Vegfc (vascular endothelial growth factor C) - Rat Genome Database

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Gene: Vegfc (vascular endothelial growth factor C) Mus musculus
Analyze
Symbol: Vegfc
Name: vascular endothelial growth factor C
RGD ID: 732215
MGI Page MGI
Description: Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of lymphangiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; morphogenesis of embryonic epithelium; and positive regulation of glial cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW228853; flt4 ligand; flt4-L; vascular endothelial growth factor C isoform 129; vascular endothelial growth factor C isoform 184; vascular endothelial growth factor-related protein; VEGF-; VEGF-C; VRP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39854,530,567 - 54,639,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl854,530,641 - 54,640,131 (+)EnsemblGRCm39 Ensembl
GRCm38854,077,532 - 54,186,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,077,606 - 54,187,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv37855,162,886 - 55,271,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36855,576,324 - 55,685,149 (+)NCBIMGSCv36mm8
Celera856,790,779 - 56,893,425 (+)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
baicalin  (ISO)
bendroflumethiazide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
BQ 123  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
chlorpyrifos  (EXP)
chlorthalidone  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cypermethrin  (ISO)
cytarabine  (EXP,ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP)
dieldrin  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
hexaconazole  (EXP)
hexane  (ISO)
hydrogen chloride  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
LY294002  (EXP)
maneb  (EXP)
manganese(II) chloride  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
minocycline  (ISO)
naringin  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
NS-398  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD 0325901  (ISO)
PhIP  (ISO)
prostaglandin E2  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
streptozocin  (ISO)
succimer  (EXP)
sulprostone  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
animal organ morphogenesis  (IMP)
cell population proliferation  (IMP)
cellular response to leukemia inhibitory factor  (IEP)
glial cell proliferation  (IMP)
induction of positive chemotaxis  (IBA,IEA,ISO)
morphogenesis of embryonic epithelium  (IMP)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of osteoblast differentiation  (IDA)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IDA)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IGI,IMP,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of lymphangiogenesis  (IDA)
positive regulation of mast cell chemotaxis  (IBA,IEA,ISO)
positive regulation of mesenchymal stem cell proliferation  (IDA)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase activity  (IDA)
positive regulation of protein secretion  (IEA,ISO)
regulation of vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
response to hypoxia  (IBA)
response to xenobiotic stimulus  (IEA,ISO)
sprouting angiogenesis  (IBA)
vascular endothelial growth factor receptor signaling pathway  (IBA,IDA,IGI,ISO)
vascular endothelial growth factor signaling pathway  (IBA)

Cellular Component
extracellular space  (HDA,IBA,IDA)
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential vascular endothelial growth factor A protein expression between small hepatocellular carcinoma and cirrhosis correlates with serum vascular endothelial growth factor A and alpha-fetoprotein. Corradini SG, etal., Liver Int. 2009 Jan;29(1):103-12. doi: 10.1111/j.1478-3231.2008.01781.x. Epub 2008 Jun 9.
2. Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. Di JM, etal., Arch Med Res. 2009 May;40(4):268-75. Epub 2009 Jun 4.
3. Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model. Doi K, etal., Oncology. 2007;73(3-4):252-60. Epub 2008 Apr 17.
4. [Correlation analysis of vascular endothelial growth factor-C expression and clinicopathology in breast cancer.] Fu JM, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov;29(11):2266-8.
5. Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma. Guo B, etal., Anat Rec (Hoboken). 2009 May;292(5):633-9.
6. The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Huang C, etal., Neoplasma. 2012;59(1):52-61. doi: 10.4149/neo_2012_007.
7. Interpretation of Pin-1 and VEGF-C expression in breast infiltrating duct carcinoma. Kim BC, etal., Oncol Rep. 2009 Dec;22(6):1381-90.
8. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin V, etal., Eur J Biochem 2001 Nov;268(21):5530-40.
9. Increasing lymphatic microvessel density in primary pterygia. Ling S, etal., Arch Ophthalmol. 2012 Jun;130(6):735-42. doi: 10.1001/archophthalmol.2012.293.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. CYR61 (CCN1) is essential for placental development and vascular integrity. Mo FE, etal., Mol Cell Biol 2002 Dec;22(24):8709-20.
13. Evaluation of the vascular endothelial growth factor (VEGF)-C role in urothelial carcinomas of the bladder. Mylona E, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3567-71.
14. The significance of VEGF-C/VEGFR-2 interaction in the neovascularization and prognosis of nephroblastoma (Wilms' tumour). Nowicki M, etal., Histopathology. 2007 Feb;50(3):358-64.
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia. Shin YJ, etal., Acta Neuropathol. 2008 Nov;116(5):517-27. Epub 2008 Aug 15.
23. Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue. Sinn BV, etal., Virchows Arch. 2009 Nov 13.
24. Expression of vascular endothelial growth factor family messenger RNA in diseased thyroid tissues. Tanaka K, etal., Surg Today. 2002;32(9):761-8.
25. The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma. Tanigaki Y, etal., Int J Mol Med. 2004 Sep;14(3):389-95.
26. The lymphatic system and its specific growth factor vascular endothelial growth factor C in kidney tissue and in renal cell carcinoma. Voss M, etal., BJU Int. 2009 Jul;104(1):94-9. Epub 2008 Dec 19.
27. Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects. Wada H, etal., PLoS One. 2011;6(12):e29351. doi: 10.1371/journal.pone.0029351. Epub 2011 Dec 20.
28. The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma. Yu H, etal., J Exp Clin Cancer Res. 2009 Jul 9;28:98.
29. Expression of vascular endothelial growth factors-C and -D correlate with evidence of lymphangiogenesis and angiogenesis in pancreatic adenocarcinoma. Zhang B, etal., Cancer Detect Prev. 2007;31(6):436-42. doi: 10.1016/j.cdp.2007.10.016.
30. Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis. Zu X, etal., BJU Int. 2006 Nov;98(5):1090-3.
Additional References at PubMed
PMID:9012504   PMID:9247316   PMID:9268726   PMID:9312130   PMID:9689915   PMID:9794766   PMID:10229225   PMID:10349636   PMID:10428027   PMID:10499794   PMID:10575000   PMID:10685072  
PMID:11042159   PMID:11076861   PMID:11090062   PMID:11179212   PMID:11217851   PMID:11289156   PMID:11439183   PMID:11804779   PMID:11937493   PMID:12361971   PMID:12477932   PMID:12649170  
PMID:12819011   PMID:12904583   PMID:14610273   PMID:14634646   PMID:15231646   PMID:15452344   PMID:15489334   PMID:15590642   PMID:15601855   PMID:15601856   PMID:15743836   PMID:15782199  
PMID:15882861   PMID:15890974   PMID:16141072   PMID:16141073   PMID:16267000   PMID:16462734   PMID:16648194   PMID:16678147   PMID:16778080   PMID:16912183   PMID:16924525   PMID:17032920  
PMID:17187775   PMID:17573777   PMID:17584866   PMID:17766486   PMID:18205601   PMID:18287559   PMID:18359770   PMID:18508041   PMID:18519586   PMID:18570894   PMID:18594512   PMID:18617288  
PMID:18725519   PMID:18799693   PMID:18951277   PMID:18988807   PMID:19005491   PMID:19346498   PMID:19411759   PMID:19443835   PMID:19521500   PMID:19705443   PMID:19710174   PMID:19734356  
PMID:19821979   PMID:20065093   PMID:20133819   PMID:20230750   PMID:20415667   PMID:20439489   PMID:20506647   PMID:20619341   PMID:20978081   PMID:21267068   PMID:21282654   PMID:21343305  
PMID:21352545   PMID:21481239   PMID:21658588   PMID:21666710   PMID:21704027   PMID:21704616   PMID:21873635   PMID:21909098   PMID:21940662   PMID:22096573   PMID:22235033   PMID:22574929  
PMID:22682244   PMID:22696295   PMID:22832193   PMID:22932121   PMID:23076721   PMID:23219511   PMID:23299940   PMID:23424645   PMID:23462469   PMID:23475632   PMID:23520166   PMID:23695550  
PMID:23707896   PMID:23884445   PMID:24006456   PMID:24016759   PMID:24048742   PMID:24252749   PMID:24333721   PMID:24429550   PMID:24552833   PMID:24590274   PMID:24952961   PMID:25061878  
PMID:25105363   PMID:25270205   PMID:25271623   PMID:25274728   PMID:25377552   PMID:25572963   PMID:25606800   PMID:25637798   PMID:25704818   PMID:25752543   PMID:25958091   PMID:26002917  
PMID:26038530   PMID:26276819   PMID:26362177   PMID:26446156   PMID:26459520   PMID:26764350   PMID:26926389   PMID:26934950   PMID:27006449   PMID:27107086   PMID:27159393   PMID:27343251  
PMID:27383632   PMID:27623309   PMID:27655933   PMID:27810956   PMID:27965054   PMID:28164238   PMID:28209511   PMID:28438786   PMID:28526302   PMID:28545716   PMID:28586719   PMID:28684544  
PMID:28687807   PMID:28849193   PMID:29141865   PMID:29169284   PMID:29478968   PMID:29487191   PMID:29620526   PMID:30204931   PMID:30228991   PMID:31015298   PMID:31338035   PMID:31415243  
PMID:31562136   PMID:31672914   PMID:31757960   PMID:31808745   PMID:31942068   PMID:32513927   PMID:32590044   PMID:32796823   PMID:32842144   PMID:33060128   PMID:33462113   PMID:33743353  
PMID:33783987   PMID:33836422   PMID:34148274   PMID:34321999   PMID:34403369   PMID:34673901   PMID:34853315   PMID:35271504   PMID:35831318   PMID:36064450   PMID:36715213   PMID:37735168  
PMID:38062830   PMID:38183987   PMID:39001875  


Genomics

Comparative Map Data
Vegfc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39854,530,567 - 54,639,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl854,530,641 - 54,640,131 (+)EnsemblGRCm39 Ensembl
GRCm38854,077,532 - 54,186,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,077,606 - 54,187,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv37855,162,886 - 55,271,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36855,576,324 - 55,685,149 (+)NCBIMGSCv36mm8
Celera856,790,779 - 56,893,425 (+)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.2NCBI
VEGFC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384176,683,538 - 176,792,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4176,683,538 - 176,792,922 (-)EnsemblGRCh38hg38GRCh38
GRCh374177,604,689 - 177,714,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364177,841,685 - 177,950,889 (-)NCBINCBI36Build 36hg18NCBI36
Build 344177,979,839 - 178,089,044NCBI
Celera4174,932,577 - 175,041,751 (-)NCBICelera
Cytogenetic Map4q34.3NCBI
HuRef4173,355,495 - 173,464,332 (-)NCBIHuRef
CHM1_14177,581,139 - 177,690,417 (-)NCBICHM1_1
T2T-CHM13v2.04180,022,579 - 180,131,932 (-)NCBIT2T-CHM13v2.0
Vegfc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81644,445,293 - 44,560,887 (-)NCBIGRCr8
mRatBN7.21637,712,251 - 37,827,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1643,068,855 - 43,184,449 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01646,429,675 - 46,545,267 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01641,783,170 - 41,898,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01640,440,371 - 40,555,178 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01640,216,307 - 40,331,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41640,624,435 - 40,739,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11640,624,509 - 40,739,767 (-)NCBI
Celera1635,834,400 - 35,949,683 (-)NCBICelera
Cytogenetic Map16p11NCBI
Vegfc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540331,016,423 - 31,130,892 (+)NCBIChiLan1.0ChiLan1.0
VEGFC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23174,404,689 - 174,551,470 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14174,784,868 - 174,914,832 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04168,870,941 - 168,999,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14181,104,737 - 181,236,024 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4181,104,737 - 181,236,030 (-)Ensemblpanpan1.1panPan2
VEGFC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11652,883,242 - 52,987,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1652,883,139 - 52,987,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1648,384,891 - 48,489,160 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01655,195,930 - 55,300,949 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1655,195,409 - 55,300,821 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11653,090,819 - 53,195,148 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01653,687,065 - 53,791,871 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01653,925,224 - 54,029,839 (+)NCBIUU_Cfam_GSD_1.0
Vegfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494326,803,257 - 26,918,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365167,217,543 - 7,332,559 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365167,217,543 - 7,332,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VEGFC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1539,039,311 - 39,132,936 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11539,037,764 - 39,136,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21544,742,834 - 44,773,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VEGFC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17122,772,539 - 122,893,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7122,772,182 - 122,893,512 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037102,869,061 - 102,989,877 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vegfc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247697,689,407 - 7,817,450 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247697,689,812 - 7,817,366 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vegfc
4161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:102
Interacting mature miRNAs:111
Transcripts:ENSMUST00000033919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83532109757797633Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83532109757797633Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83532109757797633Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83532109757797633Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse

Markers in Region
Vegfc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X164,402,007 - 164,402,215UniSTSGRCm38
MGSCv37X160,839,939 - 160,840,147UniSTSGRCm37
CeleraX147,617,459 - 147,617,609UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map8B3UniSTS
cM Map8 UniSTS
cM MapX70.0UniSTS
AW228853  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38854,186,191 - 54,186,287UniSTSGRCm38
MGSCv37855,271,545 - 55,271,641UniSTSGRCm37
Celera856,893,152 - 56,893,248UniSTS
Cytogenetic Map8B3UniSTS
Whitehead/MRC_RH8631.56UniSTS
Vegfc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3UniSTS
Vegfc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3UniSTS
Vegfc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38854,185,963 - 54,186,034UniSTSGRCm38
MGSCv37855,271,317 - 55,271,388UniSTSGRCm37
Celera856,892,924 - 56,892,995UniSTS
Cytogenetic Map8B3UniSTS
cM Map8 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000033919   ⟹   ENSMUSP00000033919
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl854,530,641 - 54,640,131 (+)Ensembl
GRCm38.p6 Ensembl854,077,606 - 54,187,096 (+)Ensembl
Ensembl Acc Id: ENSMUST00000209703
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl854,530,752 - 54,622,079 (+)Ensembl
GRCm38.p6 Ensembl854,077,717 - 54,169,044 (+)Ensembl
Ensembl Acc Id: ENSMUST00000210831   ⟹   ENSMUSP00000148210
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl854,530,814 - 54,633,751 (+)Ensembl
GRCm38.p6 Ensembl854,077,779 - 54,180,716 (+)Ensembl
RefSeq Acc Id: NM_009506   ⟹   NP_033532
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39854,530,567 - 54,639,489 (+)NCBI
GRCm38854,077,532 - 54,186,454 (+)ENTREZGENE
MGSCv37855,162,886 - 55,271,808 (+)RGD
Celera856,790,779 - 56,893,425 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033532   ⟸   NM_009506
- Peptide Label: precursor
- UniProtKB: C6F5T0 (UniProtKB/Swiss-Prot),   C6F5S9 (UniProtKB/Swiss-Prot),   C6F5S8 (UniProtKB/Swiss-Prot),   Q543R6 (UniProtKB/Swiss-Prot),   P97953 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000148210   ⟸   ENSMUST00000210831
Ensembl Acc Id: ENSMUSP00000033919   ⟸   ENSMUST00000033919

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97953-F1-model_v2 AlphaFold P97953 1-415 view protein structure

Promoters
RGD ID:8667083
Promoter ID:EPDNEW_M11573
Type:multiple initiation site
Name:Vegfc_1
Description:Mus musculus vascular endothelial growth factor C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38854,077,517 - 54,077,577EPDNEW
RGD ID:6843872
Promoter ID:MM_KWN:54426
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000033919
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36855,162,766 - 55,163,342 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109124 AgrOrtholog
Ensembl Genes ENSMUSG00000031520 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033919 ENTREZGENE
  ENSMUST00000033919.6 UniProtKB/Swiss-Prot
  ENSMUST00000210831.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro CXCXC_repeat UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PD_growth_factor_CS UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  PDGF/VEGF_growth_factor UniProtKB/Swiss-Prot
KEGG Report mmu:22341 UniProtKB/Swiss-Prot
MGD MGI:109124 ENTREZGENE
NCBI Gene 22341 ENTREZGENE
PANTHER VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR C UniProtKB/Swiss-Prot
Pfam CXCXC UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
PhenoGen Vegfc PhenoGen
PROSITE PDGF_1 UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
SMART PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt C6F5S8 ENTREZGENE
  C6F5S9 ENTREZGENE
  C6F5T0 ENTREZGENE
  P97953 ENTREZGENE
  Q543R6 ENTREZGENE
  VEGFC_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary C6F5S8 UniProtKB/Swiss-Prot
  C6F5S9 UniProtKB/Swiss-Prot
  C6F5T0 UniProtKB/Swiss-Prot
  Q543R6 UniProtKB/Swiss-Prot