Mir223 (microRNA 223) - Rat Genome Database

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Gene: Mir223 (microRNA 223) Mus musculus
Analyze
Symbol: Mir223
Name: microRNA 223
RGD ID: 1608237
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Is expressed in cerebral cortex intermediate zone; cortical plate; embryo; liver; and lung. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human MIR223 (microRNA 223).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: miR-2; miR-223; Mirn; Mirn223; mmu-mir-2; mmu-mir-223
RGD Orthologs
Human
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X95,286,423 - 95,286,532 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX95,286,423 - 95,286,532 (+)EnsemblGRCm39 Ensembl
GRCm38X96,242,817 - 96,242,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,438,156 - 93,438,265 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX83,247,617 - 83,247,726 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Hepatitis  (IDA)
Acute Liver Failure  (IEP,ISO)
Acute Lung Injury  (IMP,ISO)
acute myocardial infarction  (ISO)
adult respiratory distress syndrome  (ISO)
Alcoholic Liver Diseases  (IMP)
aortic atherosclerosis  (IEP)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (IDA,IMP)
autosomal hemophilia A  (ISO)
Barrett's esophagus  (ISO)
Binge Drinking  (IEP,ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (IMP)
Carotid Artery Injuries  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
Chronic Hepatitis C  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
diabetes mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP,IMP)
factor VIII deficiency  (ISO)
Febrile Seizures  (ISO)
hepatocellular carcinoma  (IMP,ISO)
Hypercholesterolemia  (IMP)
Intervertebral Disc Displacement  (ISO)
Knee Osteoarthritis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IMP)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (IEP)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatohepatitis  (IDA,IMP,ISO)
myocardial infarction  (ISO)
Neuralgia  (ISO)
obesity  (IEP)
peptic esophagitis  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Schistosomiasis Japonica  (IEP,ISO)
Sepsis  (ISO)
Sleep Deprivation  (ISO)
stomach cancer  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
thrombophlebitis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IEP,IMP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell proliferation in bone marrow  (IMP)
cellular response to decreased oxygen levels  (IEP)
cellular response to estrogen stimulus  (IDA)
cellular response to hypoxia  (ISO)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IDA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
granulocyte differentiation  (IMP)
inflammatory response  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IMP,ISO)
negative regulation of autophagy  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell size  (ISO)
negative regulation of high-density lipoprotein particle clearance  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-18 production  (ISO)
negative regulation of pyroptotic inflammatory response  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
physiological cardiac muscle hypertrophy  (ISO)
positive regulation of cell proliferation in bone marrow  (IMP)
positive regulation of D-glucose import  (ISO)
positive regulation of fibroblast chemotaxis  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte differentiation  (IMP)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
regulation of gene expression  (IDA,IMP)
regulation of vasculature development  (ISO)
response to bacterium  (IEP)
response to gravity  (ISO)
response to hypoxia  (ISO)
response to oxygen levels  (IDA)
response to psychosocial stress  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytokine and microRNA levels during different periods of paradoxical sleep deprivation and sleep recovery in rats. Brianza-Padilla M, etal., PeerJ. 2018 Sep 13;6:e5567. doi: 10.7717/peerj.5567. eCollection 2018.
2. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. Calvente CJ, etal., J Clin Invest. 2019 Jul 11;130:4091-4109. doi: 10.1172/JCI122258.
3. BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis. Chen L, etal., Mol Immunol. 2018 Jan;93:38-46. doi: 10.1016/j.molimm.2017.11.008. Epub 2017 Nov 13.
4. Association of plasma miR-223 and platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy: A preliminary report. Chyrchel B, etal., Platelets. 2015;26(6):593-7. doi: 10.3109/09537104.2014.974527. Epub 2014 Oct 28.
5. Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats. Cuomo O, etal., Mol Ther Nucleic Acids. 2019 Dec 6;18:1063-1071. doi: 10.1016/j.omtn.2019.10.022. Epub 2019 Oct 28.
6. miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8. Dou L, etal., Oncol Res. 2019 Feb 5;27(2):261-268. doi: 10.3727/096504018X15219188894056. Epub 2018 Apr 3.
7. Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. Giray BG, etal., Mol Biol Rep. 2014 Jul;41(7):4513-9. doi: 10.1007/s11033-014-3322-3. Epub 2014 Mar 5.
8. 2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension through regulating microRNA-223. Hao S, etal., J Cell Physiol. 2019 May;234(5):6324-6335. doi: 10.1002/jcp.27363. Epub 2018 Sep 24.
9. Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy. He X, etal., Parasit Vectors. 2013 Sep 20;6:272. doi: 10.1186/1756-3305-6-272.
10. MicroRNA-223 Ameliorates Nonalcoholic Steatohepatitis and Cancer by Targeting Multiple Inflammatory and Oncogenic Genes in Hepatocytes. He Y, etal., Hepatology. 2019 Oct;70(4):1150-1167. doi: 10.1002/hep.30645. Epub 2019 Jun 5.
11. Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9. Hyrina A, etal., EBioMedicine. 2017 Sep;23:68-78. doi: 10.1016/j.ebiom.2017.08.020. Epub 2017 Aug 24.
12. miR-223 and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma. Imura S, etal., Anticancer Res. 2017 Oct;37(10):5877-5883. doi: 10.21873/anticanres.12033.
13. Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Ji D, etal., Aging (Albany NY). 2020 Jan 29;12(2):1643-1655. doi: 10.18632/aging.102705. Epub 2020 Jan 29.
14. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Jimenez Calvente C, etal., Mol Ther. 2020 Feb 5;28(2):653-663. doi: 10.1016/j.ymthe.2019.09.013. Epub 2019 Sep 13.
15. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. Kawashita Y, etal., J Hepatobiliary Pancreat Sci. 2017 Oct;24(10):576-583. doi: 10.1002/jhbp.500. Epub 2017 Oct 12.
16. Expression profiling of microRNAs in lipopolysaccharide-induced acute lung injury after hypothermia treatment. Lee W, etal., Mol Cell Toxicol. 2016;12(3):243-253. doi: 10.1007/s13273-016-0029-7. Epub 2016 Oct 7.
17. Effect of miR-223 on thrombophlebitis rats through regulating Toll-like receptor signaling pathway. Li HL, etal., Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2020-2027. doi: 10.26355/eurrev_202002_20380.
18. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. Li M, etal., Gut. 2017 Apr;66(4):705-715. doi: 10.1136/gutjnl-2016-311861. Epub 2016 Sep 27.
19. miRNA-223-3p and let-7b-3p as potential blood biomarkers associated with the ischemic penumbra in rats. Li S, etal., Acta Neurobiol Exp (Wars). 2019;79(2):205-216.
20. MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways. Li Y, etal., J Biol Chem. 2019 Jul 5;294(27):10438-10448. doi: 10.1074/jbc.RA119.007755. Epub 2019 May 22.
21. Role of miR-223-3p in pulmonary arterial hypertension via targeting ITGB3 in the ECM pathway. Liu A, etal., Cell Prolif. 2019 Mar;52(2):e12550. doi: 10.1111/cpr.12550. Epub 2018 Dec 3.
22. MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1. Liu X, etal., Cell Physiol Biochem. 2018;46(4):1439-1454. doi: 10.1159/000489185. Epub 2018 Apr 19.
23. MicroRNA-223 protects neonatal rat cardiomyocytes and H9c2 cells from hypoxia-induced apoptosis and excessive autophagy via the Akt/mTOR pathway by targeting PARP-1. Liu X, etal., J Mol Cell Cardiol. 2018 May;118:133-146. doi: 10.1016/j.yjmcc.2018.03.018. Epub 2018 Mar 31.
24. The Expression of microRNA-223 and FAM5C in Cerebral Infarction Patients with Diabetes Mellitus. Long Y, etal., Cardiovasc Toxicol. 2017 Jan;17(1):42-48. doi: 10.1007/s12012-015-9354-7.
25. Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p. Lu FB, etal., Mol Cells. 2019 Dec 31;42(12):906-918. doi: 10.14348/molcells.2019.2283.
26. miR-223 reverses experimental pulmonary arterial hypertension. Meloche J, etal., Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C363-72. doi: 10.1152/ajpcell.00149.2015. Epub 2015 Jun 17.
27. MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. Moen A, etal., J Transl Med. 2017 May 1;15(1):89. doi: 10.1186/s12967-017-1194-8.
28. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Neudecker V, etal., Sci Transl Med. 2017 Sep 20;9(408). pii: 9/408/eaah5360. doi: 10.1126/scitranslmed.aah5360.
29. Serum microRNAs; miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma. Oksuz Z, etal., Mol Biol Rep. 2015 Mar;42(3):713-20. doi: 10.1007/s11033-014-3819-9. Epub 2014 Nov 13.
30. miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor. Qadir XV, etal., Am J Pathol. 2015 Dec;185(12):3141-51. doi: 10.1016/j.ajpath.2015.08.020.
31. Expression and significance of miR-223 in rats with pulmonary fibrosis. Qu SJ, etal., Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3951-3958. doi: 10.26355/eurrev_202004_20864.
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. miR-223 represents a biomarker in acute and chronic liver injury. Schueller F, etal., Clin Sci (Lond). 2017 Jul 13;131(15):1971-1987. doi: 10.1042/CS20170218. Print 2017 Aug 1.
35. Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway. Sha R, etal., Med Sci Monit. 2019 Jun 25;25:4723-4733. doi: 10.12659/MSM.917213.
36. Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients. Shaker OG and Senousy MA, J Viral Hepat. 2017 Aug;24(8):636-644. doi: 10.1111/jvh.12696. Epub 2017 Mar 13.
37. An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells: Role of MicroRNA-223 in Smooth Muscle Function and Atherogenesis. Shan Z, etal., J Am Coll Cardiol. 2015 Jun 16;65(23):2526-37. doi: 10.1016/j.jacc.2015.03.570.
38. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Streppel MM, etal., Clin Cancer Res. 2013 Aug 1;19(15):4067-78. doi: 10.1158/1078-0432.CCR-13-0601. Epub 2013 Jun 11.
39. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
40. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
41. MicroRNA-223 coordinates cholesterol homeostasis. Vickers KC, etal., Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14518-23. doi: 10.1073/pnas.1215767111. Epub 2014 Sep 22.
42. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
43. MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. Wang X, etal., PLoS One. 2017 Sep 8;12(9):e0184292. doi: 10.1371/journal.pone.0184292. eCollection 2017.
44. [Relationship between expression of microRNA and inflammatory cytokines plasma level in pediatric patients with sepsis]. Wu Y, etal., Zhonghua Er Ke Za Zhi. 2014 Jan;52(1):28-33.
45. Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain. Xie XJ, etal., Mol Pain. 2017 Jan-Dec;13:1744806917706582. doi: 10.1177/1744806917706582.
46. Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Xu J, etal., Mol Carcinog. 2011 Feb;50(2):136-42. doi: 10.1002/mc.20712. Epub 2010 Dec 10.
47. NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression. Yang F, etal., Cell Death Dis. 2018 Jan 9;9(1):12. doi: 10.1038/s41419-017-0020-9.
48. MicroRNA-223 acts as an important regulator to Kupffer cells activation at the early stage of Con A-induced acute liver failure via AIM2 signaling pathway. Yang F, etal., Cell Physiol Biochem. 2014;34(6):2137-52. doi: 10.1159/000369658. Epub 2014 Dec 2.
49. Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy. Yang L, etal., J Biol Chem. 2016 Jul 22;291(30):15700-13. doi: 10.1074/jbc.M116.715805. Epub 2016 May 20.
50. Association of MicroRNA-223 expression with hepatic ischemia/reperfusion injury in mice. Yu CH, etal., Dig Dis Sci. 2009 Nov;54(11):2362-6. doi: 10.1007/s10620-008-0629-8. Epub 2008 Dec 23.
51. EPO-cyclosporine combination therapy reduced brain infarct area in rat after acute ischemic stroke: role of innate immune-inflammatory response, micro-RNAs and MAPK family signaling pathway. Yuen CM, etal., Am J Transl Res. 2017 Apr 15;9(4):1651-1666. eCollection 2017.
52. Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats. Zhou J, etal., Mol Med Rep. 2018 Oct;18(4):4051-4057. doi: 10.3892/mmr.2018.9385. Epub 2018 Aug 13.
Additional References at PubMed
PMID:12624257   PMID:14657504   PMID:15634332   PMID:16369549   PMID:16381832   PMID:17369397   PMID:17482553   PMID:17604727   PMID:18278031   PMID:18452032   PMID:18668037   PMID:18723672  
PMID:18762567   PMID:18791161   PMID:19059913   PMID:19147652   PMID:19185580   PMID:19559694   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20826802   PMID:20935160   PMID:21094288  
PMID:21247879   PMID:21267068   PMID:21295111   PMID:21397537   PMID:21822254   PMID:22042248   PMID:22564414   PMID:22580331   PMID:22674011   PMID:22984082   PMID:23094093   PMID:23112146  
PMID:23153510   PMID:23174904   PMID:23325891   PMID:23946414   PMID:24044949   PMID:24067995   PMID:24084739   PMID:24140891   PMID:24205035   PMID:24421386   PMID:24486439   PMID:24708646  
PMID:24999035   PMID:25641499   PMID:25710917   PMID:25750188   PMID:25793640   PMID:25944670   PMID:26163797   PMID:26348153   PMID:26436647   PMID:26526992   PMID:26783338   PMID:26864305  
PMID:26876200   PMID:26893485   PMID:26967647   PMID:27013635   PMID:27083389   PMID:27148749   PMID:27226534   PMID:27354148   PMID:27502281   PMID:27704281   PMID:27812198   PMID:27951581  
PMID:28148562   PMID:28196816   PMID:28487310   PMID:28487522   PMID:28515178   PMID:28543681   PMID:28619106   PMID:28881218   PMID:29144508   PMID:29183962   PMID:29309831   PMID:30171089  
PMID:30208760   PMID:30280799   PMID:30548333   PMID:30569151   PMID:30628667   PMID:30645204   PMID:30747211   PMID:30747229   PMID:31395736   PMID:31645142   PMID:31743855   PMID:31862778  
PMID:32052546   PMID:32295141   PMID:32417375   PMID:32423405   PMID:32470877   PMID:32493731   PMID:32597702   PMID:32631807   PMID:33236445   PMID:33301423   PMID:33529332   PMID:33574820  
PMID:33637123   PMID:33647318   PMID:33650318   PMID:33867837   PMID:34162147   PMID:34421892   PMID:34668437   PMID:34843004   PMID:35089329   PMID:35229638   PMID:35576078   PMID:35608154  
PMID:35611698   PMID:35633501   PMID:35660025   PMID:35961472   PMID:36077117   PMID:36224333   PMID:36593103   PMID:36740725   PMID:36764278   PMID:36924565   PMID:36980300   PMID:37295435  
PMID:37301121   PMID:37359091   PMID:37710276   PMID:37875176   PMID:37970714   PMID:38105184   PMID:38421705   PMID:38425288   PMID:38447057   PMID:38755651   PMID:39010173   PMID:39252576  
PMID:39273069  


Genomics

Comparative Map Data
Mir223
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X95,286,423 - 95,286,532 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX95,286,423 - 95,286,532 (+)EnsemblGRCm39 Ensembl
GRCm38X96,242,817 - 96,242,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,438,156 - 93,438,265 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX83,247,617 - 83,247,726 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.69NCBI
MIR223
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X66,018,870 - 66,018,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX66,018,870 - 66,018,979 (+)EnsemblGRCh38hg38GRCh38
GRCh37X65,238,712 - 65,238,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,155,436 - 65,155,545 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX65,585,857 - 65,585,966 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX59,065,818 - 59,065,927 (+)NCBIHuRef
CHM1_1X65,131,742 - 65,131,851 (+)NCBICHM1_1
T2T-CHM13v2.0X64,445,366 - 64,445,475 (+)NCBIT2T-CHM13v2.0
Mir223
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X65,151,383 - 65,151,492 (+)NCBIGRCr8
mRatBN7.2X61,141,887 - 61,141,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX61,141,887 - 61,141,996 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,615,555 - 62,615,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X66,116,079 - 66,116,188 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,673,322 - 63,673,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,367,812 - 65,367,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,367,812 - 65,367,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X66,205,958 - 66,206,067 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX61,554,814 - 61,554,923 (+)NCBICelera
Cytogenetic MapXq22NCBI
MIR223
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X50,838,131 - 50,838,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX50,838,131 - 50,838,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX41,675,998 - 41,676,100 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X51,802,379 - 51,802,481 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X49,766,866 - 49,766,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X51,114,791 - 51,114,893 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X51,030,133 - 51,030,235 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:18569
Count of gene targets:7870
Count of transcripts:12693
Interacting mature miRNAs:mmu-miR-223-3p, mmu-miR-223-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_029801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL831708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000102112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX95,286,423 - 95,286,532 (+)Ensembl
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)Ensembl
RefSeq Acc Id: NR_029801
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X95,286,423 - 95,286,532 (+)NCBI
GRCm38X96,242,817 - 96,242,926 (+)ENTREZGENE
MGSCv37X93,438,156 - 93,438,265 (+)RGD
CeleraX83,247,617 - 83,247,726 (+)RGD
cM MapX ENTREZGENE
Sequence:
Promoters
RGD ID:13680982
Promoter ID:EPDNEW_M24640
Type:single initiation site
Name:Mir223_1
Description:Mus musculus microRNA 223 , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X96,242,909 - 96,242,969EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684360 AgrOrtholog
Ensembl Genes ENSMUSG00000076066 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000102112 ENTREZGENE
MGD MGI:2684360 ENTREZGENE
miRBase MI0000703 ENTREZGENE
NCBI Gene 723814 ENTREZGENE
PhenoGen Mir223 PhenoGen
RNAcentral URS00000B7E30 RNACentral
  URS00000D5CE2 RNACentral
  URS00006FEFE5 RNACentral