Dll4 (delta like canonical Notch ligand 4) - Rat Genome Database

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Gene: Dll4 (delta like canonical Notch ligand 4) Mus musculus
Analyze
Symbol: Dll4
Name: delta like canonical Notch ligand 4
RGD ID: 1320242
MGI Page MGI
Description: Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and retina. Used to study Adams-Oliver syndrome. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Delt; delta-like 4; delta-like 4 (Drosophila); delta-like protein 4; Delta4; drosophila Delta homolog 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,156,286 - 119,166,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,156,265 - 119,166,443 (+)EnsemblGRCm39 Ensembl
GRCm382119,325,784 - 119,335,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,325,784 - 119,335,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,151,520 - 119,161,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,017,270 - 119,027,097 (+)NCBIMGSCv36mm8
Celera2120,476,206 - 120,486,045 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
BQ 123  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
cannabidiol  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
epoxiconazole  (EXP)
folic acid  (EXP)
gentamycin  (ISO)
hydrogen cyanide  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
octadecanoic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
picoxystrobin  (ISO)
potassium chromate  (ISO)
potassium cyanide  (EXP)
propranolol  (ISO)
prostaglandin F2alpha  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP)
aortic valve morphogenesis  (ISO)
blood vessel lumenization  (IMP)
blood vessel remodeling  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
cardiac atrium morphogenesis  (IMP)
cardiac ventricle morphogenesis  (IMP)
cell communication  (IEA)
cell differentiation  (IEA)
cellular response to cholesterol  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
chondrocyte differentiation  (ISO)
dorsal aorta morphogenesis  (IMP)
luteolysis  (ISO)
negative regulation of blood vessel endothelial cell migration  (IDA)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of Notch signaling pathway  (IBA,IDA)
negative regulation of transcription by RNA polymerase II  (IMP)
nervous system development  (IEA)
Notch signaling pathway  (IBA,IDA,IMP,ISO)
pericardium morphogenesis  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of Notch signaling pathway  (IDA)
regulation of neural retina development  (IMP)
regulation of neurogenesis  (IMP)
T cell differentiation  (IDA)
ventral spinal cord interneuron fate commitment  (ISO)
ventricular trabecula myocardium morphogenesis  (IMP)
visual perception  (IEA)

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,ISS,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal artery development  (IAGP)
abnormal artery morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal capillary morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardinal vein morphology  (IAGP)
abnormal common cardinal vein morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal induced retina neovascularization  (IAGP)
abnormal internal carotid artery morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal pulmonary valve morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal sinus venosus morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal thymus cell ratio  (IAGP)
abnormal umbilical artery morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular regression  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vein development  (IAGP)
abnormal vein morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent CD4-positive, alpha-beta T cells  (IAGP)
absent CD8-positive, alpha-beta T cells  (IAGP)
absent vitelline blood vessels  (IAGP)
aorta stenosis  (IAGP)
arteriovenous malformation  (IAGP)
blood vessel atresia  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased thymocyte number  (IAGP)
double outlet right ventricle  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
increased immature B cell number  (IAGP)
no abnormal phenotype detected  (IAGP)
overriding aortic valve  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
poor circulation  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
thymus hypoplasia  (IAGP)
trabecula carnea hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The Notch Signaling System Is Involved in the Regulation of Reparative Angiogenesis in the Zone of Stasis. Abbas OL, etal., J Burn Care Res. 2017 Nov/Dec;38(6):e923-e933. doi: 10.1097/BCR.0000000000000522.
2. The Notch pathway is a critical regulator of angiogenesis in a skin model of ischemia. Abbas OL, etal., Vasc Med. 2015 Jun;20(3):205-11. doi: 10.1177/1358863X15570723. Epub 2015 Apr 1.
3. Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Al Haj Zen A, etal., Circ Res. 2010 Jul 23;107(2):283-93. doi: 10.1161/CIRCRESAHA.110.221663. Epub 2010 May 27.
4. Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development. Bassil R, etal., J Immunol. 2011 Sep 1;187(5):2322-8. doi: 10.4049/jimmunol.1100725. Epub 2011 Aug 3.
5. Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion. Billiard F, etal., Cell Rep. 2018 Jan 23;22(4):895-904. doi: 10.1016/j.celrep.2017.12.076. Epub 2018 Jan 28.
6. Murine Model of Cardiac Defects Observed in Adams-Oliver Syndrome Driven by Delta-Like Ligand-4 Haploinsufficiency. De Zoysa P, etal., Stem Cells Dev. 2021 Jun 15;30(12):611-621. doi: 10.1089/scd.2021.0058. Epub 2021 May 31.
7. Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions. Dong X, etal., PLoS One. 2011 Apr 19;6(4):e18481. doi: 10.1371/journal.pone.0018481.
8. VEGF promotes cartilage angiogenesis by phospho-ERK1/2 activation of Dll4 signaling in temporomandibular joint osteoarthritis caused by chronic sleep disturbance in Wistar rats. Dong Y, etal., Oncotarget. 2017 Mar 14;8(11):17849-17861. doi: 10.18632/oncotarget.14874.
9. Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway. Ebrahim N, etal., Stem Cell Res Ther. 2021 Jul 13;12(1):392. doi: 10.1186/s13287-021-02454-y.
10. MicroRNA-384-5p Promotes Endothelial Progenitor Cell Proliferation and Angiogenesis in Cerebral Ischemic Stroke through the Delta-Likeligand 4-Mediated Notch Signaling Pathway. Fan J, etal., Cerebrovasc Dis. 2020;49(1):39-54. doi: 10.1159/000503950. Epub 2020 Jan 10.
11. Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. Feng Q, etal., J Dig Dis. 2014 Feb;15(2):85-95. doi: 10.1111/1751-2980.12114.
12. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
13. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Fukuda D, etal., Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1868-77. doi: 10.1073/pnas.1116889109. Epub 2012 Jun 13.
14. Effect of Notch activation on the regenerative response to acute renal failure. Gupta S, etal., Am J Physiol Renal Physiol. 2010 Jan;298(1):F209-15. doi: 10.1152/ajprenal.00451.2009. Epub 2009 Oct 14.
15. Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation. Harvey DC, etal., Birth Defects Res. 2022 Feb;114(3-4):105-115. doi: 10.1002/bdr2.1968. Epub 2021 Dec 3.
16. Blockade of the sonic hedgehog signalling pathway inhibits choroidal neovascularization in a laser-induced rat model. He H, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Oct;30(5):659-65. doi: 10.1007/s11596-010-0560-z. Epub 2010 Nov 10.
17. Total Flavonoids in Caragana (TFC) Promotes Angiogenesis and Enhances Cerebral Perfusion in a Rat Model of Ischemic Stroke. He Q, etal., Front Neurosci. 2018 Sep 12;12:635. doi: 10.3389/fnins.2018.00635. eCollection 2018.
18. Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Jubb AM, etal., Am J Pathol. 2010 Apr;176(4):2019-28. doi: 10.2353/ajpath.2010.090908. Epub 2010 Feb 18.
19. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
20. Analysis of Molecular Mechanism of YiqiChutan Formula Regulating DLL4-Notch Signaling to Inhibit Angiogenesis in Lung Cancer. Li J, etal., Biomed Res Int. 2021 Feb 12;2021:8875503. doi: 10.1155/2021/8875503. eCollection 2021.
21. Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats. Li S, etal., Evid Based Complement Alternat Med. 2020 Feb 5;2020:5041629. doi: 10.1155/2020/5041629. eCollection 2020.
22. Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease. Lin J, etal., Theranostics. 2020 Jun 22;10(17):7857-7871. doi: 10.7150/thno.43154. eCollection 2020.
23. Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues. Liu R, etal., Biochem Biophys Res Commun. 2012 Feb 3;418(1):173-9. doi: 10.1016/j.bbrc.2012.01.002. Epub 2012 Jan 9.
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
27. Delivery of VEGF and delta-like 4 to synergistically regenerate capillaries and arterioles in ischemic limbs. Niu H, etal., Acta Biomater. 2022 Apr 15;143:295-309. doi: 10.1016/j.actbio.2022.03.021. Epub 2022 Mar 14.
28. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Noguera-Troise I, etal., Nature. 2006 Dec 21;444(7122):1032-7. doi: 10.1038/nature05355.
29. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
30. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
31. Study of angiogenic signaling pathways in hemangioblastoma. Pierscianek D, etal., Neuropathology. 2017 Feb;37(1):3-11. doi: 10.1111/neup.12316. Epub 2016 Jul 7.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Si-Miao-Yong-An on promoting the maturation of Vasa Vasorum and stabilizing atherosclerotic plaque in ApoE-/- mice： An experimental study. Qi Z, etal., Biomed Pharmacother. 2019 Jun;114:108785. doi: 10.1016/j.biopha.2019.108785. Epub 2019 Mar 23.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy. Rivera JC, etal., Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7897-907. doi: 10.1167/iovs.15-17146.
39. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
40. Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway. Sun W, etal., Med Sci Monit. 2019 Jan 17;25:492-499. doi: 10.12659/MSM.913828.
41. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
42. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. Tan HH, etal., J Dig Dis. 2011 Oct;12(5):349-56. doi: 10.1111/j.1751-2980.2011.00506.x.
43. Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension. Wang S, etal., Hypertension. 2022 Jan;79(1):79-92. doi: 10.1161/HYPERTENSIONAHA.120.16065. Epub 2021 Nov 5.
44. Phase II study of pazopanib as second-line treatment after sunitinib in patients with metastatic renal cell carcinoma: a Southern China Urology Cancer Consortium Trial. Xie M, etal., Eur J Cancer. 2015 Mar;51(5):595-603. doi: 10.1016/j.ejca.2015.01.005. Epub 2015 Jan 21.
45. Chronic DLL4 blockade induces vascular neoplasms. Yan M, etal., Nature. 2010 Feb 11;463(7282):E6-7. doi: 10.1038/nature08751.
46. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
47. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
48. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
49. Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic stroke. Zhou YF, etal., FASEB J. 2019 Apr;33(4):4947-4961. doi: 10.1096/fj.201801706RR. Epub 2019 Jan 17.
50. Correlation of serum delta-like ligand-4 level with the severity of diabetic retinopathy. Zhu Y, etal., BMC Endocr Disord. 2021 Aug 6;21(1):157. doi: 10.1186/s12902-021-00814-6.
Additional References at PubMed
PMID:10349636   PMID:10837024   PMID:10837027   PMID:11035934   PMID:11042159   PMID:11076861   PMID:11134954   PMID:11578869   PMID:11698278   PMID:11739188   PMID:11798067   PMID:11944948  
PMID:12477932   PMID:12588999   PMID:12617809   PMID:12971992   PMID:14701881   PMID:14757642   PMID:15146182   PMID:15465494   PMID:15466159   PMID:15466160   PMID:15520367   PMID:15533827  
PMID:15569487   PMID:15689374   PMID:15728481   PMID:15821257   PMID:15882861   PMID:15923152   PMID:16000382   PMID:16095582   PMID:16141072   PMID:16141073   PMID:16245338   PMID:16393955  
PMID:16518823   PMID:16569589   PMID:16678147   PMID:16939807   PMID:16951162   PMID:17015435   PMID:17183323   PMID:17259973   PMID:17273555   PMID:17296940   PMID:17296941   PMID:17311993  
PMID:17336907   PMID:17359917   PMID:17476283   PMID:17576775   PMID:17605079   PMID:17625108   PMID:17664272   PMID:17685488   PMID:17728344   PMID:17998388   PMID:18093989   PMID:18209061  
PMID:18287559   PMID:18300415   PMID:18505817   PMID:18528438   PMID:18545664   PMID:18550715   PMID:18559979   PMID:18594512   PMID:18694942   PMID:18804439   PMID:18824583   PMID:18824585  
PMID:18832397   PMID:18952909   PMID:19027794   PMID:19050235   PMID:19075396   PMID:19087347   PMID:19110448   PMID:19164599   PMID:19191219   PMID:19217325   PMID:19218547   PMID:19369401  
PMID:19389377   PMID:19494260   PMID:19524514   PMID:19590010   PMID:19619540   PMID:19666558   PMID:19686682   PMID:19723503   PMID:19752226   PMID:19897741   PMID:20008296   PMID:20018779  
PMID:20154142   PMID:20335360   PMID:20336138   PMID:20339091   PMID:20392836   PMID:20548034   PMID:20568246   PMID:20602435   PMID:20627076   PMID:20705756   PMID:20727173   PMID:20808960  
PMID:20871601   PMID:20890042   PMID:20944009   PMID:20944072   PMID:20947685   PMID:21092311   PMID:21097675   PMID:21238454   PMID:21252157   PMID:21267068   PMID:21311046   PMID:21352254  
PMID:21352545   PMID:21402699   PMID:21421844   PMID:21483741   PMID:21498671   PMID:21499261   PMID:21561989   PMID:21598246   PMID:21633169   PMID:21677750   PMID:21700774   PMID:21750033  
PMID:21788444   PMID:21791528   PMID:21793101   PMID:21873635   PMID:21882187   PMID:21979816   PMID:22072979   PMID:22076636   PMID:22228100   PMID:22279550   PMID:22323600   PMID:22364862  
PMID:22426001   PMID:22464328   PMID:22514637   PMID:22547652   PMID:22615585   PMID:22675208   PMID:22783020   PMID:22869002   PMID:23095891   PMID:23134786   PMID:23162128   PMID:23178125  
PMID:23223237   PMID:23229021   PMID:23285048   PMID:23314057   PMID:23362346   PMID:23379656   PMID:23394931   PMID:23406903   PMID:23477786   PMID:23533173   PMID:23665443   PMID:23675950  
PMID:23785053   PMID:23818617   PMID:23830865   PMID:23881845   PMID:23894673   PMID:23918385   PMID:23988616   PMID:24003143   PMID:24015274   PMID:24025447   PMID:24043815   PMID:24074756  
PMID:24153254   PMID:24257627   PMID:24337118   PMID:24386421   PMID:24496616   PMID:24520074   PMID:24552588   PMID:24615277   PMID:24647000   PMID:24667410   PMID:24780197   PMID:24859004  
PMID:24874427   PMID:24894949   PMID:24943269   PMID:24952961   PMID:24990151   PMID:25072663   PMID:25179941   PMID:25264302   PMID:25318679   PMID:25332287   PMID:25369423   PMID:25401743  
PMID:25497097   PMID:25535917   PMID:25561555   PMID:25607460   PMID:25687759   PMID:25691540   PMID:25766473   PMID:25767274   PMID:25791711   PMID:25918341   PMID:25976373   PMID:26002917  
PMID:26051942   PMID:26114479   PMID:26276819   PMID:26314892   PMID:26340748   PMID:26404485   PMID:26465397   PMID:26471266   PMID:26529256   PMID:26630461   PMID:26641715   PMID:26786283  
PMID:26828208   PMID:26870802   PMID:26912775   PMID:27056911   PMID:27074663   PMID:27171900   PMID:27510977   PMID:27576369   PMID:27789228   PMID:27898394   PMID:27898698   PMID:27922003  
PMID:27991863   PMID:28005008   PMID:28077598   PMID:28082864   PMID:28086833   PMID:28288569   PMID:28319044   PMID:28402857   PMID:28656980   PMID:28714968   PMID:28812183   PMID:28924218  
PMID:29086765   PMID:29437553   PMID:29444818   PMID:29445148   PMID:29540665   PMID:29743679   PMID:29791855   PMID:29891551   PMID:29956664   PMID:30038214   PMID:30181175   PMID:30289388  
PMID:30375389   PMID:30448061   PMID:30692543   PMID:30796970   PMID:30930165   PMID:30936475   PMID:31043605   PMID:31112136   PMID:31118412   PMID:31119445   PMID:31335323   PMID:31420575  
PMID:31591643   PMID:31631837   PMID:31789590   PMID:31934853   PMID:32029480   PMID:32059772   PMID:32060138   PMID:32078435   PMID:32149421   PMID:32255245   PMID:32369453   PMID:32467237  
PMID:32544090   PMID:32565279   PMID:32747435   PMID:32778568   PMID:32820046   PMID:32903671   PMID:33095124   PMID:33106502   PMID:33299176   PMID:33369874   PMID:33454003   PMID:33473260  
PMID:33578263   PMID:33590845   PMID:33730615   PMID:33830085   PMID:34497373   PMID:34665379   PMID:34741805   PMID:34838591   PMID:34910918   PMID:35064244   PMID:35079138   PMID:35091558  
PMID:35103284   PMID:35126469   PMID:35228746   PMID:35247391   PMID:35297995   PMID:35577801   PMID:35579982   PMID:35941210   PMID:36082581   PMID:36239412   PMID:36376768   PMID:37000875  
PMID:37016580   PMID:37317851   PMID:37324380   PMID:38111957   PMID:38346959   PMID:38374152  


Genomics

Comparative Map Data
Dll4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,156,286 - 119,166,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,156,265 - 119,166,443 (+)EnsemblGRCm39 Ensembl
GRCm382119,325,784 - 119,335,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,325,784 - 119,335,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,151,520 - 119,161,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,017,270 - 119,027,097 (+)NCBIMGSCv36mm8
Celera2120,476,206 - 120,486,045 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
DLL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,929,340 - 40,939,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,929,340 - 40,939,073 (+)EnsemblGRCh38hg38GRCh38
GRCh371541,221,538 - 41,231,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,008,839 - 39,018,529 (+)NCBINCBI36Build 36hg18NCBI36
Build 341539,008,838 - 39,018,529NCBI
Celera1517,989,410 - 17,999,137 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,070,066 - 18,079,793 (+)NCBIHuRef
CHM1_11541,339,420 - 41,349,204 (+)NCBICHM1_1
T2T-CHM13v2.01538,735,323 - 38,745,058 (+)NCBIT2T-CHM13v2.0
Dll4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,770,945 - 126,780,769 (+)NCBIGRCr8
mRatBN7.23106,317,114 - 106,327,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,316,986 - 106,326,931 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,990,303 - 110,000,143 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,585,843 - 118,595,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,246,228 - 116,256,068 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,135,011 - 111,146,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,135,021 - 111,145,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,685,724 - 117,695,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,844,671 - 105,854,738 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,741,099 - 105,750,240 (+)NCBI
Celera3105,230,387 - 105,240,148 (+)NCBICelera
Cytogenetic Map3q35NCBI
Dll4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,807,049 - 7,817,420 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,807,049 - 7,816,346 (+)NCBIChiLan1.0ChiLan1.0
DLL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,171,696 - 30,182,800 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,323,041 - 34,334,142 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,871,584 - 19,881,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,121,238 - 38,130,950 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,121,574 - 38,129,471 (+)Ensemblpanpan1.1panPan2
DLL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,059,463 - 8,068,742 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,059,512 - 8,067,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,114,087 - 8,123,649 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,188,070 - 8,197,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,185,217 - 8,197,617 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,111,270 - 8,120,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,217,668 - 8,227,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,349,053 - 8,358,618 (+)NCBIUU_Cfam_GSD_1.0
Dll4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,472,876 - 86,482,195 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,320,933 - 4,330,253 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,320,235 - 4,330,251 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,376,721 - 130,386,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11130,376,720 - 130,386,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,539,044 - 145,548,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,056,473 - 42,066,283 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,056,331 - 42,065,828 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,919,102 - 98,929,217 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,179,731 - 8,191,284 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248048,179,729 - 8,189,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dll4
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:774
Count of miRNA genes:477
Interacting mature miRNAs:571
Transcripts:ENSMUST00000102517, ENSMUST00000127102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1301098Cd8mts3_mCD8 memory T cell subset 3 (mouse)Not determined291089974125090104Mouse
1301909Smdq2_msegregation of mitochondrial DNA QTL 2 (mouse)Not determined292778465126778607Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
13506762Tbvq2_mtrabecular bone volume QTL 2 (mouse)2115430481124741920Mouse
1558825Aabpr_maberrant activation of B cell proliferation (mouse)Not determined2116033229122207534Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12904007Cfq7_mconditioned fear QTL 7 (mouse)2118356772125048872Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse

Markers in Region
Dll4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv372119,158,159 - 119,158,418UniSTSGRCm37
Celera2120,482,816 - 120,483,075UniSTS
Celera2120,482,814 - 120,484,510UniSTS
Cytogenetic Map2E3UniSTS
cM Map2 UniSTS
D2Mit104  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382119,328,862 - 119,329,009UniSTSGRCm38
MGSCv372119,154,598 - 119,154,745UniSTSGRCm37
Celera2120,479,284 - 120,479,430UniSTS
Cytogenetic Map2E3UniSTS
cM Map266.0UniSTS
Whitehead Genetic255.7UniSTS
Whitehead_YAC2 UniSTS
D2Dcr63  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382119,328,891 - 119,329,010UniSTSGRCm38
MGSCv372119,154,627 - 119,154,746UniSTSGRCm37
Celera2120,479,313 - 120,479,431UniSTS
Cytogenetic Map2E3UniSTS
cM Map2 UniSTS
Dll4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382119,332,423 - 119,332,682UniSTSGRCm38
MGSCv372119,158,159 - 119,158,418UniSTSGRCm37
Celera2120,482,816 - 120,483,075UniSTS
Cytogenetic Map2E3UniSTS
cM Map2 UniSTS
Dll4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera2120,482,814 - 120,484,510UniSTS
Cytogenetic Map2E3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000102517   ⟹   ENSMUSP00000099575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2119,156,265 - 119,166,443 (+)Ensembl
GRCm38.p6 Ensembl2119,325,784 - 119,335,962 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2119,159,019 - 119,162,634 (+)Ensembl
GRCm38.p6 Ensembl2119,328,538 - 119,332,153 (+)Ensembl
RefSeq Acc Id: NM_019454   ⟹   NP_062327
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392119,156,297 - 119,166,141 (+)NCBI
GRCm382119,325,784 - 119,335,666 (+)NCBI
MGSCv372119,151,520 - 119,161,402 (+)RGD
Celera2120,476,206 - 120,486,045 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_185308
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392119,157,723 - 119,166,141 (+)NCBI
RefSeq Acc Id: NR_185309
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392119,158,108 - 119,166,141 (+)NCBI
RefSeq Acc Id: XM_030251887   ⟹   XP_030107747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392119,156,286 - 119,166,145 (+)NCBI
GRCm382119,327,929 - 119,335,664 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062327   ⟸   NM_019454
- Peptide Label: precursor
- UniProtKB: Q9DBU9 (UniProtKB/Swiss-Prot),   Q9JHZ7 (UniProtKB/Swiss-Prot),   Q9JI71 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030107747   ⟸   XM_030251887
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000099575   ⟸   ENSMUST00000102517
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI71-F1-model_v2 AlphaFold Q9JI71 1-686 view protein structure

Promoters
RGD ID:6831169
Promoter ID:MM_KWN:31236
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000102517
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362119,151,421 - 119,151,921 (+)MPROMDB
RGD ID:6831175
Promoter ID:MM_KWN:31237
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000037915
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362119,153,926 - 119,154,426 (+)MPROMDB
RGD ID:6878354
Promoter ID:EPDNEW_M2628
Type:single initiation site
Name:Dll4_1
Description:Mus musculus delta like canonical Notch ligand 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382119,325,816 - 119,325,876EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859388 AgrOrtholog
Ensembl Genes ENSMUSG00000027314 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000102517 ENTREZGENE
  ENSMUST00000102517.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot
  2.60.40.3510 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro DSL UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Notch_ligand_N UniProtKB/Swiss-Prot
KEGG Report mmu:54485 UniProtKB/Swiss-Prot
MGD MGI:1859388 ENTREZGENE
NCBI Gene 54485 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/Swiss-Prot
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED UniProtKB/Swiss-Prot
Pfam DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  JAG1-like_EGF2 UniProtKB/Swiss-Prot
  MNNL UniProtKB/Swiss-Prot
PhenoGen Dll4 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
SMART DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt DLL4_MOUSE UniProtKB/Swiss-Prot
  Q9DBU9 ENTREZGENE
  Q9JHZ7 ENTREZGENE
  Q9JI71 ENTREZGENE
UniProt Secondary Q9DBU9 UniProtKB/Swiss-Prot
  Q9JHZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Dll4  delta like canonical Notch ligand 4    delta-like 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED