Ucn2 (urocortin 2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ucn2 (urocortin 2) Mus musculus
Analyze
Symbol: Ucn2
Name: urocortin 2
RGD ID: 1614218
MGI Page MGI
Description: Exhibits G protein-coupled receptor binding activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; and negative regulation of gonadotropin secretion. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human UCN2 (urocortin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Ucn II; Ucn-; Ucn-2; ucn-II; Urocortin II; urocortin-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,815,231 - 108,816,232 (+)NCBIGRCm39mm39
GRCm389108,986,163 - 108,987,164 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,986,010 - 108,987,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,888,208 - 108,889,209 (+)NCBIGRCm37mm9NCBIm37
Celera9108,544,152 - 108,545,153 (+)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11226328   PMID:11329063   PMID:11416224   PMID:12466851   PMID:12764078   PMID:12970163   PMID:14736736   PMID:15514029  
PMID:16054139   PMID:16141072   PMID:16141073   PMID:16424218   PMID:16707802   PMID:17050686   PMID:17194724   PMID:18308934   PMID:19318426   PMID:19914944   PMID:19919977   PMID:20610744  
PMID:20937857   PMID:21627635   PMID:21873635   PMID:22138165   PMID:22192627   PMID:22640813   PMID:23320836   PMID:23493376   PMID:24043794   PMID:24083959   PMID:25358399   PMID:25426872  
PMID:26648475   PMID:27699250   PMID:28665499   PMID:28851616  


Genomics

Comparative Map Data
Ucn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,815,231 - 108,816,232 (+)NCBIGRCm39mm39
GRCm389108,986,163 - 108,987,164 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,986,010 - 108,987,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,888,208 - 108,889,209 (+)NCBIGRCm37mm9NCBIm37
Celera9108,544,152 - 108,545,153 (+)NCBICelera
Cytogenetic Map9F2NCBI
UCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,561,718 - 48,563,781 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,561,718 - 48,563,781 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,599,151 - 48,601,201 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,574,155 - 48,576,205 (-)NCBINCBI36hg18NCBI36
Build 34348,574,171 - 48,576,205NCBI
Celera348,554,893 - 48,556,936 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,657,480 - 48,659,523 (-)NCBIHuRef
CHM1_1348,551,458 - 48,553,508 (-)NCBICHM1_1
Ucn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,727,216 - 117,728,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,727,877 - 117,728,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,078,961 - 117,080,510 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,003,817 - 114,005,366 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18114,023,950 - 114,024,334 (+)NCBI
Celera8108,931,358 - 108,932,907 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ucn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955532648,845 - 650,020 (-)NCBIChiLan1.0ChiLan1.0
UCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,566,535 - 49,566,873 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0348,484,628 - 48,485,179 (-)NCBIMhudiblu_PPA_v0panPan3
UCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,551,060 - 40,552,920 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ucn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936529347,411 - 348,040 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,261,196 - 31,261,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,261,196 - 31,261,824 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,505,101 - 34,506,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UCN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,962,339 - 9,964,553 (-)NCBI
Ucn2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247302,567,154 - 2,568,387 (-)NCBI

Position Markers
AW209154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389108,984,739 - 108,984,831UniSTSGRCm38
MGSCv379108,886,784 - 108,886,876UniSTSGRCm37
Celera9108,542,677 - 108,542,769UniSTS
Cytogenetic Map9F2UniSTS
cM Map961.0UniSTS
Whitehead/MRC_RH91108.69UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:228
Count of miRNA genes:194
Interacting mature miRNAs:209
Transcripts:ENSMUST00000052724
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000052724   ⟹   ENSMUSP00000060405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,986,010 - 108,987,164 (+)Ensembl
RefSeq Acc Id: NM_145077   ⟹   NP_659543
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,815,231 - 108,816,232 (+)NCBI
GRCm389108,986,163 - 108,987,164 (+)ENTREZGENE
MGSCv379108,888,208 - 108,889,209 (+)RGD
Celera9108,544,152 - 108,545,153 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_659543 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK16157 (Get FASTA)   NCBI Sequence Viewer  
  EDL21326 (Get FASTA)   NCBI Sequence Viewer  
  Q99ML8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_659543   ⟸   NM_145077
- Peptide Label: preproprotein
- UniProtKB: Q99ML8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000060405   ⟸   ENSMUST00000052724


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2176375 AgrOrtholog
Ensembl Genes ENSMUSG00000049699 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000060405 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052724 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CRF UniProtKB/Swiss-Prot
  Urocortin_II UniProtKB/Swiss-Prot
  Urocortin_II/III UniProtKB/Swiss-Prot
KEGG Report mmu:171530 UniProtKB/Swiss-Prot
MGD MGI:2176375 ENTREZGENE
NCBI Gene 171530 ENTREZGENE
PANTHER PTHR17575 UniProtKB/Swiss-Prot
  PTHR17575:SF0 UniProtKB/Swiss-Prot
Pfam CRF UniProtKB/Swiss-Prot
PharmGKB UCN2 RGD
PhenoGen Ucn2 PhenoGen
UniGene Mm.388865 ENTREZGENE
UniProt Q99ML8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F8WIL4 UniProtKB/Swiss-Prot