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Gene: MASP1 (mannan binding lectin serine peptidase 1) Homo sapiens
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Symbol: MASP1
Name: mannan binding lectin serine peptidase 1
Description: Exhibits several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Involved in complement activation, lectin pathway and negative regulation of complement activation. Localizes to cytosol; extracellular space; and nucleoplasm. Implicated in 3MC syndrome 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3MC1; C4/C2 activating component of Ra-reactive factor; complement factor MASP-3; complement-activating component of Ra-reactive factor; CRARF; CRARF1; DKFZp686I01199; FLJ26383; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); mannan-binding lectin serine protease 1; mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor); mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; mannose-binding protein-associated serine protease; MAP1; MAp44; MASP; MASP3; MGC126283; MGC126284; PRSS5; Ra-reactive factor serine protease p100; RaRF; serine protease 5
Orthologs:
Mus musculus (house mouse) : Masp1 (mannan-binding lectin serine peptidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Masp1 (mannan-binding lectin serine peptidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Masp1 (mannan binding lectin serine peptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MASP1 (mannan binding lectin serine peptidase 1)
Canis lupus familiaris (dog) : MASP1 (mannan binding lectin serine peptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Masp1 (mannan binding lectin serine peptidase 1)
Sus scrofa (pig) : MASP1 (mannan binding lectin serine peptidase 1)
Chlorocebus sabaeus (African green monkey) : MASP1 (mannan binding lectin serine peptidase 1)
Heterocephalus glaber (naked mole-rat) : Masp1 (mannan binding lectin serine peptidase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3187,217,285 - 187,292,022 (-)EnsemblGRCh38hg38GRCh38
GRCh383187,216,085 - 187,293,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373186,933,873 - 187,009,810 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,418,632 - 188,492,446 (-)NCBINCBI36hg18NCBI36
Build 343188,434,575 - 188,492,172NCBI
Celera3185,365,700 - 185,441,644 (-)NCBI
Cytogenetic Map3q27.3NCBI
HuRef3184,338,300 - 184,414,290 (-)NCBIHuRef
CHM1_13186,897,245 - 186,973,187 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on MASP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733853
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.