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Gene: Kmt2d (lysine (K)-specific methyltransferase 2D) Mus musculus
Symbol: Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Description: Predicted to have several functions, including histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Involved in chromatin organization; in utero embryonic development; and oocyte growth. Predicted to localize to the MLL3/4 complex. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Is expressed in several structures, including alimentary system; integumental system; limb; nervous system; and tail. Orthologous to human KMT2D (lysine methyltransferase 2D); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ALL1-related protein; ALR; BC032281; BC058659; C430014K11Rik; histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase MLL2; KMT2B; lysine N-methyltransferase 2B; lysine N-methyltransferase 2D; Mll2; Mll4; myeloid/lymphoid or mixed-lineage leukemia 2; myeloid/lymphoid or mixed-lineage leukemia protein 2; RIKEN cDNA C430014K11 gene
Homo sapiens (human) : KMT2D (lysine methyltransferase 2D)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kmt2d (lysine methyltransferase 2D)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2d (lysine methyltransferase 2D)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2D (lysine methyltransferase 2D)
Canis lupus familiaris (dog) : KMT2D (lysine methyltransferase 2D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2d (lysine methyltransferase 2D)
Sus scrofa (pig) : KMT2D (lysine methyltransferase 2D)
Chlorocebus sabaeus (green monkey) : KMT2D (lysine methyltransferase 2D)
Heterocephalus glaber (naked mole-rat) : Kmt2d (lysine methyltransferase 2D)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1598,831,669 - 98,871,204 (-)Ensembl
GRCm381598,831,669 - 98,874,077 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371598,662,100 - 98,701,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv361598,662,534 - 98,679,000 (-)NCBImm8
Celera15100,981,213 - 101,020,801 (-)NCBICelera
Cytogenetic Map15 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kmt2d
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319223
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.