Mir223 (microRNA 223) - Rat Genome Database
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Gene: Mir223 (microRNA 223) Mus musculus
Analyze
Symbol: Mir223
Name: microRNA 223
RGD ID: 1608237
MGI Page MGI
Description: Involved in several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Is expressed in embryo and lung. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human MIR223 (microRNA 223).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: miR-2; miR-223; Mirn; Mirn223; mmu-mir-2; mmu-mir-223
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X95,286,423 - 95,286,532 (+)NCBIGRCm39mm39
GRCm38X96,242,817 - 96,242,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,438,156 - 93,438,265 (+)NCBIGRCm37mm9NCBIm37
CeleraX83,247,617 - 83,247,726 (+)NCBICelera
Cytogenetic MapXC3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
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19. Li S, etal., Acta Neurobiol Exp (Wars). 2019;79(2):205-216.
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24. Long Y, etal., Cardiovasc Toxicol. 2017 Jan;17(1):42-48. doi: 10.1007/s12012-015-9354-7.
25. Lu FB, etal., Mol Cells. 2019 Dec 31;42(12):906-918. doi: 10.14348/molcells.2019.2283.
26. Meloche J, etal., Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C363-72. doi: 10.1152/ajpcell.00149.2015. Epub 2015 Jun 17.
27. Moen A, etal., J Transl Med. 2017 May 1;15(1):89. doi: 10.1186/s12967-017-1194-8.
28. Neudecker V, etal., Sci Transl Med. 2017 Sep 20;9(408). pii: 9/408/eaah5360. doi: 10.1126/scitranslmed.aah5360.
29. Oksuz Z, etal., Mol Biol Rep. 2015 Mar;42(3):713-20. doi: 10.1007/s11033-014-3819-9. Epub 2014 Nov 13.
30. Qadir XV, etal., Am J Pathol. 2015 Dec;185(12):3141-51. doi: 10.1016/j.ajpath.2015.08.020.
31. Qu SJ, etal., Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3951-3958. doi: 10.26355/eurrev_202004_20864.
32. RGD automated import pipeline
33. RGD automated import pipeline for gene-chemical interactions
34. Schueller F, etal., Clin Sci (Lond). 2017 Jul 13;131(15):1971-1987. doi: 10.1042/CS20170218. Print 2017 Aug 1.
35. Sha R, etal., Med Sci Monit. 2019 Jun 25;25:4723-4733. doi: 10.12659/MSM.917213.
36. Shaker OG and Senousy MA, J Viral Hepat. 2017 Aug;24(8):636-644. doi: 10.1111/jvh.12696. Epub 2017 Mar 13.
37. Shan Z, etal., J Am Coll Cardiol. 2015 Jun 16;65(23):2526-37. doi: 10.1016/j.jacc.2015.03.570.
38. Streppel MM, etal., Clin Cancer Res. 2013 Aug 1;19(15):4067-78. doi: 10.1158/1078-0432.CCR-13-0601. Epub 2013 Jun 11.
39. Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
40. Vickers KC, etal., Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14518-23. doi: 10.1073/pnas.1215767111. Epub 2014 Sep 22.
41. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
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43. Wu Y, etal., Zhonghua Er Ke Za Zhi. 2014 Jan;52(1):28-33.
44. Xie XJ, etal., Mol Pain. 2017 Jan-Dec;13:1744806917706582. doi: 10.1177/1744806917706582.
45. Xu J, etal., Mol Carcinog. 2011 Feb;50(2):136-42. doi: 10.1002/mc.20712. Epub 2010 Dec 10.
46. Yang F, etal., Cell Physiol Biochem. 2014;34(6):2137-52. doi: 10.1159/000369658. Epub 2014 Dec 2.
47. Yu CH, etal., Dig Dis Sci. 2009 Nov;54(11):2362-6. doi: 10.1007/s10620-008-0629-8. Epub 2008 Dec 23.
48. Yuen CM, etal., Am J Transl Res. 2017 Apr 15;9(4):1651-1666. eCollection 2017.
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Additional References at PubMed
PMID:12624257   PMID:14657504   PMID:15634332   PMID:16369549   PMID:16381832   PMID:17369397   PMID:17482553   PMID:17604727   PMID:18278031   PMID:18452032   PMID:18668037   PMID:18723672  
PMID:18762567   PMID:18791161   PMID:19059913   PMID:19147652   PMID:19185580   PMID:19559694   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20826802   PMID:20935160   PMID:21094288  
PMID:21247879   PMID:21267068   PMID:21295111   PMID:21397537   PMID:21822254   PMID:22042248   PMID:22564414   PMID:22580331   PMID:22674011   PMID:22984082   PMID:23094093   PMID:23112146  
PMID:23153510   PMID:23174904   PMID:23325891   PMID:23946414   PMID:24044949   PMID:24067995   PMID:24084739   PMID:24140891   PMID:24205035   PMID:24421386   PMID:24486439   PMID:24708646  
PMID:24999035   PMID:25641499   PMID:25710917   PMID:25750188   PMID:25793640   PMID:25944670   PMID:26163797   PMID:26348153   PMID:26436647   PMID:26526992   PMID:26783338   PMID:26864305  
PMID:26876200   PMID:26893485   PMID:26967647   PMID:27013635   PMID:27083389   PMID:27148749   PMID:27226534   PMID:27226563   PMID:27354148   PMID:27502281   PMID:27704281   PMID:27812198  
PMID:27951581   PMID:28148562   PMID:28196816   PMID:28487310   PMID:28487522   PMID:28515178   PMID:28543681   PMID:28619106   PMID:28881218   PMID:29144508   PMID:29183962   PMID:29309831  
PMID:30171089   PMID:30208760   PMID:30280799   PMID:30548333   PMID:30569151   PMID:30628667   PMID:30645204   PMID:30747211   PMID:30747229   PMID:30791741   PMID:31395736   PMID:31645142  
PMID:31743855   PMID:31862778   PMID:32295141   PMID:32417375   PMID:32493731  


Genomics

Comparative Map Data
Mir223
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X95,286,423 - 95,286,532 (+)NCBIGRCm39mm39
GRCm38X96,242,817 - 96,242,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,438,156 - 93,438,265 (+)NCBIGRCm37mm9NCBIm37
CeleraX83,247,617 - 83,247,726 (+)NCBICelera
Cytogenetic MapXC3NCBI
MIR223
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX66,018,870 - 66,018,979 (+)EnsemblGRCh38hg38GRCh38
GRCh38X66,018,870 - 66,018,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X65,238,712 - 65,238,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,155,436 - 65,155,545 (+)NCBINCBI36hg18NCBI36
CeleraX65,585,857 - 65,585,966 (+)NCBI
Cytogenetic MapXq12NCBI
HuRefX59,065,818 - 59,065,927 (+)NCBIHuRef
CHM1_1X65,131,742 - 65,131,851 (+)NCBICHM1_1
Mir223
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X61,141,887 - 61,141,996 (+)NCBI
Rnor_6.0 EnsemblX65,367,812 - 65,367,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X65,367,812 - 65,367,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X66,205,958 - 66,206,067 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX61,554,814 - 61,554,923 (+)NCBICelera
Cytogenetic MapXq22NCBI
MIR223
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX50,838,131 - 50,838,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X50,838,131 - 50,838,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined48090244130864007Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X55000000150000000Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7150000097500000Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined72410246140302463Mouse
12879918Shm4_msperm head morphology 4 (mouse)X73028444103019114Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX76263065110263152Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX77080730103019114Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X81146308115146453Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined86019000120019114Mouse
13208552Wght12_mweight 12 (mouse)X95000000151000000Mouse
13208556Lgth14_mbody length 14 (mouse)X95000000151000000Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mef2cmmu-miR-223-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI21213211
Mef2cmmu-miR-223-3pMirtarbaseexternal_infoReporter assay;Other//Reporter assayFunctional MTI18278031
Fbxw7mmu-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI20826802
Gzmbmmu-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI20935160
Gria2mmu-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//pSILAC//Western blotFunctional MTI23112146
Gopcmmu-miR-223-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)19536157
Igf1rmmu-miR-223-3pMirtarbaseexternal_infoReporter assay;Western blotFunctional MTI18278031
Mef2cmmu-miR-223-3pTarbaseexternal_infoReporter GenePOSITIVE
Igf1rmmu-miR-223-3pTarbaseexternal_infoWesternblitPOSITIVE
Mef2cmmu-miR-223-3pTarbaseexternal_infoqPCRPOSITIVE
Hpcal4mmu-miR-223-3pTarbaseexternal_infoSequencingPOSITIVE
Mef2cmmu-miR-223-3pMirecordsexternal_info{changed}NA18278031
Rc3h1mmu-miR-223-3pMirecordsexternal_info{changed}NA22043014
Hsp90b1mmu-miR-223-3pOncomiRDBexternal_infoNANA23208072
Foxo1mmu-miR-223-3pOncomiRDBexternal_infoNANA22569260
Stmn1mmu-miR-223-3pOncomiRDBexternal_infoNANA22470493
Fbxw7mmu-miR-223-3pOncomiRDBexternal_infoNANA22270966
Fbxw7mmu-miR-223-3pOncomiRDBexternal_infoNANA22108521
Epb41l3mmu-miR-223-3pOncomiRDBexternal_infoNANA21628394
Artnmmu-miR-223-3pOncomiRDBexternal_infoNANA21453483
Cxcl12mmu-miR-223-3pOncomiRDBexternal_infoNANA21343399
E2f1mmu-miR-223-3pOncomiRDBexternal_infoNANA20029046
Stmn1mmu-miR-223-3pOncomiRDBexternal_infoNANA18555017

Predicted Targets
Summary Value
Count of predictions:18569
Count of gene targets:7870
Count of transcripts:12693
Interacting mature miRNAs:mmu-miR-223-3p, mmu-miR-223-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_029801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL831708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000102112
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)Ensembl
RefSeq Acc Id: NR_029801
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X95,286,423 - 95,286,532 (+)NCBI
GRCm38X96,242,817 - 96,242,926 (+)ENTREZGENE
MGSCv37X93,438,156 - 93,438,265 (+)RGD
CeleraX83,247,617 - 83,247,726 (+)RGD
cM MapX ENTREZGENE
Sequence:
Promoters
RGD ID:13680982
Promoter ID:EPDNEW_M24640
Type:single initiation site
Name:Mir223_1
Description:Mus musculus microRNA 223 , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X96,242,909 - 96,242,969EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684360 AgrOrtholog
Ensembl Genes ENSMUSG00000076066 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000102112 ENTREZGENE
MGD MGI:2684360 ENTREZGENE
miRBase MI0000703 ENTREZGENE
NCBI Gene 723814 ENTREZGENE
PhenoGen Mir223 PhenoGen
RNAcentral URS00000B7E30 RNACentral
  URS00000D5CE2 RNACentral
  URS00006FEFE5 RNACentral