SA, etal., Hepatology. 2007 Sep;46(3):871-84.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus. Su K, etal., J Immunol 2004 Jun 1;172(11):7186-91.
31. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Wu CL, etal., Shock. 2009 Sep;32(3):276-85.
32. FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese. Zhou XJ, etal., Nephrol Dial Transplant. 2010 Jan;25(1):97-101. Epub 2009 Jul 29.
Additional References at PubMed
PMID:303687   PMID:1290451   PMID:1301170   PMID:1347284   PMID:1358808   PMID:1386873   PMID:1387140   PMID:1431091   PMID:1686571   PMID:1693656   PMID:1709914   PMID:1824594  
PMID:1910686   PMID:2119497   PMID:2138587   PMID:2138787   PMID:2139735   PMID:2140613   PMID:2414215   PMID:2474894   PMID:2531187   PMID:2570566   PMID:2591369   PMID:2885153  
PMID:2894402   PMID:2944118   PMID:2946078   PMID:2957319   PMID:2971615   PMID:2971731   PMID:2997987   PMID:3024012   PMID:3148667   PMID:3159826   PMID:3161943   PMID:3653943  
PMID:3865190   PMID:4042679   PMID:4054960   PMID:6173319   PMID:6321340   PMID:6403543   PMID:6454730   PMID:6601056   PMID:6967858   PMID:6973596   PMID:6974691   PMID:6984003  
PMID:7474114   PMID:7529744   PMID:7607670   PMID:7607671   PMID:7636231   PMID:7664793   PMID:8051101   PMID:8069908   PMID:8105477   PMID:8107887   PMID:8228228   PMID:8398981  
PMID:8422330   PMID:8482578   PMID:8537115   PMID:8552190   PMID:8563167   PMID:8683114   PMID:8769481   PMID:8824160   PMID:8827514   PMID:8889548   PMID:8900432   PMID:8903730  
PMID:8906852   PMID:8976173   PMID:9143687   PMID:9200458   PMID:9218544   PMID:9218579   PMID:9250876   PMID:9383291   PMID:9551950   PMID:9651528   PMID:9653099   PMID:9693045  
PMID:9874574   PMID:9874575   PMID:10051626   PMID:10201978   PMID:10330436   PMID:10349636   PMID:10395649   PMID:10397164   PMID:10449433   PMID:10464288   PMID:10508186   PMID:10640769  
PMID:10693874   PMID:10704418   PMID:10704470   PMID:10742152   PMID:10790435   PMID:10842103   PMID:10843680   PMID:10866109   PMID:10889306   PMID:10981970   PMID:11042159   PMID:11076861  
PMID:11132158   PMID:11217851   PMID:11237803   PMID:11238587   PMID:11283678   PMID:11418650   PMID:11433381   PMID:11489951   PMID:11672534   PMID:11698426   PMID:11733380   PMID:11777955  
PMID:11828370   PMID:11869678   PMID:11872097   PMID:11911824   PMID:11970986   PMID:11983693   PMID:11994421   PMID:12055217   PMID:12055255   PMID:12077245   PMID:12114523   PMID:12121667  
PMID:12165510   PMID:12370366   PMID:12384440   PMID:12385742   PMID:12389094   PMID:12417629   PMID:12421967   PMID:12444173   PMID:12466851   PMID:12471137   PMID:12477718   PMID:12477932  
PMID:12528127   PMID:12672068   PMID:12732659   PMID:12753808   PMID:12794146   PMID:12893283   PMID:12898452   PMID:12937154   PMID:12960309   PMID:14610273   PMID:14643301   PMID:14742542  
PMID:14764729   PMID:14981111   PMID:14990693   PMID:15034067   PMID:15100265   PMID:15197227   PMID:15322209   PMID:15383609   PMID:15456754   PMID:15592473   PMID:15634937   PMID:15723811  
PMID:15728518   PMID:15843524   PMID:15921521   PMID:16034080   PMID:16039578   PMID:16115887   PMID:16141072   PMID:16141073   PMID:16177324   PMID:16227149   PMID:16269657   PMID:16284651  
PMID:16286018   PMID:16301658   PMID:16322460   PMID:16352741   PMID:16375976   PMID:16418399   PMID:16449529   PMID:16453025   PMID:16476768   PMID:16476769   PMID:16492738   PMID:16493085  
PMID:16498503   PMID:16513171   PMID:16517735   PMID:16520389   PMID:16520392   PMID:16585547   PMID:16634805   PMID:16709748   PMID:16757681   PMID:16849473   PMID:16920981   PMID:16920988  
PMID:16925577   PMID:17013985   PMID:17077181   PMID:17108042   PMID:17202351   PMID:17239631   PMID:17277081   PMID:17307801   PMID:17322888   PMID:17328787   PMID:17417641   PMID:17420263  
PMID:17435165   PMID:17446931   PMID:17475849   PMID:17502348   PMID:17548594   PMID:17617565   PMID:17664287   PMID:17713556   PMID:17893199   PMID:17921137   PMID:17934470   PMID:17956862  
PMID:17997333   PMID:18063701   PMID:18097026   PMID:18178817   PMID:18199802   PMID:18207575   PMID:18217946   PMID:18227164   PMID:18256364   PMID:18292558   PMID:18322187   PMID:18354234  
PMID:18362174   PMID:18391000   PMID:18420815   PMID:18463609   PMID:18495955   PMID:18581336   PMID:18604868   PMID:18662772   PMID:18791164   PMID:18798552   PMID:18949059   PMID:18991288  
PMID:19060331   PMID:19109188   PMID:19155486   PMID:19327966   PMID:19355789   PMID:19447681   PMID:19621440   PMID:19644866   PMID:19705113   PMID:19758787   PMID:19795417   PMID:19949107  
PMID:19951957   PMID:19965673   PMID:19996316   PMID:20007534   PMID:20018631   PMID:20083655   PMID:20097865   PMID:20133862   PMID:20368175   PMID:20484044   PMID:20610564   PMID:20699442  
PMID:20709951   PMID:20809520   PMID:20819092   PMID:20869045   PMID:21040907   PMID:21078890   PMID:21084088   PMID:21135140   PMID:21159799   PMID:21187399   PMID:21191074   PMID:21248252  
PMID:21262349   PMID:21308776   PMID:21357255   PMID:21360699   PMID:21477339   PMID:21551362   PMID:21604261   PMID:21724994   PMID:21742972   PMID:21746933   PMID:21824820   PMID:21852502  
PMID:21859955   PMID:21873635   PMID:21940940   PMID:21969314   PMID:22078222   PMID:22116829   PMID:22138510   PMID:22147765   PMID:22156345   PMID:22244885   PMID:22290146   PMID:22337713  
PMID:22387002   PMID:22415018   PMID:22430937   PMID:22431569   PMID:22432050   PMID:22474370   PMID:22508937   PMID:22516957   PMID:22647731   PMID:22649202   PMID:22661700   PMID:22692512  
PMID:22723355   PMID:22845035   PMID:22908282   PMID:22908332   PMID:22922409   PMID:23053513   PMID:23053716   PMID:23069625   PMID:23071771   PMID:23109709   PMID:23123062   PMID:23150715  
PMID:23150718   PMID:23186369   PMID:23203925   PMID:23209322   PMID:23345428   PMID:23345431   PMID:23411782   PMID:23504312   PMID:23509363   PMID:23526819   PMID:23610371   PMID:23646151  
PMID:23675429   PMID:23744294   PMID:23749409   PMID:23754379   PMID:23897982   PMID:23898202   PMID:23921129   PMID:23979161   PMID:24026082   PMID:24038083   PMID:24072822   PMID:24163420  
PMID:24218606   PMID:24285839   PMID:24401277   PMID:24412922   PMID:24442438   PMID:24477292   PMID:24505033   PMID:24509813   PMID:24523933   PMID:24563255   PMID:24608040   PMID:24654803  
PMID:24665136   PMID:24752483   PMID:24790152   PMID:24842758   PMID:24869670   PMID:25100742   PMID:25215485   PMID:25267791   PMID:25339546   PMID:25368023   PMID:25384086   PMID:25404305  
PMID:25475856   PMID:25500122   PMID:25516435   PMID:25557539   PMID:25680277   PMID:25692415   PMID:25792447   PMID:25824719   PMID:25859222   PMID:25904149   PMID:25926454   PMID:25961064  
PMID:25987743   PMID:26210906   PMID:26216934   PMID:26245154   PMID:26261340   PMID:26342897   PMID:26373277   PMID:26410627   PMID:26451966   PMID:26619292   PMID:26621863   PMID:26643908  
PMID:26768664   PMID:26891734   PMID:26941575   PMID:27059595   PMID:27066907   PMID:27207525   PMID:27210762   PMID:27221338   PMID:27265505   PMID:27297794   PMID:27511731   PMID:27753080  
PMID:27834631   PMID:27837109   PMID:27999175   PMID:28028748   PMID:28165503   PMID:28218627   PMID:28384255   PMID:28389502   PMID:28409542   PMID:28479335   PMID:28492697   PMID:28539825  
PMID:28561280   PMID:28849025   PMID:28852207   PMID:29138419   PMID:29190833   PMID:29202472   PMID:29275858   PMID:29369823   PMID:29523656   PMID:29556231   PMID:29576376   PMID:29597194  
PMID:29599777   PMID:29774664   PMID:30024985   PMID:30026744   PMID:30116830   PMID:30185465   PMID:30210494   PMID:30261661   PMID:30361088   PMID:30373853   PMID:30446386   PMID:30610165  
PMID:30768140   PMID:30889825   PMID:31092015   PMID:31202927   PMID:31534958   PMID:31560714   PMID:31562320   PMID:31570755   PMID:31578241   PMID:31681256   PMID:31758072   PMID:31801071  
PMID:31940267   PMID:31964918   PMID:31980518   PMID:32133407   PMID:32195245   PMID:32582149   PMID:32684632   PMID:32795896   PMID:32907997   PMID:33083760   PMID:33117338   PMID:33244759  
PMID:33573095   PMID:33616086   PMID:33662988   PMID:33813142   PMID:33861790   PMID:33863984   PMID:34197340   PMID:34248948   PMID:34536564   PMID:34976216   PMID:35236989   PMID:35963953  
PMID:36227848   PMID:36581304   PMID:36759517   PMID:36948194   PMID:37030590   PMID:37488116   PMID:37539049   PMID:37844994   PMID:37910485   PMID:38069267   PMID:38087748   PMID:38147316  
PMID:38314895   PMID:38649840   PMID:38762740   PMID:38902261  


Genomics

Comparative Map Data
Fcgr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,786,186 - 170,804,141 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,786,186 - 170,804,116 (-)EnsemblGRCm39 Ensembl
GRCm381170,960,558 - 170,976,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,958,617 - 170,976,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,890,689 - 172,906,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,797,258 - 172,812,708 (-)NCBIMGSCv36mm8
Celera1173,410,273 - 173,425,760 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.02NCBI
FCGR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,647,243 - 161,678,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,663,143 - 161,678,654 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,617,033 - 161,648,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,899,564 - 159,914,575 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,364,610 - 158,379,618NCBI
Celera1134,746,188 - 134,751,893 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,877,468 - 132,892,993 (+)NCBIHuRef
CHM1_11163,054,757 - 163,070,270 (+)NCBICHM1_1
T2T-CHM13v2.01160,991,589 - 161,022,983 (+)NCBIT2T-CHM13v2.0
Fcgr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,725,897 - 85,740,517 (-)NCBIGRCr8
mRatBN7.21383,191,253 - 83,207,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,193,163 - 83,207,778 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,812,894 - 85,827,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,106,375 - 87,120,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,344,287 - 84,358,917 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,329,298 - 89,343,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,327,794 - 89,433,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,968,425 - 93,983,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,809,011 - 86,823,599NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,845,906 - 82,860,494 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fcgr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546214,639,396 - 14,653,801 (-)NCBIChiLan1.0ChiLan1.0
FCGR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,107,912 - 88,123,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,776,270 - 87,791,796 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,074,342 - 137,090,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,882,104 - 140,890,036 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,882,043 - 140,890,637 (+)Ensemblpanpan1.1panPan2
FCGR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,980,777 - 20,994,403 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,032,683 - 21,053,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,063,938 - 21,084,394 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13821,035,622 - 21,062,414 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,388,877 - 21,409,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,664,830 - 21,685,450 (-)NCBIUU_Cfam_GSD_1.0
Fcgr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,560,625 - 7,575,166 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493713180,014 - 96,114 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCGR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1488,873,762 - 88,892,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,889,007 - 96,908,224 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223672
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,398,425 - 2,413,328 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,453,854 - 1,469,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcgr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482697,605 - 112,101 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fcgr2b
656 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:679
Count of miRNA genes:349
Interacting mature miRNAs:381
Transcripts:ENSMUST00000027966, ENSMUST00000081103, ENSMUST00000159688, ENSMUST00000159969, ENSMUST00000160106, ENSMUST00000161503, ENSMUST00000161730
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1302037Nktcn1_mnatural killer T cell numbers 1 (mouse)Not determined1168186243171632257Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
10412205Bbaa30_mB.burgdorferi-associated arthritis 30 (mouse)Not determined1169038741174456436Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
38456000Lick2_mlick rate 2, sucralose (mouse)1170397438173397435Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
38456001Lick1_mlick rate 1, water (mouse)1170397438173397435Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
13452397Leusq4_mleucocytosis susceptibility QTL 4 (mouse)1156602037170803640Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
13452393Ity3b_mimmunity to S. typhimurium 3b (mouse)1156497439172097436Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
4142065Bmd5b_mbone mineral density 5b (mouse)Not determined168835111171765633Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
13207571Tcq11_mtotal cholesterol QTL 11 (mouse)1169137569179647565Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
13207587Mwmlpt1_mMorris water maze latency to platform, training, 1 (mouse)1169597438173397435Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
13207591Mwmlpa1_mMorris water maze latency to platform, all, 1 (mouse)1169797438173297435Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse

Markers in Region
X04648  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,960,787 - 170,960,959UniSTSGRCm38
MGSCv371172,890,918 - 172,891,090UniSTSGRCm37
Celera1173,410,500 - 173,410,672UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS
Whitehead_YAC1 UniSTS
D1Mit147  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,964,737 - 170,965,077UniSTSGRCm38
MGSCv371172,894,868 - 172,895,208UniSTSGRCm37
Celera1173,414,447 - 173,414,794UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS
Whitehead Genetic191.8UniSTS
D1Mit148  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,969,883 - 170,970,001UniSTSGRCm38
MGSCv371172,900,014 - 172,900,132UniSTSGRCm37
Celera1173,419,595 - 173,419,713UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS
Whitehead Genetic191.8UniSTS
Whitehead_YAC1 UniSTS
D1Dcr16  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,969,863 - 170,969,965UniSTSGRCm38
MGSCv371172,899,994 - 172,900,096UniSTSGRCm37
Celera1173,419,575 - 173,419,677UniSTS
Cytogenetic Map1H3UniSTS
cM Map1 UniSTS
AI528646  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,960,791 - 170,960,883UniSTSGRCm38
MGSCv371172,890,922 - 172,891,014UniSTSGRCm37
Celera1173,410,504 - 173,410,596UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS
Whitehead/MRC_RH12126.55UniSTS
Fcgr2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H3UniSTS
cM Map192.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001077189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD773836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000027966   ⟹   ENSMUSP00000027966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,786,186 - 170,803,696 (-)Ensembl
GRCm38.p6 Ensembl1170,958,617 - 170,976,127 (-)Ensembl
Ensembl Acc Id: ENSMUST00000081103   ⟹   ENSMUSP00000079882
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,788,127 - 170,803,696 (-)Ensembl
GRCm38.p6 Ensembl1170,960,558 - 170,976,127 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159688   ⟹   ENSMUSP00000123774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,788,562 - 170,803,696 (-)Ensembl
GRCm38.p6 Ensembl1170,960,993 - 170,976,127 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159969   ⟹   ENSMUSP00000137669
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,788,338 - 170,804,116 (-)Ensembl
GRCm38.p6 Ensembl1170,960,769 - 170,976,547 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160106
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,791,902 - 170,803,696 (-)Ensembl
GRCm38.p6 Ensembl1170,964,333 - 170,976,127 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161503
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,788,303 - 170,789,199 (-)Ensembl
GRCm38.p6 Ensembl1170,960,734 - 170,961,630 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,796,829 - 170,803,696 (-)Ensembl
GRCm38.p6 Ensembl1170,969,260 - 170,976,127 (-)Ensembl
RefSeq Acc Id: NM_001077189   ⟹   NP_001070657
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
GRCm381170,960,558 - 170,976,071 (-)NCBI
MGSCv371172,890,689 - 172,906,202 (-)RGD
Celera1173,410,273 - 173,425,760 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001419005   ⟹   NP_001405934
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,804,141 (-)NCBI
RefSeq Acc Id: NM_001419006   ⟹   NP_001405935
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
RefSeq Acc Id: NM_001419007   ⟹   NP_001405936
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
RefSeq Acc Id: NM_001419008   ⟹   NP_001405937
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
RefSeq Acc Id: NM_001419009   ⟹   NP_001405938
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
RefSeq Acc Id: NM_001419010   ⟹   NP_001405939
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
RefSeq Acc Id: NM_001419011   ⟹   NP_001405940
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
RefSeq Acc Id: NM_010187   ⟹   NP_034317
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,786,186 - 170,803,652 (-)NCBI
GRCm381170,960,558 - 170,976,071 (-)NCBI
MGSCv371172,890,689 - 172,906,202 (-)RGD
Celera1173,410,273 - 173,425,760 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001070657 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405934 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405935 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405936 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405937 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405938 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405939 (Get FASTA)   NCBI Sequence Viewer  
  NP_001405940 (Get FASTA)   NCBI Sequence Viewer  
  NP_034317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37289 (Get FASTA)   NCBI Sequence Viewer  
  AAA37605 (Get FASTA)   NCBI Sequence Viewer  
  AAA37606 (Get FASTA)   NCBI Sequence Viewer  
  AAA37607 (Get FASTA)   NCBI Sequence Viewer  
  AAA37608 (Get FASTA)   NCBI Sequence Viewer  
  AAA37609 (Get FASTA)   NCBI Sequence Viewer  
  AAA37610 (Get FASTA)   NCBI Sequence Viewer  
  AAA92707 (Get FASTA)   NCBI Sequence Viewer  
  AAA92708 (Get FASTA)   NCBI Sequence Viewer  
  AAA92709 (Get FASTA)   NCBI Sequence Viewer  
  AAA92710 (Get FASTA)   NCBI Sequence Viewer  
  AAA97464 (Get FASTA)   NCBI Sequence Viewer  
  AAB66903 (Get FASTA)   NCBI Sequence Viewer  
  AAH38070 (Get FASTA)   NCBI Sequence Viewer  
  BAC38062 (Get FASTA)   NCBI Sequence Viewer  
  BAC40820 (Get FASTA)   NCBI Sequence Viewer  
  BAE29704 (Get FASTA)   NCBI Sequence Viewer  
  BAE33196 (Get FASTA)   NCBI Sequence Viewer  
  BAE41523 (Get FASTA)   NCBI Sequence Viewer  
  BAE42346 (Get FASTA)   NCBI Sequence Viewer  
  BAE42388 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000027966
  ENSMUSP00000027966.8
  ENSMUSP00000079882
  ENSMUSP00000079882.6
  ENSMUSP00000123774
  ENSMUSP00000123774.2
  ENSMUSP00000137669
  ENSMUSP00000137669.2
GenBank Protein P08101 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034317   ⟸   NM_010187
- Peptide Label: isoform 2
- UniProtKB: Q61558 (UniProtKB/Swiss-Prot),   Q61170 (UniProtKB/Swiss-Prot),   Q60940 (UniProtKB/Swiss-Prot),   Q60939 (UniProtKB/Swiss-Prot),   Q60938 (UniProtKB/Swiss-Prot),   P97917 (UniProtKB/Swiss-Prot),   P12316 (UniProtKB/Swiss-Prot),   P08102 (UniProtKB/Swiss-Prot),   P08101 (UniProtKB/Swiss-Prot),   A0A0B4J1G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001070657   ⟸   NM_001077189
- Peptide Label: isoform 1
- UniProtKB: Q61558 (UniProtKB/Swiss-Prot),   Q61170 (UniProtKB/Swiss-Prot),   Q60940 (UniProtKB/Swiss-Prot),   Q60939 (UniProtKB/Swiss-Prot),   Q60938 (UniProtKB/Swiss-Prot),   P97917 (UniProtKB/Swiss-Prot),   P12316 (UniProtKB/Swiss-Prot),   P08102 (UniProtKB/Swiss-Prot),   P08101 (UniProtKB/Swiss-Prot),   A0A0B4J1E6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000137669   ⟸   ENSMUST00000159969
Ensembl Acc Id: ENSMUSP00000123774   ⟸   ENSMUST00000159688
Ensembl Acc Id: ENSMUSP00000027966   ⟸   ENSMUST00000027966
Ensembl Acc Id: ENSMUSP00000079882   ⟸   ENSMUST00000081103
RefSeq Acc Id: NP_001405934   ⟸   NM_001419005
- Peptide Label: isoform 1
- UniProtKB: Q61558 (UniProtKB/Swiss-Prot),   Q61170 (UniProtKB/Swiss-Prot),   Q60940 (UniProtKB/Swiss-Prot),   Q60939 (UniProtKB/Swiss-Prot),   Q60938 (UniProtKB/Swiss-Prot),   P97917 (UniProtKB/Swiss-Prot),   P12316 (UniProtKB/Swiss-Prot),   P08102 (UniProtKB/Swiss-Prot),   P08101 (UniProtKB/Swiss-Prot),   A0A0B4J1E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001405937   ⟸   NM_001419008
- Peptide Label: isoform 5
- UniProtKB: Q61558 (UniProtKB/Swiss-Prot),   Q61170 (UniProtKB/Swiss-Prot),   Q60940 (UniProtKB/Swiss-Prot),   Q60939 (UniProtKB/Swiss-Prot),   Q60938 (UniProtKB/Swiss-Prot),   P97917 (UniProtKB/Swiss-Prot),   P12316 (UniProtKB/Swiss-Prot),   P08102 (UniProtKB/Swiss-Prot),   P08101 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001405935   ⟸   NM_001419006
- Peptide Label: isoform 3
- UniProtKB: Q61558 (UniProtKB/Swiss-Prot),   Q61170 (UniProtKB/Swiss-Prot),   Q60940 (UniProtKB/Swiss-Prot),   Q60939 (UniProtKB/Swiss-Prot),   Q60938 (UniProtKB/Swiss-Prot),   P97917 (UniProtKB/Swiss-Prot),   P12316 (UniProtKB/Swiss-Prot),   P08102 (UniProtKB/Swiss-Prot),   P08101 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001405940   ⟸   NM_001419011
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001405938   ⟸   NM_001419009
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001405939   ⟸   NM_001419010
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001405936   ⟸   NM_001419007
- Peptide Label: isoform 4
- UniProtKB: Q61558 (UniProtKB/Swiss-Prot),   Q61170 (UniProtKB/Swiss-Prot),   Q60940 (UniProtKB/Swiss-Prot),   Q60939 (UniProtKB/Swiss-Prot),   Q60938 (UniProtKB/Swiss-Prot),   P97917 (UniProtKB/Swiss-Prot),   P12316 (UniProtKB/Swiss-Prot),   P08102 (UniProtKB/Swiss-Prot),   P08101 (UniProtKB/Swiss-Prot),   E9Q415 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08101-F1-model_v2 AlphaFold P08101 1-330 view protein structure

Promoters
RGD ID:6875640
Promoter ID:EPDNEW_M1271
Type:initiation region
Name:Fcgr2b_1
Description:Mus musculus Fc receptor, IgG, low affinity IIb , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,976,060 - 170,976,120EPDNEW
RGD ID:6817726
Promoter ID:MM_KWN:2813
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Kidney,   Liver,   Spleen
Transcripts:OTTMUST00000051686,   OTTMUST00000051688,   OTTMUST00000051689,   OTTMUST00000051690,   OTTMUST00000051691,   UC007DMU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361172,905,859 - 172,906,359 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95499 AgrOrtholog
Ensembl Genes ENSMUSG00000026656 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027966 ENTREZGENE
  ENSMUST00000027966.14 UniProtKB/TrEMBL
  ENSMUST00000081103 ENTREZGENE
  ENSMUST00000081103.12 UniProtKB/TrEMBL
  ENSMUST00000159688 ENTREZGENE
  ENSMUST00000159688.2 UniProtKB/TrEMBL
  ENSMUST00000159969 ENTREZGENE
  ENSMUST00000159969.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_Fc_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95499 ENTREZGENE
NCBI Gene 14130 ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fcgr2b PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0B4J1E6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0B4J1G1 ENTREZGENE, UniProtKB/TrEMBL
  E9Q415 ENTREZGENE, UniProtKB/TrEMBL
  FCGR2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P08102 ENTREZGENE
  P12316 ENTREZGENE
  P97917 ENTREZGENE
  Q60938 ENTREZGENE
  Q60939 ENTREZGENE
  Q60940 ENTREZGENE
  Q61170 ENTREZGENE
  Q61558 ENTREZGENE
UniProt Secondary P08102 UniProtKB/Swiss-Prot
  P12316 UniProtKB/Swiss-Prot
  P97917 UniProtKB/Swiss-Prot
  Q60938 UniProtKB/Swiss-Prot
  Q60939 UniProtKB/Swiss-Prot
  Q60940 UniProtKB/Swiss-Prot
  Q61170 UniProtKB/Swiss-Prot
  Q61558 UniProtKB/Swiss-Prot