carmustine - Ontology Report - Rat Genome Database

carmustine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	carmustine	go back to main search page
Accession:	CHEBI:3423	browse the term
Definition:	A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Synonyms:	exact_synonym:	1,3-bis(2-chloroethyl)-1-nitrosourea
	related_synonym:	BCNU; Bicnu (TN); Bischloroethyl nitrosourea; Formula=C5H9Cl2N3O2; Gliadel; InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11); InChIKey=DLGOEMSEDOSKAD-UHFFFAOYSA-N; N,N'-Bis(2-chloroethyl)-N-nitrosourea; SMILES=ClCCNC(=O)N(CCCl)N=O; carmustina; carmustinum
	xref:	CAS:154-93-8; DrugBank:DB00262; Drug_Central:512; KEGG:D00254
	xref_mesh:	MESH:D002330
	xref:	Wikipedia:Carmustine

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Genes (484)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

multiple interactions
increases expression

EXP

[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine
Carmustine results in increased expression of ABCB1 protein

PMID:11792417 PMID:15239124

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily C member 2

affects response to substance

EXP

ABCC2 mRNA affects the susceptibility to Carmustine

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ATP binding cassette subfamily G member 5

affects response to substance

EXP

ABCG5 mRNA affects the susceptibility to Carmustine

NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865

G

alkaline ceramidase 2

increases expression

ISO

Carmustine results in increased expression of ACER2 mRNA

NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505

G

acid phosphatase 3

decreases expression

ISO

Carmustine results in decreased expression of ACP3 mRNA

NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302

G

actin alpha cardiac muscle 1

decreases expression

EXP

Carmustine results in decreased expression of ACTC1 mRNA

NCBI chr15:34,790,230...34,795,549
Ensembl chr15:34,790,107...34,795,589

G

actin gamma 2, smooth muscle

decreases expression

EXP

Carmustine results in decreased expression of ACTG2 mRNA

NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865

G

actinin alpha 1

decreases expression

EXP

Carmustine results in decreased expression of ACTN1 mRNA

NCBI chr14:68,874,128...68,979,302
Ensembl chr14:68,874,123...68,979,440

G

ADAM metallopeptidase domain 15

decreases expression

EXP

Carmustine results in decreased expression of ADAM15 mRNA

NCBI chr 1:155,051,316...155,062,775
Ensembl chr 1:155,050,566...155,062,775

G

ADAM metallopeptidase with thrombospondin type 1 motif 4

decreases expression

EXP

Carmustine results in decreased expression of ADAMTS4 mRNA

NCBI chr 1:161,184,302...161,199,054
Ensembl chr 1:161,184,302...161,199,054

G

adenylate cyclase activating polypeptide 1

decreases expression

EXP

Carmustine results in decreased expression of ADCYAP1 mRNA

NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172

G

adrenoceptor alpha 1B

decreases expression

EXP

Carmustine results in decreased expression of ADRA1B mRNA

NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012

G

anterior gradient 3, protein disulphide isomerase family member

affects response to substance

EXP

AGR3 mRNA affects the susceptibility to Carmustine

NCBI chr 7:16,854,681...16,881,983
Ensembl chr 7:16,859,412...16,881,987

G

angiotensinogen

decreases response to substance

EXP

AGT protein mutant form results in decreased susceptibility to Carmustine; AGT protein results in decreased susceptibility to Carmustine

NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576

G

aldo-keto reductase family 1 member B

affects response to substance

EXP

AKR1B1 mRNA affects the susceptibility to Carmustine

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

aldo-keto reductase family 1 member C1

affects response to substance

EXP

AKR1C1 mRNA affects the susceptibility to Carmustine

NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions
affects response to substance

ISO
EXP

Carmustine results in decreased phosphorylation of AKT1 protein
LCN2 protein promotes the reaction [Carmustine results in decreased phosphorylation of AKT1 protein]
AKT1 protein affects the susceptibility to Carmustine

PMID:18430789 PMID:19860839

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

AKT serine/threonine kinase 2

decreases expression

EXP

Carmustine results in decreased expression of AKT2 mRNA

NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536

G

aminolevulinate dehydratase

decreases expression
multiple interactions

EXP

Carmustine results in decreased expression of ALAD mRNA
[Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein

PMID:15980968 PMID:19162187

NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290

G

5'-aminolevulinate synthase 2

decreases expression

ISO

Carmustine results in decreased expression of ALAS2 mRNA

NCBI chr X:55,009,055...55,030,977
Ensembl chr X:55,009,055...55,030,977

G

aldehyde dehydrogenase 1 family member A3

affects response to substance

EXP

ALDH1A3 mRNA affects the susceptibility to Carmustine

NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,861,924...100,916,626

G

arachidonate 12-lipoxygenase, 12S type

affects response to substance
decreases expression

ISO

ALOX12 protein affects the susceptibility to Carmustine
Carmustine results in decreased expression of ALOX12 mRNA

PMID:16005536 PMID:19373248

NCBI chr17:6,996,049...7,010,754
Ensembl chr17:6,996,049...7,010,754

G

arachidonate 15-lipoxygenase type B

decreases expression

EXP

Carmustine results in decreased expression of ALOX15B mRNA

NCBI chr17:8,039,059...8,049,134
Ensembl chr17:8,039,034...8,049,134

G

anti-Mullerian hormone

decreases expression

EXP

Carmustine results in decreased expression of AMH mRNA

NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073

G

ankyrin 2

affects response to substance

EXP

ANK2 mRNA affects the susceptibility to Carmustine

NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221

G

ankyrin repeat domain 1

affects response to substance

EXP

ANKRD1 mRNA affects the susceptibility to Carmustine

NCBI chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087

G

adaptor related protein complex 1 subunit sigma 2

affects response to substance

EXP

AP1S2 mRNA affects the susceptibility to Carmustine

NCBI chr X:15,825,806...15,854,813
Ensembl chr X:15,825,806...15,854,931

G

APC regulator of WNT signaling pathway

affects response to substance

EXP

APC mRNA affects the susceptibility to Carmustine

NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,518...112,846,239

G

APC regulator of WNT signaling pathway 2

decreases expression

EXP

Carmustine results in decreased expression of APC2 mRNA

NCBI chr19:1,446,230...1,473,244
Ensembl chr19:1,446,302...1,473,244

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases response to substance
decreases response to substance

EXP

APEX1 protein mutant form results in increased susceptibility to Carmustine
APEX1 protein results in decreased susceptibility to Carmustine

PMID:12231548 PMID:16243814 PMID:17259346 PMID:19470598

NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772

G

apelin receptor

decreases expression

EXP

Carmustine results in decreased expression of APLNR mRNA

NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,250

G

aquaporin 8

decreases expression

EXP

Carmustine results in decreased expression of AQP8 mRNA

NCBI chr16:25,216,947...25,228,932
Ensembl chr16:25,215,731...25,228,932

G

ARF GTPase 1

affects response to substance

EXP

ARF1 mRNA affects the susceptibility to Carmustine

NCBI chr 1:228,082,708...228,099,212
Ensembl chr 1:228,082,708...228,099,212

G

actin related protein 2/3 complex subunit 2

decreases expression

EXP

Carmustine results in decreased expression of ARPC2 mRNA

NCBI chr 2:218,217,189...218,254,348
Ensembl chr 2:218,217,141...218,254,356

G

arrestin domain containing 2

affects response to substance

EXP

ARRDC2 mRNA affects the susceptibility to Carmustine

NCBI chr19:18,001,124...18,014,102
Ensembl chr19:18,001,132...18,014,102

G

artemin

decreases expression

EXP

Carmustine results in decreased expression of ARTN mRNA

NCBI chr 1:43,933,801...43,937,240
Ensembl chr 1:43,933,320...43,937,240

G

acetylserotonin O-methyltransferase like

decreases expression

EXP

Carmustine results in decreased expression of ASMTL mRNA

NCBI chr  X:1,403,139...1,453,756
NCBI chr  Y:1,403,139...1,453,756
Ensembl chr  Y:1,403,139...1,453,762
Ensembl chr  X:1,403,139...1,453,762

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

EXP

Carmustine results in decreased expression of ATP1A3 mRNA

NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497

G

ATPase H+/K+ transporting subunit beta

decreases expression

EXP

Carmustine results in decreased expression of ATP4B mRNA

NCBI chr13:113,648,804...113,658,198
Ensembl chr13:113,648,804...113,658,198

G

ATP synthase F1 subunit delta

decreases expression

EXP

Carmustine results in decreased expression of ATP5F1D mRNA

NCBI chr19:1,241,751...1,244,825
Ensembl chr19:1,241,746...1,244,825

G

ATPase H+ transporting V0 subunit c

decreases expression

EXP

Carmustine results in decreased expression of ATP6V0C mRNA

NCBI chr16:2,513,726...2,520,218
Ensembl chr16:2,513,952...2,520,218

G

ATR serine/threonine kinase

multiple interactions

EXP

ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]

NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733

G

ataxin 2 like

decreases expression

EXP

Carmustine results in decreased expression of ATXN2L mRNA

NCBI chr16:28,822,999...28,837,232
Ensembl chr16:28,822,999...28,837,237

G

arginine vasopressin receptor 1A

increases expression

EXP

Carmustine results in increased expression of AVPR1A mRNA

NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,151,201

G

beta-1,4-galactosyltransferase 5

decreases expression

EXP

Carmustine results in decreased expression of B4GALT5 mRNA

NCBI chr20:49,632,945...49,713,878
Ensembl chr20:49,632,945...49,713,878

G

BAR/IMD domain containing adaptor protein 2

decreases expression

EXP

Carmustine results in decreased expression of BAIAP2 mRNA

NCBI chr17:81,035,151...81,117,434
Ensembl chr17:81,035,122...81,117,434

G

BAI1 associated protein 3

decreases expression

EXP

Carmustine results in decreased expression of BAIAP3 mRNA

NCBI chr16:1,333,645...1,349,439
Ensembl chr16:1,333,638...1,349,439

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

Carmustine results in increased expression of BAX protein

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL10 immune signaling adaptor

increases expression

EXP

Carmustine results in increased expression of BCL10 mRNA

NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632

G

BCL2 apoptosis regulator

multiple interactions
affects response to substance
decreases expression

EXP

[Fenretinide co-treated with Carmustine] results in decreased expression of BCL2 protein
BCL2 protein affects the susceptibility to Carmustine
Carmustine results in decreased expression of BCL2 protein

PMID:15332326 PMID:16187019 PMID:18430789 PMID:20920327

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

affects response to substance
decreases expression
multiple interactions

EXP
ISO

BCL2L1 protein affects the susceptibility to Carmustine
Carmustine results in decreased expression of BCL2L1 protein
[Fenretinide co-treated with Carmustine] results in decreased expression of BCL2L1 protein
Carmustine results in decreased expression of BCL2L1 mRNA; Carmustine results in decreased expression of BCL2L1 protein

PMID:15332326 PMID:16187019 PMID:19860839

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

beclin 1

decreases expression

EXP

Carmustine results in decreased expression of BECN1 mRNA

NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350

G

BICD cargo adaptor 1

decreases expression

EXP

Carmustine results in decreased expression of BICD1 mRNA

NCBI chr12:32,106,847...32,383,633
Ensembl chr12:32,106,835...32,383,633

G

BLK proto-oncogene, Src family tyrosine kinase

decreases expression

EXP

Carmustine results in decreased expression of BLK mRNA

NCBI chr 8:11,494,387...11,564,599
Ensembl chr 8:11,486,894...11,564,599

G

basic helix-loop-helix ARNT like 1

decreases expression

ISO

Carmustine results in decreased expression of BMAL1 mRNA

NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266

G

bone morphogenetic protein 5

affects response to substance

EXP

BMP5 mRNA affects the susceptibility to Carmustine

NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590

G

bone morphogenetic protein 7

decreases expression

EXP

Carmustine results in decreased expression of BMP7 mRNA

NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641

G

BRF1 general transcription factor IIIB subunit

decreases expression

EXP

Carmustine results in decreased expression of BRF1 mRNA

NCBI chr14:105,209,286...105,315,589
Ensembl chr14:105,209,286...105,315,589

G

carbonic anhydrase 6

decreases expression

EXP

Carmustine results in decreased expression of CA6 mRNA

NCBI chr 1:8,945,868...8,975,092
Ensembl chr 1:8,945,867...8,975,092

G

cell adhesion molecule 1

affects response to substance

EXP

CADM1 mRNA affects the susceptibility to Carmustine

NCBI chr11:115,169,236...115,504,415
Ensembl chr11:115,169,218...115,504,957

G

calbindin 2

decreases expression

EXP

Carmustine results in decreased expression of CALB2 mRNA

NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436

G

caspase 3

increases activity
multiple interactions
increases cleavage
increases expression

ISO
EXP

Carmustine results in increased activity of CASP3 protein
[Carmustine co-treated with 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid] results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; [LCN2 protein co-treated with Carmustine] results in increased cleavage of and results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Carmustine results in increased activity of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Zinc Sulfate inhibits the reaction [Carmustine results in increased activity of CASP3 protein]
Carmustine results in increased expression of CASP3 protein

PMID:18590702 PMID:19860839 PMID:20046642 PMID:20920327 PMID:21600974 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

catalase

decreases activity
multiple interactions

ISO

Carmustine results in decreased activity of CAT protein
Acetylcysteine inhibits the reaction [Carmustine results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

affects activity
affects response to substance
decreases expression
increases expression

EXP

Carmustine affects the activity of CCL2 protein
CCL2 mRNA affects the susceptibility to Carmustine
Carmustine results in decreased expression of CCL2 protein
Carmustine results in increased expression of CCL2 mRNA

PMID:15980968 PMID:16365179 PMID:17522861

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cellular communication network factor 4

affects response to substance

EXP

CCN4 mRNA affects the susceptibility to Carmustine

NCBI chr 8:133,191,039...133,231,690
Ensembl chr 8:133,191,039...133,231,690

G

cyclin D1

affects response to substance

EXP

CCND1 mRNA affects the susceptibility to Carmustine

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin E1

increases expression

ISO

Carmustine results in increased expression of CCNE1 mRNA

NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312

G

CD151 molecule (Raph blood group)

decreases expression

EXP

Carmustine results in decreased expression of CD151 mRNA

NCBI chr11:832,952...838,831
Ensembl chr11:832,887...839,831

G

CD44 molecule (IN blood group)

affects response to substance

EXP

CD44 mRNA affects the susceptibility to Carmustine

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

CD68 molecule

decreases expression

EXP

Carmustine results in decreased expression of CD68 mRNA

NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111

G

CD79a molecule

decreases expression

EXP

Carmustine results in decreased expression of CD79A mRNA

NCBI chr19:41,877,279...41,881,372
Ensembl chr19:41,877,279...41,881,372

G

CD80 molecule

increases expression

EXP

Carmustine results in increased expression of CD80 mRNA

NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614

G

cell division cycle 25B

decreases expression

ISO

Carmustine results in decreased expression of CDC25B mRNA

NCBI chr20:3,786,951...3,806,115
Ensembl chr20:3,786,772...3,806,121

G

cadherin 13

affects response to substance

EXP

CDH13 mRNA affects the susceptibility to Carmustine

NCBI chr16:82,626,969...83,800,640
Ensembl chr16:82,626,965...83,800,640

G

cyclin dependent kinase 8

decreases expression

EXP

Carmustine results in decreased expression of CDK8 mRNA

NCBI chr13:26,254,129...26,405,238
Ensembl chr13:26,254,104...26,420,982

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

EXP

[Carmustine co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein; MDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]

PMID:15735757 PMID:16193384 PMID:18632648 PMID:20472715

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397

G

cyclin dependent kinase inhibitor 1C

affects response to substance

EXP

CDKN1C mRNA affects the susceptibility to Carmustine

NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775

G

cyclin dependent kinase inhibitor 2A

increases response to substance

EXP

CDKN2A protein results in increased susceptibility to Carmustine

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

cyclin dependent kinase inhibitor 3

decreases expression

ISO

Carmustine results in decreased expression of CDKN3 mRNA

NCBI chr14:54,397,007...54,420,218
Ensembl chr14:54,396,849...54,420,218

G

caudal type homeobox 4

decreases expression

EXP

Carmustine results in decreased expression of CDX4 mRNA

NCBI chr X:73,447,053...73,455,171
Ensembl chr X:73,447,053...73,455,171

G

CEA cell adhesion molecule 3

decreases expression

EXP

Carmustine results in decreased expression of CEACAM3 mRNA

NCBI chr19:41,796,587...41,811,554
Ensembl chr19:41,796,587...41,811,554

G

CCAAT enhancer binding protein beta

decreases expression

EXP

Carmustine results in decreased expression of CEBPB mRNA

NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,734...50,192,690

G

cell growth regulator with EF-hand domain 1

increases expression

ISO

Carmustine results in increased expression of CGREF1 mRNA

NCBI chr 2:27,099,353...27,119,128
Ensembl chr 2:27,098,889...27,119,128

G

chromodomain helicase DNA binding protein 2

affects response to substance

EXP

CHD2 mRNA affects the susceptibility to Carmustine

NCBI chr15:92,900,324...93,027,996
Ensembl chr15:92,886,203...93,027,996

G

checkpoint kinase 1

multiple interactions

EXP

ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein; O(6)-benzylguanine promotes the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

cholinergic receptor muscarinic 4

decreases expression

EXP

Carmustine results in decreased expression of CHRM4 mRNA

NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776

G

cholinergic receptor nicotinic beta 3 subunit

decreases expression

EXP

Carmustine results in decreased expression of CHRNB3 mRNA

NCBI chr 8:42,697,366...42,737,407
Ensembl chr 8:42,697,366...42,737,407

G

cholinergic receptor nicotinic gamma subunit

decreases expression

EXP

Carmustine results in decreased expression of CHRNG mRNA

NCBI chr 2:232,539,692...232,548,115
Ensembl chr 2:232,539,692...232,548,115

G

creatine kinase, M-type

decreases expression

EXP

Carmustine results in decreased expression of CKM mRNA

NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875

G

chloride intracellular channel 1

multiple interactions
decreases response to substance

EXP

[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of CLIC1 protein] which results in increased susceptibility to Carmustine
CLIC1 protein results in decreased susceptibility to Carmustine

NCBI chr 6:31,730,581...31,737,318
Ensembl chr 6:31,730,581...31,739,763

G

clathrin heavy chain like 1

increases expression

EXP

Carmustine results in increased expression of CLTCL1 mRNA

NCBI chr22:19,179,473...19,291,719
Ensembl chr22:19,179,473...19,291,719

G

contactin associated protein 1

increases expression

EXP

Carmustine results in increased expression of CNTNAP1 mRNA

NCBI chr17:42,682,531...42,699,993
Ensembl chr17:42,682,531...42,699,993

G

collagen type I alpha 1 chain

affects response to substance

EXP

COL1A1 mRNA affects the susceptibility to Carmustine

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type V alpha 3 chain

decreases expression

ISO

Carmustine results in decreased expression of COL5A3 mRNA

NCBI chr19:9,959,561...10,010,504
Ensembl chr19:9,959,561...10,010,504

G

collagen type IX alpha 1 chain

decreases expression

EXP

Carmustine results in decreased expression of COL9A1 mRNA

NCBI chr 6:70,215,061...70,303,084
Ensembl chr 6:70,216,040...70,303,084

G

cytochrome c oxidase subunit 6A2

decreases expression

EXP

Carmustine results in decreased expression of COX6A2 mRNA

NCBI chr16:31,427,731...31,428,360
Ensembl chr16:31,427,731...31,428,360

G

cellular retinoic acid binding protein 1

decreases expression

EXP

Carmustine results in decreased expression of CRABP1 mRNA

NCBI chr15:78,340,353...78,348,225
Ensembl chr15:78,340,353...78,348,225

G

carnitine O-acetyltransferase

decreases expression

EXP

Carmustine results in decreased expression of CRAT mRNA

NCBI chr 9:129,094,794...129,110,793
Ensembl chr 9:129,094,142...129,111,189

G

crystallin beta B1

decreases expression

EXP

Carmustine results in decreased expression of CRYBB1 mRNA

NCBI chr22:26,599,278...26,618,027
Ensembl chr22:26,599,278...26,618,027

G

colony stimulating factor 2

affects response to substance

EXP

CSF2 mRNA affects the susceptibility to Carmustine

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

chondroitin sulfate N-acetylgalactosaminyltransferase 1

affects response to substance

EXP

CSGALNACT1 mRNA affects the susceptibility to Carmustine

NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029

G

cysteine and glycine rich protein 3

affects response to substance

EXP

CSRP3 mRNA affects the susceptibility to Carmustine

NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571

G

cystatin D

decreases expression

EXP

Carmustine results in decreased expression of CST5 mRNA

NCBI chr20:23,875,934...23,879,748
Ensembl chr20:23,875,934...23,879,748

G

cardiotrophin 1

decreases expression

EXP

Carmustine results in decreased expression of CTF1 mRNA

NCBI chr16:30,895,846...30,903,560
Ensembl chr16:30,896,614...30,903,547

G

catenin alpha like 1

increases expression

EXP

Carmustine results in increased expression of CTNNAL1 mRNA

NCBI chr 9:108,942,577...109,013,499
Ensembl chr 9:108,942,569...109,013,522

G

cathepsin L

increases expression

ISO

Carmustine results in increased expression of CTSL mRNA

NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469

G

cut like homeobox 2

affects expression

ISO

Carmustine affects the expression of CUX2 mRNA

NCBI chr12:111,034,165...111,350,554
Ensembl chr12:111,034,165...111,350,554

G

C-X-C motif chemokine ligand 1

affects response to substance

EXP

CXCL1 mRNA affects the susceptibility to Carmustine

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 2

affects response to substance

EXP

CXCL2 mRNA affects the susceptibility to Carmustine

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

cytochrome P450 family 19 subfamily A member 1

decreases expression

EXP

Carmustine results in decreased expression of CYP19A1 mRNA

NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions

EXP

CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

cytochrome P450 family 3 subfamily A member 5

multiple interactions

EXP

CYP3A5 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]

NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996

G

cytohesin 1

increases expression

EXP

Carmustine results in increased expression of CYTH1 mRNA

NCBI chr17:78,674,048...78,782,273
Ensembl chr17:78,674,048...78,782,297

G

DEF6 guanine nucleotide exchange factor

affects response to substance

EXP

DEF6 mRNA affects the susceptibility to Carmustine

NCBI chr 6:35,297,818...35,321,771
Ensembl chr 6:35,297,818...35,321,771

G

dehydrogenase/reductase 3

affects response to substance

EXP

DHRS3 mRNA affects the susceptibility to Carmustine

NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,909...12,620,133

G

DEAH-box helicase 16

decreases expression

EXP

Carmustine results in decreased expression of DHX16 mRNA

NCBI chr 6:30,653,127...30,673,006
Ensembl chr 6:30,653,119...30,673,006

G

DEAH-box helicase 37

affects response to substance

EXP

DHX37 mRNA affects the susceptibility to Carmustine

NCBI chr12:124,946,826...124,989,131
Ensembl chr12:124,946,825...124,989,131

G

dickkopf WNT signaling pathway inhibitor 1

increases response to substance

EXP

DKK1 protein results in increased susceptibility to Carmustine

NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042

G

DMRT like family C2

affects response to substance

EXP

DMRTC2 mRNA affects the susceptibility to Carmustine

NCBI chr19:41,844,916...41,852,333
Ensembl chr19:41,844,743...41,852,333

G

DNA replication helicase/nuclease 2

affects response to substance

EXP

DNA2 mRNA affects the susceptibility to Carmustine

NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121

G

deoxyribonuclease 1 like 2

decreases expression

EXP

Carmustine results in decreased expression of DNASE1L2 mRNA

NCBI chr16:2,236,444...2,238,711
Ensembl chr16:2,235,816...2,238,711

G

DTX2P1-UPK3BP1-PMS2P11

DTX2P1-UPK3BP1-PMS2P11 readthrough, transcribed pseudogene

decreases expression

EXP

Carmustine results in decreased expression of DTX2P1-UPK3BP1-PMS2P11 mRNA

NCBI chr 7:76,980,822...77,023,761
Ensembl chr 7:76,959,835...77,198,626

G

dishevelled segment polarity protein 1

decreases expression

EXP

Carmustine results in decreased expression of DVL1 mRNA

NCBI chr 1:1,335,278...1,349,418
Ensembl chr 1:1,335,276...1,349,418

G

dual specificity tyrosine phosphorylation regulated kinase 1B

affects response to substance

EXP

DYRK1B mRNA affects the susceptibility to Carmustine

NCBI chr19:39,825,350...39,834,162
Ensembl chr19:39,825,350...39,834,201

G

E2F transcription factor 1

increases expression

EXP

Carmustine results in increased expression of E2F1 protein

NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385

G

extracellular matrix protein 2

increases expression

EXP

Carmustine results in increased expression of ECM2 mRNA

NCBI chr 9:92,493,547...92,559,106
Ensembl chr 9:92,493,554...92,536,655

G

endothelin receptor type A

affects response to substance

EXP

EDNRA mRNA affects the susceptibility to Carmustine

NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954

G

eukaryotic translation elongation factor 1 gamma

increases expression

EXP

Carmustine results in increased expression of EEF1G mRNA

NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086

G

eukaryotic translation initiation factor 2B subunit alpha

increases expression

EXP

Carmustine results in increased expression of EIF2B1 mRNA

NCBI chr12:123,620,406...123,633,686
Ensembl chr12:123,620,406...123,633,766

G

eukaryotic translation initiation factor 4A2

affects response to substance

EXP

EIF4A2 mRNA affects the susceptibility to Carmustine

NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897

G

eukaryotic translation initiation factor 6

decreases expression

EXP

Carmustine results in decreased expression of EIF6 mRNA

NCBI chr20:35,278,906...35,284,772
Ensembl chr20:35,278,907...35,284,985

G

engulfment and cell motility 1

affects response to substance

EXP

ELMO1 mRNA affects the susceptibility to Carmustine

NCBI chr 7:36,852,906...37,449,326
Ensembl chr 7:36,852,906...37,449,223

G

ectodermal-neural cortex 1

increases expression

ISO

Carmustine results in increased expression of ENC1 mRNA

NCBI chr 5:74,627,409...74,640,728
Ensembl chr 5:74,627,406...74,641,424

G

epoxide hydrolase 1

decreases expression

EXP

Carmustine results in decreased expression of EPHX1 mRNA

NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563

G

espin

increases expression

ISO

Carmustine results in increased expression of ESPN mRNA

NCBI chr 1:6,424,776...6,461,370
Ensembl chr 1:6,424,776...6,461,367

G

estrogen related receptor alpha

increases expression

EXP

Carmustine results in increased expression of ESRRA mRNA

NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743

G

ETS variant transcription factor 1

affects response to substance
affects expression

EXP
ISO

ETV1 mRNA affects the susceptibility to Carmustine
Carmustine affects the expression of ETV1 mRNA

PMID:16365179 PMID:19174181

NCBI chr 7:13,891,229...13,991,425
Ensembl chr 7:13,891,229...13,991,425

G

exostosin like glycosyltransferase 1

affects response to substance

EXP

EXTL1 mRNA affects the susceptibility to Carmustine

NCBI chr 1:26,021,775...26,036,464
Ensembl chr 1:26,019,884...26,036,464

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

EXP

Carmustine results in decreased expression of EZH2 mRNA

NCBI chr 7:148,807,383...148,884,291
Ensembl chr 7:148,807,257...148,884,321

G

coagulation factor III, tissue factor

increases expression

ISO

Carmustine results in increased expression of F3 mRNA

NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759

G

FA complementation group C

affects response to substance

EXP

FANCC mRNA affects the susceptibility to Carmustine

NCBI chr 9:95,099,054...95,317,709
Ensembl chr 9:95,099,054...95,426,796

G

FA complementation group D2

increases ubiquitination
affects localization

EXP

Carmustine results in increased ubiquitination of FANCD2 protein
Carmustine affects the localization of FANCD2 protein

NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932

G

fibulin 5

decreases expression

ISO

Carmustine results in decreased expression of FBLN5 mRNA

NCBI chr14:91,869,411...91,947,694
Ensembl chr14:91,869,411...91,947,987

G

fibrillin 1

decreases expression

EXP

Carmustine results in decreased expression of FBN1 mRNA

NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,313...48,645,721

G

F-box protein 32

affects response to substance

EXP

FBXO32 mRNA affects the susceptibility to Carmustine

NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206

G

ferrochelatase

multiple interactions

EXP

[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]

NCBI chr18:57,544,377...57,586,702
Ensembl chr18:57,544,377...57,586,732

G

fibroblast growth factor 2

decreases response to substance

EXP

FGF2 protein results in decreased susceptibility to Carmustine

NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236

G

four and a half LIM domains 2

affects response to substance

EXP

FHL2 mRNA affects the susceptibility to Carmustine

NCBI chr 2:105,357,712...105,438,529
Ensembl chr 2:105,357,712...105,438,513

G

FKBP prolyl isomerase 1A

decreases expression

EXP

Carmustine results in decreased expression of FKBP1A mRNA

NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164

G

FKBP prolyl isomerase 5

increases expression

ISO

Carmustine results in increased expression of FKBP5 mRNA

NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583

G

farnesyltransferase, CAAX box, subunit alpha

decreases expression
increases expression

EXP

Carmustine results in decreased expression of FNTA mRNA
Carmustine results in increased expression of FNTA mRNA

NCBI chr 8:43,056,323...43,085,785
Ensembl chr 8:43,034,194...43,085,788

G

forkhead box F2

affects response to substance

EXP

FOXF2 mRNA affects the susceptibility to Carmustine

NCBI chr 6:1,389,576...1,395,603
Ensembl chr 6:1,389,576...1,395,603

G

forkhead box J1

decreases expression

EXP

Carmustine results in decreased expression of FOXJ1 mRNA

NCBI chr17:76,136,333...76,141,245
Ensembl chr17:76,136,333...76,141,245

G

ferritin heavy chain 1

multiple interactions
decreases response to substance
decreases expression

EXP

Carmustine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA]
FTH1 results in decreased susceptibility to Carmustine
Carmustine results in decreased expression of FTH1 mRNA

PMID:15980968 PMID:16631525 PMID:21385903

NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634

G

ferritin light chain

decreases expression

EXP

Carmustine results in decreased expression of FTL mRNA

NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,967,896

G

fucosyltransferase 8

affects response to substance

EXP

FUT8 mRNA affects the susceptibility to Carmustine

NCBI chr14:65,356,842...65,744,121
Ensembl chr14:65,410,592...65,744,121

G

FYN proto-oncogene, Src family tyrosine kinase

decreases expression

EXP

Carmustine results in decreased expression of FYN mRNA

NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452

G

gamma-aminobutyric acid type A receptor subunit alpha2

affects response to substance
decreases expression

EXP

GABRA2 mRNA affects the susceptibility to Carmustine
Carmustine results in decreased expression of GABRA2 mRNA

PMID:15980968 PMID:16365179

NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230

G

gamma-aminobutyric acid type A receptor subunit alpha6

decreases expression

EXP

Carmustine results in decreased expression of GABRA6 mRNA

NCBI chr 5:161,685,721...161,702,592
Ensembl chr 5:161,547,063...161,702,593

G

polypeptide N-acetylgalactosaminyltransferase 15

affects response to substance

EXP

GALNT15 mRNA affects the susceptibility to Carmustine

NCBI chr 3:16,174,680...16,248,224
Ensembl chr 3:16,174,680...16,231,992

G

guanidinoacetate N-methyltransferase

decreases expression

EXP

Carmustine results in decreased expression of GAMT mRNA

NCBI chr19:1,397,026...1,401,542
Ensembl chr19:1,397,026...1,401,570

G

GTPase activating Rap/RanGAP domain like 3

affects response to substance

EXP

GARNL3 mRNA affects the susceptibility to Carmustine

NCBI chr 9:127,224,613...127,393,660
Ensembl chr 9:127,224,265...127,393,660

G

gastrin

decreases expression

EXP

Carmustine results in decreased expression of GAST mRNA

NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969

G

glutamate-cysteine ligase catalytic subunit

multiple interactions

ISO

[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein

PMID:12967637 PMID:16288907

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glial cells missing transcription factor 1

increases expression

EXP

Carmustine results in increased expression of GCM1 mRNA

NCBI chr 6:53,126,961...53,148,841
Ensembl chr 6:53,126,961...53,148,841

G

GDP dissociation inhibitor 1

increases expression

EXP

Carmustine results in increased expression of GDI1 mRNA

NCBI chr X:154,437,154...154,443,467
Ensembl chr X:154,436,913...154,443,467

G

GDP dissociation inhibitor 2

increases expression

EXP

Carmustine results in increased expression of GDI2 mRNA

NCBI chr10:5,765,223...5,813,434
Ensembl chr10:5,765,222...5,842,132

G

glial cell derived neurotrophic factor

decreases response to substance

EXP

GDNF protein results in decreased susceptibility to Carmustine

NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041

G

glial fibrillary acidic protein

decreases expression
multiple interactions

EXP
ISO

Carmustine results in decreased expression of GFAP mRNA
Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]

PMID:15980968 PMID:17572393

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogene

affects response to substance

EXP

GFOD3P mRNA affects the susceptibility to Carmustine

NCBI chr 1:3,735,984...3,747,373
Ensembl chr 1:3,735,511...3,747,373
Ensembl chr 1:3,735,511...3,747,373

G

growth hormone secretagogue receptor

decreases expression

EXP

Carmustine results in decreased expression of GHSR mRNA

NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456

G

glycine receptor beta

affects response to substance

EXP

GLRB mRNA affects the susceptibility to Carmustine

NCBI chr 4:157,076,150...157,172,090
Ensembl chr 4:157,076,125...157,172,090

G

gonadotropin releasing hormone receptor

increases expression

EXP

Carmustine results in increased expression of GNRHR mRNA

NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388

G

golgin A2

decreases expression

EXP

Carmustine results in decreased expression of GOLGA2 mRNA

NCBI chr 9:128,255,829...128,276,007
Ensembl chr 9:128,255,829...128,276,026

G

golgin A4

increases expression

EXP

Carmustine results in increased expression of GOLGA4 mRNA

NCBI chr 3:37,243,271...37,366,879
Ensembl chr 3:37,243,191...37,366,879

G

golgin A8 family member B

affects response to substance

EXP

GOLGA8B mRNA affects the susceptibility to Carmustine

NCBI chr15:34,525,095...34,583,651
Ensembl chr15:34,525,095...34,588,503

G

glycoprotein Ib platelet subunit beta

decreases expression

EXP

Carmustine results in decreased expression of GP1BB mRNA

NCBI chr22:19,723,539...19,724,771
Ensembl chr22:19,723,539...19,724,771

G

G protein-coupled receptor 25

decreases expression

EXP

Carmustine results in decreased expression of GPR25 mRNA

NCBI chr 1:200,872,981...200,874,178
Ensembl chr 1:200,872,981...200,874,178

G

G protein-coupled receptor 32

decreases expression

EXP

Carmustine results in decreased expression of GPR32 mRNA

NCBI chr19:50,770,464...50,771,732
Ensembl chr19:50,770,464...50,771,732

G

G protein-coupled receptor 37

decreases expression

EXP

Carmustine results in decreased expression of GPR37 mRNA

NCBI chr 7:124,743,885...124,765,792
Ensembl chr 7:124,743,885...124,765,792

G

G protein-coupled receptor 65

increases expression

EXP

Carmustine results in increased expression of GPR65 mRNA

NCBI chr14:88,005,135...88,014,811
Ensembl chr14:88,005,135...88,014,811

G

growth factor receptor bound protein 7

decreases expression

EXP

Carmustine results in decreased expression of GRB7 mRNA

NCBI chr17:39,737,938...39,747,285
Ensembl chr17:39,737,927...39,747,291

G

granulin precursor

decreases expression

EXP

Carmustine results in decreased expression of GRN mRNA

NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106

G

glutathione-disulfide reductase

multiple interactions
decreases activity

EXP
ISO

[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Doxorubicin; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to zinc chloride; Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]; NADP affects the reaction [Carmustine results in decreased activity of GSR protein]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Streptozocin; [Carmustine results in decreased activity of GSR protein] which results in increased uptake of Calcium; MT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; Zinc Sulfate inhibits the reaction [Carmustine results in decreased activity of GSR protein]
[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Carmustine results in decreased activity of GSR protein] which results in decreased susceptibility to chromium hexavalent ion; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein

PMID:2116959 PMID:12114195 PMID:12433058 PMID:12477282 PMID:12632252 More...

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione S-transferase mu 1

affects response to substance
decreases response to substance
multiple interactions

EXP

GSTM1 gene affects the susceptibility to Carmustine
GSTM1 protein results in decreased susceptibility to Carmustine
GSTM1 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]

PMID:16087946 PMID:20067466

NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039

G

glutathione S-transferase mu 2

decreases nitrosation

EXP

GSTM2 protein results in decreased nitrosation of Carmustine

NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551

G

glutathione S-transferase mu 3

affects metabolic processing
decreases nitrosation
multiple interactions

EXP

GSTM3 protein affects the metabolism of Carmustine
GSTM3 protein results in decreased nitrosation of Carmustine
GSTM3 protein results in decreased nitrosation of and results in decreased activity of Carmustine

PMID:8395980 PMID:11841793 PMID:15247628

NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038

G

glutathione S-transferase pi 1

multiple interactions
decreases response to substance

EXP

GSTP1 gene SNP results in increased susceptibility to [Carmustine co-treated with Doxorubicin co-treated with Cyclophosphamide co-treated with Melphalan]
GSTP1 protein results in decreased susceptibility to Carmustine

PMID:12791655 PMID:16899598

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

G

glutathione S-transferase theta 1

decreases nitrosation
affects metabolic processing
affects response to substance

EXP
ISO

GSTT1 protein results in decreased nitrosation of Carmustine
GSTT1 protein affects the metabolism of Carmustine
GSTT1 protein affects the susceptibility to Carmustine

PMID:11841793 PMID:16874663 PMID:17827337

G

general transcription factor IIF subunit 1

decreases expression

EXP

Carmustine results in decreased expression of GTF2F1 mRNA

NCBI chr19:6,379,572...6,393,164
Ensembl chr19:6,379,572...6,393,981

G

guanylate cyclase 1 soluble subunit beta 2 (pseudogene)

decreases expression

ISO

Carmustine results in decreased expression of GUCY1B2 mRNA

NCBI chr13:50,994,511...51,066,157
Ensembl chr13:51,006,991...51,062,894
Ensembl chr13:51,006,991...51,062,894

G

H2A.X variant histone

decreases expression
increases phosphorylation
multiple interactions
affects localization

EXP

Carmustine results in decreased expression of H2AX mRNA
Carmustine results in increased phosphorylation of H2AX protein
MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein]; MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein]

PMID:15980968 PMID:20472715

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

2-hydroxyacyl-CoA lyase 1

decreases expression

ISO

Carmustine results in decreased expression of HACL1 mRNA

NCBI chr 3:15,560,699...15,601,569
Ensembl chr 3:15,560,699...15,601,852

G

hydroxyacyl-CoA dehydrogenase

decreases expression

EXP

Carmustine results in decreased expression of HADH mRNA

NCBI chr 4:107,989,889...108,035,171
Ensembl chr 4:107,989,714...108,035,241

G

hydroxyacylglutathione hydrolase

decreases expression

EXP

Carmustine results in decreased expression of HAGH mRNA

NCBI chr16:1,807,629...1,827,194
Ensembl chr16:1,795,620...1,827,157

G

host cell factor C1

decreases expression

EXP

Carmustine results in decreased expression of HCFC1 mRNA

NCBI chr X:153,947,557...153,971,818
Ensembl chr X:153,947,557...153,971,818

G

hedgehog acyltransferase

affects response to substance

EXP

HHAT mRNA affects the susceptibility to Carmustine

NCBI chr 1:210,327,328...210,676,290
Ensembl chr 1:210,328,252...210,676,296

G

hypoxia inducible factor 1 subunit alpha

decreases response to substance
multiple interactions

ISO

HIF1A protein results in decreased susceptibility to Carmustine
[cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to Carmustine; [Deferoxamine results in increased activity of HIF1A protein] which results in decreased susceptibility to Carmustine

PMID:14980978 PMID:15965067

NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259

G

high mobility group nucleosomal binding domain 2

decreases expression

EXP

Carmustine results in decreased expression of HMGN2 mRNA

NCBI chr 1:26,472,440...26,476,642
Ensembl chr 1:26,472,440...26,478,209

G

heme oxygenase 1

multiple interactions

EXP

Carmustine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

HNF1 homeobox A

decreases expression

EXP

Carmustine results in decreased expression of HNF1A mRNA

NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512

G

homeobox A4

decreases expression

EXP

Carmustine results in decreased expression of HOXA4 mRNA

NCBI chr 7:27,128,525...27,130,757
Ensembl chr 7:27,128,507...27,130,780

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

ISO

Carmustine results in increased mutagenesis of HPRT1 gene

NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513

G

intercellular adhesion molecule 5

decreases expression

EXP

Carmustine results in decreased expression of ICAM5 mRNA

NCBI chr19:10,289,952...10,296,778
Ensembl chr19:10,289,952...10,296,778

G

iduronate 2-sulfatase

decreases expression

EXP

Carmustine results in decreased expression of IDS mRNA

NCBI chr X:149,476,988...149,505,306
Ensembl chr X:149,476,988...149,521,096

G

immediate early response 3

decreases expression

EXP

Carmustine results in decreased expression of IER3 mRNA

NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548

G

interferon induced protein with tetratricopeptide repeats 1

affects response to substance

EXP

IFIT1 mRNA affects the susceptibility to Carmustine

NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487

G

insulin like growth factor 1

decreases expression
increases expression

EXP

Carmustine results in decreased expression of IGF1 protein
Carmustine results in increased expression of IGF1 protein

PMID:15286697 PMID:18443378

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 2

affects response to substance

EXP

IGF2 mRNA affects the susceptibility to Carmustine

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

insulin like growth factor binding protein 3

decreases expression

ISO

Carmustine results in decreased expression of IGFBP3 mRNA

NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

decreases expression

EXP

Carmustine results in decreased expression of IKBKG mRNA

NCBI chr X:154,541,238...154,565,046
Ensembl chr X:154,541,199...154,565,046

G

interleukin 12B

multiple interactions

ISO

Carmustine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]

NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863

G

interleukin 1 beta

multiple interactions

ISO

Carmustine promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:11970852 PMID:12433058

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 1 receptor type 1

affects response to substance

EXP

IL1R1 mRNA affects the susceptibility to Carmustine

NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874

G

interleukin 6

affects response to substance
multiple interactions

EXP
ISO

IL6 mRNA affects the susceptibility to Carmustine
Carmustine promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Carmustine promotes the reaction [Oligodeoxyribonucleotides analog results in increased secretion of IL6 protein]

PMID:11970852 PMID:12433058 PMID:12477282 PMID:16365179

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inhibin subunit beta A

affects response to substance

EXP

INHBA mRNA affects the susceptibility to Carmustine

NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834

G

inositol polyphosphate phosphatase like 1

decreases expression

EXP

Carmustine results in decreased expression of INPPL1 mRNA

NCBI chr11:72,223,563...72,239,147
Ensembl chr11:72,223,701...72,239,147

G

insulin induced gene 1

decreases expression

EXP

Carmustine results in decreased expression of INSIG1 mRNA

NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235

G

insulin like 3

decreases expression

EXP

Carmustine results in decreased expression of INSL3 mRNA

NCBI chr19:17,816,512...17,821,519
Ensembl chr19:17,816,512...17,821,574

G

importin 4

affects response to substance

EXP

IPO4 mRNA affects the susceptibility to Carmustine

NCBI chr14:24,180,219...24,188,816
Ensembl chr14:24,180,219...24,188,869

G

inositol 1,4,5-triphosphate receptor associated 2

decreases expression

EXP

Carmustine results in decreased expression of IRAG2 mRNA

NCBI chr12:24,997,575...25,108,335
Ensembl chr12:25,004,342...25,108,335

G

insulin receptor substrate 1

decreases expression

EXP

Carmustine results in decreased expression of IRS1 mRNA

NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820

G

immunoglobulin superfamily containing leucine rich repeat

decreases expression

EXP
ISO

Carmustine results in decreased expression of ISLR mRNA

PMID:15980968 PMID:16005536

NCBI chr15:74,173,710...74,176,871
Ensembl chr15:74,173,710...74,176,872

G

integrin subunit alpha 3

decreases expression

EXP

Carmustine results in decreased expression of ITGA3 mRNA

NCBI chr17:50,056,110...50,090,481
Ensembl chr17:50,055,968...50,090,481

G

integrin subunit beta 1

decreases expression

EXP

Carmustine results in decreased expression of ITGB1 protein

NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792

G

integrin subunit beta 3

increases response to substance
multiple interactions

EXP
ISO

ITGB3 protein results in increased susceptibility to Carmustine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ITGB3 protein results in increased susceptibility to Carmustine]

NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743

G

inter-alpha-trypsin inhibitor heavy chain 1

decreases expression

EXP

Carmustine results in decreased expression of ITIH1 mRNA

NCBI chr 3:52,777,599...52,792,068
Ensembl chr 3:52,777,595...52,792,068

G

potassium voltage-gated channel subfamily A member 4

multiple interactions

ISO

[Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCNA4 protein

NCBI chr11:30,009,730...30,017,030
Ensembl chr11:30,009,730...30,017,030

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

affects response to substance

EXP

KCNAB2 mRNA affects the susceptibility to Carmustine

NCBI chr 1:5,992,676...6,101,180
Ensembl chr 1:5,990,927...6,101,193

G

potassium voltage-gated channel subfamily D member 2

multiple interactions

ISO

[Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 mRNA; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 protein

NCBI chr 7:120,272,908...120,750,337
Ensembl chr 7:120,273,175...120,750,337

G

potassium voltage-gated channel subfamily H member 2

decreases expression

EXP

Carmustine results in decreased expression of KCNH2 mRNA

NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321

G

kinesin family member 2C

decreases expression

ISO

Carmustine results in decreased expression of KIF2C mRNA

NCBI chr 1:44,739,837...44,767,767
Ensembl chr 1:44,739,818...44,767,767

G

kinesin family member 5A

decreases expression

EXP

Carmustine results in decreased expression of KIF5A mRNA

NCBI chr12:57,550,044...57,586,633
Ensembl chr12:57,546,026...57,586,633

G

keratin 17

decreases expression

EXP

Carmustine results in decreased expression of KRT17 mRNA

NCBI chr17:41,619,442...41,624,575
Ensembl chr17:41,619,442...41,624,842

G

keratin 31

decreases expression

EXP

Carmustine results in decreased expression of KRT31 mRNA

NCBI chr17:41,393,721...41,397,608
Ensembl chr17:41,393,721...41,397,608

G

keratin 8

affects response to substance

EXP

KRT8 mRNA affects the susceptibility to Carmustine

NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954

G

ladinin 1

decreases expression

EXP

Carmustine results in decreased expression of LAD1 mRNA

NCBI chr 1:201,380,833...201,399,324
Ensembl chr 1:201,380,833...201,399,915

G

leukocyte associated immunoglobulin like receptor 1

increases expression

EXP

Carmustine results in increased expression of LAIR1 mRNA

NCBI chr19:54,351,384...54,376,088
Ensembl chr19:54,351,384...54,370,558

G

laminin subunit beta 3

decreases expression

EXP

Carmustine results in decreased expression of LAMB3 mRNA

NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425

G

lipopolysaccharide binding protein

affects response to substance

EXP

LBP mRNA affects the susceptibility to Carmustine

NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013

G

lipocalin 2

increases response to substance
multiple interactions

EXP
ISO

LCN2 protein results in increased susceptibility to Carmustine
[LCN2 protein co-treated with Carmustine] results in increased cleavage of and results in increased activity of CASP3 protein; LCN2 protein promotes the reaction [Carmustine results in decreased phosphorylation of AKT1 protein]

NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453

G

low density lipoprotein receptor

affects uptake

EXP

LDLR protein affects the uptake of Carmustine analog

NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820

G

LIF interleukin 6 family cytokine

increases response to substance

EXP

LIF mRNA results in increased susceptibility to Carmustine

NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759

G

DNA ligase 1

decreases expression

ISO

Carmustine results in decreased expression of LIG1 mRNA

NCBI chr19:48,115,445...48,170,344
Ensembl chr19:48,115,445...48,170,603

G

lines homolog 1

affects response to substance

EXP

LINS1 mRNA affects the susceptibility to Carmustine

NCBI chr15:100,566,924...100,602,184
Ensembl chr15:100,559,369...100,603,230

G

lectin, mannose binding 1 like

affects response to substance

EXP

LMAN1L mRNA affects the susceptibility to Carmustine

NCBI chr15:74,812,835...74,825,754
Ensembl chr15:74,812,716...74,825,757

G

lemur tyrosine kinase 2

affects response to substance

EXP

LMTK2 mRNA affects the susceptibility to Carmustine

NCBI chr 7:98,106,862...98,209,638
Ensembl chr 7:98,106,862...98,209,638

G

LIM homeobox transcription factor 1 beta

decreases expression

EXP

Carmustine results in decreased expression of LMX1B mRNA

NCBI chr 9:126,613,928...126,701,032
Ensembl chr 9:126,613,928...126,701,032

G

lysyl oxidase like 1

decreases expression

EXP

Carmustine results in decreased expression of LOXL1 mRNA

NCBI chr15:73,926,462...73,952,136
Ensembl chr15:73,925,989...73,952,137

G

leucine rich repeats and calponin homology domain containing 4

decreases expression

EXP

Carmustine results in decreased expression of LRCH4 mRNA

NCBI chr 7:100,574,011...100,586,129
Ensembl chr 7:100,574,011...100,586,129

G

lymphocyte specific protein 1

decreases expression

ISO

Carmustine results in decreased expression of LSP1 mRNA

NCBI chr11:1,853,084...1,892,263
Ensembl chr11:1,850,904...1,892,267

G

mitotic arrest deficient 1 like 1

decreases expression

EXP

Carmustine results in decreased expression of MAD1L1 mRNA

NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243

G

metastasis associated lung adenocarcinoma transcript 1

affects response to substance

EXP

MALAT1 mRNA affects the susceptibility to Carmustine

NCBI chr11:65,497,738...65,506,516
Ensembl chr11:65,497,606...65,508,073

G

mitogen-activated protein kinase kinase kinase kinase 2

decreases expression

EXP

Carmustine results in decreased expression of MAP4K2 mRNA

NCBI chr11:64,784,918...64,803,214
Ensembl chr11:64,784,918...64,803,241

G

mitogen-activated protein kinase 10

decreases expression

EXP

Carmustine results in decreased expression of MAPK10 mRNA

NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625

G

MBL associated serine protease 1

affects response to substance

EXP

MASP1 mRNA affects the susceptibility to Carmustine

NCBI chr 3:187,217,282...187,291,737
Ensembl chr 3:187,217,282...187,291,980

G

methionine adenosyltransferase 1A

decreases expression

EXP

Carmustine results in decreased expression of MAT1A mRNA

NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658

G

midkine

decreases expression

EXP

Carmustine results in decreased expression of MDK mRNA

NCBI chr11:46,380,784...46,383,837
Ensembl chr11:46,380,756...46,383,837

G

MDM4 regulator of p53

multiple interactions
decreases response to substance

EXP

[Carmustine co-treated with MDM4 protein] results in increased expression of POLH protein; MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein]; MDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]; MDM4 protein promotes the reaction [Carmustine results in increased expression of TP53 protein]; MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein]
MDM4 protein results in decreased susceptibility to Carmustine

NCBI chr 1:204,516,406...204,558,120
Ensembl chr 1:204,516,379...204,558,120

G

MDS1 and EVI1 complex locus

affects response to substance

EXP

MECOM mRNA affects the susceptibility to Carmustine

NCBI chr 3:169,083,507...169,663,712
Ensembl chr 3:169,083,499...169,663,775

G

mediator complex subunit 1

decreases expression

EXP

Carmustine results in decreased expression of MED1 mRNA

NCBI chr17:39,404,285...39,451,263
Ensembl chr17:39,404,285...39,451,272

G

maternally expressed 3

affects response to substance

EXP

MEG3 mRNA affects the susceptibility to Carmustine

NCBI chr14:100,826,108...100,861,026
Ensembl chr14:100,779,206...100,861,031

G

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

decreases expression

EXP

Carmustine results in decreased expression of MGAT3 mRNA

NCBI chr22:39,457,012...39,492,194
Ensembl chr22:39,457,012...39,492,194

G

O-6-methylguanine-DNA methyltransferase

increases alkylation
increases response to substance
multiple interactions
decreases expression
decreases response to substance
affects response to substance
decreases activity

EXP
ISO

Carmustine results in increased alkylation of MGMT protein
MGMT mutant form results in increased susceptibility to Carmustine
[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine; [MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; [O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein; [O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; O(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine]
Carmustine results in decreased expression of MGMT protein
MGMT protein results in decreased susceptibility to Carmustine
[O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]
MGMT protein affects the susceptibility to Carmustine
Carmustine results in decreased activity of MGMT protein
MGMT mRNA results in decreased susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine analog; MGMT results in decreased susceptibility to Carmustine
MGMT gene modified form affects the susceptibility to Carmustine; MGMT promoter modified form affects the susceptibility to Carmustine; MGMT protein affects the susceptibility to Carmustine

PMID:8823159 PMID:9918549 PMID:11792417 PMID:11945064 PMID:12036916 More...

NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983

G

microsomal glutathione S-transferase 2

affects response to substance

EXP

MGST2 mRNA affects the susceptibility to Carmustine

NCBI chr 4:139,665,819...139,754,618
Ensembl chr 4:139,665,768...139,740,745

G

mutL homolog 1

affects response to substance

EXP

MLH1 protein affects the susceptibility to Carmustine

NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896

G

melanophilin

affects response to substance

EXP

MLPH mRNA affects the susceptibility to Carmustine

NCBI chr 2:237,486,410...237,555,322
Ensembl chr 2:237,485,428...237,555,322

G

N-methylpurine DNA glycosylase

decreases response to substance

EXP

MPG protein results in decreased susceptibility to Carmustine

NCBI chr16:77,007...85,846
Ensembl chr16:77,007...85,851

G

mercaptopyruvate sulfurtransferase

affects response to substance

EXP

MPST mRNA affects the susceptibility to Carmustine

NCBI chr22:37,019,742...37,029,815
Ensembl chr22:37,019,635...37,029,821

G

mutS homolog 2

affects response to substance

EXP

MSH2 protein affects the susceptibility to Carmustine

NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146

G

macrophage scavenger receptor 1

decreases expression

EXP

Carmustine results in decreased expression of MSR1 mRNA

NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490

G

metallothionein 1F

affects response to substance

EXP

MT1F mRNA affects the susceptibility to Carmustine

NCBI chr16:56,657,959...56,659,303
Ensembl chr16:56,657,731...56,660,698

G

metallothionein 1X

affects response to substance

EXP

MT1X mRNA affects the susceptibility to Carmustine

NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196

G

metallothionein 2A

affects response to substance
multiple interactions

EXP
ISO

MT2A mRNA affects the susceptibility to Carmustine
MT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; MT2 protein inhibits the reaction [Carmustine results in increased expression of TNF protein]
MT2 protein affects the susceptibility to Carmustine

PMID:16365179 PMID:18528683

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

maturin, neural progenitor differentiation regulator homolog

affects response to substance

EXP

MTURN mRNA affects the susceptibility to Carmustine

NCBI chr 7:30,134,986...30,162,762
Ensembl chr 7:30,134,986...30,162,765

G

mucin 2, oligomeric mucus/gel-forming

decreases expression

EXP

Carmustine results in decreased expression of MUC2 mRNA

NCBI chr11:1,074,874...1,110,508
Ensembl chr11:1,074,875...1,110,511

G

mevalonate diphosphate decarboxylase

decreases expression

EXP

Carmustine results in decreased expression of MVD mRNA

NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161

G

MYB proto-oncogene like 2

increases expression

ISO

Carmustine results in increased expression of MYBL2 mRNA

NCBI chr20:43,667,114...43,716,482
Ensembl chr20:43,667,019...43,716,495

G

myosin binding protein H

decreases expression

EXP

Carmustine results in decreased expression of MYBPH mRNA

NCBI chr 1:203,167,811...203,179,214
Ensembl chr 1:203,167,811...203,175,826

G

MYD88 innate immune signal transduction adaptor

decreases expression

EXP

Carmustine results in decreased expression of MYD88 mRNA

NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024

G

myogenic differentiation 1

decreases expression

EXP

Carmustine results in decreased expression of MYOD1 mRNA

NCBI chr11:17,719,571...17,722,136
Ensembl chr11:17,719,571...17,722,136

G

myogenin

decreases expression

EXP

Carmustine results in decreased expression of MYOG mRNA

NCBI chr 1:203,083,129...203,086,012
Ensembl chr 1:203,083,129...203,086,012

G

NBL1, DAN family BMP antagonist

affects response to substance

EXP

NBL1 mRNA affects the susceptibility to Carmustine

NCBI chr 1:19,643,229...19,658,452
Ensembl chr 1:19,596,979...19,658,456

G

NADH:ubiquinone oxidoreductase subunit C1

decreases expression

EXP

Carmustine results in decreased expression of NDUFC1 mRNA

NCBI chr 4:139,289,917...139,302,551
Ensembl chr 4:139,266,880...139,302,551

G

NIMA related kinase 6

increases expression

ISO

Carmustine results in increased expression of NEK6 mRNA

NCBI chr 9:124,257,606...124,353,307
Ensembl chr 9:124,257,606...124,353,307

G

nestin

increases expression
multiple interactions

ISO

Carmustine results in increased expression of NES protein
Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]

NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407

G

nuclear factor of activated T cells 5

affects response to substance

EXP

NFAT5 mRNA affects the susceptibility to Carmustine

NCBI chr16:69,565,966...69,704,654
Ensembl chr16:69,565,094...69,704,666

G

NFE2 like bZIP transcription factor 2

affects response to substance

ISO

[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Carmustine

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor I B

affects response to substance

EXP

NFIB mRNA affects the susceptibility to Carmustine

NCBI chr 9:14,081,843...14,532,077
Ensembl chr 9:14,081,843...14,398,983

G

nuclear factor I X

affects response to substance

EXP

NFIX mRNA affects the susceptibility to Carmustine

NCBI chr19:12,995,475...13,098,796
Ensembl chr19:12,995,475...13,098,796

G

nuclear factor kappa B subunit 1

multiple interactions

EXP
ISO

Carmustine results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]]
Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carmustine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to NFKB1 protein]; [Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:11970852 PMID:12433058 PMID:12477282 PMID:12675310

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor alpha

multiple interactions
increases response to substance

EXP
ISO

NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]]
Carmustine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Carmustine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
NFKBIA gene mutant form results in increased susceptibility to Carmustine; NFKBIA mRNA results in increased susceptibility to Carmustine

PMID:11970852 PMID:12433058 PMID:12675310 PMID:16365179

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

neuronal guanine nucleotide exchange factor

decreases expression

ISO

Carmustine results in decreased expression of NGEF mRNA

NCBI chr 2:232,878,701...233,013,256
Ensembl chr 2:232,878,701...233,013,256

G

nerve growth factor

affects activity

ISO

Carmustine affects the activity of NGF protein

NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770

G

nidogen 2

decreases expression

ISO

Carmustine results in decreased expression of NID2 mRNA

NCBI chr14:52,004,809...52,069,059
Ensembl chr14:52,004,809...52,069,059

G

ninein

affects response to substance

EXP

NIN mRNA affects the susceptibility to Carmustine

NCBI chr14:50,719,763...50,831,503
Ensembl chr14:50,719,763...50,831,162

G

NKD inhibitor of WNT signaling pathway 2

affects response to substance

EXP

NKD2 mRNA affects the susceptibility to Carmustine

NCBI chr 5:1,008,802...1,038,943
Ensembl chr 5:1,008,802...1,038,943

G

NK2 homeobox 2

decreases expression

EXP

Carmustine results in decreased expression of NKX2-2 mRNA

NCBI chr20:21,511,017...21,522,689
Ensembl chr20:21,511,017...21,514,064

G

nitric oxide synthase 2

multiple interactions
decreases response to substance

EXP
ISO

[NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine
NOS2 protein results in decreased susceptibility to Carmustine
[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]

PMID:7532384 PMID:15110396 PMID:15965067

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

notch 2 N-terminal like A

affects response to substance

EXP

NOTCH2NLA mRNA affects the susceptibility to Carmustine

NCBI chr 1:146,148,865...146,229,021
Ensembl chr 1:146,146,203...146,229,041

G

neuronal PAS domain protein 1

decreases expression

EXP

Carmustine results in decreased expression of NPAS1 mRNA

NCBI chr19:47,019,837...47,045,775
Ensembl chr19:47,019,837...47,045,775

G

neuronal PAS domain protein 2

affects response to substance

EXP

NPAS2 mRNA affects the susceptibility to Carmustine

NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829

G

neuropeptides B and W receptor 2

decreases expression

EXP

Carmustine results in decreased expression of NPBWR2 mRNA

NCBI chr20:64,103,802...64,107,565
Ensembl chr20:64,103,802...64,107,565

G

N-acetylneuraminate pyruvate lyase

affects response to substance

EXP

NPL mRNA affects the susceptibility to Carmustine

NCBI chr 1:182,789,773...182,830,384
Ensembl chr 1:182,789,293...182,830,384

G

natriuretic peptide receptor 1

decreases expression

ISO

Carmustine results in decreased expression of NPR1 mRNA

NCBI chr 1:153,678,688...153,693,992
Ensembl chr 1:153,678,688...153,693,992

G

nuclear receptor subfamily 2 group F member 1

affects response to substance

EXP

NR2F1 mRNA affects the susceptibility to Carmustine

NCBI chr 5:93,583,222...93,594,611
Ensembl chr 5:93,583,222...93,594,611

G

nuclear receptor subfamily 4 group A member 2

affects expression

ISO

Carmustine affects the expression of NR4A2 mRNA

NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348

G

neurturin

decreases expression

EXP

Carmustine results in decreased expression of NRTN mRNA

NCBI chr19:5,805,067...5,828,324
Ensembl chr19:5,805,067...5,828,324

G

8-oxoguanine DNA glycosylase

decreases response to substance

EXP

OGG1 protein results in decreased susceptibility to Carmustine

PMID:11181913 PMID:11741815

NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219

G

olfactory marker protein

decreases expression

EXP

Carmustine results in decreased expression of OMP mRNA

NCBI chr11:77,102,840...77,103,331
Ensembl chr11:77,102,840...77,103,331

G

orosomucoid 1

increases expression

ISO

Carmustine results in increased expression of ORM1 mRNA

NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479

G

prolyl 3-hydroxylase 3

affects response to substance

EXP

P3H3 mRNA affects the susceptibility to Carmustine

NCBI chr12:6,828,407...6,839,847
Ensembl chr12:6,828,407...6,839,847

G

progestagen associated endometrial protein

decreases expression

EXP

Carmustine results in decreased expression of PAEP mRNA

NCBI chr 9:135,561,756...135,566,955
Ensembl chr 9:135,561,756...135,566,955

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases cleavage

EXP

Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein]

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

paired box 8

decreases expression

EXP

Carmustine results in decreased expression of PAX8 mRNA

NCBI chr 2:113,215,997...113,278,921
Ensembl chr 2:113,215,997...113,278,921

G

PBX homeobox 2

decreases expression

EXP

Carmustine results in decreased expression of PBX2 mRNA

NCBI chr 6:32,184,733...32,190,202
Ensembl chr 6:32,184,733...32,190,202

G

pterin-4 alpha-carbinolamine dehydratase 1

decreases expression

EXP

Carmustine results in decreased expression of PCBD1 mRNA

NCBI chr10:70,882,280...70,888,565
Ensembl chr10:70,882,280...70,888,565

G

protocadherin beta 2

affects response to substance

EXP

PCDHB2 mRNA affects the susceptibility to Carmustine

NCBI chr 5:141,094,615...141,098,703
Ensembl chr 5:141,094,606...141,098,703

G

protocadherin gamma subfamily C, 3

decreases expression

EXP

Carmustine results in decreased expression of PCDHGC3 mRNA

NCBI chr 5:141,475,966...141,512,975
Ensembl chr 5:141,475,947...141,512,977

G

procollagen C-endopeptidase enhancer

decreases expression

EXP

Carmustine results in decreased expression of PCOLCE mRNA

NCBI chr 7:100,602,363...100,608,175
Ensembl chr 7:100,602,363...100,608,175

G

phosphate cytidylyltransferase 1A, choline

decreases expression

EXP

Carmustine results in decreased expression of PCYT1A mRNA

NCBI chr 3:196,234,368...196,287,726
Ensembl chr 3:196,214,222...196,287,957

G

phosphodiesterase 5A

affects response to substance

EXP

PDE5A mRNA affects the susceptibility to Carmustine

NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804

G

platelet derived growth factor subunit B

increases expression

EXP

Carmustine results in increased expression of PDGFB protein

NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

decreases expression

EXP

Carmustine results in decreased expression of PFKFB2 mRNA

NCBI chr 1:207,034,416...207,081,027
Ensembl chr 1:207,034,366...207,081,024

G

phosphofructokinase, muscle

decreases expression

EXP

Carmustine results in decreased expression of PFKM mRNA

NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404

G

profilin 1

decreases expression

EXP

Carmustine results in decreased expression of PFN1 mRNA

NCBI chr17:4,945,652...4,948,530
Ensembl chr17:4,945,652...4,949,061

G

phosphoglucomutase 2

affects response to substance

EXP

PGM2 mRNA affects the susceptibility to Carmustine

NCBI chr 4:37,826,686...37,862,937
Ensembl chr 4:37,826,660...37,862,937

G

polyhomeotic homolog 2

affects response to substance

EXP

PHC2 mRNA affects the susceptibility to Carmustine

NCBI chr 1:33,323,626...33,431,095
Ensembl chr 1:33,323,623...33,431,095

G

pleckstrin homology like domain family A member 1

affects response to substance

EXP

PHLDA1 mRNA affects the susceptibility to Carmustine

NCBI chr12:76,025,447...76,031,776
Ensembl chr12:76,025,447...76,031,776

G

phosphatidylinositol 3-kinase catalytic subunit type 3

affects response to substance

EXP

PIK3C3 mRNA affects the susceptibility to Carmustine

NCBI chr18:41,955,234...42,087,830
Ensembl chr18:41,955,234...42,087,830

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

affects response to substance

EXP

PIK3CD mRNA affects the susceptibility to Carmustine

NCBI chr 1:9,627,258...9,729,114
Ensembl chr 1:9,629,889...9,729,114

G

phosphoinositide-3-kinase regulatory subunit 3

increases expression

EXP

Carmustine results in increased expression of PIK3R3 mRNA

NCBI chr 1:46,040,140...46,174,901
Ensembl chr 1:46,040,140...46,133,036

G

phosphatidylinositol transfer protein cytoplasmic 1

affects response to substance

EXP

PITPNC1 mRNA affects the susceptibility to Carmustine

NCBI chr17:67,377,281...67,697,256
Ensembl chr17:67,377,281...67,697,256

G

PBX/knotted 1 homeobox 2

decreases expression

ISO

Carmustine results in decreased expression of PKNOX2 mRNA

NCBI chr11:125,164,751...125,433,389
Ensembl chr11:125,164,687...125,433,389

G

plakophilin 2

increases expression

ISO

Carmustine results in increased expression of PKP2 mRNA

NCBI chr12:32,790,755...32,896,777
Ensembl chr12:32,790,745...32,896,798

G

plakophilin 3

affects response to substance

EXP

PKP3 mRNA affects the susceptibility to Carmustine

NCBI chr11:392,596...404,908
Ensembl chr11:392,614...404,908

G

pleckstrin homology and RhoGEF domain containing G5

affects response to substance

EXP

PLEKHG5 mRNA affects the susceptibility to Carmustine

NCBI chr 1:6,467,122...6,520,092
Ensembl chr 1:6,467,122...6,520,074

G

patatin like phospholipase domain containing 2

increases expression

ISO

Carmustine results in increased expression of PNPLA2 mRNA

NCBI chr11:818,914...825,573
Ensembl chr11:818,914...825,573

G

DNA polymerase gamma 2, accessory subunit

affects response to substance

EXP

POLG2 mRNA affects the susceptibility to Carmustine

NCBI chr17:64,477,785...64,497,054
Ensembl chr17:64,477,785...64,497,054

G

DNA polymerase eta

multiple interactions

EXP

[Carmustine co-treated with MDM4 protein] results in increased expression of POLH protein

NCBI chr 6:43,576,185...43,620,523
Ensembl chr 6:43,576,185...43,620,523

G

RNA polymerase II, I and III subunit E

decreases expression

EXP

Carmustine results in decreased expression of POLR2E mRNA

NCBI chr19:1,086,574...1,095,375
Ensembl chr19:1,086,574...1,095,380

G

popeye domain cAMP effector 3

affects response to substance

EXP

POPDC3 mRNA affects the susceptibility to Carmustine

NCBI chr 6:105,157,900...105,180,014
Ensembl chr 6:105,157,900...105,180,014

G

protein phosphatase, Mg2+/Mn2+ dependent 1G

decreases expression

EXP

Carmustine results in decreased expression of PPM1G mRNA

NCBI chr 2:27,381,199...27,409,591
Ensembl chr 2:27,381,195...27,409,591

G

protein regulator of cytokinesis 1

decreases expression

EXP

Carmustine results in decreased expression of PRC1 mRNA

NCBI chr15:90,966,040...90,994,535
Ensembl chr15:90,966,040...90,995,629

G

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

affects response to substance

EXP

PREX1 mRNA affects the susceptibility to Carmustine

NCBI chr20:48,624,252...48,888,185
Ensembl chr20:48,624,252...48,827,999

G

protein kinase AMP-activated catalytic subunit alpha 2

affects response to substance

EXP

PRKAA2 mRNA affects the susceptibility to Carmustine

NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335

G

prolactin

decreases expression

EXP

Carmustine results in decreased expression of PRL mRNA

NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826

G

protamine 2

decreases expression

EXP

Carmustine results in decreased expression of PRM2 mRNA

NCBI chr16:11,275,639...11,276,480
Ensembl chr16:11,275,639...11,276,480

G

peripherin

decreases expression

ISO

Carmustine results in decreased expression of PRPH mRNA

NCBI chr12:49,295,147...49,298,686
Ensembl chr12:49,295,147...49,298,686

G

paired related homeobox 2

affects response to substance

EXP

PRRX2 mRNA affects the susceptibility to Carmustine

NCBI chr 9:129,665,647...129,722,674
Ensembl chr 9:129,665,647...129,722,674

G

serine protease 12

affects response to substance

EXP

PRSS12 mRNA affects the susceptibility to Carmustine

NCBI chr 4:118,280,038...118,353,003
Ensembl chr 4:118,280,038...118,353,003

G

parathyroid hormone 2 receptor

decreases expression

ISO

Carmustine results in decreased expression of PTH2R mRNA

NCBI chr 2:208,359,692...208,494,506
Ensembl chr 2:208,359,714...208,854,503

G

protein tyrosine phosphatase non-receptor type 3

decreases expression

EXP

Carmustine results in decreased expression of PTPN3 mRNA

NCBI chr 9:109,375,694...109,538,420
Ensembl chr 9:109,375,466...109,498,313

G

PZP alpha-2-macroglobulin like

decreases expression

EXP

Carmustine results in decreased expression of PZP mRNA

NCBI chr12:9,136,472...9,208,395
Ensembl chr12:9,148,840...9,208,395

G

glutaminyl-peptide cyclotransferase

affects response to substance

EXP

QPCT mRNA affects the susceptibility to Carmustine

NCBI chr 2:37,344,630...37,373,322
Ensembl chr 2:37,342,827...37,373,322

G

RAB27B, member RAS oncogene family

affects response to substance

EXP

RAB27B mRNA affects the susceptibility to Carmustine

NCBI chr18:54,717,857...54,895,516
Ensembl chr18:54,717,860...54,895,516

G

RAD23 homolog A, nucleotide excision repair protein

decreases expression

EXP

Carmustine results in decreased expression of RAD23A mRNA

NCBI chr19:12,945,862...12,953,642
Ensembl chr19:12,945,855...12,953,642

G

RAD51 recombinase

decreases expression

EXP

Carmustine results in decreased expression of RAD51 mRNA

NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340

G

RAD9 checkpoint clamp component A

decreases expression

EXP

Carmustine results in decreased expression of RAD9A mRNA

NCBI chr11:67,391,986...67,398,412
Ensembl chr11:67,317,871...67,398,410

G

RNA binding motif protein 19

affects response to substance

EXP

RBM19 mRNA affects the susceptibility to Carmustine

NCBI chr12:113,816,740...113,966,325
Ensembl chr12:113,816,738...113,966,325

G

reticulocalbin 1

decreases expression

EXP

Carmustine results in decreased expression of RCN1 mRNA

NCBI chr11:32,091,074...32,105,722
Ensembl chr11:32,091,074...32,105,722

G

REL proto-oncogene, NF-kB subunit

multiple interactions

ISO

Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]

PMID:11970852 PMID:12433058

NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]]
Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Carmustine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:11970852 PMID:12433058 PMID:12477282 PMID:12675310

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

ISO

Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of RELB protein]

PMID:11970852 PMID:12433058

NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,461...45,038,192

G

replication factor C subunit 3

decreases expression

ISO

Carmustine results in decreased expression of RFC3 mRNA

NCBI chr13:33,818,149...33,977,377
Ensembl chr13:33,818,069...33,966,558

G

regulator of cell cycle

affects response to substance

EXP

RGCC mRNA affects the susceptibility to Carmustine

NCBI chr13:41,457,550...41,470,871
Ensembl chr13:41,457,550...41,470,871

G

RGP1 homolog, RAB6A GEF complex partner 1

affects response to substance

EXP

RGP1 mRNA affects the susceptibility to Carmustine

NCBI chr 9:35,749,287...35,790,428
Ensembl chr 9:35,749,287...35,758,585

G

retinal G protein coupled receptor

decreases expression

EXP

Carmustine results in decreased expression of RGR mRNA

NCBI chr10:84,245,053...84,259,960
Ensembl chr10:84,230,666...84,259,960

G

Rho related BTB domain containing 3

affects response to substance

EXP

RHOBTB3 mRNA affects the susceptibility to Carmustine

NCBI chr 5:95,717,624...95,796,361
Ensembl chr 5:95,713,522...95,824,383

G

Ras like without CAAX 2

decreases expression

EXP

Carmustine results in decreased expression of RIT2 mRNA

NCBI chr18:42,743,227...43,115,685
Ensembl chr18:42,743,227...43,115,691

G

ribonuclease A family member 4

increases expression

EXP

Carmustine results in increased expression of RNASE4 mRNA

NCBI chr14:20,684,560...20,701,216
Ensembl chr14:20,684,560...20,701,216

G

RAR related orphan receptor B

affects expression

ISO

Carmustine affects the expression of RORB mRNA

NCBI chr 9:74,497,335...74,693,177
Ensembl chr 9:74,497,335...74,693,177

G

sphingosine-1-phosphate receptor 3

affects response to substance

EXP

S1PR3 mRNA affects the susceptibility to Carmustine

NCBI chr 9:88,990,863...89,005,155
Ensembl chr 9:88,990,863...89,005,155

G

spermidine/spermine N1-acetyltransferase 1

affects response to substance

EXP

SAT1 mRNA affects the susceptibility to Carmustine

NCBI chr X:23,783,173...23,786,210
Ensembl chr X:23,783,173...23,786,210

G

secretory carrier membrane protein 5

affects response to substance

EXP

SCAMP5 mRNA affects the susceptibility to Carmustine

NCBI chr15:74,995,563...75,021,495
Ensembl chr15:74,957,219...75,021,495

G

sodium voltage-gated channel beta subunit 1

increases expression

ISO

Carmustine results in increased expression of SCN1B mRNA

NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449

G

sodium voltage-gated channel alpha subunit 8

affects response to substance

EXP

SCN8A mRNA affects the susceptibility to Carmustine

NCBI chr12:51,591,233...51,812,864
Ensembl chr12:51,590,266...51,812,864

G

syndecan 1

affects response to substance

EXP

SDC1 mRNA affects the susceptibility to Carmustine

NCBI chr 2:20,200,797...20,225,475
Ensembl chr 2:20,200,797...20,225,433

G

semaphorin 3A

affects response to substance

EXP

SEMA3A mRNA affects the susceptibility to Carmustine

NCBI chr 7:83,955,777...84,492,725
Ensembl chr 7:83,955,777...84,492,724

G

septin 4

decreases expression

ISO

Carmustine results in decreased expression of SEPTIN4 mRNA

NCBI chr17:58,520,256...58,544,328
Ensembl chr17:58,520,250...58,544,368

G

septin 5

decreases expression

EXP

Carmustine results in decreased expression of SEPTIN5 mRNA

NCBI chr22:19,714,503...19,723,319
Ensembl chr22:19,714,503...19,724,224

G

serpin family B member 1

affects response to substance

EXP

SERPINB1 mRNA affects the susceptibility to Carmustine

NCBI chr 6:2,832,332...2,841,863
Ensembl chr 6:2,832,332...2,841,959

G

splicing factor 1

affects response to substance

EXP

SF1 mRNA affects the susceptibility to Carmustine

NCBI chr11:64,764,606...64,778,542
Ensembl chr11:64,764,606...64,778,786

G

splicing factor proline and glutamine rich

decreases expression

EXP

Carmustine results in decreased expression of SFPQ mRNA

NCBI chr 1:35,176,380...35,193,145
Ensembl chr 1:35,176,378...35,193,446

G

sarcoglycan alpha

decreases expression

EXP

Carmustine results in decreased expression of SGCA mRNA

NCBI chr17:50,166,005...50,175,928
Ensembl chr17:50,164,214...50,175,928

G

serine hydroxymethyltransferase 2

decreases expression

EXP

Carmustine results in decreased expression of SHMT2 mRNA

NCBI chr12:57,229,711...57,234,935
Ensembl chr12:57,229,573...57,234,935

G

SHOX homeobox

decreases expression

EXP

Carmustine results in decreased expression of SHOX mRNA

NCBI chr  Y:624,344...659,411
NCBI chr  X:624,344...659,411
Ensembl chr  Y:624,344...659,411
Ensembl chr  X:624,344...659,411

G

solute carrier family 10 member 1

increases expression

EXP

Carmustine results in increased expression of SLC10A1 mRNA

NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241

G

solute carrier family 12 member 1

decreases expression

ISO

Carmustine results in decreased expression of SLC12A1 mRNA

NCBI chr15:48,206,302...48,304,078
Ensembl chr15:48,178,438...48,304,078

G

solute carrier family 12 member 2

increases expression

ISO

Carmustine results in increased expression of SLC12A2 mRNA

NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677

G

solute carrier family 14 member 1 (Kidd blood group)

affects response to substance

EXP

SLC14A1 mRNA affects the susceptibility to Carmustine

NCBI chr18:45,724,181...45,752,520
Ensembl chr18:45,687,025...45,752,520

G

solute carrier family 15 member 2

affects response to substance

EXP

SLC15A2 mRNA affects the susceptibility to Carmustine

NCBI chr 3:121,894,401...121,944,188
Ensembl chr 3:121,894,401...121,944,188

G

solute carrier family 16 member 2

increases expression

EXP

Carmustine results in increased expression of SLC16A2 mRNA

NCBI chr X:74,421,493...74,533,916
Ensembl chr X:74,421,493...74,533,917

G

solute carrier family 19 member 2

decreases expression

ISO

Carmustine results in decreased expression of SLC19A2 mRNA

NCBI chr 1:169,463,909...169,485,970
Ensembl chr 1:169,463,909...169,485,944

G

solute carrier family 22 member 5

affects response to substance

EXP

SLC22A5 mRNA affects the susceptibility to Carmustine

NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613

G

solute carrier family 30 member 3

decreases expression

EXP

Carmustine results in decreased expression of SLC30A3 mRNA

NCBI chr 2:27,253,684...27,275,817
Ensembl chr 2:27,253,684...27,275,817

G

solute carrier family 3 member 2

increases expression

ISO

Carmustine results in increased expression of SLC3A2 mRNA

NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880

G

solute carrier family 6 member 2

increases expression

EXP

Carmustine results in increased expression of SLC6A2 mRNA

NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645

G

solute carrier organic anion transporter family member 1A2

decreases expression

EXP

Carmustine results in decreased expression of SLCO1A2 mRNA

NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594

G

secretory leukocyte peptidase inhibitor

affects response to substance

EXP

SLPI mRNA affects the susceptibility to Carmustine

NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564

G

SWI/SNF related BAF chromatin remodeling complex subunit D1

increases expression

EXP

Carmustine results in increased expression of SMARCD1 mRNA

NCBI chr12:50,085,342...50,100,707
Ensembl chr12:50,085,200...50,100,707

G

sphingomyelin phosphodiesterase 2

increases expression

EXP

Carmustine results in increased expression of SMPD2 mRNA

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,724...109,443,919

G

small nuclear RNA activating complex polypeptide 1

increases expression

EXP

Carmustine results in increased expression of SNAPC1 mRNA

NCBI chr14:61,762,420...61,796,428
Ensembl chr14:61,762,420...61,796,428

G

small nuclear RNA activating complex polypeptide 3

increases expression

EXP

Carmustine results in increased expression of SNAPC3 mRNA

NCBI chr 9:15,422,876...15,466,735
Ensembl chr 9:15,422,734...15,465,953

G

synuclein gamma

increases expression

EXP

Carmustine results in increased expression of SNCG mRNA

NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258

G

small nuclear ribonucleoprotein polypeptide B2

increases expression

EXP

Carmustine results in increased expression of SNRPB2 mRNA

NCBI chr20:16,730,026...16,742,564
Ensembl chr20:16,729,961...16,742,564

G

suppressor of cytokine signaling 1

decreases expression

EXP

Carmustine results in decreased expression of SOCS1 mRNA

NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204

G

superoxide dismutase 1

decreases activity

EXP

Carmustine results in decreased activity of SOD1 protein

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

superoxide dismutase 2

affects response to substance
increases response to substance
multiple interactions
decreases activity

EXP

SOD2 mRNA affects the susceptibility to Carmustine
SOD2 protein results in increased susceptibility to Carmustine
Pyruvates inhibits the reaction [SOD2 protein results in increased susceptibility to Carmustine]
Carmustine results in decreased activity of SOD2 protein

PMID:8877099 PMID:16365179 PMID:19856331

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

sorbin and SH3 domain containing 2

decreases expression

EXP

Carmustine results in decreased expression of SORBS2 mRNA

NCBI chr 4:185,585,523...185,956,372
Ensembl chr 4:185,585,444...185,956,652

G

SRY-box transcription factor 9

affects response to substance

EXP

SOX9 mRNA affects the susceptibility to Carmustine

NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416

G

secreted protein acidic and cysteine rich

affects response to substance

EXP

SPARC mRNA affects the susceptibility to Carmustine

NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975

G

spermatogenesis associated 12

affects response to substance

EXP

SPATA12 mRNA affects the susceptibility to Carmustine

NCBI chr 3:57,060,664...57,075,432
Ensembl chr 3:57,060,664...57,075,432

G

striated muscle enriched protein kinase

decreases expression

EXP

Carmustine results in decreased expression of SPEG mRNA

NCBI chr 2:219,434,843...219,493,629
Ensembl chr 2:219,434,843...219,493,629

G

spen family transcriptional repressor

affects response to substance

EXP

SPEN mRNA affects the susceptibility to Carmustine

NCBI chr 1:15,847,707...15,940,456
Ensembl chr 1:15,836,095...15,940,456

G

small proline rich protein 2B

decreases expression

EXP

Carmustine results in decreased expression of SPRR2B mRNA

NCBI chr 1:153,070,226...153,087,799
Ensembl chr 1:153,070,226...153,071,611

G

squalene epoxidase

affects response to substance

EXP

SQLE mRNA affects the susceptibility to Carmustine

NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283

G

signal recognition particle 14

decreases expression

EXP

Carmustine results in decreased expression of SRP14 mRNA

NCBI chr15:40,035,690...40,039,202
Ensembl chr15:40,035,690...40,039,181

G

sex determining region Y

decreases expression

EXP

Carmustine results in decreased expression of SRY mRNA

NCBI chr Y:2,786,855...2,787,682
Ensembl chr Y:2,786,855...2,787,682

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

affects response to substance

EXP

ST3GAL1 mRNA affects the susceptibility to Carmustine

NCBI chr 8:133,454,848...133,571,887
Ensembl chr 8:133,454,848...133,571,926

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

increases expression

EXP

Carmustine results in increased expression of ST6GAL1 mRNA

NCBI chr 3:186,930,526...187,078,553
Ensembl chr 3:186,930,325...187,078,553

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

increases expression

EXP

Carmustine results in increased expression of ST8SIA1 mRNA

NCBI chr12:22,193,391...22,334,707
Ensembl chr12:22,063,773...22,437,041

G

signal transducing adaptor molecule

decreases expression

EXP

Carmustine results in decreased expression of STAM mRNA

NCBI chr10:17,644,151...17,716,824
Ensembl chr10:17,644,151...17,716,824

G

stanniocalcin 1

affects response to substance

EXP

STC1 mRNA affects the susceptibility to Carmustine

NCBI chr 8:23,841,929...23,854,806
Ensembl chr 8:23,841,929...23,854,806

G

stathmin 1

affects response to substance

EXP

STMN1 mRNA affects the susceptibility to Carmustine

NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991

G

steroid sulfatase

increases expression

EXP

Carmustine results in increased expression of STS mRNA

NCBI chr X:7,147,290...7,354,641
Ensembl chr X:7,147,237...7,804,358

G

syntaxin 1B

decreases expression

EXP

Carmustine results in decreased expression of STX1B mRNA

NCBI chr16:30,989,256...31,010,638
Ensembl chr16:30,989,256...31,010,638

G

syntaxin binding protein 2

decreases expression

EXP

Carmustine results in decreased expression of STXBP2 mRNA

NCBI chr19:7,629,793...7,647,873
Ensembl chr19:7,636,772...7,647,873

G

syntaxin binding protein 6

affects response to substance

EXP

STXBP6 mRNA affects the susceptibility to Carmustine

NCBI chr14:24,809,454...25,050,147
Ensembl chr14:24,809,454...25,050,147

G

synaptopodin 2

affects response to substance

EXP

SYNPO2 mRNA affects the susceptibility to Carmustine

NCBI chr 4:118,850,681...119,061,247
Ensembl chr 4:118,850,688...119,061,247

G

synaptophysin

multiple interactions
decreases expression

ISO

Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]

NCBI chr X:49,187,815...49,200,193
Ensembl chr X:49,187,815...49,200,218

G

tachykinin precursor 1

decreases expression

EXP

Carmustine results in decreased expression of TAC1 mRNA

NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472

G

transgelin

affects response to substance

EXP

TAGLN mRNA affects the susceptibility to Carmustine

NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464

G

T-box transcription factor 3

affects response to substance

EXP

TBX3 mRNA affects the susceptibility to Carmustine

NCBI chr12:114,670,255...114,684,175
Ensembl chr12:114,670,255...114,684,175

G

transcription factor 21

decreases expression

EXP

Carmustine results in decreased expression of TCF21 mRNA

NCBI chr 6:133,889,113...133,895,537
Ensembl chr 6:133,889,113...133,895,553

G

transcriptional and immune response regulator

increases response to substance

EXP

TCIM mRNA results in increased susceptibility to Carmustine

NCBI chr 8:40,153,482...40,155,310
Ensembl chr 8:40,153,482...40,155,310

G

testis development related protein

affects response to substance

EXP

TDRP mRNA affects the susceptibility to Carmustine

NCBI chr 8:489,946...545,780
Ensembl chr 8:489,803...545,781

G

telomerase reverse transcriptase

decreases response to substance

EXP

TERT protein mutant form results in decreased susceptibility to Carmustine

NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068

G

transcription factor AP-2 gamma

affects response to substance

EXP

TFAP2C mRNA affects the susceptibility to Carmustine

NCBI chr20:56,629,306...56,639,283
Ensembl chr20:56,629,306...56,639,283

G

transcription factor Dp-1

affects response to substance

EXP

TFDP1 mRNA affects the susceptibility to Carmustine

NCBI chr13:113,584,688...113,641,473
Ensembl chr13:113,584,721...113,641,473

G

tissue factor pathway inhibitor 2

affects response to substance

EXP

TFPI2 mRNA affects the susceptibility to Carmustine

NCBI chr 7:93,885,396...93,890,753
Ensembl chr 7:93,885,396...93,890,753

G

transforming growth factor beta 1

multiple interactions
decreases expression

ISO

Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

tyrosine hydroxylase

increases activity
increases expression

ISO

Carmustine results in increased activity of TH protein
Carmustine results in increased expression of TH mRNA; Carmustine results in increased expression of TH protein

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

thrombomodulin

affects response to substance

EXP

THBD mRNA affects the susceptibility to Carmustine

NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672

G

TLE family member 3, transcriptional corepressor

decreases expression

EXP

Carmustine results in decreased expression of TLE3 mRNA

NCBI chr15:70,047,790...70,097,917
Ensembl chr15:70,047,790...70,098,176

G

transmembrane BAX inhibitor motif containing 6

decreases expression
increases expression

EXP

Carmustine results in decreased expression of TEGT mRNA
Carmustine results in increased expression of TEGT mRNA

NCBI chr12:49,741,557...49,764,934
Ensembl chr12:49,707,725...49,764,934

G

transmembrane protein 158

affects response to substance

EXP

TMEM158 mRNA affects the susceptibility to Carmustine

NCBI chr 3:45,224,466...45,226,287
Ensembl chr 3:45,224,466...45,226,287

G

transmembrane protein 19

affects response to substance

EXP

TMEM19 mRNA affects the susceptibility to Carmustine

NCBI chr12:71,686,082...71,705,047
Ensembl chr12:71,686,082...71,705,047

G

transmembrane serine protease 15

affects response to substance

EXP

TMPRSS15 mRNA affects the susceptibility to Carmustine

NCBI chr21:18,269,116...18,485,884
Ensembl chr21:18,269,116...18,485,879

G

tenascin C

affects response to substance

EXP

TNC mRNA affects the susceptibility to Carmustine

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

tumor necrosis factor

multiple interactions
increases expression

ISO

[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Carmustine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MT2 protein inhibits the reaction [Carmustine results in increased expression of TNF protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Zinc Sulfate inhibits the reaction [Carmustine results in increased expression of TNF protein]
Carmustine promotes the reaction [Oligodeoxyribonucleotides analog results in increased secretion of TNF protein]

PMID:7532384 PMID:11970852 PMID:12433058 PMID:12477282 PMID:18528683 More...

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF alpha induced protein 3

increases response to substance

EXP

TNFAIP3 mRNA results in increased susceptibility to Carmustine

NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314

G

TNF receptor superfamily member 11b

decreases expression

EXP

Carmustine results in decreased expression of TNFRSF11B mRNA

NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885

G

TNF receptor superfamily member 19

affects response to substance

EXP

TNFRSF19 mRNA affects the susceptibility to Carmustine

NCBI chr13:23,570,412...23,676,093
Ensembl chr13:23,570,370...23,676,104

G

TNF superfamily member 10

affects response to substance

EXP

TNFSF10 mRNA affects the susceptibility to Carmustine

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

tumor protein p53

multiple interactions
increases expression
increases response to substance
decreases response to substance
affects response to substance

EXP

[Carmustine co-treated with O(6)-benzylguanine] results in increased expression of TP53 protein; MDM4 protein promotes the reaction [Carmustine results in increased expression of TP53 protein]
TP53 results in increased susceptibility to Carmustine
TP53 protein results in decreased susceptibility to Carmustine
TP53 protein modified form affects the susceptibility to Carmustine

PMID:10455409 PMID:11861384 PMID:15735757 PMID:16193384 PMID:18632648 More...

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

TPD52 like 1

affects response to substance

EXP

TPD52L1 mRNA affects the susceptibility to Carmustine

NCBI chr 6:125,153,773...125,264,407
Ensembl chr 6:125,119,049...125,264,407

G

TNF receptor associated factor 1

decreases expression

EXP

Carmustine results in decreased expression of TRAF1 mRNA

NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173

G

three prime repair exonuclease 1

increases expression

EXP

Carmustine results in increased expression of TREX1 mRNA

NCBI chr 3:48,465,830...48,467,645
Ensembl chr 3:48,465,811...48,467,645

G

tripartite motif containing 50

affects response to substance

EXP

TRIM50 mRNA affects the susceptibility to Carmustine

NCBI chr 7:73,312,536...73,328,082
Ensembl chr 7:73,312,536...73,328,082

G

tetraspanin 4

decreases expression

EXP

Carmustine results in decreased expression of TSPAN4 mRNA

NCBI chr11:842,852...867,111
Ensembl chr11:842,812...867,116

G

tubulin beta class I

increases expression

EXP

Carmustine results in increased expression of TUBB mRNA

NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538

G

tubulin gamma 1

decreases expression

EXP

Carmustine results in decreased expression of TUBG1 mRNA

NCBI chr17:42,609,683...42,615,238
Ensembl chr17:42,609,641...42,615,238

G

Tu translation elongation factor, mitochondrial

affects response to substance

EXP

TUFM mRNA affects the susceptibility to Carmustine

NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,411...28,846,348

G

TUB like protein 3

affects response to substance

EXP

TULP3 mRNA affects the susceptibility to Carmustine

NCBI chr12:2,890,891...2,941,138
Ensembl chr12:2,877,223...2,941,138

G

thioredoxin reductase 1

multiple interactions
decreases activity

ISO

[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein
Carmustine results in decreased activity of TXNRD1 protein

PMID:16085187 PMID:16288907

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

UDP glycosyltransferase 8

increases expression

EXP

Carmustine results in increased expression of UGT8 mRNA

NCBI chr 4:114,598,402...114,678,225
Ensembl chr 4:114,598,770...114,678,588

G

UPF1 RNA helicase and ATPase

decreases expression

EXP

Carmustine results in decreased expression of UPF1 mRNA

NCBI chr19:18,831,959...18,868,230
Ensembl chr19:18,831,959...18,868,230

G

vesicle associated membrane protein 4

affects response to substance

EXP

VAMP4 mRNA affects the susceptibility to Carmustine

NCBI chr 1:171,700,160...171,742,065
Ensembl chr 1:171,700,160...171,742,074

G

vesicle amine transport 1 like

affects response to substance

EXP

VAT1L mRNA affects the susceptibility to Carmustine

NCBI chr16:77,788,564...77,980,107
Ensembl chr16:77,788,564...77,980,107

G

VGF nerve growth factor inducible

decreases expression

EXP

Carmustine results in decreased expression of VGF mRNA

NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569

G

very low density lipoprotein receptor

affects response to substance

EXP

VLDLR mRNA affects the susceptibility to Carmustine

NCBI chr 9:2,621,787...2,660,056
Ensembl chr 9:2,621,182...2,660,056

G

WASP family member 2

affects response to substance

EXP

WASF2 mRNA affects the susceptibility to Carmustine

NCBI chr 1:27,404,230...27,490,167
Ensembl chr 1:27,404,230...27,490,167

G

WAP four-disulfide core domain 1

affects response to substance

EXP

WFDC1 mRNA affects the susceptibility to Carmustine

NCBI chr16:84,294,878...84,329,844
Ensembl chr16:84,294,846...84,329,844

G

WAS/WASL interacting protein family member 1

decreases expression

EXP

Carmustine results in decreased expression of WIPF1 mRNA

NCBI chr 2:174,559,574...174,682,913
Ensembl chr 2:174,559,572...174,682,916

G

Wnt family member 5A

affects response to substance

EXP

WNT5A mRNA affects the susceptibility to Carmustine

NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539

G

WT1 transcription factor

decreases response to substance

EXP

WT1 results in decreased susceptibility to Carmustine

NCBI chr11:32,387,775...32,435,539
Ensembl chr11:32,387,775...32,435,564

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

decreases expression

EXP

Carmustine results in decreased expression of YWHAH mRNA

NCBI chr22:31,944,535...31,957,603
Ensembl chr22:31,944,522...31,957,603

G

zinc finger and BTB domain containing 17

decreases expression

EXP

Carmustine results in decreased expression of ZBTB17 mRNA

NCBI chr 1:15,941,869...15,976,101
Ensembl chr 1:15,941,869...15,976,132

G

zinc finger CCCH-type containing 13

affects response to substance

EXP

ZC3H13 mRNA affects the susceptibility to Carmustine

NCBI chr13:45,954,465...46,052,746
Ensembl chr13:45,954,465...46,052,759

G

zinc finger protein 112

affects response to substance

EXP

ZNF112 mRNA affects the susceptibility to Carmustine

NCBI chr19:44,326,553...44,367,217
Ensembl chr19:44,326,555...44,367,217

G

zinc finger protein 189

increases expression

ISO

Carmustine results in increased expression of ZNF189 mRNA

NCBI chr 9:101,398,851...101,410,654
Ensembl chr 9:101,398,851...101,410,660

G

zinc finger protein 655

affects response to substance

EXP

ZNF655 mRNA affects the susceptibility to Carmustine

NCBI chr 7:99,558,642...99,576,453
Ensembl chr 7:99,558,406...99,576,453

G

zyxin

decreases expression

EXP

Carmustine results in decreased expression of ZYX mRNA

NCBI chr 7:143,381,345...143,391,111
Ensembl chr 7:143,381,295...143,391,111

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26827
role	26655
application	25676
pharmaceutical	25100
drug	25097
antineoplastic agent	21529
carmustine	484
Path 2
Term	Annotations
CHEBI ontology	26827
subatomic particle	26803
composite particle	26803
hadron	26803
baryon	26803
nucleon	26803
atomic nucleus	26803
atom	26803
main group element atom	26554
p-block element atom	26554
carbon group element atom	26035
carbon atom	25998
organic molecular entity	25998
heteroorganic entity	25379
organochalcogen compound	24991
organooxygen compound	24621
carbon oxoacid	22985
carboxylic acid	22972
carboacyl group	20181
univalent carboacyl group	20181
carbamoyl group	19703
carboxamide	19703
monocarboxylic acid amide	17095
urea	6502
ureas	6500
N-nitrosoureas	2246
carmustine	484

paths to the root