Ttpa (tocopherol (alpha) transfer protein) - Rat Genome Database

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Gene: Ttpa (tocopherol (alpha) transfer protein) Mus musculus
Analyze
Symbol: Ttpa
Name: tocopherol (alpha) transfer protein
RGD ID: 731915
MGI Page MGI
Description: Enables anion binding activity; lipid transfer activity; and vitamin E binding activity. Involved in several processes, including intermembrane lipid transfer; negative regulation of establishment of blood-brain barrier; and vitamin transport. Acts upstream of or within embryonic placenta development; positive regulation of amyloid-beta clearance; and vitamin E metabolic process. Predicted to be located in cytosol. Predicted to be active in late endosome. Is expressed in liver; placenta; uterus; and yolk sac. Used to study familial isolated deficiency of vitamin E. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alph; alpha TTP; alpha-tocopherol transfer protein; alpha-TTP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39420,007,867 - 20,030,822 (+)NCBIGRCm39mm39
GRCm39 Ensembl420,007,938 - 20,030,785 (+)Ensembl
GRCm38420,007,894 - 20,030,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl420,007,938 - 20,030,785 (+)EnsemblGRCm38mm10GRCm38
MGSCv37419,935,575 - 19,957,932 (+)NCBIGRCm37mm9NCBIm37
MGSCv36419,935,575 - 19,957,932 (+)NCBImm8
Celera419,766,254 - 19,788,914 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (TAS)
cytosol  (ISO)
late endosome  (IBA,ISO)

References

Additional References at PubMed
PMID:10349636   PMID:10553000   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11076932   PMID:11095717   PMID:11752462   PMID:12135902   PMID:12477932   PMID:14610273   PMID:14630814  
PMID:14642382   PMID:14871478   PMID:15721988   PMID:15939374   PMID:16014812   PMID:16141072   PMID:16141073   PMID:16257640   PMID:16787402   PMID:16895792   PMID:17026966   PMID:17197560  
PMID:17382327   PMID:17400288   PMID:17576803   PMID:17707975   PMID:18180306   PMID:18289715   PMID:18299118   PMID:18799693   PMID:19679659   PMID:19695323   PMID:19923370   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:22147702   PMID:22388090   PMID:23599266   PMID:24342566   PMID:26637123   PMID:29315537   PMID:30629958   PMID:32290105   PMID:33086686  


Genomics

Comparative Map Data
Ttpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39420,007,867 - 20,030,822 (+)NCBIGRCm39mm39
GRCm39 Ensembl420,007,938 - 20,030,785 (+)Ensembl
GRCm38420,007,894 - 20,030,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl420,007,938 - 20,030,785 (+)EnsemblGRCm38mm10GRCm38
MGSCv37419,935,575 - 19,957,932 (+)NCBIGRCm37mm9NCBIm37
MGSCv36419,935,575 - 19,957,932 (+)NCBImm8
Celera419,766,254 - 19,788,914 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.76NCBI
TTPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl863,048,553 - 63,086,053 (-)EnsemblGRCh38hg38GRCh38
GRCh38863,059,488 - 63,086,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37863,972,047 - 63,998,612 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36864,135,985 - 64,161,166 (-)NCBINCBI36hg18NCBI36
Build 34864,135,984 - 64,161,166NCBI
Celera859,962,246 - 59,988,643 (-)NCBI
Cytogenetic Map8q12.3NCBI
HuRef859,459,917 - 59,486,481 (-)NCBIHuRef
CHM1_1864,025,060 - 64,051,623 (-)NCBICHM1_1
Ttpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,497,537 - 33,518,936 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)Ensembl
Rnor_6.0534,007,926 - 34,029,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,661,259 - 38,681,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,638,551 - 34,659,077 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1534,638,729 - 34,659,256 (+)NCBI
Celera532,573,008 - 32,593,536 (+)NCBICelera
Cytogenetic Map5q13NCBI
Ttpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544415,869,940 - 15,894,544 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544415,877,972 - 15,891,949 (+)NCBIChiLan1.0ChiLan1.0
TTPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1861,266,954 - 61,293,165 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl861,266,954 - 61,293,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0859,591,592 - 59,619,658 (-)NCBIMhudiblu_PPA_v0panPan3
TTPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12913,177,690 - 13,198,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2913,182,308 - 13,192,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2913,507,263 - 13,526,254 (-)NCBI
ROS_Cfam_1.02913,283,050 - 13,302,075 (-)NCBI
UMICH_Zoey_3.12913,294,501 - 13,313,489 (-)NCBI
UNSW_CanFamBas_1.02913,412,121 - 13,431,143 (-)NCBI
UU_Cfam_GSD_1.02913,677,780 - 13,696,792 (-)NCBI
Ttpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530364,318,193 - 64,375,529 (-)NCBI
SpeTri2.0NW_00493649610,409,948 - 10,466,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1858,952,685 - 58,979,083 (-)NCBI
ChlSab1.1 Ensembl858,950,626 - 58,978,258 (-)Ensembl
Vero_WHO_p1.0NW_02366603982,604,603 - 82,632,422 (+)NCBI
Ttpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474428,713,596 - 28,738,435 (+)NCBI

Position Markers
AA416453  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38420,019,967 - 20,020,098UniSTSGRCm38
MGSCv37419,947,114 - 19,947,245UniSTSGRCm37
Celera419,777,838 - 19,777,969UniSTS
Cytogenetic Map4A3UniSTS
cM Map422.7UniSTS
Whitehead/MRC_RH4283.03UniSTS
Ttpa  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A3UniSTS
cM Map4 UniSTS
D17Jpk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38420,017,117 - 20,017,245UniSTSGRCm38
MGSCv37419,944,264 - 19,944,392UniSTSGRCm37
Celera419,774,970 - 19,775,097UniSTS
Cytogenetic Map4A3UniSTS
cM Map1756.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763365441Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261689063979Mouse
1357645Lvrq9_mliver weight QTL 9 (mouse)Not determined41789261689063979Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261689063979Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261689063979Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1660
Count of miRNA genes:397
Interacting mature miRNAs:472
Transcripts:ENSMUST00000098244, ENSMUST00000117632, ENSMUST00000121491, ENSMUST00000125799
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF218416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL732527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV026942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY072913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000098244   ⟹   ENSMUSP00000095845
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl420,008,428 - 20,030,785 (+)Ensembl
GRCm38.p6 Ensembl420,008,428 - 20,030,785 (+)Ensembl
RefSeq Acc Id: ENSMUST00000117632   ⟹   ENSMUSP00000113026
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl420,008,357 - 20,030,785 (+)Ensembl
GRCm38.p6 Ensembl420,008,357 - 20,030,785 (+)Ensembl
RefSeq Acc Id: ENSMUST00000121491   ⟹   ENSMUSP00000113966
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl420,008,007 - 20,030,470 (+)Ensembl
GRCm38.p6 Ensembl420,008,007 - 20,030,470 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125799   ⟹   ENSMUSP00000117031
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl420,007,938 - 20,021,312 (+)Ensembl
GRCm38.p6 Ensembl420,007,938 - 20,021,312 (+)Ensembl
RefSeq Acc Id: NM_001317723   ⟹   NP_001304652
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39420,008,243 - 20,030,822 (+)NCBI
GRCm38420,008,243 - 20,030,822 (+)NCBI
Sequence:
RefSeq Acc Id: NM_015767   ⟹   NP_056582
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39420,008,329 - 20,030,822 (+)NCBI
GRCm38420,008,329 - 20,030,822 (+)NCBI
MGSCv37419,935,575 - 19,957,932 (+)RGD
Celera419,766,254 - 19,788,914 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017320306   ⟹   XP_017175795
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39420,007,867 - 20,030,605 (+)NCBI
GRCm38420,007,894 - 20,030,605 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164225   ⟹   XP_036020118
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39420,007,897 - 20,030,605 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_056582   ⟸   NM_015767
- Peptide Label: isoform 1
- UniProtKB: Q8BWP5 (UniProtKB/Swiss-Prot),   Q499J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017175795   ⟸   XM_017320306
- Peptide Label: isoform X2
- UniProtKB: A8Y5N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304652   ⟸   NM_001317723
- Peptide Label: isoform 2
- UniProtKB: A8Y5N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117031   ⟸   ENSMUST00000125799
RefSeq Acc Id: ENSMUSP00000113966   ⟸   ENSMUST00000121491
RefSeq Acc Id: ENSMUSP00000095845   ⟸   ENSMUST00000098244
RefSeq Acc Id: ENSMUSP00000113026   ⟸   ENSMUST00000117632
RefSeq Acc Id: XP_036020118   ⟸   XM_036164225
- Peptide Label: isoform X1
Protein Domains
CRAL-TRIO

Promoters
RGD ID:6836586
Promoter ID:MM_KWN:36812
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000098245,   ENSMUST00000117632,   NM_015767,   OTTMUST00000070668,   UC008SCI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36419,935,526 - 19,936,026 (+)MPROMDB
RGD ID:6882906
Promoter ID:EPDNEW_M4904
Type:multiple initiation site
Name:Ttpa_2
Description:Mus musculus tocopherol transfer protein , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4905  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38420,008,217 - 20,008,277EPDNEW
RGD ID:6882908
Promoter ID:EPDNEW_M4905
Type:initiation region
Name:Ttpa_1
Description:Mus musculus tocopherol transfer protein , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4904  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38420,008,436 - 20,008,496EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354168 AgrOrtholog
Ensembl Genes ENSMUSG00000028241
  ENSMUSG00000073988 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000095845 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113026 UniProtKB/TrEMBL
  ENSMUSP00000113966 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000117031 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098244 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000117632 UniProtKB/TrEMBL
  ENSMUST00000121491 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000125799 UniProtKB/TrEMBL
Gene3D-CATH 3.40.525.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL/TRIO_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL/TRIO_N_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1354168 ENTREZGENE
NCBI Gene 50500 ENTREZGENE
Pfam CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL_TRIO_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ttpa PhenoGen
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CRAL_TRIO_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46938 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AIT6_MOUSE UniProtKB/TrEMBL
  A8Y5N9 ENTREZGENE, UniProtKB/TrEMBL
  A8Y5P0_MOUSE UniProtKB/TrEMBL
  Q499J1_MOUSE UniProtKB/TrEMBL
  Q499J3 ENTREZGENE, UniProtKB/TrEMBL
  Q8BWP5 ENTREZGENE
  Q8QZU5_MOUSE UniProtKB/TrEMBL
  TTPA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9CW51 UniProtKB/Swiss-Prot
  Q9JL07 UniProtKB/Swiss-Prot