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Gene: Dll4 (delta like canonical Notch ligand 4) Mus musculus
Symbol: Dll4
Name: delta like canonical Notch ligand 4
Description: Exhibits Notch binding activity. Involved in several processes, including circulatory system development; negative regulation of blood vessel endothelial cell migration; and regulation of Notch signaling pathway. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and sensory organ. Orthologous to human DLL4 (delta like canonical Notch ligand 4); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: delta-like 4; delta-like 4 (Drosophila); delta-like protein 4; Delta4; drosophila Delta homolog 4
Homo sapiens (human) : DLL4 (delta like canonical Notch ligand 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dll4 (delta like canonical Notch ligand 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dll4 (delta like canonical Notch ligand 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DLL4 (delta like canonical Notch ligand 4)
Canis lupus familiaris (dog) : DLL4 (delta like canonical Notch ligand 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dll4 (delta like canonical Notch ligand 4)
Sus scrofa (pig) : DLL4 (delta like canonical Notch ligand 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2119,325,784 - 119,335,962 (+)Ensembl
GRCm382119,325,784 - 119,335,666 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372119,151,520 - 119,161,402 (+)NCBIGRCm37mm9NCBIm37
MGSCv362119,017,270 - 119,027,097 (+)NCBImm8
Celera2120,476,206 - 120,486,045 (+)NCBICelera
Cytogenetic Map2 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dll4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320242
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.