Krt8 (keratin 8) - Rat Genome Database

Name: Krt8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Krt8 (keratin 8) Chinchilla lanigera

Analyze

Symbol:

Krt8

Name:

keratin 8

RGD ID:

8749760

Description:

ENCODES a protein that exhibits protein-containing complex binding (ortholog); scaffold protein binding (ortholog); INVOLVED IN cell differentiation involved in embryonic placenta development (ortholog); extrinsic apoptotic signaling pathway (ortholog); hepatocyte apoptotic process (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); adenocarcinoma (ortholog); Breast Neoplasms (ortholog); FOUND IN apicolateral plasma membrane (ortholog); cell periphery (ortholog); cell-cell junction (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

keratin 8, type II; keratin, type II cytoskeletal 8

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KRT8 (keratin 8)	NCBI	Ortholog
Mus musculus (house mouse):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955458	178,954 - 190,310 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

adenocarcinoma (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Hepatitis C (ISO)

Cryptogenic Cirrhosis (ISO)

Experimental Liver Cirrhosis (ISO)

Familial Cirrhosis (ISO)

genetic disease (ISO)

hepatitis C (ISO)

inflammatory bowel disease (ISO)

liver cirrhosis (ISO)

Liver Injury (ISO)

Liver Neoplasms (ISO)

pre-malignant neoplasm (ISO)

renal cell carcinoma (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation involved in embryonic placenta development (ISO)

extrinsic apoptotic signaling pathway (ISO)

hepatocyte apoptotic process (ISO)

response to hydrostatic pressure (ISO)

response to other organism (ISO)

sarcomere organization (ISO)

tumor necrosis factor-mediated signaling pathway (ISO)

Cellular Component

apicolateral plasma membrane (ISO)

cell periphery (ISO)

cell-cell junction (ISO)

costamere (ISO)

cytoplasm (ISO)

dystrophin-associated glycoprotein complex (ISO)

intermediate filament (ISO)

intermediate filament cytoskeleton (ISO)

keratin filament (ISO)

sarcolemma (ISO)

Z disc (ISO)

Molecular Function

protein binding (ISO)

protein-containing complex binding (ISO)

scaffold protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Krt8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955458	178,954 - 190,310 (-)	NCBI	ChiLan1.0	ChiLan1.0

KRT8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	52,897,191 - 52,949,860 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	52,897,187 - 52,949,954 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	53,290,975 - 53,343,644 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	51,577,238 - 51,585,127 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	51,577,241 - 51,585,089	NCBI
Celera	12	52,937,521 - 52,945,403 (-)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	50,334,669 - 50,387,466 (-)	NCBI		HuRef
CHM1_1	12	53,257,746 - 53,310,407 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	52,861,778 - 52,914,419 (-)	NCBI		T2T-CHM13v2.0

Krt8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	101,905,146 - 101,912,777 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	101,905,133 - 101,912,917 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	101,996,711 - 102,004,342 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	101,996,698 - 102,004,482 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	101,827,142 - 101,834,773 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	101,824,745 - 101,832,317 (-)	NCBI		MGSCv36	mm8
Celera	15	104,151,508 - 104,159,109 (-)	NCBI		Celera
Cytogenetic Map	15	F2	NCBI
cM Map	15	57.2	NCBI

Krt8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	135,002,886 - 135,010,339 (-)	NCBI		GRCr8
mRatBN7.2	7	133,124,203 - 133,131,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	133,124,203 - 133,131,728 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	134,885,801 - 134,893,230 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	137,115,319 - 137,122,748 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	137,093,977 - 137,101,412 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	143,596,511 - 143,603,745 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	143,596,511 - 143,603,803 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	141,393,004 - 141,400,457 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	140,713,902 - 140,721,199 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	140,790,339 - 140,797,636 (-)	NCBI
Celera	7	129,561,335 - 129,568,866 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

KRT8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	41,287,911 - 41,295,899 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	41,284,674 - 41,292,662 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	35,855,367 - 35,863,248 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	36,634,582 - 36,642,564 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	36,634,582 - 36,642,564 (+)	Ensembl	panpan1.1		panPan2

KRT8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	2,221,608 - 2,229,343 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,022,937 - 44,030,605 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	2,222,635 - 2,230,328 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	27	2,239,283 - 2,246,949 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	2,225,535 - 2,233,175 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	44,422,008 - 44,429,675 (-)	NCBI		UU_Cfam_GSD_1.0

Krt8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	62,910,080 - 62,917,785 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	10,246,991 - 10,254,827 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	10,247,049 - 10,254,748 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KRT8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	18,167,553 - 18,180,404 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	18,172,423 - 18,180,277 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	18,663,339 - 18,671,193 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KRT8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	49,027,879 - 49,051,753 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	197,035,944 - 197,043,662 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Krt8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624904	970,136 - 978,211 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005397487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01047108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01047109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01047110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01007276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01019216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005397487 ⟹ XP_005397544

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955458	178,954 - 190,310 (-)	NCBI

Sequence:

show sequence

TCCTCCCTCCCCTGCCTCCGGGCTGTGTTTTATATAAGGGGCCTTTCCTGGGTGCAGTCCCATC
TTCCAGAAGCAGCTGCCCGGCTCCTTCTTGAATCTTCGTCTTCAGCTCGCCTGCCTCCACCTCA
GCCTCCACCATGTCCATAAGGGTGACCCAGAAGTCCTACAAGGTGTCCACCTCCGGCCCCCGGG
CCTTCAGCAGCCTCTCCTACACCAGCGGGCCCGCTTCCCGCATCAGCTCCTCCAGCTTCTCTCG
AATGGGCAGCAGCGGCAGCTTTCGGGGCGGCCTGGGGCTGGGCGGCTATGGCGGGGCTGGTGGT
GTGGGGGGCATCACAGCCGTCCAGGTGAACCAGAGCCTGCTGAACCCCCTGAACCTGGAGGTGG
ACCCCAACATCCAGGCCGTGCGCATTCAGGAGAAGGAGCAGATCAAGAACCTCAACAACAAGTT
CGCCTCCTTCATCGACAAGGTGCGGTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAGTGG
AGCCTCCTGCAGCAGCAGAAGACCTCCCGTAGTAACATGGACAACATGTTCGAAAGCTATATCA
ACAACCTCCGGCGGCAGCTGGACACACTGGGTCAGGAGAAGCTGAAGCTGGAGGCGGAGCTCGG
CAACATGCAGGGGCTGGTGGAGGACTTCAAGAATAAGTATGAAGATGAGATCAATAAACGTACA
GAGATGGAGAATGAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTTACATGAACAAGGTGG
AGCTCGAGTCTCGCCTGGAAGGGCTGACTGACGAGATCAACTTCCTCAGGCAGCTCTATGAAGA
GGAGATACGCGAGCTGCAGTCTCAGATCTCAGACACTTCTGTGGTGCTGTCCATGGACAACAGC
CGCTCCCTGGACCTGGACGGTATCATCGCTGAGGTCAAGGCCCAGTACGAGGAGATCGCCAACC
GCAGCCGGGCCGAGGCTGAGAGCATGTACCAGATCAAGTATGAAGAGCTGCAGACTCTGGCTGG
GAAGCACGGGGATGACCTCCGCCGCACGAAGTCTGAGATCTCTGAGATGAACCGCAGCATCAGC
CGCCTCCAGGCGGAGATTGAGGCCCTCAAAGGCCAGAGAGCATCCCTGGAGGCCGCCATCGCCG
ATGCCGAGCAGCGCGGGGAGATGGCCATTAAGGATGCCAACGCCAAGCTGGCCCAGCTGGAGGC
CGCCCTGCAGAAGGCCAAGCAGGACATGGCCCGCCAGCTGCGTGAGTACCAGGAGCTCATGAAC
GTCAAGCTGGCGCTGGACATCGAGATTGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAGAACA
GGCTGGAGGCTGGGATGCAGAACTTGAGTATCCACACGAAGACCACCAGTGGCTATGCAGGAGT
GGTGAGCTCACCGTATGGGGGCCTCACAAGCCCTGGCTTTGGGACCCTCCAAAGCCCTGGCTTC
ACCCGCACCAAGTCTGCCGTGGTCGTGAAGAAGATCGAGACCCGTGATGGGAAGCTGGTGTCTG
AGACCTCTGATGTCCTACCCAAGTGAATGGGCCACAGCAGCCTCTCCCAGCCCATACCCCGCCT
GTAGCTGCCCCAGAGCCTGTGGGGGAGACAGCTGCACATGGGAGCATTGGGAACAAGAGACCCA
CCTGAGGCTCAGCCCTAGTCCTCAGCCCACCCTTGCGGGGAATCTACTGCCTGGGGTACCCCTT
CTTGCCCATGCCCTTCACCAAAAACCAATTGAATTGTTTTTTCCAAAATAAAGCCTGGTTTTGC
CACCTGAA

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Protein Sequences


Protein RefSeqs	XP_005397544	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005397544 ⟸ XM_005397487

- Sequence:

show sequence

MSIRVTQKSYKVSTSGPRAFSSLSYTSGPASRISSSSFSRMGSSGSFRGGLGLGGYGGAGGVGG
ITAVQVNQSLLNPLNLEVDPNIQAVRIQEKEQIKNLNNKFASFIDKVRFLEQQNKMLETKWSLL
QQQKTSRSNMDNMFESYINNLRRQLDTLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEME
NEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSL
DLDGIIAEVKAQYEEIANRSRAEAESMYQIKYEELQTLAGKHGDDLRRTKSEISEMNRSISRLQ
AEIEALKGQRASLEAAIADAEQRGEMAIKDANAKLAQLEAALQKAKQDMARQLREYQELMNVKL
ALDIEIATYRKLLEGEENRLEAGMQNLSIHTKTTSGYAGVVSSPYGGLTSPGFGTLQSPGFTRT
KSAVVVKKIETRDGKLVSETSDVLPK

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Krt8	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Krt8	keratin 8		keratin 8, type II	Symbol and/or name change	5135510	APPROVED
2015-08-25	Krt8	keratin 8, type II		keratin 8	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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