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Gene: MDM4 (MDM4 regulator of p53) Homo sapiens
Symbol: MDM4
Name: MDM4 regulator of p53
RGD ID: 1319584
Description: Exhibits enzyme binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of nitrogen compound metabolic process; and protein stabilization. Localizes to nucleoplasm. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMFS6; DKFZp781B1423; double minute 4 homolog; double minute 4 protein; double minute 4, human homolog of; HDMX; mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein; MDM4-related protein 1; MDMX; MGC132766; MRP1; p53-binding protein Mdm4
Mus musculus (house mouse) : Mdm4 (transformed mouse 3T3 cell double minute 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mdm4 (MDM4 regulator of p53)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdm4 (MDM4 regulator of p53)
Pan paniscus (bonobo/pygmy chimpanzee) : MDM4 (MDM4 regulator of p53)
Canis lupus familiaris (dog) : MDM4 (MDM4 regulator of p53)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdm4 (MDM4 regulator of p53)
Sus scrofa (pig) : MDM4 (MDM4 regulator of p53)
Chlorocebus sabaeus (African green monkey) : MDM4 (MDM4 regulator of p53)
Heterocephalus glaber (naked mole-rat) : Mdm4 (MDM4 regulator of p53)
more info ...
Related Pseudogenes: MDM4P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1204,516,379 - 204,558,120 (+)EnsemblGRCh38hg38GRCh38
GRCh381204,516,377 - 204,558,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371204,485,507 - 204,596,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,752,134 - 202,786,349 (+)NCBINCBI36hg18NCBI36
Build 341201,217,222 - 201,409,318NCBI
Celera1177,620,715 - 177,662,398 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1175,650,570 - 175,692,491 (+)NCBIHuRef
CHM1_11205,908,863 - 205,950,615 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MDM4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319584
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.