KRT8 (keratin 8) - Rat Genome Database

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Gene: KRT8 (keratin 8) Homo sapiens
Analyze
Symbol: KRT8
Name: keratin 8
RGD ID: 735536
HGNC Page HGNC:6446
Description: Enables scaffold protein binding activity. Predicted to be involved in response to hydrostatic pressure and sarcomere organization. Predicted to act upstream of or within several processes, including cell differentiation involved in embryonic placenta development; cell surface receptor signaling pathway; and hepatocyte apoptotic process. Located in cytoplasm and keratin filament. Implicated in liver cirrhosis. Biomarker of liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CARD2; CK-8; CK8; CYK8; cytokeratin 8; cytokeratin-8; K2C8; K8; keratin 8, type II; keratin, type II cytoskeletal 8; keratin-8; KO; type-II keratin Kb8
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: KRT8P1   KRT8P10   KRT8P11   KRT8P12   KRT8P13   KRT8P14   KRT8P15   KRT8P16   KRT8P17   KRT8P18   KRT8P19   KRT8P2   KRT8P20   KRT8P21   KRT8P22   KRT8P23   KRT8P24   KRT8P25   KRT8P26   KRT8P27   KRT8P28   KRT8P29   KRT8P3   KRT8P30   KRT8P31   KRT8P32   KRT8P33   KRT8P34   KRT8P35   KRT8P36   KRT8P37   KRT8P38   KRT8P39   KRT8P4   KRT8P40   KRT8P41   KRT8P42   KRT8P43   KRT8P44   KRT8P45   KRT8P46   KRT8P47   KRT8P48   KRT8P49   KRT8P5   KRT8P50   KRT8P51   KRT8P52   KRT8P6   KRT8P7   KRT8P8   KRT8P9   KRT90P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,897,191 - 52,949,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,897,187 - 52,949,954 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,290,975 - 53,343,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,577,238 - 51,585,127 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,577,241 - 51,585,089NCBI
Celera1252,937,521 - 52,945,403 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,334,669 - 50,387,466 (-)NCBIHuRef
CHM1_11253,257,746 - 53,310,407 (-)NCBICHM1_1
T2T-CHM13v2.01252,861,778 - 52,914,419 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
KRT8HumanChronic Hepatitis C  IEP 14401583protein:increased phosphorylation:liver (human)RGD 
KRT8Humanliver cirrhosis  IEP 14401583protein:increased phosphorylation:liver (human)RGD 
KRT8Humanliver cirrhosis  IAGP 1600062 RGD 
KRT8HumanLiver Injury susceptibilityIMP 14398758DNA:missense mutation:cds:p.S73A (human gene in a mouse model)RGD 
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Original Reference(s)
KRT8HumanCryptogenic Cirrhosis  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Cirrhosis and cryptogenicClinVarPMID:12724528 and PMID:9011570
KRT8HumanCryptogenic Cirrhosis  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Cirrhosis and cryptogenicClinVarPMID:11372009 more ...
KRT8HumanCryptogenic Cirrhosis  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Cirrhosis and cryptogenicClinVarPMID:11372009 more ...
KRT8HumanFamilial Cirrhosis  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Cirrhosis more ...ClinVarPMID:12724528 and PMID:9011570
KRT8HumanFamilial Cirrhosis  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Cirrhosis and familialClinVarPMID:25741868
KRT8Humanhepatitis C  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hepatitis C virus and susceptibility toClinVarPMID:28492532
KRT8Humanhepatitis C  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hepatitis C virus and susceptibility toClinVarPMID:11372009 more ...
KRT8Humanhepatitis C  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hepatitis C virus and susceptibility toClinVarPMID:15090596 and PMID:25741868
KRT8Humanhepatitis C  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hepatitis C virus and susceptibility toClinVar 
KRT8Humaninflammatory bowel disease  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inflammatory bowel diseaseClinVarPMID:15090596 and PMID:25741868
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1 to 10 of 10 rows
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Original Reference(s)
KRT8HumanAcute Liver Failure  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20538000
KRT8Humanadenocarcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15378696
KRT8HumanBreast Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20061804
KRT8HumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
KRT8HumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980 and PMID:25380136
KRT8Humanliver cirrhosis  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:20538000
KRT8HumanLiver Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19409407 and PMID:19796649
KRT8Humanpre-malignant neoplasm  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21472284
KRT8Humanrenal cell carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15108329
KRT8HumanStomach Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15378696
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Object Symbol
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Original Reference(s)
KRT8Human(+)-schisandrin B multiple interactionsISOKrt8 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of KRT8 mRNA]CTDPMID:31150632
KRT8Human(-)-ephedrine multiple interactionsEXP 6480464Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 mRNA] and Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 protein]CTDPMID:37778983
KRT8Human(1->4)-beta-D-glucan multiple interactionsISOKrt8 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of KRT8 mRNACTDPMID:36331819
KRT8Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOKrt8 (Mus musculus)6480464o and p'-DDT results in increased expression of KRT8 mRNACTDPMID:24096037
KRT8Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOKrt8 (Rattus norvegicus)6480464o and p'-DDT results in increased expression of KRT8 mRNACTDPMID:24096037
KRT8Human1,2-dichloroethane increases expressionISOKrt8 (Mus musculus)6480464ethylene dichloride results in increased expression of KRT8 mRNACTDPMID:28960355
KRT8Human1,2-dimethylhydrazine multiple interactionsISOKrt8 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KRT8 mRNACTDPMID:22206623
KRT8Human1-aminobenzotriazole multiple interactionsISOKrt8 (Mus musculus)64804641-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of KRT8 protein]CTDPMID:32435916
KRT8Human1-naphthyl isothiocyanate increases expressionISOKrt8 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of KRT8 mRNACTDPMID:17522070 more ...
KRT8Human1-naphthyl isothiocyanate multiple interactionsISOKrt8 (Mus musculus)6480464O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1 and 2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT8 mRNA]CTDPMID:15913567
KRT8Human1-naphthyl isothiocyanate increases expressionISOKrt8 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of KRT8 mRNACTDPMID:15913567
KRT8Human17alpha-ethynylestradiol multiple interactionsISOKrt8 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRT8 mRNACTDPMID:17942748
KRT8Human17alpha-ethynylestradiol decreases expressionISOKrt8 (Rattus norvegicus)6480464Ethinyl Estradiol results in decreased expression of KRT8 mRNACTDPMID:29097150 and PMID:30387366
KRT8Human17alpha-ethynylestradiol increases expressionISOKrt8 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of KRT8 mRNACTDPMID:15576828 more ...
KRT8Human17alpha-ethynylestradiol increases expressionISOKrt8 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of KRT8 mRNACTDPMID:17942748 more ...
KRT8Human17beta-estradiol decreases expressionISOKrt8 (Rattus norvegicus)6480464Estradiol results in decreased expression of KRT8 mRNACTDPMID:17522070 and PMID:32145629
KRT8Human17beta-estradiol multiple interactionsISOKrt8 (Rattus norvegicus)6480464[bisphenol A co-treated with Estradiol] results in increased expression of KRT8 mRNACTDPMID:26496021
KRT8Human17beta-estradiol increases expressionISOKrt8 (Mus musculus)6480464Estradiol results in increased expression of KRT8 mRNACTDPMID:15289156 more ...
KRT8Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of KRT8 mRNACTDPMID:14605097
KRT8Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of KRT8 mRNA more ...CTDPMID:20061804 and PMID:20823114

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Biological Process

  

Cellular Component
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Object Symbol
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Reference
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Original Reference(s)
KRT8Humanapicolateral plasma membrane located_inIEAUniProtKB:P11679 and ensembl:ENSMUSP00000023952150520179 EnsemblGO_REF:0000107
KRT8Humancell periphery located_inIEAUniProtKB:P11679 and ensembl:ENSMUSP00000023952150520179 EnsemblGO_REF:0000107
KRT8Humancell-cell junction located_inIEAUniProtKB:P11679 and ensembl:ENSMUSP00000023952150520179 EnsemblGO_REF:0000107
KRT8Humancostamere  ISOKrt8 (Rattus norvegicus)9068941 RGDPMID:15247274 and REF_RGD_ID:1600063
KRT8Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
KRT8Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
KRT8Humancytoplasm located_inIDA 150520179 PMID:15846844 and PMID:19188445AgBasePMID:15846844 and PMID:19188445
KRT8Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-6805546 more ...
KRT8Humancytosol located_inIEAARBA:ARBA00029243150520179 UniProtGO_REF:0000117
KRT8Humandystrophin-associated glycoprotein complex  ISOKrt8 (Rattus norvegicus)9068941 RGDPMID:15247274 and REF_RGD_ID:1600063
KRT8Humandystrophin-associated glycoprotein complex part_ofISOKrt8 (Rattus norvegicus)9068941PMID:15247274UniProtPMID:15247274 and REF_RGD_ID:1600063
KRT8Humanextracellular exosome located_inHDA 150520179 PMID:19199708 and PMID:23533145UniProtPMID:19199708 and PMID:23533145
KRT8Humanintermediate filament located_inIEAUniProtKB-KW:KW-0403 and UniProtKB-KW:KW-0416150520179 UniProtGO_REF:0000043
KRT8Humanintermediate filament located_inIEAUniProtKB:P11679 and ensembl:ENSMUSP00000023952150520179 EnsemblGO_REF:0000107
KRT8Humanintermediate filament located_inIDA 150520179 PMID:10852826BHF-UCLPMID:10852826
KRT8Humanintermediate filament cytoskeleton located_inIDA 150520179 HPAGO_REF:0000052
KRT8Humankeratin filament located_inIEAInterPro:IPR003054150520179 InterProGO_REF:0000002
KRT8Humankeratin filament located_inIPI 150520179 PMID:10852826ComplexPortalPMID:10852826
KRT8Humankeratin filament  ISOKrt8 (Rattus norvegicus)9068941 RGDPMID:1370816 more ...
KRT8Humannuclear matrix located_inIEAUniProtKB-SubCell:SL-0181150520179 UniProtGO_REF:0000044
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Molecular Function
1 to 20 of 24 rows

  
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Reference
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Original Reference(s)
KRT8Humanprotein binding  ISOKrt19 (Rattus norvegicus)9068941 RGDPMID:15247274 and REF_RGD_ID:1600063
KRT8Humanprotein binding enablesIPIUniProtKB:P13569150520179 PMID:22038833 and PMID:36012204IntActPMID:22038833 and PMID:36012204
KRT8Humanprotein binding enablesIPIUniProtKB:P05783 and UniProtKB:Q15149150520179 PMID:24940650UniProtPMID:24940650
KRT8Humanprotein binding enablesIPIUniProtKB:P62993150520179 PMID:12577067 and PMID:20936779IntActPMID:12577067 and PMID:20936779
KRT8Humanprotein binding enablesIPIUniProtKB:O75022150520179 PMID:26769854IntActPMID:26769854
KRT8Humanprotein binding enablesIPIUniProtKB:O76015150520179 PMID:31515488IntActPMID:31515488
KRT8Humanprotein binding enablesIPIUniProtKB:P05783 and UniProtKB:Q9Y6K9150520179 PMID:21988832IntActPMID:21988832
KRT8Humanprotein binding enablesIPIUniProtKB:P14079150520179 PMID:22458338IntActPMID:22458338
KRT8Humanprotein binding enablesIPIUniProtKB:Q86V38150520179 PMID:32814053IntActPMID:32814053
KRT8Humanprotein binding enablesIPIUniProtKB:P05783 and UniProtKB:Q13835-2150520179 PMID:10852826IntActPMID:10852826
KRT8Humanprotein binding enablesIPIUniProtKB:P27695150520179 PMID:19188445UniProtPMID:19188445
KRT8Humanprotein binding enablesIPIUniProtKB:P05783 and UniProtKB:P58107150520179 PMID:15671067UniProtPMID:15671067
KRT8Humanprotein binding enablesIPIUniProtKB:P08670150520179 PMID:15846844IntActPMID:15846844
KRT8Humanprotein binding enablesIPIUniProtKB:O76011 more ...150520179 PMID:32296183IntActPMID:32296183
KRT8Humanprotein binding enablesIPIUniProtKB:A1A4E9 more ...150520179 PMID:25416956IntActPMID:25416956
KRT8Humanprotein binding enablesIPIUniProtKB:P35900150520179 PMID:16608857UniProtPMID:16608857
KRT8Humanprotein binding enablesIPIUniProtKB:P05783 and UniProtKB:P08670150520179 PMID:30021884IntActPMID:30021884
KRT8Humanprotein binding enablesIPIUniProtKB:P08670 and UniProtKB:P27958-PRO_0000037566150520179 PMID:15846844AgBasePMID:15846844
KRT8Humanprotein binding enablesIPIUniProtKB:P05783150520179 PMID:10954706 more ...IntActPMID:10954706 more ...
KRT8Humanprotein binding enablesIPIUniProtKB:Q9BT92150520179 PMID:15731013HGNC-UCLPMID:15731013
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Object Symbol
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Term
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Evidence
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Reference
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Source
Original Reference(s)
KRT8HumanInflammation of the large intestine  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Inflammatory bowel diseaseClinVarPMID:15090596 and PMID:25741868

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. A disease- and phosphorylation-related nonmechanical function for keratin 8. Ku NO and Omary MB, J Cell Biol. 2006 Jul 3;174(1):115-25. doi: 10.1083/jcb.200602146.
3. Keratin 8 mutations in patients with cryptogenic liver disease. Ku NO, etal., N Engl J Med. 2001 May 24;344(21):1580-7.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
8. Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Toivola DM, etal., Hepatology. 2004 Aug;40(2):459-66. doi: 10.1002/hep.20277.
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PMID:1371500   PMID:1374067   PMID:1690513   PMID:1691124   PMID:1692965   PMID:1705144   PMID:1711732   PMID:2434381   PMID:2456993   PMID:2459839   PMID:2467436   PMID:2471065  
PMID:2482017   PMID:6186379   PMID:8037842   PMID:8125298   PMID:8895530   PMID:9054461   PMID:9150948   PMID:9211903   PMID:9409741   PMID:9459484   PMID:9560222   PMID:9630597  
PMID:9988531   PMID:10809736   PMID:10852826   PMID:10954706   PMID:11076863   PMID:11581269   PMID:11684708   PMID:11781324   PMID:11788583   PMID:11790298   PMID:11923318   PMID:12168793  
PMID:12218095   PMID:12235123   PMID:12366696   PMID:12367790   PMID:12388748   PMID:12429849   PMID:12474161   PMID:12477932   PMID:12577067   PMID:12724528   PMID:12868678   PMID:14556659  
PMID:14568682   PMID:14744259   PMID:14756564   PMID:15090596   PMID:15194421   PMID:15235035   PMID:15248378   PMID:15252834   PMID:15314064   PMID:15319370   PMID:15489334   PMID:15489336  
PMID:15529338   PMID:15671067   PMID:15731013   PMID:15737616   PMID:15822942   PMID:15838910   PMID:15846844   PMID:15952740   PMID:15972820   PMID:16000376   PMID:16083285   PMID:16143128  
PMID:16169070   PMID:16212417   PMID:16327287   PMID:16341674   PMID:16344560   PMID:16381901   PMID:16565220   PMID:16608857   PMID:16831889   PMID:16892178   PMID:16911694   PMID:16944923  
PMID:16964243   PMID:17034788   PMID:17039343   PMID:17081983   PMID:17126832   PMID:17213200   PMID:17353931   PMID:17373842   PMID:17509943   PMID:17954264   PMID:18236071   PMID:18343496  
PMID:18353540   PMID:18432282   PMID:18497550   PMID:18577580   PMID:18725232   PMID:18941637   PMID:18953437   PMID:19032382   PMID:19115206   PMID:19188445   PMID:19190970   PMID:19199708  
PMID:19204726   PMID:19211765   PMID:19246484   PMID:19282868   PMID:19380743   PMID:19419944   PMID:19585610   PMID:19615732   PMID:19738201   PMID:19755983   PMID:19845941   PMID:20098747  
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KRT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,897,191 - 52,949,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,897,187 - 52,949,954 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,290,975 - 53,343,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,577,238 - 51,585,127 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,577,241 - 51,585,089NCBI
Celera1252,937,521 - 52,945,403 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,334,669 - 50,387,466 (-)NCBIHuRef
CHM1_11253,257,746 - 53,310,407 (-)NCBICHM1_1
T2T-CHM13v2.01252,861,778 - 52,914,419 (-)NCBIT2T-CHM13v2.0
Krt8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,905,146 - 101,912,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,905,133 - 101,912,917 (-)EnsemblGRCm39 Ensembl
GRCm3815101,996,711 - 102,004,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,996,698 - 102,004,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,827,142 - 101,834,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,824,745 - 101,832,317 (-)NCBIMGSCv36mm8
Celera15104,151,508 - 104,159,109 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.2NCBI
Krt8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,002,886 - 135,010,339 (-)NCBIGRCr8
mRatBN7.27133,124,203 - 133,131,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,124,203 - 133,131,728 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,885,801 - 134,893,230 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,115,319 - 137,122,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,093,977 - 137,101,412 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,596,511 - 143,603,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,596,511 - 143,603,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,393,004 - 141,400,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,713,902 - 140,721,199 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,790,339 - 140,797,636 (-)NCBI
Celera7129,561,335 - 129,568,866 (-)NCBICelera
Cytogenetic Map7q36NCBI
Krt8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955458178,954 - 190,310 (-)NCBIChiLan1.0ChiLan1.0
KRT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,287,911 - 41,295,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,284,674 - 41,292,662 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,855,367 - 35,863,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,634,582 - 36,642,564 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,634,582 - 36,642,564 (+)Ensemblpanpan1.1panPan2
KRT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,221,608 - 2,229,343 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,022,937 - 44,030,605 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,222,635 - 2,230,328 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1272,239,283 - 2,246,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,225,535 - 2,233,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,422,008 - 44,429,675 (-)NCBIUU_Cfam_GSD_1.0
Krt8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,910,080 - 62,917,785 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,246,991 - 10,254,827 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,247,049 - 10,254,748 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,167,553 - 18,180,404 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,172,423 - 18,180,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,663,339 - 18,671,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,027,879 - 49,051,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037197,035,944 - 197,043,662 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624904970,136 - 978,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in KRT8
97 total Variants

1 to 10 of 97 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_002273.4(KRT8):c.184G>T (p.Gly62Cys) single nucleotide variant Cirrhosis, cryptogenic [RCV000015735]|not provided [RCV000056938]|not specified [RCV002247346] Chr12:52904798 [GRCh38]
Chr12:52904798..52904799 [GRCh38]
Chr12:53298582 [GRCh37]
Chr12:53298582..53298583 [GRCh37]
Chr12:12q13.13
pathogenic|risk factor|benign|likely benign|uncertain significance|not provided
NM_002273.4(KRT8):c.160T>C (p.Tyr54His) single nucleotide variant Cirrhosis, cryptogenic [RCV000015737]|Hepatitis C virus, susceptibility to [RCV000988859]|not provided [RCV000056936]|not specified [RCV001777139] Chr12:52904822 [GRCh38]
Chr12:53298606 [GRCh37]
Chr12:12q13.13
pathogenic|risk factor|benign|uncertain significance|not provided
NM_002273.4(KRT8):c.1033G>T (p.Ala345Ser) single nucleotide variant Hepatitis C virus, susceptibility to [RCV000049579] Chr12:52898848 [GRCh38]
Chr12:53292632 [GRCh37]
Chr12:12q13.13
not provided
NM_002273.4(KRT8):c.1340C>T (p.Ala447Val) single nucleotide variant Hepatitis C virus, susceptibility to [RCV000049580]|not provided [RCV001455226] Chr12:52897540 [GRCh38]
Chr12:53291324 [GRCh37]
Chr12:12q13.13
likely benign|not provided
NM_002273.4(KRT8):c.1412G>A (p.Gly471Glu) single nucleotide variant Hepatitis C virus, susceptibility to [RCV000049581]|not specified [RCV004018966] Chr12:52897468 [GRCh38]
Chr12:53291252 [GRCh37]
Chr12:12q13.13
uncertain significance|not provided
NM_002273.4(KRT8):c.*31C>T single nucleotide variant not provided [RCV000056922] Chr12:52897397 [GRCh38]
Chr12:53291181 [GRCh37]
Chr12:12q13.13
not provided
NM_002273.4(KRT8):c.*38G>A single nucleotide variant not provided [RCV000056923] Chr12:52897390 [GRCh38]
Chr12:53291174 [GRCh37]
Chr12:12q13.13
not provided
NM_002273.4(KRT8):c.*8C>T single nucleotide variant not provided [RCV000056924] Chr12:52897420 [GRCh38]
Chr12:53291204 [GRCh37]
Chr12:12q13.13
not provided
NM_002273.4(KRT8):c.1021C>T (p.Arg341Cys) single nucleotide variant not provided [RCV000056925] Chr12:52898860 [GRCh38]
Chr12:53292644 [GRCh37]
Chr12:12q13.13
not provided
NM_002273.4(KRT8):c.1022G>A (p.Arg341His) single nucleotide variant not provided [RCV000056926] Chr12:52898859 [GRCh38]
Chr12:53292643 [GRCh37]
Chr12:12q13.13
benign|not provided
1 to 10 of 97 rows

Predicted Target Of
Summary Value
Count of predictions:5281
Count of miRNA genes:1061
Interacting mature miRNAs:1343
Transcripts:ENST00000293308, ENST00000546542, ENST00000546583, ENST00000546826, ENST00000546897, ENST00000546900, ENST00000546921, ENST00000547031, ENST00000547176, ENST00000547413, ENST00000548998, ENST00000549176, ENST00000549198, ENST00000550170, ENST00000551318, ENST00000552150, ENST00000552551, ENST00000552877
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597146903GWAS1242977_Hprostate carcinoma QTL GWAS1242977 (human)3e-18prostate carcinoma125291882852918829Human
597099158GWAS1195232_Hprostate carcinoma QTL GWAS1195232 (human)1e-12prostate carcinoma125293544752935448Human
597098644GWAS1194718_Hprostate carcinoma QTL GWAS1194718 (human)3e-12prostate carcinoma125291514852915149Human
597401055GWAS1497129_Hserum alanine aminotransferase measurement QTL GWAS1497129 (human)1e-08serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)125290129752901298Human
597099217GWAS1195291_Hprostate carcinoma QTL GWAS1195291 (human)2e-10prostate carcinoma125292188152921882Human
597477659GWAS1573733_Hserum alanine aminotransferase measurement QTL GWAS1573733 (human)5e-08serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)125290129752901298Human
597450459GWAS1546533_Hpancreatic carcinoma QTL GWAS1546533 (human)7e-10pancreatic carcinoma125290213352902134Human
597100880GWAS1196954_Hprostate carcinoma QTL GWAS1196954 (human)2e-12prostate carcinoma125293544752935448Human
597203600GWAS1299674_Hfamilial sick sinus syndrome QTL GWAS1299674 (human)9e-14sick sinus syndrome125290479852904799Human
597586066GWAS1642926_Hprostate carcinoma QTL GWAS1642926 (human)3e-26prostate carcinoma125291514852915149Human

1 to 10 of 30 rows
D12S765  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,291,129 - 53,291,563UniSTSGRCh37
Build 361251,577,396 - 51,577,830RGDNCBI36
Celera1252,937,679 - 52,938,113RGD
Cytogenetic Map12q13UniSTS
HuRef1250,334,827 - 50,335,261UniSTS
GDB:376877  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,295,118 - 53,295,467UniSTSGRCh37
Build 361251,581,385 - 51,581,734RGDNCBI36
Celera1252,941,668 - 52,942,017RGD
Cytogenetic Map12q13UniSTS
HuRef1250,338,816 - 50,339,165UniSTS
D17S1697  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
RH79790  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
RH47175  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
GeneMap99-GB4 RH Map12227.97UniSTS
NCBI RH Map12442.2UniSTS
GDB:277179  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
1204 2438 2788 2246 4942 1725 2350 5 624 1803 465 2268 7142 6311 52 3708 1 851 1739 1615 171


1 to 30 of 36 rows
RefSeq Transcripts NG_008402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054372022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI150751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE300986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM854215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX417476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX166336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA051933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA825311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M77025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 36 rows

Ensembl Acc Id: ENST00000293308   ⟹   ENSP00000293308
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,194 - 52,906,618 (-)Ensembl
Ensembl Acc Id: ENST00000546542   ⟹   ENSP00000450228
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,904,676 - 52,907,060 (-)Ensembl
Ensembl Acc Id: ENST00000546583
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,208 - 52,905,052 (-)Ensembl
Ensembl Acc Id: ENST00000546826   ⟹   ENSP00000447881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,899,935 - 52,949,882 (-)Ensembl
Ensembl Acc Id: ENST00000546897   ⟹   ENSP00000447402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,281 - 52,949,824 (-)Ensembl
Ensembl Acc Id: ENST00000546900   ⟹   ENSP00000450340
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,900,588 - 52,903,648 (-)Ensembl
Ensembl Acc Id: ENST00000546921
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,949,216 - 52,949,954 (-)Ensembl
Ensembl Acc Id: ENST00000547031
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,898,469 - 52,901,867 (-)Ensembl
Ensembl Acc Id: ENST00000547176   ⟹   ENSP00000449010
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,899,996 - 52,901,947 (-)Ensembl
Ensembl Acc Id: ENST00000548998   ⟹   ENSP00000447040
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,900,008 - 52,949,776 (-)Ensembl
Ensembl Acc Id: ENST00000549176
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,899,794 - 52,902,204 (-)Ensembl
Ensembl Acc Id: ENST00000549198
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,948,484 - 52,949,831 (-)Ensembl
Ensembl Acc Id: ENST00000550170
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,216 - 52,905,044 (-)Ensembl
Ensembl Acc Id: ENST00000551318
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,948,651 - 52,949,920 (-)Ensembl
Ensembl Acc Id: ENST00000552150   ⟹   ENSP00000449404
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,297 - 52,926,469 (-)Ensembl
Ensembl Acc Id: ENST00000552551   ⟹   ENSP00000447566
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,187 - 52,949,842 (-)Ensembl
Ensembl Acc Id: ENST00000619952   ⟹   ENSP00000489174
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,946,614 - 52,949,874 (-)Ensembl
Ensembl Acc Id: ENST00000692008   ⟹   ENSP00000509398
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1252,897,191 - 52,905,076 (-)Ensembl
RefSeq Acc Id: NM_001256282   ⟹   NP_001243211
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,897,191 - 52,926,469 (-)NCBI
GRCh371253,290,971 - 53,343,650 (-)NCBI
HuRef1250,334,669 - 50,387,466 (-)NCBI
CHM1_11253,257,746 - 53,287,034 (-)NCBI
T2T-CHM13v2.01252,861,778 - 52,891,057 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001256293   ⟹   NP_001243222
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,897,191 - 52,949,860 (-)NCBI
HuRef1250,334,669 - 50,387,466 (-)NCBI
CHM1_11253,257,746 - 53,310,407 (-)NCBI
T2T-CHM13v2.01252,861,778 - 52,914,419 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002273   ⟹   NP_002264
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,897,191 - 52,905,076 (-)NCBI
GRCh371253,290,971 - 53,343,650 (-)NCBI
Build 361251,577,238 - 51,585,127 (-)NCBI Archive
HuRef1250,334,669 - 50,387,466 (-)NCBI
CHM1_11253,257,746 - 53,265,652 (-)NCBI
T2T-CHM13v2.01252,861,778 - 52,869,657 (-)NCBI
Sequence:
RefSeq Acc Id: NR_045962
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,897,191 - 52,949,860 (-)NCBI
GRCh371253,290,971 - 53,343,650 (-)NCBI
HuRef1250,334,669 - 50,387,466 (-)NCBI
CHM1_11253,257,746 - 53,310,407 (-)NCBI
T2T-CHM13v2.01252,861,778 - 52,914,419 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054372022   ⟹   XP_054227997
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01252,861,778 - 52,891,052 (-)NCBI
1 to 30 of 34 rows
Protein RefSeqs NP_001243211 (Get FASTA)   NCBI Sequence Viewer  
  NP_001243222 (Get FASTA)   NCBI Sequence Viewer  
  NP_002264 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227997 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35748 (Get FASTA)   NCBI Sequence Viewer  
  AAA35763 (Get FASTA)   NCBI Sequence Viewer  
  AAA51542 (Get FASTA)   NCBI Sequence Viewer  
  AAB18966 (Get FASTA)   NCBI Sequence Viewer  
  AAH00654 (Get FASTA)   NCBI Sequence Viewer  
  AAH08200 (Get FASTA)   NCBI Sequence Viewer  
  AAH11373 (Get FASTA)   NCBI Sequence Viewer  
  AAH63513 (Get FASTA)   NCBI Sequence Viewer  
  AAH73760 (Get FASTA)   NCBI Sequence Viewer  
  AAH75839 (Get FASTA)   NCBI Sequence Viewer  
  BAD96661 (Get FASTA)   NCBI Sequence Viewer  
  BAF83627 (Get FASTA)   NCBI Sequence Viewer  
  BAF98717 (Get FASTA)   NCBI Sequence Viewer  
  CAA31376 (Get FASTA)   NCBI Sequence Viewer  
  CAA52882 (Get FASTA)   NCBI Sequence Viewer  
  CAA52916 (Get FASTA)   NCBI Sequence Viewer  
  CAA67203 (Get FASTA)   NCBI Sequence Viewer  
  EAW96651 (Get FASTA)   NCBI Sequence Viewer  
  EAW96652 (Get FASTA)   NCBI Sequence Viewer  
  EAW96653 (Get FASTA)   NCBI Sequence Viewer  
  EAW96654 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000293308.6
  ENSP00000447402
  ENSP00000447402.1
  ENSP00000447566.1
  ENSP00000449404
1 to 30 of 34 rows
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_002264   ⟸   NM_002273
- Peptide Label: isoform 2
- UniProtKB: Q6P4C7 (UniProtKB/Swiss-Prot),   Q6GMY0 (UniProtKB/Swiss-Prot),   Q6DHW5 (UniProtKB/Swiss-Prot),   Q53GJ0 (UniProtKB/Swiss-Prot),   Q14717 (UniProtKB/Swiss-Prot),   Q14716 (UniProtKB/Swiss-Prot),   Q14099 (UniProtKB/Swiss-Prot),   F8VXB4 (UniProtKB/Swiss-Prot),   B0AZN5 (UniProtKB/Swiss-Prot),   A8K4H3 (UniProtKB/Swiss-Prot),   Q96J60 (UniProtKB/Swiss-Prot),   P05787 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243222   ⟸   NM_001256293
- Peptide Label: isoform 2
- UniProtKB: Q6P4C7 (UniProtKB/Swiss-Prot),   Q6GMY0 (UniProtKB/Swiss-Prot),   Q6DHW5 (UniProtKB/Swiss-Prot),   Q53GJ0 (UniProtKB/Swiss-Prot),   Q14717 (UniProtKB/Swiss-Prot),   Q14716 (UniProtKB/Swiss-Prot),   Q14099 (UniProtKB/Swiss-Prot),   F8VXB4 (UniProtKB/Swiss-Prot),   B0AZN5 (UniProtKB/Swiss-Prot),   A8K4H3 (UniProtKB/Swiss-Prot),   Q96J60 (UniProtKB/Swiss-Prot),   P05787 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243211   ⟸   NM_001256282
- Peptide Label: isoform 1
- UniProtKB: Q7L4M3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000293308   ⟸   ENST00000293308
Ensembl Acc Id: ENSP00000450228   ⟸   ENST00000546542
IF rod   Keratin type II head

Name Modeler Protein Id AA Range Protein Structure
AF-P05787-F1-model_v2 AlphaFold P05787 1-483 view protein structure

RGD ID:6810327
Promoter ID:HG_ACW:17071
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:KRT8.NAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,583,639 - 51,584,139 (-)MPROMDB
RGD ID:6790185
Promoter ID:HG_KWN:15718
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:NM_002273,   UC009ZMJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,584,766 - 51,585,266 (-)MPROMDB
RGD ID:7224049
Promoter ID:EPDNEW_H17770
Type:initiation region
Name:KRT8_1
Description:keratin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,926,469 - 52,926,529EPDNEW


1 to 40 of 65 rows
Database
Acc Id
Source(s)
COSMIC KRT8 COSMIC
Ensembl Genes ENSG00000170421 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000293308.11 UniProtKB/Swiss-Prot
  ENST00000546897 ENTREZGENE
  ENST00000546897.5 UniProtKB/Swiss-Prot
  ENST00000552150 ENTREZGENE
  ENST00000552150.5 UniProtKB/Swiss-Prot
  ENST00000552551.5 UniProtKB/Swiss-Prot
  ENST00000692008 ENTREZGENE
  ENST00000692008.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
GTEx ENSG00000170421 GTEx
HGNC ID HGNC:6446 ENTREZGENE
Human Proteome Map KRT8 Human Proteome Map
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report hsa:3856 UniProtKB/Swiss-Prot
NCBI Gene 3856 ENTREZGENE
OMIM 148060 OMIM
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 8 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PharmGKB PA30234 PharmGKB
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
  Prefoldin UniProtKB/Swiss-Prot
UniProt A0A0U1RQU6_HUMAN UniProtKB/TrEMBL
  A8K4H3 ENTREZGENE
  B0AZN5 ENTREZGENE
  F8VP67_HUMAN UniProtKB/TrEMBL
  F8VQY3_HUMAN UniProtKB/TrEMBL
  F8VUG2_HUMAN UniProtKB/TrEMBL
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 KRT8  keratin 8    keratin 8, type II  Symbol and/or name change 5135510 APPROVED
2015-01-27 KRT8  keratin 8, type II    keratin 8  Symbol and/or name change 5135510 APPROVED